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Bayesian Non-Parametric Mixture Model with Application to Modeling Biological Markers

Journal of Data Analysis and Information Processing 2019年第4期7卷 141-152页

作者： Mercy K. Peter levi Mbugua Anthony Wanjoya Department of Mathematics Pan African University Institute for Basic Sciences Technology and Innovation Nairobi Kenya Department of Statistics and Actuarial science Technical University of Kenya Nairobi Kenya Department of Statistics and Actuarial science Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

The effect of treatment on patient’s outcome can easily be determined through the impact of the treatment on biological events. Observing the treatment for patients for a certain period of time can help in determining whether there is any change in the biomarker of the patient. It is important to study how the biomarker changes due to treatment and whether for different individuals located in separate centers can be clustered together since they might have different distributions. The study is motivated by a Bayesian non-parametric mixture model, which is more flexible when compared to the Bayesian Parametric models and is capable of borrowing information across different centers allowing them to be grouped together. To this end, this research modeled Biological markers taking into consideration the Surrogate markers. The study employed the nested Dirichlet process prior, which is easily peaceable on different distributions for several centers, with centers from the same Dirichlet process component clustered automatically together. The study sampled from the posterior by use of Markov chain Monte carol algorithm. The model is illustrated using a simulation study to see how it performs on simulated data. Clearly, from the simulation study it was clear that, the model was capable of clustering data into different clusters.

关键词： Bayesian Non-Parametric Nested Dirichlet Process Biomarker Clustering Surrogate Markers Dirichlet Process Markov Chain Monte Carlo

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Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual

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Bone Research 2019年第1期7卷 91-104页

作者： Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin levi Amato J.Giaccia Ernestina Schipani Department of Orthopaedic Surgery School of MedicineUniversity of MichiganAnn ArborMIUSA Division of Plastic and Reconstructive Surgery Department of SurgeryUniversity of MichiganAnn ArborMIUSA Department of Radiation Oncology Stanford University Medical SchoolStanfordCAUSA

Osteoblasts,which are the bone-forming cells,operate in a hypoxic *** transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to *** are expressed in ***1 is known to be a positive regulator of bone ***,the role of HIF2 in the control osteoblast biology is still poorly *** this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass ***,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor *** findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through *** HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging.

关键词： is cells has

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Applied quantum mechanics 1st

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2003年

作者： A. F. J. levi

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Meal timing and Jet lag effects on Tumor Growth in Mice : relation to circadian timing system

Meal timing and Jet lag effects on Tumor Growth in Mice : re...

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2004全国时间生物医学学术会议

作者： levi Francis 吴明玮 INSERM E 0354 hronothapeutique des cancers? Hital. Paul Brousse and Universit?Paris XI 94807 Villejuif Cedex France 中山大学肿瘤防治中心实验研究部

BACKGROUND & OBJECTIVE : The circadian timing system plays an important role in cancer genesis and progression. Several hormonal, metabolic or molecular variables which closely related to cancer proc

关键词： Tumor Circadian rhythm Meal timing Jet lag

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Changes in soil free-living nematode communities and their trophic composition along a climatic gradient

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Open Journal of Ecology 2012年第2期2卷 79-89页

作者： Tal levi Chen Sherman Stanislav Pen-Mouratov Yosef Steinberger The Mina & Everard Goodman Faculty of Life Sciences Bar-Ilan University Ramat-Gan Israel

Ambiguity exists concerning the effects of climate on soil nematode-community composition. In this study, we examined the free-living nematode communities in soil along a climatic gradient representing humid-Mediterranean, Mediterranean, semi-arid, and arid climate types. The relationships between abiotic soil characteristics (organic carbon, soil moisture (SM), water-holding capacity) and nematode parameters, such as abundance, trophic group composition, and diversity indices, were explored in the context of climate and seasonality. Nematode abundance was lowest at the arid site. At the humid Mediterranean and Mediterranean locations, nematode abundance reached its peak in winter, while at the semi-arid and arid sites, an almost opposite trend was observed, with lowest abundances in winter, presumably due to a nutrient washout from the soil profile during the rainy season. On the trophic level, one trophic group demonstrated a positive correlation with SM and one trophic group demonstrated a negative one at each location, while the other two groups remained constant. Fungi-feeding nematodes were found to be unaffected by SM at the humid-Mediterranean and Mediterranean locations, while at the semi-arid and arid sites their proportion increased in correlation with decreasing SM. Bacteria-feeders increased with SM at the arid site, were unaffected at the semi-arid location, and decreased with SM at the humid-Mediterranean and Mediterranean sites. Plant-parasites were associated with SM only at the humid-Mediterranean site. Omnivores-predators were positively affected by SM at the two middle locations, staying constant at the humid-Mediterranean and arid sites. These findings point to the strong linkage existing between nematode trophic behavior and climatic factors, demonstrating distinctive communal fingerprints for each climate type.

关键词： Climate Gradient Diversity Soil Nematode Trophic Group

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Cloning of a novel cDNA regulated by all-trans retinoic acid in human lung adenocarcinoma

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Progress in Natural Science:Materials International 1999年第10期 3-5页

作者：刘桂中,刘芝华,Giovanni levi,吴旻 State Key Laboratory of Molecular Oncology Cancer Institute Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China State Key Laboratory of Molecular Oncology Cancer Institute Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China Laboratory of Molecular Biology National Institute for Cancer Research Genova Italy State Key Laboratory of Molecular Oncology Cancer Institute Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100021 China

To characterize genes associated with differentiation/apoptosis induced by all- trans retinoic acid (ATRA) in human lung cancer cells, the mRNA differential display was employed and a cDNA fragment RAa7 was obtained which is up-regulated by ATRA. Search for homologous sequences in GenBank databases demonstrates that RAa7 is a novel sequence which has never been reported. Here evidence is provided that the RAa7 gene may be a tissue-specific expressing gene and has a major transcript of 1.4 kb. RAa7 gene is down-regulated during differentiation or apoptosis in several other kinds of lung cancer cells induced by ATRA and N- (4-hydroxyphenyl) retinamide (4HPR) . This suggests that either the up- or down-regulation of RAa7 gene may be involved in the processes of cell differentiation or apoptosis.

关键词： mRNA differential display retinoic acids cell differentiation apoptosis cancer

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A ten-year experience of inferior vena cava reconstruction for malignancy:The importance of a multidisciplinary approach with hepatobiliary surgery

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 396-398页

作者： Maria R.Baimas-George Ryan C.Pickens Jesse K.Sulzer Dionisios Vrochides John B.Martinie David M.levi David A.Iannitti Division of Hepatopancreatobiliary Surgery Department of SurgeryCarolinas Medical Center1025 Morehead Medical DriveSuite 600CharlotteNC 28204USA Division of Transplant Surgery Department of SurgeryCarolinas Medical CenterCharlotteNCUSA

To the Editor,Tumor invasion of the inferior vena cava(IVC)through direct erosion is a rare and poor prognostic feature of aggressive hepatic or perihepatic malignancies[1,2].Literature shows poor response to chemotherapy,such that resection often is the only option for improved survival[3].Multidisciplinary collaborations can expand technical options;incorporation of transplant techniques has led to successful R0 resection involving difficult vascular reconstruction and extended resection[4,5].This study describes and analyzes the ten-year collaborative experience of hepatobiliary(HPB)surgeons in management of malignancies involving the perihepatic IVC.

关键词： hepato hepatic invasion

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Pancreaticoduodenectomy in elderly patients:a special place for minimally invasive surgery?

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 665-665页

作者： francesco guerra lapo bencini giovanni battista levi sandri division of oncological and robotic general surgery careggi university hospital FlorenceItaly division of general surgery and liver transplantation san camillo hospitalRomeItaly

To the Editor： We read with keen interest the recent paper by El Nakeeb et al, and the subsequent editorial published by Dudeja and Livingstone. Globally, the authors have correctly and timely portrayed the current r... 详细信息

关键词： Pancreaticoduodenectomy in elderly patients

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Designing and managing the supply chain : concepts, strategies, and case studies

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2000年

作者： Simchi-levi David.

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Chelyabinskaya省地甲病防治工作

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国外医学（医学地理分册） 1993年第4期14卷 178-179页

作者： levi.,JD 李协德

本文介绍了对加碘预防应采取严格控制的必要必。预防碘缺乏必须有相庆的和同样有效的措施来防止过量碘摄入及其后果。

关键词：地方性甲状腺肿碘预防

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