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Health 2010年第6期2卷 595-602页

作者： Nishi Sondhi renu Bhardwaj Satwinderjeet Kaur Madhu Chandel Neeraj Kumar Bikram Singh 不详

Brassinosteroids (BRs) are a large group of polyhydroxy steroids, which regulate numerous aspects of plant growth and development, including stem elongation, leaf bending, tracheary element differentiation, stress protection and photomorphogenesis. Recent studies indicate antigenotoxic and anticancerous activities of these compounds. The role of natural BRs in H2O2 (hydrogen peroxide) -induced DNA damage in human lymphocytes is still unknown. The present study reports the presence of Castasterone from leaves of Centella asiatica, an important medicinal herb commonly used as a memory enhancer and immunomodulator. CA50 fraction isolated from Centella asiatica was characterized as Castasterone by electrospray ionization mass spectral data with standard Castasterone. An attempt has been made to study antigenotoxic activity of the isolated Castasterone against H2O2 -induced DNA damage in human blood lymphocytes using Single cell gel electrophoresis assay (Comet Assay). Castasterone at 10–9 M concentration proved to be effective in diminishing the DNA damage by 89.42 %.

关键词： Brassinosteroids Castasterone Comet Assay Hydrogen Peroxide

Prevalence of HIV in a Tertiary Care Centre in Delhi: A Five-Year ICTC Based Study

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World Journal of AIDS 2015年第1期5卷 1-9页

作者： Banke Lal Sherwal Poonam Gupta Rojalin Nayak Sanjib Gogoi Sarika Suri renu Dutta Department of Microbiology Lady Hardinge Medical College New Delhi India

Objective: The purpose of this study is to estimate the prevalence of HIV infection among the clients attending ICTC, LHMC of New Delhi, for a period of five years, i.e., from 2008 to 2012. Material & Method: A total of 25,413 clients attended ICTC, LHMC from the year 2008 to 2012. Serum samples were collected after taking informed consent and pre-test counseling. In India for all ICTCs, NACO (National AIDS Control Organization), a national guidelines has been followed for HIV testing, reporting and release of results with post test counseling. Results: Out of the total 25,413 clients tested for HIV infection, 963 (3.78%) were found to be HIV-1 seropositive. Seropositivity was higher in male clients i.e. 625 (64.4%) than female i.e. 336 (34.8%) followed by transgender (TG), i.e., 2 (0.2%). Heterosexual route of transmission was the major route seen in 676 clients (70.1%). Maximum HIV seropositivity was in the age group of 25 - 34 years (35.4%). No HIV-2 case was found among the studied population. Conclusion: HIV prevalence of 3.78% among the clients attending ICTC, LHMC, New Delhi, puts light on the burden on HIV in this part of the country and suggests the need for the scaling up of focused prevention efforts in high-risk groups.

关键词： HIV Seropositivity ICTC Heterosexual Transgender

Role of intraluminal brachytherapy in palliation of biliary obstruction in cholangiocarcinoma:A brief review

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 106-112页

作者： Divya Khosla Samreen Zaheer Rahul Gupta renu Madan Shikha Goyal Narendra Kumar Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Educa Department of Gastroenterology and Hepatology Shalby Multispeciality HospitalMohali 160062PunjabIndiation and ResearchChandigarh 160012U.T.India

Surgery is the only curative treatment for cholangiocarcinoma. However, mostpatients present with advanced disease, and hence are unresectable. Thus, theintent of treatment shifts from curative to palliative in the majority of *** drainage with intraluminal brachytherapy is an effective means ofrelieving the malignant biliary obstruction. In this review, we discuss the role ofbrachytherapy in the palliation of obstructive symptoms in extrahepatic cholangiocarcinoma.

关键词： Biliary tract Cholangiocarcinoma Extrahepatic Intraluminal brachytherapy

Specimen Radiography for MRI-Guided Biopsies

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Open Journal of Radiology 2021年第4期11卷 139-150页

作者： Stefanie Woodard Elizabeth Allen renu Pandit Glenn Irby Shi Wei Yufeng Li Jeong Mi Park Department of Radiology The University of Alabama at Birmingham Birmingham USA School of Medicine The University of Alabama at Birmingham Birmingham USA Department of Anatomic Pathology The University of Alabama at Birmingham Birmingham USA Department of Medicine The University of Alabama at Birmingham Birmingham USA

