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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.maleki Ahmad reza Bahrami maryam m.matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

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Temperature-jump tensile tests to induce optimized TRIP/TWIP effect in a metastable austenitic stainless steel

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International Journal of minerals,metallurgy and materials 2024年第9期31卷 2025-2036页

作者： mohammad Javad Sohrabi Hamed mirzadeh Saeed Sadeghpour Abdol reza Geranmayeh reza mahmudi School of metallurgy and materials Engineering College of EngineeringUniversity of Tehran14395-515TehranIran Centre for Advanced Steels Research Materials and Mechanical EngineeringUniversity of Oulu90014 OuluFinland

In the present work,plastic deformation mechanisms were initially tailored by adjusting the deformation temperature in the range of 0 to 200℃ in AISI 304L austenitic stainless steel,aiming to optimize the strength-ductility *** was shown that the combined twinning-induced plasticity(TWIP)/transformation-induced plasticity(TRIP)effects and a wider strain range for the TRIP effect up to higher strains by adjusting the deformation temperature are good strategies to improve the strength-ductility synergy of this metastable stainless *** this regard,by consideration of the observed temperature-dependency of plastic deformation,the controlled sequence of TWIP and TRIP effects for archiving superior strength-ductility trade-off was intended by the pre-designed temperature jump tensile ***,the optimum tensile toughness of 846 mJ/m^(3) and total elongation to 133% were obtained by this strategy via exploiting the advantages of the TWIP effect at 100℃ and the TRIP effect at 25℃ at the later stages of the ***,a deformation-temperature-transformation(DTT)diagram was developed for this metastable ***,based on work-hardening analysis,it was found that the main phenomenon constraining further improvement in the ductility and strengthening was the yielding of the deformation-induced α′-martensite.

关键词： metastable stainless steels transformation-induced plasticity twinning-induced plasticity stacking fault energy mechanical properties

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AGGREGATE SPECIAL FUNCTIONS TO APPROXImATE PERmUTING TRI-HOmOmORPHISmS AND PERmUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS

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Acta mathematica Scientia 2024年第1期44卷 311-338页

作者： Safoura rezaei ADERYANI Azam AHADI reza SAADATI Hari m.SRIVASTAVA School of mathematics Iran University of Science and TechnologyNarmakTehranIran Department of mathematics and Statistics Universtity of VictoriaVictoriaCanada Department of medical Research China Medical University HospitalChina Medical UniversityTaichung40402China Department of mathematics and Informatics Azerbaijan University71 Jeyhun Hajibeyli StreetAZ1007BakuAzerbaijan Section of mathematics International TelematicUniversity UninettunoI-00186RomeItaly

In this paper,we define a new class of control functions through aggregate special *** class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem.

关键词： permuting tri-homomorphism in Banach algebra permuting tri-derivation on C*-algebra fixed point theorem Ulam-Hyers-Rassias stability aggregate special functions tri-additiveψ-functional inequality

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Particle size distribution in a multi-zone circulating fluidized bed polymerization reactor

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Particuology 2024年第10期93卷 291-299页

作者： mohammadhossein Hadadiyan Navid mostoufi reza marandi Process Design and Simulation Research Centre School of Chemical EngineeringCollege of EngineeringUniversity of TehranP.O.Box 11155-4563TehranIran Polymer Research Group Petrochemical Research and Technology CompanyNational Petrochemical CompanyP.O.Box 14358/84711TehranIran

