检索结果-南通市图书馆

Multidisciplinary perspective of hepatocellular carcinoma: A Pacific Northwest experience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第11期7卷 1460-1483页

作者： Matthew M Yeh Raymond S Yeung Smith Apisarnthanarax renuka bhattacharya Carlos Cuevas William P Harris Tony Lim Kiat Hon Siddharth A Padia James O Park Kevin M Riggle Sayed S Daoud Department of Pathology University of Washington School of Medicine Department of Medicine University of Washington School of Medicine Northwest Liver Research Program Depart-ment of Surgery University of Washington School of Medicine Department of Radiation Oncology University of Washington School of Medicine Department of Radiology University of Washington School of Medicine Seattle Department of Pathology Singapore General Hospital Department of Pharmaceutical Sciences Washington State University Health Sciences

Hepatocellular carcinoma(HCC) is the most rapidly increasing type of cancer in the United States. HCC is a highly malignant cancer, accounting for at least 14000 deaths in the United States annually, and it ranks third as a cause of cancer mortality in men. One major difficulty is that most patients with HCC are diagnosed when the disease is already at an advanced stage, and the cancer cannot be surgically removed. Furthermore, because almost all patients have cirrhosis, neither chemotherapy nor major resections are well tolerated. Clearly there is need of a multidisciplinary approach for the management of HCC. For example, there is a need for better understanding of the fundamental etiologic mechanisms that are involved in hepatocarcinogenesis, which could lead to the development of successful preventive and therapeutic modalities. It is also essential to define the cellular and molecular bases for malignant transformation of hepatocytes. Such knowledge would:(1) greatly facilitate the identification of patients at risk;(2) prompt efforts to decrease risk factors; and(3) improve surveillance and early diagnosis through diagnostic imaging modalities. Possible benefits extend also to the clinical management of this disease. Because there are many factors involved in pathogenesis of HCC,this paper reviews a multidisciplinary perspective of recent advances in basic and clinical understanding of HCC that include: molecular hepatocarcinogenesis, noninvasive diagnostics modalities, diagnostic pathology, surgical modality, transplantation, local therapy and oncological/target therapeutics.

关键词： Genetic alterations Epigenetic alterations Diagnostic pathology Diagnostic imaging Surgicalmodality Liver transplantation Locoregional therapy Sorafenib Hepatocellular carcinoma Liver resection

D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2014年第3期4卷 206-215页

作者： Jeffrey B Halldorson Robert L Carithers Jr renuka bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins Division of Transplant Surgery Department of Surgery University of California San Diego CA 92103-8401 United States Division of Transplantation Department of Surgery University of Washington Seattle WA 98195 United States Division of Gastroenterology Department of Medicine University of Washington Seattle WA 98195 United States

AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after ***: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was ***: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant ***: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient.

关键词： Liver transplantation The product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age Donor/recipient matching Markov microsimulation Model for End-Stage Liver Disease Donor age

Surface ozone scenario and air quality in the north-central part of India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2017年第9期29卷 72-79页

作者： renuka Saini Ajay Taneja Pradyumn Singh Department of Chemistry Dr.Bhim Rao Ambedkar UniversityAgra 282002India

Tropospheric pollutants including surface ozone（O3）, nitrogen dioxide（NO2）, carbon monoxide（CO） and meteorological parameters were measured at a traffic junction（78°2′ E and 27°11′ N） in Agra, India from January 2012 to December 2012. Temporal analysis of pollutants suggests that annual average mixing ratios of tropospheric pollutants were： O3— 22.97 ± 23.36 ppbV,NO2— 19.84 ± 16.71 ppb V and CO — 0.91 ± 0.86 ppm V, with seasonal variations of O3 having maximum mixing ratio during summer season（32.41 ± 19.31 ppbV）, whereas lowest was found in post-monsoon season（8.74 ± 3.8 ppbV）. O3 precursors： NO2 and CO, showed inverse relationship with O3. Seasonal variation and high O3 episodes during summer are associated with meteorological parameters such as high solar radiation, atmospheric temperature and transboundary transport. The interdependence of these variables showed a link between the daytime mixing ratios of O3 with the nighttime level of NO2. The mixing ratios of CO and NO2 showed tight correlations, which confirms the influence of vehicular emissions combined with other anthropogenic activities due to office/working hours, shallowing, and widening of boundary layer. FLEXTRA backward trajectories for the O3 episode days clearly indicate the transport from the NW and W to S/SE and SW direction at Agra in different seasons.