Background: Specimen radiography is important for the biopsy of breast microcalcifications, and MRI is limited in the detection of microcalcifications. It is unknown whether or not the presence of microcalcifications on MRI-guided biopsies is significant. Purpose: To determine whether specimen radiography of MRI-guided biopsy samples provides any added benefits in tissue assessment. Materials and Methods: This is an IRB-approved, HIPPA-compliant retrospective review of MRI-guided biopsy reports whose tissue underwent specimen radiography from 2010 to 2017. Pathology reports were queried to compare samples with and without calcium and reviewed to determine if calcifications correlated with the lesion of interest. If there was a correlation, the original MRI was reviewed. Final pathology reports were also reviewed if excision was performed. Results: A total of 889 patients ages 22 - 85 were included with 140 (15.7%, 140/889) containing calcifications. Of 140 specimens, 119 (85.0%, 119/140) cases separated the calcifications. A total of 41 (34.5%, 41/119) were malignant or high-risk lesions/atypia of which 15 (36.6%, 15/41) showed a higher-grade lesion in the specimen containing calcium. Out of these 15, 4 (26.7%, 4/15) were pathologically associated with calcium;however, pathologic diagnosis was not dependent on the presence of calcifications. All 4 were high-risk lesions and none were malignancies. MRI in these cases showed three enhancing masses and one non-mass enhancement. None were upgraded at excision. Conclusion: The presence of microcalcifications on MRI-guided biopsies does not aid in tissue assessment and does not impact pathologic diagnosis. Specimen radiography provides no added benefits in the setting of MRI-guided biopsies.

关键词： MRI-Guided Breast Biopsy Specimen Radiography Microcalcifications High-Risk Lesion Breast Cancer Upgrade

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计算行为学研究进展

科学通报 2021年第30期66卷 3799-3810页

作者：任炜余山张永清中国科学院遗传与发育生物学研究所分子发育生物学国家重点实验室北京100101 中国科学院自动化研究所北京100190 中国科学院脑科学与智能技术卓越创新中心上海200031 中国科学院大学生命科学学院北京100049 中国科学院大学未来技术学院北京100049

20世纪的行为学研究通过在自然状态下和受控的实验室条件下的观察揭示了动物行为的众多本质特点.但这两种途径都存在各自的局限,不能完全满足动物行为学研究发展的需要.近年来,计算技术的发展与突破给行为学研究带来了新的机遇,"计算行... 详细信息

20世纪的行为学研究通过在自然状态下和受控的实验室条件下的观察揭示了动物行为的众多本质特点.但这两种途径都存在各自的局限,不能完全满足动物行为学研究发展的需要.近年来,计算技术的发展与突破给行为学研究带来了新的机遇,"计算行为学"这一新兴学科正在形成.计算行为学的发展、完善和应用使得高效量化分析动物行为成为可能.本文对计算行为学的发展历史和前沿进展进行了系统梳理和总结,介绍了人工智能技术用于动物行为分析的基本概念、方法和应用场景.此外,还对计算行为学在行为的神经机制解析和神经精神疾病诊断方面的应用进行了概述,分析了目前该领域所面临的挑战与机遇,希望能为行为科学、脑科学,以及神经精神疾病的临床转化研究提供参考.

关键词：动物行为人工智能计算行为学姿态估计机器学习

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为获得在印度的政治权利而奋斗

人类居住 2005年第3期 13-14页

作者： renu Kumari 宗思语

由于在社会传统和现实中存在着性别偏见，印度社会的妇女长期以来一直受到歧视。这在各级政府中都有所反映，从中央政府一直到地方政府——不管是只占少数的妇女当选代表、官场上的性别敏感、还是在制订的有利于妇女的法律法规的实施问... 详细信息

由于在社会传统和现实中存在着性别偏见，印度社会的妇女长期以来一直受到歧视。这在各级政府中都有所反映，从中央政府一直到地方政府——不管是只占少数的妇女当选代表、官场上的性别敏感、还是在制订的有利于妇女的法律法规的实施问题上。

关键词：印度政治权利妇女权益性别法律规范

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单克隆抗体-酶结合物选择性清除淋巴细胞亚群

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细胞与分子免疫学杂志 1986年第Z1期 121-130页

作者： renu B.Lal 王晓丹

本文建立了一种选择性清除淋巴细胞亚群的新方法。葡萄糖氧化酶(GO_x)、磷脂酶(PL-C)分别与小鼠抗大鼠单克隆IgG(MAR)的结合物,在不同的大鼠单克隆抗体存在下(可识别鼠细胞表面抗原),已表明对靶淋巴细胞亚群有选择性细胞毒作用。细胞计... 详细信息

