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Geometric triangular chiral hexagon complexes and clonal embryogenic body organization on the Turin Shroud crucified man image: A predictable tissue response to injury

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Natural Science 2013年第10期5卷 1102-1111页

作者： Jairo A. diaz Department of Pathology Medicine School Laboratory of Pathology Hospital Departmental of Villavicencio Hospital Departmental of Granada University Cooperative of Colombia Villavicencio Colombia

The shroud continues to remain one of the most studied and controversial artifacts in human history. Many tests, X-ray fluorescence, reflectance, spectrometry and low energy/high-resolution X ray transmission have shown that the crucified body is not compatible with a painted image. Researchers confirm that the alleged blood is real blood. We documented the self-assembly of geometric triangular chiral hexagon complex (GTCHC) with structural organization of embryoid bodies in cancer tissues. The identification of these structures is not only limited to malignant tumors but also appears in extreme injured tissues. Our interest is to determine if we can predict and identify these patterns in the Shroud of Turin. Based on pattern recognition image was analyzed over 100 shroud images. We identified a central spectral emission line that exhibits a characteristic signature on a plot of residual electromagnetic radiation, head area narrowing and low extremities broadening, indication of decay energy changes in the velocity of the molecules in the traversal trajectory. This Electromagnetic collision event generates in the cloth stagnant blood areas with patterns identical to those identified for us in cancer damage tissues. Inflammatory cytokines activate stem cells and Notch signaling proteins in cascade of interactions to generate real clonal human embryoid template. Can we predict function from structure? These structures evoke life, regeneration, but not death. Our findings suggest the image of a crucified man on the Shroud of Turin is a real physical electromagnetic collision event in response to extreme tissue injury, with the fact that supports our previous findings in cancer tissues as real and predictable. Proteins derived from these emergent damage tissue derivate stem cells could be used to design biologic templates in regenerative medicine and develop novel strategies in cancer therapy.

关键词： Turin Shroud Geometric Triangular Chiral Hexagon Embryogenic

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Computational solution of an acid-mediated tumor-growth radial model under logistic growth regimes for normal and cancer cells

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International Journal of Biomathematics 2023年第3期16卷 45-62页

作者： Farhan Khan Mudassar Abbas Jorge E.Macias-diaz Muhammad Bilal Khan Safar M.Alghamdi Department of Mathematics and Computer Sciences University of Palermo 90133 PalermoItaly Department of Mathematics and Applications “R.Caccioppoli”University of Naples Federico iiVia Cintia 80126NaplesItaly Department of Mathematics School of Digital Technologies Tallinn University10120 TallinnEstonia Departamento de Matematicas y Fisica Universidad Autonoma de Aguascalientes AguascalientesAgs.20131Merico Department of Mathematics COMSATS University Islamabad Islambad44000 Pakistan Department of Mathematics and Statistics College of Science Taif University Taif 21944Saudi Arabia

Tumor invasion follows a complex mechanism which involves cell migration and *** study the processes in which primary and secondary metastases invade and damage the normal cells,mathematical models are often extremely *** this paper,we present a mathematical model of acid-mediated tumor growth consisting of radially symmetric reaction-diffusion *** assumption on the radial symmetry of the solutions is imposed here in view that tumors present spherical symmetry at the microscopic ***,we consider various empirical mechanisms which describe the propagation of tumors by considering cancer cells,normal cells,and the concentration of H+*** other assumptions,we suppose that these components follow logistictype growth ***,this is an important difference with respect to various other mathematical models for tumor growth available in the ***,we also add competition terms of normal and tumor cells *** carry out a balancing study of the equations of the model,and a numerical model is proposed to produce *** practical remarks derived from our assumptions are provided in the discussion of our simulations.

