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Preventive treatments for recurrence after curative resection of hepatocellular carcinoma-A literature review of randomized control trials

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World Journal of Gastroenterology 2003年第4期9卷 635-640页

作者： Hui-Chuan Sun Zhao-You Tang liver cancer institute and Zhong Shan Hospital,fudan university,Shanghai 200032,China Associate Professor of Surgery Liver Cancer Institute and Zhong Shan Hospital Fudan University 136 Yi Xue Yuan Road Shanghai 200032 China. sunhc@***

To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications. reporting randomized control trial indexed in PubMed. The treatment approaches presented above included preoperative transcatheter arterial chemoembolization (TACE),post-operative TACE, systemic or locoregional chemotherapy,immunotherapy, Interferons and acyclic retinoic acid Although no standard treatment has been established,several approaches presented promising results, which were both effective and tolerable in post-operative patients. Preoperative TACE was not effective on prolonging survivals,while post-operative TACE was shown with both diseasefree survival and overall survival benefits in some papers,however, it was also questioned by others. Systemic chemotherapy was generally not effective on prolonging survival but also poorly tolerated for its significant *** immunotherapy using LAK cells was proved to be beneficial to patients' survival in a recent paper. Interferon and Interferon β can inhibit recurrence in HCC patients with HCV infection background, though the mechanism is not fully understood. Acyclic retinoic acid was shown to decrease multi-centric recurrence after operation, which was reported by only one group. In conclusion, several adjuvant approaches have been studied for their efficacy on recurrence in HCC patients in randomized control trials; however, multi-centric randomized control trial is still needed for further evaluation on their efficacy and systemic or local toxicities;in addition, new adjuvant treatment should be investigated to provide more effective and tolerable methods for the patients with HCC after operation.

关键词：预防性治疗肝细胞癌肿瘤切除术复发随机对照研究肝动脉化疗栓塞术

Plateau of α-function and c-minimal homoclinic orbits

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Science China Mathematics 2006年第7期49卷 922-931页

作者： LI Xia & CUI Xiaojun Department of Mathematics, university of Science and Technology of Suzhou, Suzhou 215009, China Mathematical research institute, fudan university, Shanghai 200433, China Department of Mathematics University of Science and Technology of Suzhou Suzhou China Mathematical research institute Fudan University Shanghai 200433 China

We consider the construction of the plateau of the α-function in a hyperbolic and positive definite Lagrangian system, and link the boundries of the α-function's plateau with the distribution of c-minimal homoclinic... 详细信息

关键词： α-function, β-function, plateau, Aubry sets.

原发性肝癌转化及围手术期治疗中国专家共识(2024版)

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中华消化外科杂志 2024年第4期23卷 492-513页

作者：中国抗癌协会肝癌专业委员会转化治疗协作组樊嘉白雪莉毕新宇纪元英卫东黎功刘嵘刘秀峰饶圣祥沈顺利施国明唐浩文王嘉倍王征吴志峰谢青徐立曾昭冲张岚张伟赵明朱小东不详复旦大学附属中山医院、复旦大学肝癌研究所上海200032 浙江大学医学院附属第一医院肝胆胰外科浙江省胰腺病研究重点实验室国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院肝胆外科复旦大学附属中山医院病理科中国科学技术大学附属第一医院肝脏外科清华大学附属北京清华长庚医院肝胆胰中心复旦大学附属中山医院介入治疗科东部战区总医院秦淮医疗区肿瘤科复旦大学附属中山医院放射科中山大学附属第一医院肝胆胰外科中心复旦大学附属中山医院肝肿瘤外科复旦大学肝癌研究所解放军总医院肝胆胰外科医学部中国科学技术大学附属第一医院肝胆外科复旦大学附属中山医院放疗科复旦大学附属中山医院肿瘤防治中心上海交通大学医学院附属瑞金医院感染科中山大学肿瘤防治中心肝脏外科复旦大学附属中山医院肝肿瘤内科天津医科大学肿瘤医院肝胆肿瘤科中山大学肿瘤防治中心微创介入治疗科华南国家重点实验室

我国目前仍有超过一半的肝癌患者在初诊时即为中晚期,丧失手术切除机会,而部分可手术患者术后复发转移率高,导致患者总体生存较差.随着外科手术技术的革新、系统治疗和局部治疗手段的丰富和进步,通过多模式综合治疗策略为肿瘤转化提供... 详细信息