This research focuses on modeling a multi-zone circulating reactor(mZCR)in the polypropylene production *** these reactors,designed for polyolefin production,small catalyst particles(20–300μm)initiate polymerization in the presence of monomer *** reactor consists of two main regions:the riser and the *** riser operates in the fast fluidization and the downer is in the moving bed *** the two-fluid model with the Eulerian-Eulerian approach,the dynamics of both solid and gas phases were modeled by applying Newton's laws of motion and assuming spherical *** population balance of particles within the reactor was also coupled with the equations of *** simultaneous solution of these equations provides valuable insights into particle and fluid behavior,revealing trends such as the growth of polymer ***,the impact of various operating conditions was *** study also examined the effects of design parameters(gas inlet velocity,average inlet diameter,and temperature)on the system *** instance,it was shown that in the case where the solid circulation flux is 30 kg/(m^(2) s)the velocity of particles in the bed increases from 0.4 at the inlet to 1.1 m/s in the fully developed zone,when it is 43 kg/(m^(2) s)the velocity of particles increases from 0.3 to 1.4 m/s,and when it is 55 kg/(m^(2) s),it is increased from 0.22 to 1.5 m/***,trends in particle size distribution based on temperature adjustments were *** study showed that higher temperatures accelerate the polymerization reaction rate,promoting faster growth kinetics and the formation of larger particles.

关键词： Fluidization Polymerization Gas-solid flow multi-zone circulating reactor(mZCR) CFD-PBm Two-fluidmodel

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Using satellite-derived land surface temperatures to clarify the spatiotemporal warming trends of the Alborz mountains in northern Iran

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Journal of mountain Science 2024年第2期21卷 449-469页

作者： ROSHAN Gholamreza SARLI reza GHANGHERmEH Abdolazim TAHERIZADEH mehrnoosh NIKNAm Arman Department of Geography Golestan UniversityGorgan 49138-15759Iran Department of Forest Resources management Faculty of ForestryUniversity of Agriculture in KrakowAL.29 Listopada 4631-425 KrakówPoland Department of Geoinformatics Physical and Environmental GeographyUniversity of SzegedSzeged 6722Hungary

The Alborz mountains are some of the highest in Iran,and they play an important role in controlling the climate of the country’s northern *** land surface temperature(LST)is an important variable that affects the ecosystem of this *** study investigated the spatiotemporal changes and trends of the nighttime LST in the western region of the Central Alborz mountains at elevations of 1500-4000 m above sea *** data were extracted for the period of 2000-2021,and the mann-Kendall nonparametric test was applied to evaluating the changes in the *** results indicated a significant increasing trend for the monthly average LST in may-August along the southern *** the northern and southern aspects showed decreasing trends for the monthly average LST in October,November,and march and an increasing trend in other *** all elevations,the average decadal change in the monthly average LST was more severe along the southern aspect(0.60°C)than along the northern aspect(0.37°C).The LST difference between the northern and southern aspects decreased in the cold months but increased in the hot *** the same elevation,the difference in the lapse rate between the northern and southern aspects was greater in the hot months than in the cold *** increasing elevation,the lapse rate between the northern and southern aspects *** change was concluded to greatly decrease the difference in LST at different elevations for April-July.

关键词： Global warming mountainous areas Lapse rate Surface air temperatures Alborz

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Improvement of Surface mechanical and Tribological Characteristics of L-PBF Processed Commercially Pure Titanium through Ultrasonic Impact Treatment

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Acta metallurgica Sinica(English Letters) 2024年第6期37卷 1034-1046页

作者： Iman Ansarian reza Taghiabadi Saeid Amini mohammad Hossein mosallanejad Luca Iuliano Abdollah Saboori Department of materials Science and metallurgy Imam Khomeini International University(IKIU)QazvinIran Department of mechanical Engineering University of KashanKashanIran Integrated Additive manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

