检索结果-南通市图书馆

From the unknown to spotlight:newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2845-2847页

作者： Yakum Bertrand Nkeh resul Gökberk Elgin Gesine Saher Project Group Biology of Lipids Department of NeurogeneticsMax Planck Institute for Multidisciplinary SciencesGöttingenGermany

In a study published in Cell,Hu and colleagues discovered that the signaling activity of the intestinal hormone Cholesin leads to the attenuation of hepatic cholesterol synthesis in response to intestinal absorption thereby maintaining homeostatic levels of circulating cholesterol.1 These findings have major translational implications as they provide a potential new target for the management of hypercholesterolemia and associated disorders.

关键词： cholesterol hepatic synthesis

Kinetics and mechanistic investigation of epoxide/CO2 cycloaddition by a synergistic catalytic effect of pyrrolidinopyridinium iodide and zinc halides

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第10期28卷 35-42页

作者： Abdul Rehman Valentine C. Eze M.F.M.Gunam resul Adam Harvey School of Engineering Merz CourtNewcastle UniversityNewcastle Upon Tyne NE1 7RUUK Department of Chemical and Polymer Engineering University of Engineering and Technology LahoreFaisalabad CampusPakistan

Formation of styrene carbonate (SC) by the cycloaddition of CO2 to styrene oxide (SO) catalysed by pyrrolidinopyridinium iodide (PPI) in combination with zinc halides (ZnCl2, ZnBr2 and ZnI2) was investigated. Complete conversion of the SO to SC was achieved in 3 h with 100% selectivity using 1/0.5 molar (PPI/ZnI2) catalyst ratio under mild reaction conditions i.e., 100℃ and 10 bar CO2 pressure. The synergistic effect of ZnI2 and PPI resulted in more than 7-fold increase in reaction rate than using PPI alone. The cycloaddition reaction demonstrated the first-order dependence with respect to the epoxide, CO2 and catalyst concentrations. Moreover, the kinetic and thermodynamic activation parameters of SC formation were determined using the Arrhenius and Eyring equations. The positive values of △H(42.8 kJ mol^-1) and △G(102.3 kJ mol^-1) revealed endergonic and chemically controlled nature of the reaction, whereas the large negative values of △S(-159.4 J mol^-1 K^-1) indicate a highly ordered activated complex at the transition state. The activation energy for SC formation catalyzed by PPI alone was found to be 73.2 kJ mol^-1 over a temperature range of 100-140℃, which was reduced to 46.1 kJ mol^-1 when using PPI in combination with ZnI2 as a binary catalyst. Based on the kinetic study, a synergistic acid-based reaction mechanism was proposed.

关键词： Cycloaddition CO2 utilization Cyclic carbonates Homogeneous catalysis Activation energy

Retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in children with obesity

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第3期9卷 434-438页

作者： Selim Demir Samet ozer Sait alim alper Günes Hüseyin Ortak resul Yilmaz Department of Ophthalmology Faculty of Medicine Gaziosmanpasa University Tokat 60030 Turkey Department of Pediatrics Faculty of Medicine Gaziosmanpasa University Tokat 60030 Turkey

AIM：To evaluate retinal nerve fiber layer（RNFL）thickness analysis of peripapillary optic nerve head（PONH） and macula as well as ganglion cell-inner plexiform layer（GCIPL） thickness in obese children.· METHODS：Eighty-five children with obesity and 30 controls were included in the *** thicknesses of the PONH and macula of each subject＇s right eye were measured by high-resolution spectral-domain optic coherence tomography（OCT）.· resulTS：The RNFL thicknesses of central macular and PONH were similar between the groups（all P 〉0.05）.The GCIPL thickness was also similar between the ***,the RNFL thickness of temporal outer macula were 261.7±13.7 and 268.9±14.3 μm for the obesity and the control group,respectively（P =0.034）.· CONCLUSION：Obesity may cause a reduction in temporal outer macular RNFL thickness.

