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Validation of a Novel Method for Cardiac Output Estimation by CT Coronary Angiography

Advances in Computed Tomography 2012年第2期1卷 11-16页

作者： Hetal H. Mehta Brian G. Choi reza sanai Raman S. Dusaj Amr Mohsen Chunlei Liang Jannet F. Lewis Robert K. Zeman Department of Mechanical and Aerospace Engineering The George Washington University Washington DC USA Department of Medicine The George Washington University Washington DC USA Department of Radiology The George Washington University Washington DC USA

Background: Cardiac output can be estimated during retrospectively gated CT coronary angiography by anatomically determining left ventricular volumes;prospective triggering to minimize radiation precludes this methodology. We propose an alternative method for cardiac output estimation based on preclinical models suggesting that cardiac output may be inversely related to contrast washout from the aortic root during timing bolus scanning, as measured by peak aortic root contrast attenuation. Methods: 34 patients had CT coronary angiography timing bolus performed with 20 ml iodixanol at 5.5 ml/s followed by 20 ml normal saline at 5.5 ml/s through an 18-Ga antecubital catheter. Peak aortic root contrast attenuation was correlated to cardiac output calculated by echocardiography using heart rate stroke volume from biplane Simpson’s ***: Mean age was 58 ± 13 years;body surface area, 2.0 ± 0.5 m2. 53% were women. Stroke volume, cardiac output and cardiac index were 67 ± 19 ml, 4.5 ± 1.6 L/min, and 2.2 ± 0.7 L/min/m2, respectively. Peak aortic root contrast attenuation was 207 ± 46 HU and correlated to cardiac output and cardiac index with r = –0.64, p Conclusion: This novel method for cardiac output estimation by CTCA appears feasible. The CT physiologic parameters using the timing test-bolus data moderately correlated with echocardiographic assessment of cardiac output. The calculation of cardiac output adds important hemodynamic data to anatomic information provided by CTCA, and further development of this method may preserve assessment of left ventricular performance in prospective triggering.

关键词： Cardiac Output Coronary CT Angiography Hemodynamics Prospective Triggering Validation

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Simultaneous determination of LY3214996,abemaciclib,and M2 and M20 metabolites in human plasma,cerebrospinal fluid,and brain tumor by LC-MS/MS

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Journal of Pharmaceutical Analysis 2022年第4期12卷 601-609页

作者： Tigran Margaryan Mackenna Elliott Nader sanai Artak Tovmasyan Ivy Brain Tumor Center Barrow Neurological InstitutePhoenixAZ85013USA

A sensitive and rapid liquid chromatography tandem mass spectrometry(LC-MS/MS)method was established for the quantification of total and unbound concentrations of LY3214996,an extracellular signal-regulated kinase inhibitor;abemaciclib,a cyclin-dependent kinase 4/6 inhibitor;and abemaciclib active metabolites,M2 and M20,in human plasma,brain tumor,and cerebrospinal fluid *** method was validated over a concentration range of 0.2e500 nM within a total run time of 3.8 min using isocratic elution on a Kinetex^(TM) F_(5) *** was performed on a Sciex QTRAP 6500t mass spectrometer employing multiple reaction monitoring mode under positive electrospray *** intra-and inter-batch accuracy as well as the precision of the method for all matrices was within ±20% and ≤20% at the lower limit of quantification,and within ±15% and ≤15% for other quality control levels for all *** unbound fractions of drugs and metabolites in spiked and patient samples were determined using an optimized equilibrium *** validated method was successfully applied in a phase 0/2 clinical trial to assess the central nervous system penetration of LY3214996 and abemaciclib.