我国目前仍有超过一半的肝癌患者在初诊时即为中晚期,丧失手术切除机会,而部分可手术患者术后复发转移率高,导致患者总体生存较差.随着外科手术技术的革新、系统治疗和局部治疗手段的丰富和进步,通过多模式综合治疗策略为肿瘤转化提供可能、使患者获得手术切除机会,同时有效降低术后复发转移率,从而实现患者长期生存获益.此外,近年来研究者对转化及围手术期治疗过程中手术时机的选择、病灶评估、疗效预测、并发症处理等方面进行了进一步有益探索.在原有共识的基础上修订并更新形成《原发性肝癌转化及围手术期治疗中国专家共识(2024版)》,提出了在肝癌转化治疗和围手术期治疗领域的治疗策略和实施过程需要解决的问题,以期为推动该领域研究和临床实践奠定基础.

关键词：肝肿瘤转化治疗围手术期治疗共识中国

Sorafenib in treatment of patients with advanced hepatocellular carcinoma:a systematic review

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Hepatobiliary & Pancreatic Diseases International 2012年第5期11卷 458-466页

作者： Xin Zhang, Xin-Rong Yang, Xiao-Wu Huang, Wei-Min Wang, Ruo-Yu Shi, Yang Xu, Zheng Wang, Shuang-Jian Qiu, Jia Fan ,Jian Zhou liver cancer institute, Zhongshan Hospital, fudan university, Shanghai Key Laboratory for Organ Transplantation, Shanghai 200032, China,institute of Biomedical Sciences, fudan university, Shanghai 200032, China liver cancer institute Zhongshan Hospital Fudan University and Shanghai Key Laboratory for Organ Transplantation Shanghai 200032 Shanghai China institute of Biomedical Sciences Fudan University Shanghai 200032 Shanghai China

BACKGROUND: Sorafenib has become the standard first-line treatment for patients with advanced hepatocellular carcinoma (HCC). This study aimed to assess the efficacy and safety of sorafenib in advanced HCC patients and explore its true value for specific subgroups. DATA SOURCES: A computer-based systematic search from January 2005 to June 2011 with 'sorafenib' and 'advanced hepatocellular carcinoma' as search terms was performed for possible clinical trials. Hazard ratios (HR) and their 95% confidence intervals (CI) for overall survival (OS) and time to progression (TTP), rates of partial response (PR), rates of toxicity effects, and details of subgroup analysis were extracted. Meta-analyses were done using the software Review Manager (version 5.0). RESULTS: Six trials with 1164 patients were included. Based on three randomized controlled trials, the pooled HR (sorafenib/ placebo) was 0.66 for OS (95% CI: 0.56-0.78; P<0.00001) and 0.57 for TTP (95% CI: 0.47-0.68; P<0.00001). The pooled odds ratio (OR) for PR was 2.96 (95% CI: 0.96-9.15; P=0.06). For three single-arm trials, the pooled HR was 0.69 for OS (95% CI: 0.56-0.84; P=0.0002) and 0.64 for TTP (95% CI: 0.52-0.78; P<0.00001). The pooled OR for PR in three single-arm trials was 3.56 (95% CI: 1.22-10.39; P=0.02). Subgroup analysis indicated that sorafenib was less effective in patients with extrahepatic spread (with: P=0.13 vs without: P<0.0001), with normal alpha-fetoprotein level (AFP) (P=0.15 vs elevated: P=0.0006), and with elevated level of serum bilirubin (P=0.06 vs normal: P=0.0009). Sorafenib-based therapy significantly increased the risk of grade 3/4 hand-foot skin reaction, diarrhea, fatigue, and rash/***: Sorafenib-based therapy benefits advanced HCC patients. Meanwhile, sorafenib is less effective for patients with extrahepatic spread, with normal AFP level and with elevated level of bilirubin.

