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Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells

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Bioactive Materials 2021年第2期6卷 326-332页

作者： Yushan Zhang Chandra Kumar Elechalawar Md Nazir Hossen Emmy RFrancek Anindya Dey Stefan Wilhelm resham bhattacharya Priyabrata Mukherjee Department of Pathology The University of Oklahoma Health Sciences CenterOklahoma CityOK73104USA Peggy and Charles Stephenson Cancer Center The University of Oklahoma Health Sciences CenterOklahoma CityOK73104USA Stephenson School of Biomedical Engineering University of OklahomaNormanOK73019USA Department of Obstetrics and Gynecology The University of Oklahoma Health Sciences CenterOklahoma CityOK73104USA Institute for Biomedical Engineering Scienceand Technology(IBEST)NormanOK73019USA

Cancer-associated fibroblasts(CAFs)are a major constituent of the tumor microenvironment(TME)and an important contributor to cancer progression and therapeutic *** of CAF activation is a promising strategy to influence cancer ***,we report that ovarian cancer cells(OCs)and TME cells promote the activation of ovarian CAFs,whereas gold nanoparticles(GNPs)of 20 nm in diameter inhibit the activation,as demonstrated by the changes in cell morphology,migration,and molecular *** exert the effect by altering the levels of multiple fibroblast activation or inactivation proteins,such as TGF-β1,PDGF,uPA and TSP1,secreted by OCs and TME ***,GNPs represent a potential tool to help understand multicellular communications existing in the TME as well as devise strategies to disrupt the communication.

关键词： Gold nanoparticle(GNP) Cancer-associated fibroblast(CAF) Tumor microenvironment(TME) Fibroblast activation Morphology Migration

Targeting BMI1 mitigates chemoresistance in ovarian cancer

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Genes & Diseases 2022年第6期9卷 1415-1418页

作者： Anindya Dey Shailendra Kumar Dhar Dwivedi Lin Wang Md Nazir Hossen Fiifi Neizer-Ashun Magdalena Bieniasz Priyabrata Mukherjee John DBaird Marla Weetall resham bhattacharya Department of Obstetrics and Gynecology University of Oklahoma Health Science CenterOklahoma CityOK 73104USA Department of Aging and Metabolism Research Program Oklahoma Medical Research FoundationOklahoma CityOK 73104USA Department of Pathology University of Oklahoma Health Science CenterOklahoma CityOK 73104USA Department of Pharmaceutical and Biomedical Sciences College of PharmacyCalifornia Northstate UniversityElk GroveCA 95757USA Department of Cell Biology University of Oklahoma Health Science CenterOklahoma CityOK 73104USA Peggy and Charles Stephenson Cancer Center University of Oklahoma Health Science CenterOklahoma CityOK 73104USA PTC Therapeutics IncSouth PlainfieldNJ 07080USA

Resistance to chemotherapy is a prominent clinical problem in high grade serous ovarian cancer(HGSOC).1 An inadequate understanding of adaptive signaling coupled with limited treatment options for a chemoresistant tumor are likely causes for poor *** previously reported that BMI1,a stem-cell factor is instrumental in regulating chemoresistance.2,3 However,to advance anti-BMI1 therapy from the bench to the bedside,efficacy needs to be tested in patient-derived chemoresistant HGSOC models,which is lacking.

关键词： BMI1 cancer chemotherapy

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CORRIGENDUM

Genes & Diseases 2015年第4期2卷 353-353页

作者： resham bhattacharya Soumyajit Banerjee Mustafi Mark Street Anindya Dey Shailendra Kumar Dhar Dwivedi Department of Obstetrics and Gynecology Stephenson Cancer Center University of Oklahoma Health Science Center Oklahoma City OK 73104 USA.

[This corrects the article DOI: 10.1016/***.2015.04.001.].

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Carbon Dioxide and Nitrous Oxide Emissions from Naturally Occurring Sulfate-Based Saline Soils at Different Moisture Contents

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Pedosphere 2017年第5期27卷 868-876页

作者： resham THAPA Amitava CHATTERJEE Abbey WICK Kirsten BUTCHER Department of Soil Sciences School of Natural Resources Management North Dakota State University