关键词： Cancer growth model radially symmetric system acid-mediated tumor growth computer simulations

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Infuence of elemental composition in environmental impacts of steel

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Journal of Iron and Steel Research International 2020年第5期27卷 598-607页

作者： E.Batuecas C.Mayo R.diaz F.J.Perez Thermal and Fluid Engineering Department Carlos III University of Madrid28911 LeganesMadridSpain Chemical and Materials Engineering Department Complutense University of Madrid28040 MadridSpain Technical Sciences and Engineering UDIMA University28400 Collado VillalbaMadridSpain。

The environmental behavior of four steels was *** the operation phase of concentrating solar power plants,steels withstand high temperature because of its contact with molten ***,choosing the steel type for the molten salt tanks remains a great *** the cold tank,carbon steel is usually used although an approach with low chromium content steel is being studied for these ***,in high temperature applications,such as hot store tank,austenitic stainless steel is the most frequent ***,ferritic steel is being considered as a promising material in these *** many researchers studied the steel technical properties without considering their environmental damages,this work aimed to introduce the environmental aspects into the material choice by using the life cycle assessment *** one hand,the results showed the environmental adequacy of carbon steel against low chromium content *** the other hand,the results obtained in those steels suitable in high temperature application revealed signifcant environmental benefts from the ferritic steel instead of the austenitic steel.

关键词： Renewable energy Concentrating solar power Life cycle assessment Molten salt Ferritic steel Austenitic steel

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A position resolution MRPC for muon tomography

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Chinese Physics C 2014年第4期38卷 50-54页

作者：樊星明王义王学武曾智曾鸣赵自然程建平 D.Gonzalez-diaz Key Laboratory of Particle & Radiation Imaging (Tsinghua University) Ministry of EducationDepartment of Engineering Physics Tsinghua University Laboratorio de Física Nuclear y Altas Energías University of Zaragoza

Muon tomography is a promising method in the detection and imaging of high Z material. In general, considering the quality of track reconstruction in imaging, a detector of good position resolution, high efficiency and large area is required. This paper presents the design and study of a prototype of position sensitive MRPC with 0.15 mm narrow gas gap and 2.54 mm strip readout. Through a cosmic-ray experiment, the performance of MRPC module is carefully observed and each channel is calibrated. Through an X ray experiment with a narrow slit, the position resolution is studied. The results show that the time resolution of the module can reach 61ps and the spatial resolution can reach 0.36 mm.

关键词： MRPC muon tomography position resolution

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Draft genome of the Native American cold hardy grapevine Vitis riparia Michx.‘Manitoba 37’

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Horticulture Research 2020年第1期7卷 1676-1688页

作者： Sagar Patel Michael Robben Anne Fennell Jason P.Londo Dilmini Alahakoon Roberto Villegas-diaz Padmapriya Swaminathan Agronomy Horticulture and Plant Science Department and BioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Grape Genetics Research Unit USDA ARSGenevaNY 14456USA

Vitis riparia,a critically important Native American grapevine species,is used globally in rootstock and scion breeding and contributed to the recovery of the French wine industry during the mid-19th century phylloxera *** species has abiotic and biotic stress tolerance and the largest natural geographic distribution of the North American grapevine *** we report an Illumina short-read 369X coverage,draft de novo heterozygous genome sequence of *** Michx.‘Manitoba 37’with the size of~495 Mb for 69,616 scaffolds and a N50 length of 518,740 *** RNAseq data,40,019 coding sequences were predicted and *** with Universal Single-Copy Orthologs(BUSCO)analysis of predicted gene models found 96%of the complete BUSCOs in this *** assembly continuity and completeness were further validated using *** ESTs,BACs,and three de novo transcriptome assemblies of three different *** genotypes resulting in>98%of respective sequences/transcripts mapping with this *** of the *** assembly and predicted CDS with the latest ***‘PN40024’CDS and genome assembly showed 99%CDS alignment and a high degree of *** analysis of plant transcription factors indicates a high degree of homology with the *** transcription *** mapping to ***‘Manitoba 37’and *** PN40024 has identified genetic relationships to phenotypic variation between *** assembly provides reference sequences,gene models for marker development and understanding ***’s genetic contributions in grape breeding and research.