关键词： ganglion cell-inner plexiform layer retinalnerve fiber layer thickness optical coherence tomography obesity

Anesthetic management of a child with Cornelia de Lange Syndrome undergoing open heart surgery:A case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2022年第1期14卷 54-63页

作者： Oguzhan Arun Bahar Oc Esma Nur Metin Ahmet Sert resul Yilmaz Mehmet Oc Department of Anesthesiology and Reanimation Selcuk University Faculty of MedicineKonya 42130Turkey Department of Pediatric Cardiology Selcuk University Faculty of MedicineKonya 42130Turkey Pediatric Intensive Care Selcuk University Faculty of MedicineKonya 42130Turkey Department of Cardiovascular Surgery Selcuk University Faculty of MedicineKonya 42130Turkey

BACKGROUND Cornelia de Lange syndrome(CdLS)is a congenital multisystemic genetic *** expected lifespan of children with this disorder has been prolonged in parallel with the advances in medicine in recent ***,they still more frequently undergo cardiac *** are some challenges for clinicians when faced with CdLS *** present the perioperative management of a child with CdLS undergoing open-heart *** SUMMARY Severe pulmonic and subpulmonic valvular stenosis,enlargement of the right side of the heart,mild tricuspid regurgitation,atrial septal defect,and patent ductus arteriosus were diagnosed in a 14-month-old boy with manifested cyanosis,developmental delay,and *** balloon valvuloplasty was unsuccessful due to a severe stenotic pulmonary valve,therefore it was decided to perform an open surgical *** a successful and uncomplicated intraoperative course,the patient was extubated on postoperative day 5,and adrenalin and dopamine infusions were gradually decreased and stopped on postoperative days 6 and 10,*** laryngomalacia and suboptimal vocal cord movements were diagnosed,and tracheotomy and percutaneous endoscopic gastrostomy were performed under general anesthesia in the same session at postoperative day *** patient was discharged on postoperative day 85 after a challenging postoperative period with additional airway and nutritional *** This is the first report of the perioperative anesthetic and clinical management of a CdLS patient undergoing open-heart surgery.

关键词： Cornelia de Lange Syndrome Brachmann de Lange Syndrome Pulmonary valve stenosis Valvular heart disease Cardiac surgery Anesthesia Case report

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

玛纳斯河流域春季一次降雹过程能量分析

沙漠与绿洲气象 2007年第2期1卷 40-43页

作者：热苏里.阿布都拉新疆人工影响天气办公室新疆乌鲁木齐830002

利用常规气象资料和FY-2气象卫星资料,从天气形势、能量场特征和卫星TBB演变特征分析2006年4月23日发生在新疆玛纳斯河流域的强降雹天气过程的成因。结果表明,降雹当日冰雹云生成前低层是高能舌,中高层低能中心和负能量平流中心位于其... 详细信息

利用常规气象资料和FY-2气象卫星资料,从天气形势、能量场特征和卫星TBB演变特征分析2006年4月23日发生在新疆玛纳斯河流域的强降雹天气过程的成因。结果表明,降雹当日冰雹云生成前低层是高能舌,中高层低能中心和负能量平流中心位于其西—西北方。东北—西南向的强能量锋区是触发这次强降雹过程的重要条件之一。这次强降雹天气过程出现在强对流云团前沿TBB梯度大值区内,云顶温度值及其水平梯度是识别冰雹云的重要参量。

关键词：降雹环流背景湿比有效能量 FY-2相当黑体亮温

在线全文

学校读者我要写书评

暂无评论

天山山区有利人工增雨的综合条件分析

新疆气象 2005年第2期28卷 23-25,31页

作者：热苏里.阿布都拉李霞魏旭辉徐文霞新疆人工影响天气办公室新疆乌鲁木齐830002 中国气象局乌鲁木齐沙漠气象研究所新疆乌鲁木齐830002

利用天山山区2001～2002年6～7月31次较强降水天气过程的实况资料和20个降水日的28例云系的711数字化雷达资料,对天山山区夏季有利于人工增雨的气象条件、雷达回波资料及探空资料,分析了影响天山山区降水的几种主要天气系统、各种系统... 详细信息

利用天山山区2001～2002年6～7月31次较强降水天气过程的实况资料和20个降水日的28例云系的711数字化雷达资料,对天山山区夏季有利于人工增雨的气象条件、雷达回波资料及探空资料,分析了影响天山山区降水的几种主要天气系统、各种系统下降水回波源地、性质、变化、移向移速等活动规律,归纳出相关雷达回波参数和判据,为今后山区高炮—火箭人工增雨作业提供了一些科学依据。

关键词：人工增雨雷达回波播云条件

奎—玛两河流域冰雹灾害时空分布规律及特征分析

在线全文

学校读者我要写书评

暂无评论

沙漠与绿洲气象 2007年第3期1卷 37-40页

作者：热苏里.阿布都拉瓦黑提.阿扎买提麦丽开.沙海提王梅英新疆人工影响天气办公室新疆乌鲁木齐830002 新疆气象学会新疆乌鲁木齐830002

利用奎—玛两河流域7个气象站和33个农业点(兵团团场,农场)1970—2005年4—9月的成灾冰雹资料,对其发生的天气气候规律、时空分布特征,本区域内分布情况及差异、移动路径、冰雹直径、强度等方面进行分析,旨在为该区域成灾降雹天气的分... 详细信息

利用奎—玛两河流域7个气象站和33个农业点(兵团团场,农场)1970—2005年4—9月的成灾冰雹资料,对其发生的天气气候规律、时空分布特征,本区域内分布情况及差异、移动路径、冰雹直径、强度等方面进行分析,旨在为该区域成灾降雹天气的分析预报提供背景依据。

关键词：奎-玛流域冰雹灾害特征统计分析

在线全文

学校读者我要写书评

暂无评论

正常人24小时胃电图检测分析

中华消化杂志 1998年第2期18卷 76-78页

作者：许国铭邹多武尹宁李兆申第二军医大学长海医院

目的研究正常人２４小时胃电变化规律。方法用动态胃电图检测仪检测３０例正常人２４小时胃电图。结果平均正常胃电频率占６７．６５％（６４．５％～９４．２％），胃动过缓占１４．１５％（１．９％－２１．２％），胃动过速占８．９... 详细信息

目的研究正常人２４小时胃电变化规律。方法用动态胃电图检测仪检测３０例正常人２４小时胃电图。结果平均正常胃电频率占６７．６５％（６４．５％～９４．２％），胃动过缓占１４．１５％（１．９％－２１．２％），胃动过速占８．９６％（２．０％～２０．０％）。餐后胃电主要功率较餐前明显增加（Ｐ＝０．０１４），餐后餐前主功率比值为３．１５±２．７８。三餐对胃电频率影响相似，餐后１５分钟胃电频率稍降低（Ｐ＜０．０１），此后胃电频率恢复至餐前水平。将２４小时胃电图资料，按每６小时一段，分为４段，各段时间内胃电图检测结果相似（Ｐ＞０．０５）。结论动态２４小时胃电图监测是研究长时间胃电节律变化的有效方法。

关键词：胃电图进餐胃电节律功率

自体外周血干细胞移植对急性心肌梗死患者左室重构和心功能的影响

在线全文

学校读者我要写书评

暂无评论

中国心血管病研究 2008年第5期6卷 349-351页

作者：张翔张彤李文刘超杨俊云南省第一人民医院心内科昆明市650032

目的评价自体外周血干细胞移植对急性心肌梗死患者左室重构和心功能的影响。方法共有65例急性心肌梗死患者入选本项前瞻性、非随机、开放试验(其中35例患者为细胞移植组,30例为对照组)。两组患者均接受标准的介入治疗和药物治疗,细胞移... 详细信息

目的评价自体外周血干细胞移植对急性心肌梗死患者左室重构和心功能的影响。方法共有65例急性心肌梗死患者入选本项前瞻性、非随机、开放试验(其中35例患者为细胞移植组,30例为对照组)。两组患者均接受标准的介入治疗和药物治疗,细胞移植组的35例患者同时接受自体外周血干细胞移植。两组患者在移植前及移植后6个月应用超声心动观察左室形态、室壁运动情况及左室功能指标的变化。结果6个月后干细胞移植组术前后比较左室舒张末期容LVEDV)明显缩小[(136.4±14.9)ml比(120.6±19.6)ml,P<0.01],左室收缩末期容量(LVESV)明显缩小[(84.5±18.9)ml比(70.5±14.9)ml,P<0.01],左室射血分数(LVEF)明显增高[(48.8±7.2)%比(56.5±7.4)%,P<0.01]。左室壁节段性运动指数(WMSI)明显降低[(1.41±0.21)比(1.10±0.15),P<0.01];左室射血前时间/射血时间比值显著降低[(0.46±0.08)比(0.40±0.07),P<0.01],左室舒张功能指标:舒张早期峰值速度(Em)增高,舒张晚期峰值速度(Am)降低,Em/Am增高。对照组治疗前后比较上述指标均有改善,但差异无统计学意义,两组术后上述指标比较差异有统计学意义。结论经皮经腔冠状动脉内自体干细胞移植术能明显改善急性心肌梗死患者的左室功能,减小左室容量,阻止或延缓左室重构,改善心功能。

关键词：超声心动描记术心肌梗死干细胞心室复建