Soil salinization may negatively affect microbial processes related to carbon dioxide （CO2） and nitrous oxide （N20） emissions. A short-term laboratory incubation experiment was conducted to investigate the effects of soil electrical conductivity （EC） and moisture content on CO2 and N20 emissions from sulfate-based natural saline soils. Three separate 100-m long transects were established along the salinity gradient on a salt-affected agricultural field at Mooreton, North Dakota, USA. Surface soils were collected from four equally spaced sampling positions within each transect, at the depths of 0-15 and 15-30 cm. In the laboratory, artificial soil cores were formed combining soils from both the depths in each transect, and incubated at 60% and 90% water-filled pore space （WFPS） at 25 ~C. The measured depth-weighted EC of the saturated paste extract （ECe） across the sampling positions ranged from 0.43 to 4.65 dS m-1. Potential nitrogen （N） mineralization rate and CO2 emissions decreased with increasing soil ECe, but the relative decline in soil CO2 emissions with increasing ECe was smaller at 60% WFPS than at 90% WFPS. At 60% WFPS, soil N20 emissions decreased from 133 g N20-N kg-1 soil at ECe （ 0.50 dS m-1 to 72 μg N20-N kg-1 soil at ECe = 4.65 dS m-1. In contrast, at 90% WFPS, soil N20 emissions increased from 262 g N20-N kg-1 soil at ECe ： 0.81 dS m-1 to 849 g N20-N kg-1 soil at ECe ： 4.65 dS m-1, suggesting that N20 emissions were linked to both soil ECe and moisture content. Therefore, spatial variability in soil ECe and pattern of rainfall over the season need to be considered when up-scaling N20 and CO2 emissions from field to landscape scales.

关键词： electric conductivity C and N mineralization salinity sulfate salts soil salinization soil water-filled pore space

Saline-Sodic Soils:Potential Sources of Nitrous Oxide and Carbon Dioxide Emissions?

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Pedosphere 2017年第1期27卷 65-75页

作者： Upasana GHOSH resham THAPA Thomas DESUTTER HE Yangbo Amitava CHATTERJEE Department of Soil Science North Dakota State University Key Laboratory of Arable Land Conservation(Middle and Lower Reaches of the Yangtze River) Ministry of AgricultureHuazhong Agricultural University

Increasing salt-affected agricultural land due to low precipitation, high surface evaporation, irrigation with saline water, and poor cultural practices has triggered the interest to understand the influence of salt on nitrous oxide （N20） and carbon dioxide （CO2） emissions from soil. Three soils with varying electrical conductivity of saturated paste extract （ECe）（0.44-7.20 dS m-1） and sodium adsorption ratio of saturated paste extract （SARe）（1.1-27.7）, two saline-sodic soils （S2 and S3） and a non-saline, non-sodic soil （S1）, were incubated at moisture levels of 40%, 60%, and 80% water-filled pore space （WFPS） for 30 d, with or without nitrogen （N） fertilizer addition （urea at 525μg g-1 soil）. Evolving CO2 and N20 were estimated by analyzing the collected gas samples during the incubation period. Across all moisture and N levels, the cumulative N20 emissions increased significantly by 39.8% and 42.4% in S2 and S3, respectively, compared to S1. The cumulative CO2 emission from the three soils did not differ significantly as a result of the complex interactions of salinity and sodicity. Moisture had no significant effect oi1 N20 emissions, but cumulative CO2 emissions increased significantly with an increase in moisture. Addition of N significantly increased cumulative N20 and CO2 emissions. These showed that saline-sodic soils can be a significant contributor of N20 to the environment compared to non-saline, non-sodic soils. The application of N fertilizer, irrigation, and precipitation may potentially increase greenhouse gas （N20 and CO2） releases from saline-sodic soils.

关键词： CO2 electrical conductivity greenhouse gas emission moisture N fertilizer application N20 salinity sodicity sodiumadsorption ratio

Hepatitis B virus therapy:What's the future holding for us?

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World Journal of Gastroenterology 2015年第44期21卷 12558-12575页

作者： Sobia Manzoor Muhammad Saalim Muhammad Imran Saleha resham Javed Ashraf Atta-ur-Rahman School of Applied BioSciences Department of Healthcare Biotechnology National University of Sciences and Technology Islam Dental College

Hepatitis B is one of the leading causes of liver cancer worldwide and unfortunately the number of people affected with hepatitis B virus(HBV) infection is still on the rise. Although the HBV has been known to cause fatal illness since decades but the population effected by this lethal virus have still only a few options for its management. The major treatment strategies include interferons and nucleos(t)ide analogues. These agents have so far produced unsatisfactory results in terms of complete virus eradication. Interferons cannot be used for long term therapy because of their potential side effects. Prolong treatment with nucleos(t)ide analogues has also been reported to cause serious side effects besides the increasing resistance by the virus. The need for new innovative solutions for treatment of HBV has been realized by global research institutes and pharmaceutical industry. Present review focuses in detail on the new ideas that are being transformed into therapeutic tools for use as future therapies in HBV infection. Modern drug designing and screening methods have made the drug discovery process shorter and more reliable. HBV therapeutics will take a new turn in coming years owing to these intelligent drug designing and screening methods. Future therapy of HBV is aiming to include the use of vaccines(both prophylactic and therapeutic), immunomodulators such as antibodies, non-nucleoside antivirals such as RNAi and inhibitors of viral life cycle.