关键词： continuity globally alignment

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Diagnosis of Laron syndrome using monoplex-polymerase chain reaction technology with a whole-genome amplification template: A case report

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World Journal of Clinical Cases 2019年第23期7卷 4029-4035页

作者： Adina Neumann Miguel Angel Alcantara-Ortigoza Ariadna Gonzalez-del Angel Felipe Camargo-diaz Esther Lopez-Bayghen Laboratorio de Investigacion y Diagnostico Molecular Instituto de Infertilidad y Genetica Mexico SCINGENESMexico City 05320Mexico Instituto Nacional de Pediatria Torre de InvestigacionMexico City 04530Mexico Laboratorio de Biologia Molecular Departamento de Genetica HumanaInstituto Nacional de PediatriaMexico City 04530Mexico Departamento de Toxicologia Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional(CINVESTAV-IPN)Mexico City 07360Mexico

BACKGROUND Laron syndrome(LS)is an autosomal recessive hereditary condition affecting only 1/1000000 *** cause is associated with mutations in the growth hormone(GH)receptor(GHR),leading to GH *** patients typically present with severe growth retardation,obesity,and abnormal sexual ***,LS diagnosis is performed ***,we assessed the efficiency of Pre-implantation Genetic Testing(PGT)coupled with monoplex-polymerase chain reaction(PCR)technology for detecting this monogenic disease in embryos from a couple confirmed as LS heterozygous carriers CASE SUMMARY The couple LS-carriers were confirmed by the presence of a first child born with *** couple underwent a standard in vitro fertilization(IVF)*** was collected from trophectoderm cells from day 5 *** genome amplification(WGA)was performed using a Sureplex DNA Amplification System and analyzed by PCR,targeting the deletion of the exons 5 and 6 in the GHR gene as well as PGT by Next-generation Sequencing(Illumina).Eleven embryos were collected and analyzed.27.3%were the wild type for GHR,45.5%were heterozygotes,and 18.2%homozygous *** embryo yielded no *** 2-embryos transfers were performed;2 normal homozygous and four heterozygous carriers were selected for *** first two transfers were unsuccessful,whereas the final transfer with two heterozygous embryos resulted in clinical *** genomic composition of the fetus was verified,applying the same techniques using amniocytes,extracted after 21 wk of the ongoing *** fetus was confirmed as GHR deletion in exon 5-6,carrier.A non-affected baby was *** Here,we present a case demonstrating that using WGA as a template in addition to PCR targeting specific gene regions,exons 5 and 6 on the GHR gene,could identify LS carrier *** provides evidence that WGA and PCR serve as an excellent tool to detect this specific monogenic disease in IVF e

关键词： Growth hormone insensitivity Growth hormone receptor mutations Intragenic deletions Molecular diagnosis Embryo diagnosis Laron syndrome Case report

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Electromagnetic Field Released in Collision-Impact Events Generate in the Matrix Interface Fractal Scalable Invariant Geometric Triangular Chiral Hexagonal Structures

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Open Journal of Geology 2013年第3期3卷 187-200页

作者： Jairo A. diaz Department of Pathology Medicine School Laboratory of Pathology Hospital Department of Villavicencio Hospital Department of Granada University Cooperative of Colombia Villavicencio Colombia

In biology, cancer is the most beautiful natural model of a chaotic system, which under uncontrolled proliferations, generates extreme disorder that finally causes intercellular collisions. The authors have described and documented fractal self-assembly of geometric triangular chiral hexagonal crystal-like complex organizations (GTCHC) and interface comet tail effect patterns in cancer processes. According to this novel observation cancer incorporates a real visualization world with a great surprising finding in biology, physics, and geology. This visualization platform literally allows us to see what would otherwise remain completely invisible. From theory to practice this irreducible geometric matrix allowed us to identify in geology, real measurable green infrared-electromagnetic stripe line in interface with hexagonal geomorphic pattern, triangular chiral pyramidal rock structures, geology well defined mirror images, template platform to bio signature characterization of ancestral primitive polar head-tail organization, embryoid and human-like shape pattern embedded as giant fossils in rocks that have never been seen before. Electromagnetic field released in collision-impact events generate in the matrix interphase fractal scalable invariant order of geometric triangular chiral hexagonal structures. The laws of biology and geology can finally be redirected to the laws of physics;specifically magnetic fields create a new kind of classification based on these fractal structural similarities of the relationship. Further interdisciplinary collaboration must be carried out to study these geometric self-assembly geological structures, ancient sediments and rocks that could provide insights into antecedents of life.