关键词： LC-MS/MS LY3214996 Abemaciclib Brain tumor penetration Equilibrium dialysis

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A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor

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Journal of Pharmaceutical Analysis 2018年第1期8卷 20-26页

作者： Xun Bao Jianmei Wu Nader sanai Jing Li Karmanos Cancer Institute Wayne State University Barrow Neurological Institute St. Joseph's Hospital& Medical Center

A rapid, sensitive, and robust reversed-phase liquid chromatography with tandem mass spectrometry method was developed and validated for the determination of total and unbound ceritinib, a secondgeneration ALK inhibitor, in patient plasma and brain tumor tissue samples. Sample preparation involved simple protein precipitation with acetonitrile. Chromatographic separation was achieved on a Waters ACQUITY UPLC BEH C_(18) column using a 4-min gradient elution consisting of mobile phase A(0.1% formic acid in water) and mobile phase B(0.1% formic acid in acetonitrile), at a flow rate of 0.4 m L/min. Ceritinib and the internal standard([^(13)C_6]ceritinib) were monitored using multiple reaction monitoring mode under positive electrospray ionization. The lower limit of quantitation(LLOQ) was 1 n M of ceritinib in plasma. The calibration curve was linear over ceritinib concentration range of 1–2000 n M in plasma. The intra-and interday precision and accuracy were within the generally accepted criteria for bioanalytical method( o15%).The method was successfully applied to assess ceritinib brain tumor penetration, as assessed by the unbound drug brain concentration to unbound drug plasma concentration ratio, in patients with brain tumors.

关键词： Ceritinib Reversed-phase liquid chromatography with tandem mass spectrometry (LC–MS/MS) Fraction unbound in plasma Fraction unbound in brain tissue Brain tumor penetration Unbound brain-to-plasma partition coefficient

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Six Minute Walk Test to assess functional capacity in chronic liver disease patients

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World Journal of Gastroenterology 2007年第29期13卷 3996-4001页

作者： Hatem F Alameri Faisal M sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo Unit of Pulmonary Medicine Department of Medicine King Saud University Riyadh Saudi Arabia Hepatology Division Department of Medicine Riyadh Military Hospital Riyadh Saudi Arabia Unit of Gastroenterology Department of Medicine King Saud University Riyadh Saudi Arabia

AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis.

关键词： Six Minute Walk Test Chronic liver disease Functional capacity

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Management of nonalcoholic fatty liver disease in the Middle East

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World Journal of Gastroenterology 2020年第25期26卷 3528-3541页

作者： Faisal M sanai Faisal Abaalkhail Fuad Hasan Muhammad Hamed Farooqi Nawal Al Nahdi Zobair M Younossi Gastroenterology Unit Department of MedicineKing Abdulaziz Medical CityJeddah 21423Saudi Arabia Department of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Liver Transplant King Fahad Specialist HospitalDammam 32253Saudi Arabia Department of Internal Medicine Faculty of MedicineKuwait UniversitySafat 13110Kuwait Dubai Diabetes Center Dubai Health AuthorityDubai 00000United Arab Emirates Department of Gastroenterology and Hepatology Dubai Health AuthorityRashid hospitalDubai 00000United Arab Emirates Department of Medicine Inova Fairfax Medical CampusFalls ChurchVA 22042United States

The prevalence of nonalcoholic fatty liver disease(NAFLD)in the Middle East is increasing in parallel to an increase in the prevalence of associated risk factors such as obesity,metabolic syndrome,and type 2 diabetes *** 20%to 30%of the patients progress to develop nonalcoholic steatohepatitis(NASH),a histological subtype of NAFLD,with features of hepatocyte injury such as hepatocyte *** can progress to fibrosis,cirrhosis,and even hepatocellular *** thus causes a substantial burden on healthcare systems and it is imperative that appropriate strategies are discussed at a regional level to facilitate effective management tailored to the needs of the *** fulfil this unmet need,expert gastroenterologists,hepatologists,and endocrinologists from the region came together in three advisory board meetings that were conducted in Saudi Arabia,United Arab Emirates,and Kuwait,to discuss current local challenges in NAFLD screening and diagnosis,and the different available management *** experts discussed the disease burden of NAFLD/NASH in the Middle East;screening,diagnosis,and referral patterns in NAFLD;and available treatment options for NAFLD and *** paper summarizes the discussions and opinion of the expert panel on the management of NAFLD/NASH and also presents an extensive literature review on the topic.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Middle East Expert opinion

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Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia

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World Journal of Gastroenterology 2006年第43期12卷 7019-7024页