关键词： Hepatitis B virus treatment Hepatitis B virus vacc

The Compulsion of Foreign Employment: Socio-Economic Circumstances of Developing Country

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Sociology Study 2020年第4期10卷 184-191页

作者： Shukra Raj Adhikari resham Khadka Tribhuvan University KathmanduNepal

Foreign employment is a burning issue for developing countries like Nepal. Nearly thousand Nepalese depart forforeign employment everyday. This paper is focused on exploring the reasons of foreign employment. Both primaryand secondary facts are used in this paper. Primary facts are collected through the case study and observationmethod. The purposive sampling method is used to select the cases. The cases are located in the Pokharametropolitan city of Nepal. Most people have gone abroad after marriage because of the financial burden and theresponsibility of earning money. Lack of cash, superstition, traditional beliefs, political and family conflicts,inter-caste marriages, and family structure have led to foreign employment. Most people go for foreign employmentwithout skills, and they work in construction, sanitation and, they get paid less and return home without *** facts are partially congruent to the theoretical explanation of Wallerstein.

关键词： employment family foreign globalization livelihood

Effect of row spacing and direction of sowing on yield and yield attributing characters of wheat cultivated in Western Chitwan, Nepal

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Agricultural Sciences 2013年第7期4卷 309-316页

作者： Bisheshwor Prasad Pandey Komal Bahadur Basnet Madan Raj Bhatta Shrawan Kumar Sah resham Bahadur Thapa Tanka Prasad Kandel Department of Agroecology Aarhus University Research Centre Foulum Tjele Denmark Institute of Agriculture and Animal Science Tribhuvan University Rampur Nepal National Wheat Research Program (NWRP) Rupendehi Nepal

A field experiment was conducted to study the growth and productivity of wheat as affected by row spacing and direction of sowing at Rampur, Chitwan, Nepal during the 2007-2008 wheat growing season. The experiment was carried out in 3-factors factorial randomized complete block design comprising two varieties (Gautam and BL-2800), three row spacings (15, 20 and25 cm) and two row directions of sowing (east-west and north-south). The effects of variety and row direction of sowing on grain yield were significant (p < 0.05), but the grain yield was not affected by the row spacing treatment. BL-2800 variety produced higher grain yield (3.53 t·ha-1) as compared to Gautam (3.11 t·ha-1). Both wheat varieties yielded about 11% higher (p < 0.05) grain in the north-south sowing as compared to the eastwest sowing.

关键词： Grain Yield Row Direction Row Spacing Triticum Aestivum Wheat Variety

Peoples’ Perception and Conservation of Dactylorhiza hatagirea (D. Don) Soóin Manaslu Conservation Area, Central Nepal

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American Journal of Plant Sciences 2016年第12期7卷 1662-1672页

作者： Bikram Pandey Arbindra Timilsina Binita Pandey Chhabi Lal Thapa Kamal Bahadur Nepali Pradeep Neupane resham Thapa Sunil Kumar Gaire Mohan Siwakoti Central Department of Botany Tribhuvan University Kirtipur Nepal Key Laboratory of Agricultural Water Resources Center for Agricultural Resources Research Institute of Genetic and Developmental Biology The Chinese Academy of Sciences Shijiazhuang China University of Chinese Academy of Sciences Beijing China Central Department of Zoology Tribhuvan University Kirtipur Nepal National Botanical Garden Godawari Lalitpur Nepal

The present study analyzes the information and perception of the local community of Samagaun VDC, Manaslu Conservation Area Project (MCAP) regarding Dactylorhiza hatagirea (D. Don) Soó (Orchidaceae). We assessed the local peoples’ perception on its population status, its availability, factors causing its decline and management practices of this terrestrial orchids. A pre-designed questionnaire was used to gather information targeting the age group between 25 and 60 years (n = 75, 45 male and 30 female). Most of the informants (76%) believe that the abundance of this orchid is declining. Over grazing of domestic animals, over harvesting and lack of awareness among the local community were determined to be the major causes of decline of D. hatagirea in the study area. Protection measures as prescribed by the informants were control grazing, raising awareness among the individuals and sustainable harvestings for the long-term conservation of the species. Systematic management plans that incorporate the participation of local individuals and prioritization of their views will be applicable for the proper conservation of the species.

关键词： Local Perceptions Conservation and Management Orchid Dactylorhiza hatagirea Samagaun VDC Manaslu Conservation Area