multi-pass ultrasonic impact treatment(UIT)was applied to modify the microstructure and improve the mechanical and tribological characteristics at the near-surface region of commercially pure Ti(CP-Ti)specimens produced by the laser powder bed fusion(L-PBF)*** considerably refined the L-PBF process-related acicular martensites(α′-m)and produced a well-homogenized and dense surface microstructure,where the porosity content of 1-,3-,and 5-pass UITed samples was reduced by 43,60,and 67%,*** UITed samples showed an enhancement in their near-surface mechanical properties up to a depth of about 300μ*** nanoindentation results for the 3-pass UITed sample revealed an increase of about 53,45,and 220%in its nanohardness,H/E_(r),and H_(3)/E_(r)^(2)indices,*** stylus profilometry results showed that performing the UIT removed the L-PBF-related features/defects and offered a smooth *** roughness average(R_(a))and the skewness(R_(sk))of the 3-pass UITed sample were found to be lower than those of the L-PBFed sample by 95 and 223%,*** the UIT also enhanced the material ratio,where the maximum load-bearing capacity(~100%)in as-L-PBFed(as-built)and 3-pass UITed samples was obtained at 60-and 10-µm depths,*** tribological investigations showed that applying the UIT resulted in a significant reduction of wear rate and average coefficient of friction(COF)of *** instance,under the normal pressures of 0.05 and 0.2 mPa,the wear rate and COF of the 3-pass UITed sample were lower than those of the L-PBFed sample by 65 and 58%,and 20 and 17%,respectively.

关键词： Laser powder bed fusion Ultrasonic impact treatment Commercially pure Ti(CP-Ti) Surface mechanical properties Tribological properties

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Effect of age on the standardized ileal amino acid digestibility of soybean meal and canola meal in broilers

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Animal Nutrition 2024年第1期16卷 11-22页

作者： mukti Barua m.reza Abdollahi Faegheh Zaefarian Timothy J.Wester Channarayapatna K.Girish Peter V.Chrystal Velmurugu Ravindran monogastric Research Center School of Agriculture and Environment Massey University Department of Animal Science and Nutrition Faculty of Veterinary Medicine Chattogram Veterinary and Animal Sciences University Nutrition and Care Animal NutritionEvonik (SEA) Pte. Ltd Complete Feed Solutions

Standardized ileal digestibility coefficients (SIDC) of nitrogen (N) and amino acids (AA) in two protein sources (soybean meal [SBm] and canola meal [Cm]) were investigated at six broiler ages (d 7, 14, 21, 28, 35, and 42). Two assay diets were formulated to contain either SBm (413 g/kg) or Cm (553 g/kg) as the sole dietary AA source. Titanium dioxide (5 g/kg) was added as an indigestible marker. A total of 696 male broilers at 1 d old were allotted to 12 replicate cages per age group. Each assay diet was offered to birds for 4 d prior to the ileal digesta collection on d 7 (14 birds/cage), 14 (12 birds/cage), 21 (10 birds/cage), 28 (8 birds/cage), 35 (8 birds/cage) and 42 (6 birds/cage), respectively. The apparent digestibility coefficients were standardized using age-specific basal endogenous AA flows. In the SBm group, though the SIDC of N tended to be influenced (quadratic; P=0.075) by age, no linear or quadratic response of age effect was observed on the average SIDC of indispensable (IAA) and total AA (TAA). An age effect (quadratic; Pm with the highest value recorded at d 7, followed by a decrease from d 14 to 28, which increased beyond d 35. The SIDC of some individual AA (Arg, Thr, Trp, Cys, Pro) were affected (Pmanner by age. In the Cm, the SIDC of N, average SIDC of IAA, DAA and TAA were influenced (quadratic; Pm d 7 to 14, declined at d 21, and then increased beyond d 28. The average SIDC of IAA was low between d 7 and 28 and increased thereafter. The SIDC of individual AA were affected (linear or quadratic; Pmagnitudes by age. The age influence on the SIDC AA was variable, depending on the protein source and AA. The results demonstrate that age-specific SIDC AA data might need consideration in broiler feed formulations.

关键词： Age Amino acid Broiler Digestibility Protein source

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Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

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Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin David Hwang Hossein Zamani Siboni Ehsanollah Fathi reza Chaji Dayan Ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal InC. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-LEDs)with a metal–insulator-semiconductor(mIS)structure on the sidewall are proposed to improve *** this mIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the ***(EL)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the *** band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)*** suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of mIS micro-LEDs in future fabrication.

