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Journal of Pharmaceutical and Biopharmaceutical Research 2019年第1期1卷 21-27页

作者： Janhvi Dureja renu Chadha Maninder Karan Akshita Jindal Kunal Chadha University Institute of Pharmaceutical Sciences Panjab University Chandigarh 160014 India

The binding pursuits of trans-resveratrol(t-RSV),an amazing health supplement are investigated with an antioxidant enzyme,superoxide dismutase(SOD1).The aim of the study is to dock t-RSV on the adrenaline binding site on SOD1 in order to explore its potential to act as a safety net against amyotrophic lateral sclerosis(ALS),a fatal neurodegenerative disorder that affects motor *** silico GLIDE docking methodology and in vitro microcalorimetry technique is utilized for the investigation of binding parameters of t-RSV with *** study provides useful and distinct information about the amino acids involved in the interactions at molecular level along with the nature of forces involved in binding of t-RSV with *** docking analysis using the scoring functions of Schrodinger’s Glide package depicts that GLU100,PRO28,LYS23,TRP32 residues of the peptide backbone on SOD1 interact with phenolic groups of *** information on thermodynamic parameters,*** constant(Kb),free energy(△G)and enthalpy(△H)generated through calorimetric titrations suggests that the reaction between t-RSV and SOD1 is spontaneous and *** the studies are found to be in close agreement with each other based as far as the magnitude of binding constant(Kb=9.9×10^4)is concerned.

关键词： trans-Resveratrol superoxide dismutase docking microcalorimetry binding constant free energy

p53-independent upregulation of p21WAF1 in NIH 3T3 cells malignantly transformed by mot-2

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Cell Research 2001年第1期11卷 55-60页

作者： TAKANO SYUICHI, renu WADHWA, YOUJI MITSUI, SUNIL C KAUL (National Institute of Bioscience and Human-Technology, AIST, 1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan) (Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japa National Institute of Bioscience and Human-Technology AIST Tsukuba Japan Institute of Applied Biochemistry University of Tsukuba Tsukuba Japan Chugai Research Institute for Molecular Medicine Niihari-mura Japan

Mot-2 protein is shown to interact with p53 and inhibit its transcriptional activation function. Mot-2 overexpressing stable clones of NIH 3T3 cells were malignantly transformed, however, they had a high level of expression of a p53 downstream gene, p21WAF1. The present study was undertaken to elucidate possible molecular mechanism(s) of such upregulation. An inCreased level of p21WAF1, expression was detected in sta- ble transfectants although an exogenous reporter gene driven by p21WAF1, promoter exhibited lower activity in these cells suggesting that some post-transcriptional mechanism contributes to upregulation. Western analyses of transient and stable clones revealed that upregulation of p21WAF1, in stable NIH 3T3/mot-2 cells may be mediated by cyclin D1 and cdk-2.

关键词： Mouse fibroblasts malignant transformation mot-2 p53 p21WAF1 p16INK4a cyclin D1 cdk-2.

Glutathione (GSH) improves sperm quality and testicular morphology in streptozotocin-induced diabetic mice

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Asian Journal of Andrology 2021年第3期23卷 281-287页

作者： Fathiah Abdullah Mohamed Noor Khan Nor-Ashikin renu Agarwal Yuhaniza Shafinie Kamsani Mastura Abd Malek Nor Salmah Bakar Aqila-Akmal Mohammad Kamal Mimi-Sophia Sarbandi Nor-Shahida Abdul Rahman Nurul Huda Musa Maternofetal and Embryo Research Group(MatE) Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia Faculty of Applied Sciences Universiti Teknologi MARAPerak BranchTapah CampusTapah Road 35400PerakMalaysia Faculty of Medicine Universiti Teknologi MARASelangor BranchSungai Buloh CampusSungai Buloh 47000SelangorMalaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Faculty of Health Sciences Universiti Teknologi MARASelangor BranchPuncak Alam CampusBandar Puncak Alam 42300SelangorMalaysia Centre of Foundation Studies Universiti Teknologi MARASelangor BranchDengkil CampusDengkil 43800SelangorMalaysia

