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Journal of Integrative Medicine 2021年第2期19卷 104-110页

作者： rex-clovis c.njoku Sunny O.Abarikwu Department of chemistry&Molecular Biology Alex Ekwueme-Federal UniversityNdufu-AlikeIkwoP.M.B.1010AbakalikiNigeria Department of Biochemistry University of Port HarcourtChoba.P.M.B.5323Port HarcourtNigeria

Fluted pumpkin(FP;Telfairia occidentalis)is an edible vegetable,grown in West Africa,that is used in traditional medicine for its regulatory effects on the male *** articles concerning the effects of FP were identified by searching PubMed,Pubchem,Scopus,Springer,ResearchGate,Google Scholar and Web of Science;this literature was to better understand the effects of FP seed(FPS)and leaf(FPL)extracts on the *** showed that in experimental animals extracts of FPL and FPS at 1/100 of the lethal dose promoted testis regeneration and improved testosterone concentration and sperm quality,while at higher doses they had antifertility *** extracts of FPS and FPL,including ethanol,aqueous,methanol and hydroethanolic,had protective effects on the testes of study animals at lower doses(>50 mg/kg body weight),but at higher doses(>200 mg/kg body weight)they inhibited hormone synthesis,sperm quality and histomorphological structure,under both normal and disease *** posttreatment effects of FPS on the gonads were reversible in young mature rats and FPS had slight systemic toxic ***,there are inconsistencies in some of the published results,the current evidence suggests that FPS and FPL have both profertility and reversible antifertility effects in experimental animals.

关键词： Fluted pumpkin Sperm Male reproduction Seeds Fertility

Effect of Anthocleista djalonensis A. chev Root Extract on Testis of Matured Rats

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chinese Journal of Integrative Medicine 2020年第12期26卷 929-935页

作者： chioma Yvonne Ezirim Sunny O.Abarikwu chidimma J.Mgbudom-Okah Augustine A.Uwakwe rex-clovis c.njoku Aemere Ogunlaja Department of Biochemistry University of Port HarcourtChobaNigeria Department of Biological Sciences Redeemer’s UniversityEdeNigeria

Objective:To investigate the effects of different extracts of Anthocleista djalonensis on the testis and epididymal sperms of ***:Fifty male Wistar rats were randomly divided into 10 groups(n=5 in each group)and orally treated with 50,100 and 200 mg/kg body weight each of methanol,aqueous ethanol(H-EtOH)and chloroform extracts of *** oil was used as vehicle(2 mL/kg).After 60 days of treatment,testosterone(T)and cholesterol(cHOL)concentrations,catalase(cAT),lactate dehydrogenase(LDH),3β-hydroxysteroid dehydrogenase(3β-HSD)and superoxide dismutase(SOD)activities in the testes along with myeloperoxidase(MPO)activities and nitrite concentrations(NO)in the serum and testes as well as sperm quality were ***:T and cHOL concentrations along with 3β-HSD activity were significantly higher in the animals treated with the low dose than in those treated with the high dose of the chloroform extract(Pchloroform extract was more effective than the methanol extract that had the most marginal effect on T level at the high dose and the H-Et OH extract that was only effective at the medium *** activity was dose-dependently increased by the extracts in all *** cAT-SOD antioxidant system was increased in the treated animals at all doses compared to the control values,but the increase in glutathione level reached significant level in those treated with the low dose H-Et OH aqueous ethanol extract(Pchloroform extract had significant inhibitory effects on MPO activity(Pconcentration was decreased at all doses of the *** inhibitory effects of the extracts on testicular NO concentrations follow this order,chloroform extract>H-Et OH>*** all extracts at all doses showed excellent stimulatory effects on sperm quality(count,motility and morphology),the methanol extract at the high dose was the most effective on sperm count(Pconclusion:The chloroform ex

关键词： Anthocleista djalonensis testis epididymis sperm quality antioxidants testosterone

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Inhibition of sulfate-reducing bacteria influenced corrosion on hydrophobic poly(dimethylsiloxane)coatings

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Journal of Materials Science & Technology 2020年第17期52卷 198-206页

作者： Innocent O.Arukalam c.N.njoku Lihui Yang Baorong Hou Ying Li corrosion and Protection Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China Department of Polymer and Textile Engineering Federal University of TechnologyP.M.B.1526 Owerri Nigeria Key Laboratory of Marine Environmental corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China Open Studio for Marine corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Advanced Functional Materials/corrosion Research Group Africa Centre of Excellence in Future Energies and Electrochemical Systems(ACE-FUELS)Federal University of Technology Owerri(FUTO)Nigeria