关键词： Electromagnetic Fields Geomorphic Patterns Irreducible Geometric Matrix

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Mesenchymal stem cells and cell-free preparations for treating atopic dermatitis

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BIOCELL 2022年第11期46卷 2363-2367页

作者： TRINIDAD MONTERO-VILCHEZ MANUEL SANCHEZ-diaz CAROLINA MONTERO-VILCHEZ ALVARO SIERRA-SANCHEZ SALVADOR ARIAS-SANTIAGO Dermatology Department Virgen de las Nieves University HospitalGranadaSpain Instituto de Investigación Biosanitaria Granada GranadaSpain Pharmacy Department Virgen de las Nieves University HospitalGranadaSpain Dermatology Department Faculty of MedicineUniversity of GranadaGranadaSpain

Atopic dermatitis(AD)is a chronic cutaneous inflammatory disease caused by an interaction between genetic,immune and epidermal barrier *** treatments can be used to treat this disease but there are patients that do not respond to actual ***,there is a need to develop effective therapies for *** stem cells(MSCs)are non-hematopoietic multipotent adult progenitor cells with immunomodulatory power and self-regenerating capacity to repair tissue damage,so they could be a potential effective treatment for ***-Conditioned Medium(CM)and MSCs-exosomes are cell-free preparation with molecules secreted by stem cells that could be also beneficial for *** viewpoint reviews the actual development of MSCs,MSCs-CM and MSCs-exosomes for treating patients with AD.

关键词： Atopic dermatitis Conditioned medium Dermatology Mesenchymal stem cells Stem cells

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Earth Map:A Novel Tool for Fast Performance of Advanced Land Monitoring and Citation:Morales C,diazAS,Climate Assessment Climate Assessment

Journal of Remote Sensing

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Journal of Remote Sensing 2023年第1期3卷 1-18页

作者： Carmen Morales Alfonso Sanchez-Paus diaz Daniel Dionisio Laura Guarnieri Giulio Marchi Danae Maniatis Danilo Mollicone Food and Agriculture Organization of the United Nations 00153 RomeItaly

Earth Map(https://***/)is an innovative and free application developed by the Food and Agriculture Organization of the United Nations that was designed in the framework of the Food and Agriculture Organization of the United Nations-Google partnership and facilitates the visualization,processing,and analysis ofland and climate *** Map makes petabytes of multitemporal,multiscale,multiparametric,and quasi-real-time satellite imagery and geospatial datasets available to any user thanks to the power of Google Earth Engine(https://***/)and a point-and-click graphical user *** are further complemented with more planetary-scale analytical capabilities so that global and local changes and trends on Earth's surface can be easily detected,quantified,and *** does not require users to master coding techniques,thereby avoiding bottlenecks in terms of technical capacities of nonexpert *** ultimately paves the way for countries,research institutes,farmers,and members of the general public to access critical knowledge to develop science-based policy interventions,leverage investments,and sustain *** provide a full overview of Earth Map's software architecture,design,features,and *** illustrate the possible applications of the tool,different examples are presented including a few case studies that show how quick historical analysis of environmental and climate parameters can be performed and research questions *** examples demonstrate that Earth Map is a comprehensive and user-friendly tool for land monitoring and climate assessment and that it has the potential to be used to assess land use,land use change,climate change impacts,and natural disasters.

关键词： Earth Map thereby

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Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik diaz Miguel Angel Morales Armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

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