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Oryzalexin S biosynthesis:a cross-stitched disappearing pathway

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aBIOTECH 2023年第1期4卷 1-7页

作者： Le Zhao Richard Oyagbenro Yiling Feng Meimei Xu reuben j.peters Roy j.Carver Department of Biochemistry Biophysics and Molecular BiologyIowa State UniversityAmesIA50011USA

Rice produces many diterpenoid phytoalexins and,reflecting the importance of these natural products in this important cereal crop plant,its genome contains three biosynthetic gene clusters(BGCs)for such *** chromosome 4 BGC(c4BGC)is largely associated with momilactone production,in part due to the presence of the initiating syn-copalyl diphosphate(CPP)synthase gene(OsCPS4).Oryzalexin S is also derived from ***,the relevant subsequently acting syn-stemarene synthase gene(OsKSL8)is not located in the *** of oryzalexin S further requires hydroxylation at carbons 2 and 19(C2 and C19),presumably catalyzed by cytochrome P450(CYP)*** it is reported the closely related CYP99A2 and CYP99A3,whose genes are also found in the c4BGC catalyze the necessary C19-hydroxylation,while the closely related CYP71Z21 and CYP71Z22,whose genes are found in the recently reported chromosome 7 BGC(c7BGC),catalyze subsequent hydroxylation at C2α.Thus,oryzalexin S biosynthesis utilizes two distinct BGCs,in a pathway cross-stitched together by ***,in contrast to the widely conserved c4BGC,the c7BGC is subspecies(ssp.)specific,being prevalent in *** and only rarely found in the other major ***,while the closely related syn-stemodene synthase OsKSL11 was originally considered to be distinct from OsKSL8,it has now been reported to be a *** derived allele at the same genetic ***,more detailed analysis indicates that OsKSL8(j)is being replaced by OsKSL11(OsKSL8i),suggesting introgression from *** to(sub)tropical japonica,with concurrent disappearance of oryzalexin S production.

关键词： Biosynthetic gene clusters Phytoalexins Diterpenoids Rice evolution

水稻二萜植保素Oryzalexin D和E生物合成解析

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水稻二萜植保素Oryzalexin D和E生物合成解析

A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights

生态文明建设中的植物学：现在与未来——中国植物学会第十五届会员代表大会暨八十周年学术年会

作者：王强 Yisheng Wu reuben j.peters 四川农业大学农学院植物生理学系 Iowa State University

水稻为重要的粮食作物,但受到广泛的病害侵袭。稻瘟病为水稻主要病害,每年在世界各地导致水稻大量减产。水稻在受到稻瘟菌侵染时产生一系列二萜植保素,包括Momilactone,Phytocassane,Oryzalexin,Oryzalide等,这些二萜植保素具有抑制稻... 详细信息

水稻为重要的粮食作物,但受到广泛的病害侵袭。稻瘟病为水稻主要病害,每年在世界各地导致水稻大量减产。水稻在受到稻瘟菌侵染时产生一系列二萜植保素,包括Momilactone,Phytocassane,Oryzalexin,Oryzalide等,这些二萜植保素具有抑制稻瘟菌孢子萌发和孢子管伸长的活性。研究这些二萜植保素的生物合成途径对于开发利用这些重要生物活性物质具有重要意义。这些二萜植保素的上游生物合成是通过MEP途径,利用3‐磷酸

关键词：水稻二萜植保素生物合成 Oryzalexin D&E

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A Functional Genomics Approach to Tanshinone Biosynthesis Pr...

Recent advances in graphene-based phase change composites for thermal energy storage and management

作者： Wei Gao Matthew L.Hillwig 黄璐琦 Guanghong Cui Xueyong Wang jianqiang Kong Bin Yang reuben j.peters Chinese Academy of Chinese Medical Science Capital Medical University Iowa State University 中国中医科学院 Peking Union Medical College

Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza *** initial results from a functional genomics-based investigation of tanshinone biosynthesis,specifically the functional identification of the relevant diterpene synthases from ***,are *** cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.

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Nano Materials Science 2024年第2期6卷 115-138页

作者： Qiang Zhu Pin jin Ong Si Hui Angela Goh reuben j.Yeo Suxi Wang Zhiyuan Liu Xian jun Loh Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)2 Fusionopolis WayInnovis#08-03138634Singapore Institute of Sustainability for Chemicals Energy and EnvironmentA*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong Island627833Singapore School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological University21 Nanyang Link637371Singapore Shenzhen Institutes of Advanced Technology(SIAT) Chinese Academy of Sciences(CAS)1068 Xueyuan AvenueShenzhen518055China Department of Material Science and Engineering National University of Singapore9 Engineering Drive 1#03-09 EA117575Singapore

Energy storage and conservation are receiving increased attention due to rising global energy ***,the development of energy storage materials is *** energy storage(TES)systems based on phase change materials(PCMs)have increased in prominence over the past two decades,not only because of their outstanding heat storage capacities but also their superior thermal energy regulation ***,issues such as leakage and low thermal conductivity limit their applicability in a variety of ***-based materials such as graphene and its derivatives can be utilized to surmount these *** study examines the recent advancements in graphene-based phase change composites(PCCs),where graphene-based nanostructures such as graphene,graphene oxide(GO),functionalized graphene/GO,and graphene aerogel(GA)are incorporated into PCMs to substantially enhance their shape stability and thermal conductivity that could be translated to better storage capacity,durability,and temperature response,thus boosting their attractiveness for TES *** addition,the applications of these graphene-based PCCs in various TES disciplines,such as energy conservation in buildings,solar utilization,and battery thermal management,are discussed and summarized.

关键词： Phase change material Nanocomposites Solar energy Sustainable energy Thermo-regulation

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

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Biosafety and Health 2024年第2期6卷 125-132页

作者： reuben Kiggundu j.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello Eric Lugada Cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula Kate Kikule Emmanuel Nfor Mohan P.joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 joint External Evaluation(jEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the jEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

Fungal mycobiome-mediated immune response:a non-negligible promoter in pancreatic oncogenesis and chemoresistance

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Cancer Drug Resistance 2023年第2期6卷 284-290页

作者： Yaling jiang Valentina Donati Godefridus j.peters Elisa Giovannetti Dong Mei Deng Department of Preventive Dentistry Academic Center for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdam 1081 LANetherlands Department of Medical Oncology Amsterdam University Medical Centerslocation VUMCVrije Universiteit AmsterdamAmsterdam 1081 HVNetherlands Unit of Pathological Anatomy 2 Azienda Ospedaliero-Universitaria PisanaPisa 56100Italy Department of Biochemistry Medical University of GdanskGdansk 80-210Poland Fondazione Pisana per la Scienza ONLUS San Giuliano TermePisa 56017Italy

Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal cancers in humans due to late diagnosis and poor response to *** tumor microenvironment(TME)of PDAC is characterized by a distinctive,suppressive immune profile,which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC ***,the study of Alam et *** for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant,interleukin(IL-)*** this article,we reviewed the important findings of this *** with our findings,we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.

关键词： Mycobiome pancreatic cancer chemoresistance interleukin 33 type 2 immune cells

Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International journal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benjamin j.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail Tayfur jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura jeremy P.Novak Maria Opazo Kendell Oliver Luciana peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.Brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells

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Cancer Drug Resistance 2023年第3期6卷 430-446页

作者： Gerrit jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer johan van Meerloo Gert j.Ossenkoppele jacqueline Cloos Godefridus j.peters Department of Rheumatology and Clinical Immunology Amsterdam Rheumatology and immunology CenterAmsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands The Fred Wyszkowsky Cancer Research Laboratory Faculty of BiologyThe Technion-Israel Institute of TechnologyHaifa 3200003Israel Department of Medical Oncology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Institute of Biotechnology Molecular Cell BiologyBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Department of Hematology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Department of Biochemistry Medical University of GdanskGdansk 80-210Poland

Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) ***: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 and in vitro non-toxic concentrations of various statins upon cell growth inhibition, cell cycle effects, and apoptosis induction. Mechanistic studies involved analysis of Rheb prenylation required for mTOR ***: A strong synergy of CHR2863 with the statins simvastatin, fluvastatin, lovastatin, and pravastatin was demonstrated in U937 cells and two CHR2863-resistant sublines. This potent synergy between simvastatin and CHR2863 was also observed with a series of other human AML cell lines (e.g., THP1, MV4-11, and KG1), but not with acute lymphocytic leukemia or multiple solid tumor cell lines. This synergistic activity was: (i) specific for APis (e.g., CHR2863 and Bestatin), rather than for other cytotoxic agents;and (ii) corroborated by enhanced induction of apoptosis and cell cycle arrest which increased the sub-G1 fraction. Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation;this was experimentally confirmed by impaired Rheb prenylation by ***: These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells.

关键词： Aminopeptidase statins mevalonate pathway carboxyl esterase Rheb mTOR

Cancer drug resistance: a new perspective

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Cancer Drug Resistance 2018年第1期1卷 1-5页

作者： Godefridus j.peters Laboratory Medical Oncology VU University Medical CenterCancer Center AmsterdamAmsterdam 1007 MBThe Netherlands

INTRODUCTION Cancer drug resistance has been and unfortunately still is a major problem in cancer *** any therapy(except surgery)that is being used in the treatment of cancer can result in *** there is a large group of patients that will either not respond to the applied therapy(intrinsic resistance)or will become resistant during therapy(acquired resistance).Sometimes patients can become resistant to one specific drug and remain sensitive to other drugs(one-drug resistance);another group of patients may become resistant to one drug and will be resistant to other unrelated drugs as well(multiple drug resistance,MDR).

关键词： drugs Cancer drug