关键词： advanced hepatocellular carcinoma sorafenib systematic review

Solitary fibrous tumor of the liver

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Hepatobiliary & Pancreatic Diseases International 2006年第1期5卷 151-153页

作者： Yuan Ji, Jia Fan, Yang Xu, Jian Zhou, Hai-Ying Zeng and Yun-Shan Tan Department of Pathology and liver cancer institute Zhongshan Hospital, fudan university, Shanghai 200032, China Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 China. yji@***

BACKGROUND: Solitary fibrous tumor of the liver is a rare neoplasm. So far, 23 cases have been described in the English literature. We reported an additional case. METHODS: A 46-year-old woman presented with abdominal mass for 2 weeks. Both abdominal sonography and CT scan showed a solid mass occupying the right lobe of the liver. Right lobectomy was performed and the tumor was resected. RESULTS: Pathological examination showed spindle cell and fibroblast-like cells within the collagenous troma. On immunohistochemical staining, these spindle tumor cells showed diffusely CD34 positive reactivity. The post-operative course was uneventful. The patient recovered smoothly, and was alive half a year without evidence of disease recurrence. CONCLUSIONS: The proper diagnosis was depended on CD34 immunohistochemical study. The number of solitary fibrous tumor of the liver reported to date is too limited to confirm the definite prognosis of the tumor.

关键词： liver neoplasm solitary fibrous tumor CD34

Electronic Structure Calculation for Co_6(μ_6-C)(μ_3-S)_2(CO)_(12) Cluster

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Chinese Chemical Letters 1997年第4期8卷 351-352页

作者： Wen LI Ye LIU Yuan Qi YIN( Lanzhou institute of Chemical Physics, Academia Sinica)(research Center of Analysis and Measurement, fudan university, Shanghai 200433) Res. Ctr. of Anal. and Measurement Fudan University Shanghai 200433 China Lanzhou Inst. of Chemical Physics Academia Sinica Fudan University Shanghai 200433 China

The electronic Structure ofCo6(μ_6-C)(μ_3-S)_2(CO)_(12) molecule has been calculated by DV-Xα method. The results show that the reaction mechanism of CS_2 and Co2(CO)8 in synthsis seems only to undergo the additive and decarbonyl processes. The other result worthy of being mentioned is the calculated atonmic charges that are Co0.3+,S1.29+,μ6-Cl. 16-,C0.06- and O0.21-.S atom has not only the positive charge but also four times as much as that of Co atom. This is not in accordance with the electronegativihes of 1.7 and 2.5 respectively for Co and S atom

关键词： Co CO Cluster

Risk factors for postoperative complications after liver resection

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 370-374页

作者： Hui-Chuan Sun, Lun-Xiu Qin, Lu Wang, Qin-Hai Ye, Zhi-Quan Wu, Jia Fan and Zhao-You Tang liver cancer institute and Zhongshan Hospital, fudan university, Shanghai 200032, China liver cancer institute and Zhongshan Hospital Fudan University Shanghai 200032 China. sunhc@***

liver resection is still a complicated operation with a high risk of postoperative morbidity. This study was undertaken to analyze the risk factors for postoperative complications after liver resection. METHODS:From 2001 to 2004, a total of 146 patients underwent liver resection for malignant or benign lesions. Postoperative complications after the resection were classified as surgical and medical, their incidences were analyzed *** risk factors for both surgical and medical complications were analyzed. To increase the safety of liver resection, surgical techniques were modified after April 2003, including control of inflow or outflow and intra- operative test with methylene blue. RESULTS:Before April 2003, a series of 58 patients received liver resection. Modified surgical techniques were used in liver resections for 88 patients after April 2003.A total of 36 patients (24.7%) had postoperative complications. Surgical and medical complications occurred in 24 and 13 patients respectively (One patient had both surgical and medical complications). Perioperative blood transfusion was related to a higher risk of surgical complications (Pliver resection may help to decrease postoperative medical complications also.

关键词： hepatocellular carcinoma resection complications

Harmonic Maps from Kahler Manifolds

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Acta Mathematica Sinica,English Series 1999年第2期15卷 277-292页

作者： Yuanlong Xin, institute of Mathematics and LMNS, fudan university, Shanghai 200433, P. R. ChinaE-mail: ylxin@fudan, edu. cn institute of Mathematics and LMNS Fudan University Shanghai P. R. China

Some Liouville type theorems for harmonic maps from Kahler manifolds are obtained. The main result is to prove that a harmonic map from a bounded symmetric domain (except IV（2）) to any Riemannian manifold with finit... 详细信息

关键词： Harmonic map Kahler manifold Bounded symmetric domain

Investigating inflammationary cytokines associated with recurrence of hepatocellular carcinoma

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Investigating inflammationary cytokines associated with recu...