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Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

Asian pacific Journal of Reproduction 2019年第4期8卷 141-147页

作者： Novita Eka Kusuma Wardani respatiningrum respatiningrum Anis Nur Laili Dwi Yuni Nur Hidayati Setyawati Soeharto Hidayat Sujuti Midwifery Master Program Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Midwifery Program Study of Bangkalan Midwifery Department of Health Polytechnic of Ministry of Health SurabayaEast JavaIndonesia Midwifery Program Health Polytechnic of Ministry of Health of TanjungpinangRiau ArchipelagoIndonesia Department of Microbiology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Department of Pharmacology Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia Program of Master of Biomedical Science Faculty of MedicineUniversity of BrawijayaMalangEast JavaIndonesia

Objective: To analyze the effects of subchronic cypermethrin on the ovary and endometrium as well as the involvement of apoptosis in the toxicity of cypermethrin. Methods: A total of 32 female Wistar rats were randomly divided into four groups, with 8 rats in each group. The control group received no treatment, and the other three groups received oral cypermethrin at 10, 15 or 20 mg/kg body weight for 28 days (sub-chronic). The granulosa cells were calculated histopathologically. The apoptotic index was determined by in situ technique. Histopathological examination was performed on the uterus and ovary. Results: There was no significant difference in the number of primary follicular granulosa cells between the treatment groups and the control group (P>0.05). However, the number of secondary and tertiary follicle granulosa cells in the treatment groups was significantly decreased compared to that of the control group (P all<0.05). The apoptotic index of primary follicular granulosa cells increased significantly in the groups treated with cypermethrin compared with the control group (P<0.05). The secondary, tertiary, and endometrial granulosa cell apoptosis index was significantly higher in all treatment groups compared to the control group (P<0.05). The higher the dose of cypermethrin was, the higher the apoptotic index of secondary, tertiary and endometrial granulosa cells was. There was a significant decrease in endometrial thickness in the three treatment groups compared to the control group (P<0.05). Thinning of the endometrial layer was seen in the cypermethrin exposure groups. Conclusions: Exposure to cypermethrin can suppress the number of secondary and tertiary follicular granulosa cells, and trigger thinning of the endometrium through induction of apoptosis.

关键词： Endocrine disruptor Pyrethroid pesticide Uterus Reproduction Apoptosis

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