Sulfate-reducing bacteria(SRB)has been pointed out as one of the causative agents of microbial induced corrosion in the marine *** address this problem,novel strategies are being experimented as against the earlier methods which have been banned due to their toxic effects on useful aquatic ***,the aim of this study was to investigate the effect of non-toxic perfluorodecyltrichlorosilane(PFDTS)on resistance of hydrophobic poly(dimethylsiloxane)/phosphoric acid-treated zinc oxide(PDMS/PA-treated ZnO)coatings to SRB-induced biofouling and *** surface features of the coatings before and after exposure to SRB/Nacl solution were analyzed by scanning electron microscopy(SEM).Wettability of the coatings before and after exposure was also *** interaction of SRB with the coatings was investigated by FTIR *** resistance performance of the modified coatings against SRB-induced corrosion was monitored by electrochemical impedance spectroscopy(EIS).The EIS measurements revealed that 0.20 g PFDTS-based coating displayed highest corrosion resistance with impedance modulus of 6.301×10^10 after 15 d of exposure to SRB/Nacl *** results were corroborated by surface and chemical interaction analyses,and thus,indicate that 0.20 g PFDTSmodified PDMS/PA-treated ZnO coating has potentials for excellent SRB-induced corrosion resistance and anti-biofouling performance.

关键词： corrosion Hydrophobic coating Perfluorodecyltrichlorosilane Poly(dimethylsiloxane) Sulfate-reducing bacteria

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

The second brain in Parkinson’s disease: fact or fantasy?

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Neural Regeneration Research 2022年第8期17卷 1737-1738页

作者： Nehal Yemula Paul njoku Joseph Takyi James Paget University Hospital Lowestoft Road Gorleston-on-SeaGreat YarmouthUK Norfolk and Norwich University Hospital Colney LaneNorwichUK Pinderfields Hospital Aberford WayWakefieldUK

Parkinson’s disease(PD)is a movement disorder characterized by reduced dopamine levels due to degeneration of the substantia *** clinical presentation is underlined by bradykinesia,postural instability,and *** is the second most common neurodegenerative disease worldwide,with a huge monetary *** the United States alone,it is estimated that in 2017,the total economic cost was$51.9 billion,and projected to surpass$79 billion by *** research has been conducted into the pathophysiology and clinical implications of the *** neurodegenerative disorder itself,the entity involving the brain-gut axis has been a fundamental model in understanding the disease *** so than ever in PD,the association between gut health and neurological disease is gaining momentum,with the fascinating idea of influencing neurological health by treating the gut.

关键词： degeneration clinical dopamine

Flavonoid-rich fraction of the Monodora tenuifolia seed extract attenuates behavioural alterations and oxidative damage in forced-swim stressed rats

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chinese Journal of Natural Medicines 2015年第3期13卷 183-191页

作者： EKEANYANWU Raphael chukwuma njoku Obioma Uzoma Department of Biochemistry Faculty of Medicine Imo State University Owerri Department of Biochemistry Faculty of Biological Sciences University of Nigeria Nsukka

The antidepressant effects of the flavonoid-rieh fraction of Monodora tenuifolia seed extract were examined by assess- ing the extent of attenuation of behavioural alterations and oxidative damage in the rats that were stressed by forced swim test. com- pared with the model control group, the altered behavioural parameters were attenuated significantly （P 〈 0.05） in the group treated with the flavonoid-rich fraction （100 and 200 mg·kg^-1）, comparable to the group treated with the standard drug, fluoxetine （10 mg·kg^-1）. The flavonoid-rich fraction and fluoxetine improved significantly （P 〈 0.05） the activities of the antioxidant enzymes such as superoxide dismutase and catalase as well as other biochemical parameters such as reduced glutathione, protein, and nitrite in the brain of the stressed rats. These results suggested that the flavonoid-rich fraction of Monodora tenuifolia seed extract exerted the antidepres- sant-like effects which could be useful in the management of stress induced disease.

关键词： Monodora tenuifolia Antidepressant Forced swim test Depression Oxidative damage

Acute and subacute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats

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Asian Pacific Journal of Tropical Biomedicine 2014年第3期4卷 194-202页

作者： Raphael chukwuma Ekeanyanwu Obioma Uzoma njoku Department of Biochemistry Faculty of SciencesImo State University OwerriImo StateNigeria Department of Biochemistry Faculty of Biological SciencesUniversity of Nigeria NsukkaEnugu StateNigeria

Objective:To investigate the effects of the flavonoid rich fraction of Monodora tenuifolia seed on the haematology,histopathology and liver profile of Wistar albino ***:Toxicity study was investigated on the flavonoid rich fraction of Monodora tenuifolia in rats administered different concentrations orally for 28 d using standard laboratory ***:The LD_(50)of the flavonoid rich fraction was found to be above 5000 mg/kg body weight in mice observed for 48 *** the Day 14,biochemical markers of liver injury such as serum alanine aminotransferase,and aspartate aminotransferase decreased significantly(Pcreased non-significantly(P>0.05).There was non-significant(P>0.05)effect observed across the groups in the levels of serum total protein,albumin,globulin,urea and *** result of histological examination showed various degrees of peribiliary hepatitis after the Day 14 which fizzled out after the Day ***:The result therefore suggests that the seed extract is potentially safe.

关键词： Monodora tenuifolia Toxicity Haematological parameters Biochemical parameters Histology

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory