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Phytosomal curcumin alleviates collagen-induced arthritis by downregulating Th17 and upregulating Treg cell responses in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第11期12卷 466-474页

作者： Mahnaz Ramezani Nahid Zainodini reza nosratabadi Yaser Yousefpoor Zahra Taghipour Mitra Abbasifard Mohammad reza Rahmani Immunology of Infectious Diseases Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Medical Immunology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Gastroenterology and Hepathology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran Department of Medical Biotechnology School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran Khalil Abad Health Center Mashhad University of Medical SciencesMashhadIran Department of Anatomy School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Department of Internal Medicine Ali-Ibn Abi-Talib HospitalSchool of MedicineRafsanjan University of Medical SciencesRafsanjanIran Physiology-Pharmacology Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Physiology and Pharmacology School of MedicineRafsanjan University of Medical SciencesRafsanjanIran

Objective:To explore the effects of a nano-formulation of curcumin(phytosomal curcumin)on the clinical and pathological symptoms of collagen-induced arthritis(CIA)in ***:Forty male Wistar rats were immunized with an emulsion containing bovine typeⅡcollagen and incomplete Freund's adjuvant and then administered phytosomal curcumin *** symptoms and histological analysis of the synovial tissues were *** effect of phytosomal curcumin on Th17 and Treg parameters was also ***:Phytosomal curcumin reduced the clinical severity and paw swelling in CIA-induced rats,which was accompanied by a reduction in the number of inflammatory cell infiltration in the synovial ***,treatment with phytosomal curcumin significantly inhibited CIA-associated mediators as well as increased the anti-inflammatory mediators in comparison to the control ***:Phytosomal curcumin could improve CIA autoimmune responses and can be considered a potential candidate for the treatment of rheumatoid arthritis.

关键词： Phytosomal curcumin Rheumatoid arthritis Collagen Th17 Treg Anti-inflammation Curcuma longa

Caraway extract alleviates atopic dermatitis by regulating oxidative stress,suppressing Th2 cells,and upregulating Th1 cells in mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 421-429页

作者： Fardin Khajepour Mohammad reza Zangouyee Arezu Khosravimashizi Ali Afgar Vahideh Abdollahi Shahriar Dabiri reza nosratabadi Department of Medical Immunology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Research Center for Hydatid Disease in Iran Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Student Research Committee Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Department of Animal Biology Kharazmi UniversityTehranIran Department of Pathology Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Pathology and Stem Cells Research Center Afzalipour Faculty of MedicineKerman University of Medical SciencesKermanIran Gastroenterology and Hepathology Research Center Institute of Basic and Clinical Physiology SciencesKerman University of Medical SciencesKermanIran

Objective:To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis(AD)in ***:AD was induced in two stages,including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%,*** symptoms and histological analysis of the skin were *** effects of caraway on oxidant/antioxidant parameters as well as Th1-and Th2-related cytokines were also ***:Caraway reduced the severity of dermatitis in AD-induced mice,as evidenced by significant inhibition of Th2-related cytokines(IL-4 and IL-13)and increased Th1-related cytokine(IFN-γ).Additionally,treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD ***,caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and ***:Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.

关键词： Carum carvi L. Caraway Atopic dermatitis 2,4 dinitrochlorobenzene Th2 Th1 Oxidative stress

Personalized clinical managements through exploring circulating neural cells and electroencephalography

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World Journal of Experimental Medicine 2023年第4期13卷 75-94页

作者： Parvin Mehdipour Nima Fathi Masoud nosratabadi Department of Medical Genetics Tehran University of Medical SciencesTehran 14176-1315Iran Neuro-Science Paarand Specialized Center for Human EnhancementTehran 157699304Iran Department of Research Paarand Specialized Center for Human EnhancementTehran 157699304Iran

BACKGROUND Since an initial diagnosis of Alzheimer disease(AD)in 1907,early detection,was unavailable through 116 ***-regulation of V-Ets erythroblastosis virus E26 oncogene homolog 2(Ets2)is capable to enhance neuronal susceptibility and *** expression(PE)of Ets2 has functional impact on AD and Down’s syndrome,with diverse *** of Ets2 has an influential pathogenic impact on *** aspects of neurological disorders directly interact with psychological ***,deterioration requires an early management including programmed based *** To include cell biology in neuro-genetics;personalized,prognostics,predictive,preventive,predisposing(5xP)platform,accompanied by stratifying brain channels behavior pre-and post-intervention by light music in the *** Include exploration of PE assay and electroencephalography of brain *** processes are applied according to:(1)Triangle style,by application of cellular network;and(2)PE assay of Ets2 in the peripheral blood of the patients with AD,by Manual single cell based analysis,and Flow-cytometry.(1)Applying the Genetic counselling and pedigree analysis;(2)considering the psychological status of the referral cases;(3)considering the macro-and/or micro-environmental factors;(4)performing the required Genetics’analysis;and(5)applying the required complementary test(s).RESULTS PE of Ets2 has pathogenic role in *** unmasked the nature of heterogeneity/diversity/course of evolution by exploring Ets2,D1853N polymorphism in Ataxia Telangiectasia mutated gene(ATM),vascular endothelial growth factor(VEGF),epidermal growth factor(EGF)and course of evolution at the single cell level of the ***2 revealed different cellular behavior in the blood and suggested the strategy as‘Gene Product-Based Therapy’and the personalized managements for the *** reflected weak expression of ATM,mosaic pattern of Ets2;remarkable expression of VEGF and EGF by highlighting

关键词： Alzheimer Protein expression Brain channels Predictive/early detection

Comparative study of self-compassion and sense of coherence in nurses of psychiatric hospitals

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Frontiers of Nursing 2023年第2期10卷 193-201页

作者： Iman nosratabadi Golnaz Forough Ameri Sedigheh Iranmanesh Neda Asadi Nursing Research Center Kerman University of Medical SciencesKerman ***Iran Razi School of Nursing and Midwifery Kerman University of Medical SciencesKerman ***Iran

Objective:Nurses,due to the nature of their job,are subjected to various forms of stress and physical and psychological ***-compassion and a sense of coherence have attracted much attention in research in recent years as having high potential for improving the health and performance of people in the *** present study aimed to compare self-compassion and the sense of coherence in nurses working in psychiatric hospitals and other hospitals of Kerman University of Medical ***:The present study was a descriptive-comparative study of applied type conducted on 100 nurses of Shahid Beheshti Psychiatric Hospital in Kerman by the census method and 100 nurses of other hospitals of Kerman University of Medical Sciences by the stratified random sampling *** instruments included the self-compassion questionnaire and the sense of coherence *** were analyzed using the Statistical Package for Social Sciences ***:The results of the present study showed that self-compassion and sense of coherence were higher in psychiatric nurses(39.35±7.7 and 53.02±8.01)than among other nurses(36.03±5.81 and 49.76±6.30).There was a direct and moderate relationship between a sense of coherence and self-compassion(P-value<0.005).The higher the score of compassion for oneself,the higher was the score of sense of ***,the sense of coherence had a direct and weak relationship with all dimensions of self-compassion,except for the extreme imitation dimension,which showed a direct and moderate relationship to other dimensions(P-value<0.001).Conclusions:Self-compassion and a sense of coherence,as a form of self-communication,increase nurses’satisfaction and reduce nurses’job stress and,as a result,job performance is improved.

关键词： nurses psychiatric hospital self-compassion sense of coherence compassion coherence