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Safety and Performance of Sirolimus-Eluting Coronary Stent System with Biodegradable Polymer: A Retrospective Analysis in Real-World Patient Population

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World Journal of Cardiovascular Diseases 2017年第5期7卷 163-173页

作者： Vithala Surya Prakasa Rao A. S. V. Narayana Rao Pannala Lakshmi Narasimha Kapardhi Priyen Kantilal Shah revanur viswanath Satyajit Govindrao Mehetre Avanindra Kumar Srivastava Department of Cardiology Apollo Hospitals Hyderabad India

Background and Aim: Newer generation coronary stent systems with low profile metallic frame, biodegradable polymer coating and potent but safe anti-restenosis drug from “limus family” are emerging as safe and effective stents. To evaluate the safety and performance of Metafor SES (Meril life Sciences Pvt. Ltd., Vapi, India) in consecutive patients in a real-world population. Methods: The study was a retrospective, non-randomized, single-center study which evaluated the data of 127 patients who underwent percutaneous coronary intervention (PCI) treated with Metafor SES from February 2012 to February 2015 and mean follow-up period of those patients was 3.6 ± 0.6 years. The primary endpoint was a major adverse cardiac event (MACE) including cardiac death, myocardial infarction (MI), and target lesion revascularization (TLR). In addition, Stent thrombosis (ST) was analyzed at respective follow-up period. Results: A total of 127 patients (mean age: 53.70 ± 8.41 years and 99 males) were included. Among those 80 (63%) patients had hypertension and 58 (45.7%) patients with diabetes *** follow-up, MACE in form of TLR was observed in 2 (1.6%) patients only. No cardiac death or stent thrombosis was reported in any patient. A total of 169 lesions were treated with the Metafor SES (1.3 stents per lesion). The 38.4% of patients treated with the Metafor SES with lesion length ≥24 mm, and the procedural success was 100%. Conclusions: The lower incidence of MACE in uncontrolled and real world population at long term follow-up clearly depicts the prolonged safety and performance of the Metafor SES.

关键词： Biodegradable Polymer Cobalt-Chromium Metafor SES Sirolimus-Eluting Stent Stent Thrombosis

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Endoscopic ultrasound-guided fiducial marker placement in pancreatic cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Endoscopy 2020年第8期12卷 231-240页

作者： Jaymon B Patel Vakya revanur David G Forcione Matthew L Bechtold Srinivas R Puli Department of Gastroenterology University of Illinois College of Medicine at PeoriaPeoriaIL 61637United States Department of Internal Medicine University of Illinois College of Medicine at PeoriaPeoriaIL 61637United States Department of Gastroenterology Massachusetts General HospitalBostonMA 02114United States Department of Gastroenterology University of MissouriColumbiaMO 65203United States

BACKGROUND Pancreatic cancer(PC)mortality remains high despite advances in *** chemoradiotherapy offers modest survival benefit over monotherapy with *** markers serve as needed landmarks for imageguided radiotherapy(IGRT).Traditionally,these markers were placed surgically or percutaneously with limitations of *** ultrasound-guided placement overcomes these *** To evaluate the safety,efficacy,and feasibility of endoscopic ultrasound(EUS)-guided fiducial placement for PC undergoing *** Articles were searched in MEDLINE,PubMed,and Ovid *** was conducted by fixed and random effects *** was assessed using Cochran’s Q test based upon inverse variance *** Initial search identified 1024 reference articles for EUS-guided fiducial placement in *** these,261 relevant articles were *** was extracted from 11 studies(n=820)meeting inclusion *** proportion of successful placement was 96.27%(95%CI:95.35-97.81)with fiducial migration rates low at 4.33%(95%CI:2.45-6.71).Adverse event rates remained low,with overall pooled proportion of 4.85%(95%CI:3.04-7.03).CONCLUSION EUS-guided placement of fiducial markers for IGRT of PC is safe,feasible,and *** ability to target deep structures under direct visualization while remaining minimally invasive are added ***,the ability to perform fine needle aspiration or celiac plexus neurolysis add value and increase patient-care *** EUS-guided fiducial placement improves outcomes in IGRT or offers any mortality benefits over traditional placement remains unknown and future studies are needed.

关键词： Endoscopic ultrasound Pancreatic cancer Fiducial marker Image-guided radiotherapy Systematic review Meta-analysis

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