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Pharmacokinetic Comparison and Bioequivalence Evaluation of Two 20-mg Vonoprazan Fumarate Tablets in Bangladeshi Healthy Male Subjects

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Journal of Biosciences and Medicines 2024年第8期12卷 230-243页

作者： Md. Alimur reza Uttom Kumar Bhowmik Sabrina Akter Tushi Nayan Ghosh Nithon Chandra Sahana Md. Ashraful Islam Nafisa Ahamed Arifa Akram Novus Clinical Research Services Ltd. Dhaka Bangladesh Medical College for Women & Hospital Dhaka Bangladesh National Institute of Laboratory Medicine & Referral Centre (NILMRC) Dhaka Bangladesh

Background: Vonoprazan fumarate, a novel potassium-competitive acid blocker, outperforms traditional proton pump inhibitors in acid suppression and can be effectively combined with antibiotics to eradicate Helicobacter pylori. Objective: The study aimed to determine if two Vonoprazan formulations—Vonoprazan Fumarate 20 mg Tablet of Beximco Pharmaceuticals Limited, Bangladesh (test product) and Takecab 20 mg Tablet of Takeda Pharmaceutical Company Limited, Japan (reference product)—met FDA’s bioequivalence requirements by comparing their pharmacokinetic characteristics in healthy Bangladeshi adults. Methods: This was a single-center, randomized, open-label, two-period, two-sequence, laboratory-blind, double-crossover experiment. After 10 hours of fasting, 18 subjects were randomly assigned to receive a single oral dose of either formulation. During each treatment period, blood samples were collected at specific times (pre-dose and up to 48 hours post-dose) to measure plasma Vonoprazan levels using liquid chromatography-tandem mass spectrometry. A non-compartmental model was used to calculate pharmacokinetic parameters using the plasma drug concentration-time profile. A statistical comparison of the pharmacokinetic parameters of the two formulations of the test and reference product was conducted using SAS® statistical software to assess the bioequivalence. Primary pharmacokinetic parameters (Cmax, AUC0-t, and AUC0-∞) and secondary parameters (Tmax, T1/2, Kel, and AUC extrapolation) were calculated for both drug formulations. If the confidence intervals for the natural log-transformed Cmax, AUC0-t, and AUC0-∞ values fell between 80% and 125%, the drug products would be considered bioequivalent. Result: The geometric mean ratio of Vonoprazan between the test and reference groups was found to be 109.04% (99.47% - 119.53%), 101.37% (95.58% - 107.50%), and 101.24% (95.43% - 107.41%), with 90% confidence intervals (CIs) for the Cmax, AUC0–t, and AUC0–∞, and these outcomes

关键词： Bioequivalence Vonoprazan Pharmacokinetics

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Role of molecular imaging in prognosis,diagnosis,and treatment of gastrointestinal cancers:An update on new therapeutic methods

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World Journal of Methodology 2024年第4期14卷 43-60页

作者： Mobina Fathi Hayder Jasim Taher Sabah Jassim Al-Rubiae Shirin Yaghoobpoor Ashkan Bahrami reza Eshraghi Hossein Sadri Mahsa Asadi Anar Ali Gholamrezanezhad Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Department of Radiology Hilla University CollegeBabylon 00964Iraq Faculty of Medicine Kashan University of Medical SciencesKashan ***Iran Department of Radiology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033United States

One of the leading causes of cancer-related death is gastrointestinal cancer,which has a significant morbidity and mortality *** preoperative risk assessment is essential for directing patient care,its biological behavior cannot be accurately predicted by conventional imaging *** pathophysiological information in anatomical imaging that cannot be visually identified can now be converted into high-dimensional quantitative image features thanks to the developing discipline of molecular *** order to enable molecular tissue profile in vivo,molecular imaging has most recently been utilized to phenotype the expression of single receptors and targets of biological *** is expected that molecular imaging will become increasingly important in the near future,driven by the expanding range of biological therapies for *** this live molecular fingerprinting,molecular imaging can be utilized to drive expression-tailored customized *** technical aspects of molecular imaging are first briefly discussed in this review,followed by an examination of the most recent research on the diagnosis,prognosis,and potential future clinical methods of molecular imaging for GI tract malignancies.

关键词： Molecular imaging Personalized medicine Gastrointestinal cancers Positron emission tomography-computed tomography

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Cooperative Neuro Adaptive Control of Leader Following Uncertain Multi-Agent Systems with Unknown Hysteresis and Dead-Zone

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Journal of Systems Science & Complexity 2020年第2期33卷 312-332页

作者： SHAHNAZI reza Department of Electrical Engineering Faculty of EngineeringUniversity of GuilanRasht ***Iran

In this paper,a cooperative adaptive control of leader-following uncertain nonlinear multiagent systems is *** communication network is weighted undirected graph with fixed *** uncertain nonlinear model for each agent is a higher-order integrator with unknown nonlinear functions,unknown disturbances and unknown input ***,the gains of input actuators are unknown nonlinear functions with unknown *** most common behaviors of input actuators in practical applications are hysteresis and *** this paper,backlash-like hysteresis and dead-zone are used to model the input *** universal approximation theorem proved for neural networks,the unknown nonlinear functions are *** unknown weights of neural networks are derived by proposing appropriate adaptive *** cope with modeling errors and disturbances an adaptive robust structure is *** Lyapunov synthesis approach not only all the adaptive laws are derived but also it is proved that the closed-loop network is cooperatively semi-globally uniformly ultimately bounded(CSUUB).In order to investigate the effectiveness of the proposed method,it is applied to agents modeled with highly nonlinear mathematical equations and inverted *** results demonstrate the effectiveness and applicability of the proposed method in dealing with both numerical and practical multi-agent systems.

关键词： Adaptive neural network backlash-like hysteresis dead-zone leader-following multi-agent systems weighted undirected graph

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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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Nullors, and Nullor Circuits; There Applications in Symbolic Circuit Analysis and Design

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Applied Mathematics（应用数学） 2024年第1期

作者： reza Hashemian

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Enhanced empirical models for predicting the drift capacity of less ductile RC columns with flexural,shear,or axial failure modes

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1251-1270页

作者： Mohammad reza AZADI KAKAVAND reza ALLAHVIRDIZADEH Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversity of InnsbruckInnsbruck 6020Austria ISISE Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal

Capacity of components subjected to earthquake actions is still a widely interesting research topic. Hence, developing precise tools for predicting drift capacities of reinforced concrete (RC) columns is of great interest. RC columns are not only frequently constructed, but also their composite behavior makes the capacity prediction a task faced with many uncertainties. In the current article, novel empirical approaches are presented for predicting flexural, shear and axial failure modes in RC columns. To this aim, an extensive experimental database was created by collecting outcomes of previously conducted experimental tests since 1964, which are available in the literature. It serves as the basis for deriving the equations for predicting the drift capacity of RC columns by different regression analyses (both linear with different orders and nonlinear). Furthermore, fragility curves are determined for comparing the obtained results with the experimental results and with previously proposed models, like the ones of ASCE/SEI41-13. It is demonstrated that the proposed equations predict drift capacities, which are in better agreement with experimental results than those computed by previously published models. In addition, the reliability of the proposed equations is higher from a probabilistic point of view.

关键词： flexural-shear-axial failure drift capacity reinforced concrete columns statistical analysis fragility curves

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Exponential B-spline collocation method for numerical solution of the generalized regularized long wave equation

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Chinese Physics B 2015年第5期24卷 177-190页

作者： reza Mohammadi Department of Mathematics University of Neyshabur

The aim of the present paper is to present a numerical algorithm for the time-dependent generalized regularized long wave equation with boundary conditions. We semi-discretize the continuous problem by means of the Crank-Nicolson finite difference method in the temporal direction and exponential B-spline collocation method in the spatial direction. The method is shown to be unconditionally stable. It is shown that the method is convergent with an order of θ（k2 ＋ h2）. Our scheme leads to a tri-diagonal nonlinear system. This new method has lower computational cost in comparison to the Sinc-collocation method. Finally, numerical examples demonstrate the stability and accuracy of this method.