关键词： Surface ozone Ozone precursors Diurnal and seasonal variation PCA Ozone transport

Investigation of block foundations resting on soil-rock and rock-rock media under coupled vibrations

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2017年第2期9卷 305-317页

作者： renuka Darshyamkar Ankesh Kumar Bappaditya Manna Department of Civil Engineering Indian Institute of Technology DelhiHauz KhasNew Delhi110016India

In the present study,the dynamic response of block foundations of different equivalent radius to mass（R;/m） ratios under coupled vibrations is investigated for various homogeneous and layered *** frequency-dependent stiffness and damping of foundation resting on homogeneous soils and rocks are determined using the half-space *** dynamic response characteristics of foundation resting on the layered system considering rock-rock combination are evaluated using finite element program with transmitting *** versus amplitude responses of block foundation are obtained for both translational and rotational motion.A new methodology is proposed for determination of dynamic response of block foundations resting on soil-rock and weathered rock-rock system in the form of equations and *** variations of dimensionless natural frequency and dimensionless resonant amplitude with shear wave velocity ratio are investigated for different thicknesses of top soil/weathered rock *** dynamic behaviors of block foundations are also analyzed for different rock-rock systems by considering sandstone,shale and limestone underlain by *** variations of stiffness,damping and amplitudes of block foundations with frequency are shown in this study for various rock—rock *** the analysis,two resonant peaks are observed at two different frequencies for both translational and rotational *** is observed that the dimensionless resonant amplitudes decrease and natural frequencies increase with increase in shear wave velocity ***,the parametric study is performed for block foundations with dimensions of 4 m × 3 m × 2 m and 8m×5m×2m by using generalized *** variations of natural frequency and peak displacement amplitude are also studied for different top layer thicknesses and eccentric moments.

关键词： Rock-rock system Block foundation Coupled vibration Homogeneous medium Equivalent radius to mass ratio Half-space theory

Design of soft magnetic materials

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2022年第1期8卷 17-26页

作者： Ananya renuka Balakrishna Richard D.James Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA90089USA Aerospace and Engineering Mechanics University of MinnesotaMinneapolisMN55455USA

We present a strategy for the design of ferromagnetic materials with exceptionally low magnetic hysteresis,quantified by *** this strategy,we use a micromagnetic algorithm that we have developed in previous research and which has been validated by its success in solving the“Permalloy Problem”—the well-known difficulty of predicting the composition 78.5%Ni of the lowest coercivity in the Fe–Ni system—and by the insight it provides into the“Coercivity Paradox”of ***,the design strategy predicts that cubic materials with large saturation magnetization ms and large magnetocrystalline anisotropy constant κ_(1) will have low coercivity on the order of that of Permalloy,as long as the magnetostriction constantsλ_(100),λ_(111)are tuned to special *** explicit prediction for a cubic material with low coercivity is the dimensionless number(c_(11)−c_(12))λ_(100)^(2)/(2_(κ_(1)))=81 for〈100〉easy *** results would seem to have broad potential application,especially to magnetic materials of interest in energy research.

关键词： magnetic cubic exceptional

An overview of deep eutectic solvents:Alternative for organic electrolytes,aqueous systems&ionic liquids for electrochemical energy storage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2023年第7期82卷 592-626,I0013页

作者： Akshay Sharma renuka Sharma Ramesh C.Thakur Lakhveer Singh Department of Chemistry Himachal Pradesh UniversitySummer HillShimla171005Himachal PradeshIndia Department of Chemistry Sardar Patel UniversityMandi175001Himachal PradeshIndia

As the demand for sustainable energy sources continues to rise,the need for efficient and reliable energy storage systems becomes *** order to effectively store and distribute renewable energy,new and innovative solutions must be *** review examines the deep eutectic solvents(DESs)as a green,safe,and affordable solution for the electrochemical energy storage and conversion field,offering tremendous opportunities and a promising *** are a class of environment-friendly solvents known for their low toxicity and unique properties,such as their good conductivity,high thermal stability,and *** review explores the fundamentals,preparations,and various interactions that often predominate in the formation of DESs,the properties of DESs,and how DESs are better than traditional solvents involving cost-ineffective and unsafe organic electrolytes and ionic liquids as well as inefficient aqueous systems due to low energy density for electrochemical energy storage ***,a particular focus is placed on the various electrochemical applications of DESs,including their role in the electrolytes in batteries/supercapacitors,electropolishing and electrodeposition of metals,synthesis of electrode materials,recycling of electrodes,and their potential for use in CO_(2)*** review concludes by exploring the challenges,research gaps,and future potential of DESs in electrochemical applications,providing a comprehensive overview,and highlighting key considerations for their design and use.

关键词： Deep eutectic solvent Green solventHole theory Energy storage devices Aqueous electrolyte

A Secure Energy Efficient IoT Based Fractional Correlated Bayesian Data Transmission in WSNs

在线全文

学校读者我要写书评

暂无评论

Journal of Communications and Information Networks 2019年第1期4卷 54-66页

作者： renuka Mohanraj Eduard Babulak Department of Computer Science Maharishi University of ManagementFairfieldIA 52556USA National Science Foundation USA

Wireless sensor networks(WSNs)contribute significant advantages over conventional methods for diverse applications,including healthcare,surveillance,environmental monitoring,and so *** are combined with the Internet protocol to develop the Internet of things(IoT)for associating day-to-day life objects to the *** IoT is an extensive collection of devices containing sensors associated together over wireless *** the swift growing of IoT over the past decade,security has been recognized as one of the issues to be addressed during data transmission between several *** this study,a secure machine learning-based IoT system for WSN is *** is called rectangular rationale correlated Bayesian(RRCB)method in WSNs for secure IoT data *** facilitate energy-efficient data encryption,a method named rectangular rationale energy-efficient algorithm based on an efficient key generation mechanism is *** proposed RRCB in WSNs with the Internet to develop a novel machine learning-based IoT system using correlated Bayesian secured method to ensure secure data transmission between several interconnected sensors spread over a long converge *** developed IoT based system has a significant performance by satisfying all the requisite security *** experimental results show that the proposed method consumes less energy in comparison with the state-of-the-art methods.

关键词： wireless sensor networks Internet protocol Internet of things rectangular rationale correlated Bayesian

Microalgal bioinoculants for sustainable agriculture and their interactions with soil biotic and abiotic components:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2024年第2期34卷 297-314页

作者： Shisy JOSE Nirmal renuka Sachitra Kumar RATHA Sheena KUMARI Faizal BUX Institute for Water and Wastewater Technology Durban University of TechnologyP.O.Box 1334Durban 4000South Africa Algal Biotechnology Laboratory Department of BotanyCentral University of PunjabBathinda 151401India Phycology Laboratory Council of Scientific and Industrial Research-National Botanical Research InstituteLucknowUttar Pradesh 226001India

Modern agricultural practices have posed a detrimental impact on the environment due to their intensive use to meet the food demands of an ever-increasing *** this context,microalgal bioinoculants,specifically cyanobacteria and green microalgae,have emerged as sustainable options for agricultural practices to improve soil organic carbon,nutrient availability,microbial quality,and plant *** overview of current and future perspectives on the use of microalgal bioinoculants in agriculture practices is presented in this review,along with a discussion of their interactions with soil biotic and abiotic factors that affect soil fertility,plant health,and crop *** benefits of microalgal bioinoculants include releasing agronomically important metabolites(exopolymers and phytohormones)as well as solubilizing soil ***,they function as biocontrol agents against soil-borne pathogens and facilitate the establishment of rhizosphere communities of agricultural *** far,very few studies have explored the basic mechanisms by which microalgal bioinoculants interact with soil biotic and abiotic *** recent years,advanced molecular techniques have contributed to a better understanding of these interactions.

关键词： biocontrol agent biofertilizer cyanobacteria microalgae microbial community molecular technique plant growth soil fertility

USING EARLY-STAGE ASSESSMENT TO REDUCE THE FINANCIAL RISKS AND PERCEIVED BARRIERS OF SUSTAINABLE BUILDINGS

在线全文

学校读者我要写书评

暂无评论

Journal of Green Building 2010年第2期5卷 114-128页

作者： renuka Ranaweera Robert H.Crawford Faculty of Architecture Building and PlanningThe University of MelbourneVictoria3010Australia

For sustainable buildings to become mainstream they must demonstrate not only improved environmental performance but also financial performance,benefiting both end users and *** perceived financial constraints and risks are often major barriers to sustainable *** paper discusses the application of a new tool that formalizes the traditionally intuitive-based early-stage decision making processes and assesses the potential for creating a financially feasible best-practice sustainable building across a range of environmental,social and economic parameters,using the limited data available at the outset of a *** considers the total cost of ownership,demonstrating the link between the recurrent and capital costs.A detailed feasibility assessment of those areas where greatest potential for improving environmental and financial performance exists can then be carried out,saving a considerable amount of time,money and effort otherwise spent on looking at all possible strategies for achieving a sustainable *** approach also identifies areas where incorporating environmental strategies might be financially risky,reassuring investors and developers by reducing investment *** reducing some of these risks and perceived barriers to sustainable building development,it is hoped that clients and investors will be further encouraged to adopt a more sustainable approach to their building projects.

关键词： sustainable buildings environmental performance financial performance life cycle approach early stage assessment