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Prognostic significance of preoperative Naples prognostic score on short-and long-term outcomes after pancreatoduodenectomy for ampullary carcinoma

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Hepatobiliary Surgery and Nutrition 2021年第6期10卷 825-838,I0011页

作者： Jikuan Jin Hebin Wang Feng Peng Xiaoxiang Wang Min Wang Feng Zhu Guangbing Xiong renyi qin Department of Biliary-Pancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:The Naples prognostic score(NPS)is an effective and objective tool to assess the immune-nutritional status of patients with malignant *** aim of this study was to investigate the clinical significance of preoperative NPS on short-and long-term outcomes after pancreatoduodenectomy(PD)for ampullary ***:We retrospectively analyzed 404 consecutive patients with ampullary carcinoma who underwent PD between January 2012 and June *** NPS was calculated from serum albumin and total cholesterol concentrations,and the neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio(LMR).Patients were then divided into three groups according to their *** variables,postoperative outcomes,and survival data were compared between the three *** and multivariate Cox analysis of overall survival(OS)and recurrence-free survival(RFS)were also conducted,and time-dependent receiver operating characteristic(ROC)curves were created to evaluate the discriminatory ability of the prognostic scoring ***:Patients with higher NPS had worse prognosis,and significant OS difference(group 0 vs.1,P=0.02;group 1 vs.2,P<0.001;group 0 vs.2,P<0.001)and RFS difference(group 0 vs.1,P=0.088;group 1 vs.2,P<0.001;group 0 vs.2,P<0.001).Multivariate analysis revealed that NPS was an independent significant predictor of OS(grade 2 *** 1 or 0,hazard ratio:3.067;P<0.001)and RFS(grade 2 *** 1 or 0,hazard ratio:2.732;P<0.001).The time-dependent receiver operating curve analysis showed that NPS had better prognostic performance for OS and RFS than other prognostic ***,significant differences in the incidence of postoperative morbidity were observed between the three groups,and the NPS was an independent risk factor of overall postoperative complications(grade 2 *** 1 or 0,odds ratio:1.692;P=0.02).Conclusions:The NPS was an independent predictor of overall-and RFS in patients undergoing PD for ampullary

关键词： Naples prognostic score(NPS) ampullary carcinoma prognostic factor immune-nutritional status postoperative outcomes

The current status of laparoscopic pancreaticoduodenectomy for pancreatic cancer in China

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Oncology and Translational Medicine 2016年第6期2卷 247-248页

作者： Hang Zhang renyi qin Department of Biliary-Pancreatic Surgery The Affiliated Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology

Pancreatic cancer is the fourth leading cause of cancer death worldwide and leads to an estimated 220 000 deaths per year[1].The malignancy is difficult to detect and diagnose,as there are no noticeable signs or symptoms in the early stages of the disease,and the pancreas is located deep in the *** resection is widely accepted as the only potentially curative therapy

关键词： The current status of laparoscopic pancreaticoduodenectomy for pancreatic cancer in China

Laparoscopic middle pancreatectomy

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Oncology and Translational Medicine 2016年第6期2卷 249-250页

作者： Xingjun Guo renyi qin Department of Biliary-Pancreatic Surgery The Affiliated Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology

Pancreaticoduodenectomy and distal pancreatectomy are the traditional surgical treatments of tumors in the neck or body of the pancreas. Although resecting the lesions successfully, these procedures can also, however, lead the substantial loss of normal pancreatic parenchyma, causing endocrine and exocrine function disorder. The combination of distal pancreatectomy with splenectomy increased the risk of thrombosis sometimes. So the surgical trauma is too great, especially for benign and lower malignant tumors located in the neck or body of the pancreas. While, middle pancreatectomy may decrease operative trauma with the excision of these lesions, and can maximize the retention of pancreatic parenchyma, and maintain pancreatic endocrine and exocrine function integrity. The procedure is interesting but rarely performed. With the application and development of minimally invasive surgical techniques, laparoscopic and robotic middle pancreatectomy are available now. Researches about laparoscopic and robotic middle pancreatectomy are presented, with decreased morbidity, reduced operation time and hospital stay. There is only a few reports on the two procedures, but the security and effectiveness of them are suggested.