关键词： solitary waves GRLW equation exponential B-spline collocation

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Detection mechanism and classification of design principles of peroxidase mimic based colorimetric sensors: A brief overview

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1492-1503页

作者： Ali reza Hormozi Jangi Mohammad reza Hormozi Jangi Saeed reza Hormozi Jangi Department of Chemistry College of SciencesShiraz UniversityShiraz 71454Iran

Synthesis and characterization of enzyme mimics with characteristic stability and high catalytic efficiency is an interesting field for ***,with the development of nanoscience and introducing of Fe3O4 magnetic nanoparticles as peroxidase mimics in 2007,various nanomaterials such as noble metals,metal oxides,and carbon materials were introduced as enzyme mimics(nanozymes).Various nanomaterials exhibit peroxidaselike activity,hence,most of the nanozymes are peroxidase *** the nanozyme based sensors were previously classified,the classifications have been focused on the type of nanozyme ***,the nanozyme based sensors were classified as peroxidase,hydrolase,and urease mimic-based ***,heretofore,these sensors are not classified based on the detection mechanism and principles of system *** aim of this review is the focus on the peroxidase mimic based colorimetric sensors as the most common nanozyme-based sensors and their classification based on principles of sensor design and review of the detection mechanism of the current mimic peroxidase based ***,some current challenges and future developments in this field are discussed.

关键词： Peroxidase mimic Nanozyme Enzyme-peroxidase mimic hybrids HP sensing pH sensing Enzyme co-embedded nanomaterials

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Power Quality Assessment of Voltage Positive Feedback Based Islanding Detection Algorithm

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Journal of Modern Power Systems and Clean Energy 2020年第4期8卷 787-795页

作者： reza Bakhshi-Jafarabadi reza Ghazi Javad Sadeh Electrical Engineering Department Faculty of EngineeringFerdowsi University of MashhadMashhadIran

Islanding refers to a condition where distributed generators(DGs)inject power solely to the local load after electrical separation from power *** islanding detection methods(IDMs)categorized into remote,active,and passive groups have been reported to detect this undesirable *** active techniques,a disturbance is injected into the DG’s controller to drift a local yardstick out of the permissible *** this disturbance leads to more effective detections even in well-balanced island,it raises the total harmonic distortion(THD)of the output current under the normal operation *** paper analyzes the power quality aspect of the modified sliding mode controller as a new active IDM for grid-connected photovoltaic system(GCPVS)with a string *** performance is compared with the voltage positive feedback(VPF)method,a well-known active *** evaluation is carried out for a 1 k Wp GCPVS in MATLAB/Simulink platform by measuring the output current harmonics and THD as well as the efficiency under various penetration and disturbance *** output results demonstrate that since the proposed disturbance changes the amplitude of the output current,it does not generate harmonics/***,it has a negligible adverse effect on power *** is finally concluded that the performance of the sliding mode-based IDM is reliable from the standpoints of islanding detection and power quality.

关键词： Islanding detection method(IDM) power quality sliding mode controller total harmonic distortion(THD) voltage positive feedback(VPF)

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Casting fluidity,viscosity,microstructure and tensile properties of aluminum matrix composites with different Mg_(2)Si contents

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Rare Metals 2022年第8期41卷 2767-2776页

作者： reza Vatankhah Barenji Department of Industrial Engineering Hacettepe UniveristyBeytepe Campus06800AnkaraTurkey

The effect of Mg_(2)Si amount on the properties of Al-Mg_(2)Si as-cast composites was investigated in this *** with different amounts of Mg_(2)Si(15 wt%,20 wt%and 25 wt%)were fabricated,and the fluidity,viscosity,porosity formation and tensile properties were then *** addition,optical microscope and scanning electron microscope were used for micros tructural studies and *** results reveal that with the amount of Mg_(2)Si increasing,the morphology of the primary Mg_(2)Si becomes irregular,the size of primary Mg_(2)Si increases,fluidity decreases,viscosity increases,and porosity amount *** reason for the higher amounts of porosities is the lower fluidity and higher *** addition,Al-15%Mg_(2)Si shows better tensile properties and higher quality index compared to other ***,the fracture surface of the composite with lower Mg_(2)Si amount reveals more ductile mode than those with higher Mg_(2)Si amount.

关键词： Al-Mg_(2)Si Microstructure Fluidity Tensile behavior Porosity

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