作者： Ayman A Abdo Badr M Al-Jarallah Faisal M sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh Gastroenterology Division Faculty of Medicine King Saud University Riyadh Saudi Arabia Gastroenterology Unit Department of Medicine McGill University Montreal Canada Hepatology Division Department of Medicine Riyadh Military Hospital Riyadh Saudi Arabia

AIM： To identify the most common hepatitis B virus （HBV） genob/pe in Saudi Arabia, and correlate the prevailing genob/pes with the clinical outcome of patients. METHODS： Patients were consecutively recruited from the hepatology clinics of two tertiary care referral centers. Patients were categorized into 4 different groups： group 1, patients with hepatitis B and normal liver enzymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen （HBsAg）. Genob/ping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS： Seventy patients were enrolled in this study. They were predominantly male （72.9%） in their midforty＇s （mean age 47 years）. Forty-nine （70%） patients were hepatitis B envelope antigen （HBeAg） negative. The majority of patients （64%） acquired HBV through unknown risk factors. Hepatitis B genob/ping revealed that 57 patients （81.4%） were genob/pe D, 1 patient （1.4%） had genob/pe A, 1 patient （1.4%） had genotype C, and 4 patients （5.7%） had genob/pe E, while 7 patients （10%） had mixed genob/pe （4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG）. Based on univariate analysis of genob/pe D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase （all P 〈 0.001）. In multivariate analysis decreased hemoglobin （r = -0.05; 95% CI： -0.08 to -0.03; P = 0.001） and albumin levels （r = -0.004; 95% CI： -0.007 to -0.001; P = 0.002） were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver disease （P = 0.024）. CONCLUSION： This study highlights tha

关键词： Hepatitis B virus Genotype D Cirrhosis Hepatocellular carcinoma Saudi Arabia

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不同焊接顺序的汽车用S355J2G3钢工字梁焊接结构变形和残余应力的有限元预测

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热加工工艺 2013年第9期42卷 192-195页

作者：郭三爱新疆交通职业技术学院汽车与机电工程学院新疆乌鲁木齐831401

基于焊接热弹塑性有限元分析理论,采用焊接专用有限元分析软件对不同焊接顺序的汽车用S355J2G3钢工字梁焊接结构手工MAG焊接过程进行了数值仿真,获得不同焊接顺序下焊接结构的变形和残余应力分布。模拟时,选择双椭球焊接热源模型,考虑... 详细信息

基于焊接热弹塑性有限元分析理论,采用焊接专用有限元分析软件对不同焊接顺序的汽车用S355J2G3钢工字梁焊接结构手工MAG焊接过程进行了数值仿真,获得不同焊接顺序下焊接结构的变形和残余应力分布。模拟时,选择双椭球焊接热源模型,考虑了材料热物理性能与温度的非线性关系,以及相变潜热对温度场的影响。重点研究了焊缝及临近焊缝区域焊接残余应力和变形的分布特征,并进行了理论分析。

关键词： S355J2G3钢焊接变形残余应力有限元分析

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手工MAG焊接Q345D钢工字梁结构热特性的有限元分析

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热加工工艺 2013年第7期42卷 183-185,188页

作者：郭三爱新疆交通职业技术学院汽车与机电工程学院新疆乌鲁木齐831401

采用焊接专用有限元分析软件对Q345D低合金高强钢工字梁焊接结构手工MAG焊接过程进行数值仿真,分析最优热输入条件下的温度场分布、熔池形态及熔池邻近区域金属升降温速率。此外,结合Q345D钢连续冷却组织转变图(CCT曲线),预测了焊缝及... 详细信息

采用焊接专用有限元分析软件对Q345D低合金高强钢工字梁焊接结构手工MAG焊接过程进行数值仿真,分析最优热输入条件下的温度场分布、熔池形态及熔池邻近区域金属升降温速率。此外,结合Q345D钢连续冷却组织转变图(CCT曲线),预测了焊缝及热影响区的微观组织组成。研究结果可为下一步预测该焊接变形和残余应力的分布提供热学方面的理论借鉴。

关键词： Q345D钢焊接温度场热循环曲线有限元分析

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