本文建立了一种选择性清除淋巴细胞亚群的新方法。葡萄糖氧化酶(GO_x)、磷脂酶(PL-C)分别与小鼠抗大鼠单克隆IgG(MAR)的结合物,在不同的大鼠单克隆抗体存在下(可识别鼠细胞表面抗原),已表明对靶淋巴细胞亚群有选择性细胞毒作用。细胞计数显示了两种结合物能显著地与大鼠单克隆抗体结合。PL-C-MAR比GO_x-MAR结合物稳定。根据细胞对促有丝分装原反应能力下降和细胞计数显示的特异性细胞数目明显缺失,可判定PL-C结合物(与原始小鼠抗大鼠IgG单克隆抗体结合)对T细胞和B细胞产生了选择性杀伤。正常鼠血清可抵抗由游离酶引起的细胞毒作用,但酶结合物的作用则不受影响。因为体内这些酶的底物很丰富,血清不能阻止其细胞毒作用。这些抗体-酶结合物对体内选择性清除淋巴细胞可能具有价值。

关键词：抗毒素抗体酶结合物萄萄糖氧化酶磷脂酶

Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies

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Pharmacology & Pharmacy 2011年第3期2卷 212-225页

作者： renu Chadha Sushma Gupta Natasha Pathak Geeta Shukla D.V.S. Jain Raghuvir R S Pissurlenkar Evans C Coutinho 不详

The purpose of the present work is to improve the antimalarial activity of arteether through enhancing its solubility subsequently bioavailability by incorporating the drug into the cyclodextrins cavity. The effect of hydrophilic polyvinyl propylene (PVP) polymer on the complexation and solubilizing efficiencies of cyclodextrins (CDs) is also elucidated. Inclusion of arteether molecule in solid state was evidenced by Differential scanning calorimeter (DSC), Powder X-ray diffractometery (PXRD), and in solution state by NMR and solution calorimetry. A 1:1 stoichiometry was proposed by the phase solubility studies both in presence and absence of PVP. The most plausibe mode of inclusion of arteether into the CD cavity is revealed by molecular modeling studies utalizing Fast Rigid Exhaustive Docking acronym. Solution calorimetry was used further to confirm 1:1 stiochiometry in presence or absence of PVP by determining the enthalpy of interaction between the drug and cyclodextrins. The inclusion of drug was found to be exothermic process accompanied by small positive value of entropy (ΔSo). The methylated-β-CD showed the best ability to solublize arteether which is approximately at par with β-CD in the presence of PVP. Better complexation efficiency of β-CD in presence of PVP is also reflected by the higher numerical values of stability constant (K). Compelete eradication of the parasite from the blood and highest anti-malarial pharmacological activity was observed in the complexes of arteether with M-?-CD while 83.7% was observed for ternary complexes of β-CD in presence of PVP.

关键词： Arteether cyclodextrins ternary complexes complexation efficiency in vivo studies

Staphylococcal bullous impetigo in a neonate

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World Journal of Clinical Cases 2016年第7期4卷 191-194页

作者： Shalini Dewan Duggal Tanisha Bharara Pragnya Paramita Jena Avinash Kumar Abha Sharma renu Gur Sanjay Chaudhary Department of Microbiology Dr Baba Saheb Ambedkar Hospital Department of Pediatrics Dr Baba Saheb Ambedkar Hospital

An otherwise healthy, full-term neonate presented at day 15 of life to the pediatric emergency with generalized papulo-pustular rash for 2 d. This was finally diagnosed as bullous impetigo caused by Staphylococcus aureus(S. aureus). The skin lesions decreased significantly after starting antibiotic therapy and drainage of blister fluid. There was no recurrence of the lesions on followup. This case of generalized pustular eruption due to S. aureus in a neonate is reported, as it poses a diagnostic dilemma and can have serious consequences if left untreated.

关键词： Pustular lesions Staphylococcus aureus Bullous impetigo

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红槟榔娘娘

世界文学 2000年第1期 161-173页

作者：帕尼什瓦尔那特·雷努冉斌

帕尼什瓦尔那特·雷努(Phanishwarnath renu,1921—1977)是印度当代重要的小说家。出生于比哈尔邦,属于中下阶层。曾在贝拿勒斯印度教徒大学读书,参加过民族独立运动。1946年开始尝试文学创作,陆续发表了一些报告文学作品和短篇小说。1... 详细信息

帕尼什瓦尔那特·雷努(Phanishwarnath renu,1921—1977)是印度当代重要的小说家。出生于比哈尔邦,属于中下阶层。曾在贝拿勒斯印度教徒大学读书,参加过民族独立运动。1946年开始尝试文学创作,陆续发表了一些报告文学作品和短篇小说。1954年发表的成名作《肮脏的裙裾》在印地语文学界引起过轰动,并获得了 1955年最佳小说奖。他的主要作品还有长篇小说《荒土地的故事》(1957)、《苦修女》(1962)、《游行》(1965)和《歧路漫漫》(1966),

关键词：短篇小说印度作者当代