关键词： laparoscopic middle pancreatectomy minimally invasive surgery

指导手术方式选择的胰腺癌分型及其与TNM分期相关性的探讨

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中华外科杂志 2015年第7期53卷 488-491页

作者：秦仁义华中科技大学同济医学院附属同济医院胆胰外科中心武汉430030

尽管国际上已有多个关于胰腺癌的分期方法,如UICC分期和JPS分期,但这些分期均基于TNM评估体系,尚不能指导术前手术方式的选择.笔者依据胰腺癌的位置和其与重要血管的关系提出了一种新的胰腺癌分型方法,将胰腺癌分成8型,初步提出了各型... 详细信息

尽管国际上已有多个关于胰腺癌的分期方法,如UICC分期和JPS分期,但这些分期均基于TNM评估体系,尚不能指导术前手术方式的选择.笔者依据胰腺癌的位置和其与重要血管的关系提出了一种新的胰腺癌分型方法,将胰腺癌分成8型,初步提出了各型胰腺癌的最佳手术方式和其与TNM分期的相关关系.这是以胰腺癌手术方式选择为目的的胰腺癌分型,以期对规范胰腺癌手术、提高手术安全性和R0切除率.

关键词：胰腺肿瘤肿瘤分期

Application of mastoscopic in modified radical operation for preserving nipple-areolar complex

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The Chinese-German Journal of Clinical Oncology 2008年第6期7卷 332-334页

作者： Guolou Li renyi qin Jun Hu Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Weifang Traditional Chinese Medical Hospital Weifang 261041 China

Objective: To probe the effect of mastoscopic in modified radical mastectomy operation for preserving nipple-areolar complex in the treatment of breast cancer. Methods: Thirty patients, with breast cancer of a diameter≤3 cm and a distance≥3 cm from the mammary areola were treated by mastoscopic from November 2003 to August 2006. After the lipoly- sis and suction of axillary fat, mastoscopic axillary lymph node dissection was performed. Results: The average operation time was 128.9 min (120–156 min), the intraoperative blood loss was 56 mL (30–100 mL). The mean lymph nodes harvested by endoscopy were 16 (6–34). Excellent cosmetic outcomes were obtained with symmetrical breast development and all the patients were satisfied with the treatment. Postoperative follow-up for 2–29 months (mean, 16.6 months) found no local recur-rence. Conclusion:This model of operation can protect the upper limb function and has value of aesthetics of the brisket. What’s more, improve the quality of survive of the patients.

关键词： breast neoplasms mastoscopy nipple preserving surgical operation

全腹腔镜胰十二指肠切除术路径选择和技术流程优化之我见

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中华外科杂志 2017年第5期55卷 343-345页

作者：秦仁义华中科技大学同济医学院附属同济医院胆胰外科武汉430030

全腹腔镜胰十二指肠切除术的手术路径选择和技术流程优化,以及手术安全保障和肿瘤根治性切除方法等仍是胰腺外科医师不断探索的重要课题.作者在大量全腹腔镜胰十二指肠切除手术实践的基础上,对其路径的选择、技术流程的优化措施等方面... 详细信息

全腹腔镜胰十二指肠切除术的手术路径选择和技术流程优化,以及手术安全保障和肿瘤根治性切除方法等仍是胰腺外科医师不断探索的重要课题.作者在大量全腹腔镜胰十二指肠切除手术实践的基础上,对其路径的选择、技术流程的优化措施等方面进行了阐述.

关键词：胰十二指肠切除术腹腔镜检查手术路径技术流程

EFFECT OF SOMATOSTATIN ON THE EXPRESSION OF TNF α mRNA IN MULTIORGANS OF RATS WITH ACUTE HEMORRHAGIC NECROTIC PANCREATITIS

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Chinese Medical Sciences Journal 1998年第3期13卷 134-137页

作者：秦仁义肖雪明邹声泉吴在德裘法祖 Department of Surgery Tongji Hospital Tongji Medical University Wuhan 430030 China

*** study the expression of TNF α mRNA and the effect of somatostatin on the expression of TNF α mRNA in multiorgans of rats with acute hemorrhagic necrotic pancreatitis(AHNP). *** in the rat was induced by retrograde injection of 5% sodium taurocholate into the bile-pancreatic duct. Somatostatin octapeptide (SS-OP) (2μg/kg)was injected into the femoral vein imme- diately in rats of the treatment group after inductive AHNP. Rats of the sham operative group received in- jection of saline. Sixty animals of the AHNP and sham operative groups at the designated time(0. 2h, 0. 5 h, 2h, 4h, 8h, after the operation,six animals at each time point)and tweleve animals of treatment group at 4h after the operation were sacrificed for samples of pancreas, liver and lung. The expressions of TNF α mRNA within the pancreas, liver and lung were established by RT－PCR. Results. TNF α mRNA became detectable in the pancreas as early as 0. 2h after inductive AHNP, while it was undetectable in other organs until 0. 5h. Expression of TNF α　mRNA in each tissue increased continuously and reached a peak at 4h,demonstrating a significant difference compared with that at 0. 5h and 8h. Expressions of TNF α mRNA from pancreas, liver and lung were decreased 50-80% in the　treat- ment group, the pancreatic necrosis was also attenuated dramatically. Conclusion. TNF α mRNA was detectable in pancreas,liver and lung tissues at the early stage of AH- ***-OP can significantly inhibit the expression of TNF α mRNA and attenuate the pancreatic necrosis. We feel that this may be an important mechanism of SS-OP in the treatment of AHNP.

关键词： acute hemorrhagic necrotic pancreatitis somatostatin-octapeptide TNF α mR- NA gene expression

Recombinant adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene suppresses human pancreatic cancer growth

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 464-468页

作者： Rui Tian renyi qin Zhiyong Du Wei Xia Chengjian Shi Department of Biliary-Pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Scienceand Technology Wuhan 430030 China

Objective: To investigate the antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene transfection mediated by adenovirus into human pancreatic carcinoma cell line Panc-1, and the mechanisms involved in this effect. Methods: TRAIL gene was transfected into pancreatic cancer cell line Panc-1 by an adenovirus vector (Ad-TRAIL). Level of TRAIL mRNA expression was determined using RT-PCR, and TRAIL protein synthesis was evaluated with Western blot. Cell-growth activities were determined by MTT assay. The bystander effect was observed by co-culturing the Panc-1 cells with the transfected TRAIL gene at different ratios. Apoptosis in pancreatic cancer cells was detected by flow cytometry. Procaspase-8 and procaspase-3 were determined by Western blot. Results: The stable overexpression of TRAIL was de-tected in Panc-1 cells transfected by Ad-TRAIL. Ad-TRAIL significantly inhibited of cell viability of Panc-1 cells. Furthermore, co-culture of cancer cells transfected with TRAIL with that nontransfected resulted in the cell death of both cells by bystander effect. Moreover, the percentage of apoptotic cells was significantly higher in the Ad-TRAIL-treatment group compared to the control groups (P < 0.01). And there was a diminished amount of procaspase-8 and procaspase-3 after infection with Ad-TRAIL. Conclusion: The overexpression of TRAIL gene in Panc-1 cells by Ad-TRAIL exerts its antitumor effects, and the mechanisms involved in this effect may be proapoptosis and bystander effect.

关键词： pancreatic carcinoma adenovirus vector TRAIL apoptosis bystander effect

Isolation of side population cells from gallbladder carcinoma of human being and the expression of ABCG2 gene

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 469-473页

作者： Jun Hu Jian Li Min Wang Zhiyong Du Min Chen renyi qin Department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Oncology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

Objective: To investigate whether the side population cells (SP cells) exist in human gallbladder carcinoma cell line and the differences of drug resistance gene ABCG2 expression in SP cells, non-SP cells and GBC-SD cell lines. Methods: Fluorescence activated cell sorter (FACS) was used to sort the SP and non-SP cells from GBC-SD cell line of gallbladder carcinoma of human being. Then, the sorting cells were cultured and detected the expression of ABCG2 gene among the SP cells, non-SP cells and GBC-SD cell lines by using reverse transcription polymerase chain reaction (RT-PCR), immunofluo-rescence chemistry, western blot and flow cytometry techniques. Results: A very small fraction cells (0.64 ± 0.08%) were iso-lated through FACS analysis which had the potency of stem cells and highly expressed ABCG2 gene (89.56 ± 3.86%). On the contrary, there were nearly no expression in non-SP cells (1.32 ± 0.49%) and lower expression in GBC-SD cell line (12.37 ± 1.61%). Conclusion: The side population cells that had the potency of stem cells existed in human gallbladder carcinoma cell line and over-expressed the drug resistance gene ABCG2. They may be play an important role in drug resistance of tumor.

关键词： side population cells ABCG2 gallbladder carcinoma stem cel