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Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma

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癌症 2003年第7期22卷 752-752页

作者： rhines ld DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H

OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain ***,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor *** r eport the use of a novel polymeric mic rosphere delivery vehicle to release *** demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat *** microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the *** two agents administered locally show a s ynergistic ***:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor ***:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of *** combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,***:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with

关键词：实验性神经胶质瘤 IL-2 腔内化疗

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Local immunotherapy with interleukin - 2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma.

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中国神经肿瘤杂志 2003年第2期1卷 81-81页

作者： rhines ld DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H Department of Neurosurgery University of Texas M. D.Anderson Cancer CenterHoustonTexas.

OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain ***,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor *** report the use of anovel polymeric microsphere delivery vehicle to release *** demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat *** microspheres are used to deliver IL-2,and biodegradable polymer wafers

关键词： BCNU Local immunotherapy with interleukin from delivered from biodegradable polymer microspheres combined with interstitial chemotherapy a novel treatment for experimental malignant glioma for with

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