关键词： micro-LED GaN EQE improvement micro-fabrication

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未热解厚热障涂层的隔热能力和黏接强度

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Transactions of Nonferrous metals Society of China 2024年第4期34卷 1226-1236页

作者： mohammad IZADINIA reza SOLTANI mahmoud HEYDARZADEH SOHI Javad mOSTAGHImI School of metallurgy and materials Engineering College of EngineeringUniversity of TehranTehranIran Centre for Advanced Coating Technologies Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoOntarioCanada

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTm C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和... 详细信息

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTm C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和DVC TTBC的黏接强度分别比TTBC高35%和25%。这可能是由于UPTTBC结构中存在亚微米尺度的未熔化区域,起到了阻止裂纹扩展的作用。此外,隔热测试的结果表明,DVCTTBC涂层的隔热能力最差,为0.28℃/μm,而UPTTBC涂层的隔热能力最强,为0.40℃/μm。由于UPTTBCs显微组织中存在亚微米区域,使涂层展现出优越的隔热能力。相反,DVCTTBC因其致密的结构,具有最低的隔热能力。

关键词：厚热障涂层密集垂直裂纹热障涂层未热解粉末黏接强度隔热能力

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A multi-objective and CFD based optimization of roof-flap geometry and position for simultaneous drag and lift reduction

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Propulsion and Power Research 2024年第1期13卷 26-45页

作者： mohammad Rostamzadeh-Renani mohammadreza Baghoolizadeh S.mohammad Sajadi reza Rostamzadeh-Renani Narjes Khabazian Azarkhavarani Soheil Salahshour Davood Toghraie Energy Department Politecnico di MilanoVia Lambruschini 4Milan 20156Italy Department of mechanical Engineering Shahrekord UniversityShahrekord 88186-34141Iran Department of Nutrition Cihan University-ErbilKurdistan RegionIraq Department of mechanical Engineering Jami Institute of TechnologyIsfahanIran Faculty of Engineering and Natural Sciences Istanbul Okan UniversityIstanbulTurkey Faculty of Engineering and Natural Sciences Bahcesehir UniversityIstanbulTurkey Department of Computer Science and mathematics Lebanese American UniversityBeirutLebanon Department of mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahrIran

As the transport sector is responsible for the consumption of a vast proportion of the oil produced,it is mandatory to research feasible solutions to tackle this *** appli-cation of aerodynamic attachments for passiveflow control and reducing resisting aerodynamic forces such as drag and lift is one of the most practicable ways to minimize vehicle energy *** are one of the most innovative aerodynamic attachments that can enhance theflow motion in the boundary layer at the trailing edge of the *** the present paper,theflap is designed and modeled for controlling the airflow at the roof-end of a 2D Ahmed body model,inspired by the schematic of theflap at the trailing edge of the *** a result,theflap’s geometry and position from the roof-end of the car model are parameterized,which leads to having four design *** objective functions of the present study are the vehicle’s drag coefﬁcient and lift coefﬁcient.25 Design of Experiment(DOE)points are considered enabling the Box-Behnken ***,each DOE point is modeled in the computational domain,and theflow-ﬁeld around the model is simulated using Ansys Fluent *** results obtained for the DOE points are employed by different regressors,and the relation between design variables and objective functions is extracted using *** GmDH-ANN is then coupled with three types of optimization algorithms,among which the Genetic algorithm proves to have the most ideal coupling process for ***,af-ter analyzing the variations in the geometry and position of the roofflap from the car roof-end,the roof-flap with speciﬁcations of L=0.1726 m,a=5.0875°,H=0.0188 m,and d=0.241 m can optimize the car drag and lift coefﬁcients by 21.27%and 19.91%,*** present research discusses the opportunities and challenges of optimal design roof-flap geometry and its influence on car aerodynamic performance.ª2024 The *** services by Elsevier *** behal

关键词： Drag coefﬁcient Lift coefﬁcient Roofflap Computationalfluid dynamics Artiﬁcial neural

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