Diabetes mellitus(DM)is known to cause reproductive *** men,it has been linked to altered sperm quality and testicular *** stress(OS)plays a pivotal role in the development of DM ***(GSH)is a part of a nonenzymatic antioxidant defense system that protects lipid,protein,and nucleic acids from oxidative ***,the protective effects of exogenous GSH on the male reproductive system have not been comprehensively *** study determined the impact of GSH supplementation in ameliorating the adverse effect of type 1 DM on sperm quality and the seminiferous tubules of diabetic C57BL/6NTac *** at the doses of 15 mg kg^(-1)and 30 mg kg^(-1)was given intraperitoneally to mice weekly for 6 consecutive *** mice were then weighed,euthanized,and had their reproductive organs *** diabetic(D Group)showed significant impairment of sperm quality and testicular histology compared with the nondiabetic(ND Group).Diameters of the seminiferous lumen in diabetic mice treated with 15 mg kg^(-1) GSH(DGSH15)were decreased compared with the D *** motility was also significantly increased in the DGSH15 *** in testicular morphology might be an early indication of the protective roles played by the exogenous GSH in protecting sperm quality from effects of untreated type 1 DM or diabetic *** investigation using different doses and different routes of GSH is necessary to confirm this suggestion.

关键词： diabetes mellitus glutathione mice sperm quality testis histology

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泰语“(?)（看）”研究

泰语“(?)（看）”研究

作者：宋瑛（renu JITNIYOMSILP）云南大学

学位级别：硕士

本文对泰语“(?)(看)”进行研究,首先在《皇家学院词典》和《现代泰语词典》的范围内进行语料统计,然后在借鉴前人研究成果的基础上,从泰语“看”的词义、构成能力、语法化进行描写,另外引用“(?)(看)”在泰语中的分析结果与汉语的“看... 详细信息

本文对泰语“(?)(看)”进行研究,首先在《皇家学院词典》和《现代泰语词典》的范围内进行语料统计,然后在借鉴前人研究成果的基础上,从泰语“看”的词义、构成能力、语法化进行描写,另外引用“(?)(看)”在泰语中的分析结果与汉语的“看”进行了对比,并归纳了两种语言的异同点。论文共分为六章:第一章为绪论,介绍本文的研究目的及意义、相关研究综述和研究方法。第二章分析了泰语“(?)(看)”的词义。首先“(?)(看)”表示用眼睛看,主要使视线接触人、动物和物体,后来派生出很多其他的语义。除了“(?)(看)”的类词有41个词,且将泰语中与用视线接触有关的词语分为“(?)(看)”的基本义场和5类子场。第三章分析了泰语“(?)(看)”的构成能力。分为动宾式、主从式和并列式。第四章分析了泰语“(?)(看)”的语法化,分为三个阶段。一是当“(?)(看)”在泰语中作为动词,意为使视线接触任何事物,具有实义,表示“(?)(看)”的意思。二是当“(?)(看)”放在动词或动词短语之后则发展成为表示泰语尝试态语助词。三是当“(?)(看)”前面为第二人称代词时,表示说者希望引起听者对说者正提到的事情的兴趣。第五章从词义、构成能力和语法化三个方面对泰语“(?)(看)”和汉语“看”进行研究,并找出两种语言的异同之处。研究结果表明,汉语“看”的词义、构成能力和语法化皆比泰语“(?)(看)”更为丰富。第六章为结语,总结全文,说明本文不足之处,并进行展望。希望本研究有利于解决泰国学生和中国学生在语言学习中遇到的问题,对中泰两国学习对方的语言有所帮助。

关键词：泰语“(看)” 词义构成能力语法化对比

Thermo-Protective Role of 28-Homobrassinolide in <i>Brassica juncea</i>Plants

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American Journal of Plant Sciences 2014年第15期5卷 2431-2439页

作者： Sirhindi Geetika Kaur Harpreet Bhardwaj renu Kaur Nirmal Spal Sharma Poonam Department of Botanical and Environmental Sciences GNDU Amritsar India Department of Botany Punjabi University Patiala India

The present work was undertaken to study the effects of 28-homobrassinolide on growth, stress markers, antioxidative enzyme [superoxide dismutase (EC 1.***.1.1), guaiacol peroxidase (EC 1.***.1.7), catalase (EC 1.***.1.6) ] activities and protein content in 10 days old seedlings of Brassica juncea L. treated with different degrees (4°C, 44°C) of temperature. 28-homobrassinolide at 10-9 M concentration lowered temperature stress. Different degrees of temperature treatment alone decreased the enzyme activities and protein concentration of seedlings. However, pre-sowing treatments of 28-homobrassinolide lowered the temperature stress and enhanced the contents of MDA and proline, activities of enzymes and protein concentration of seedlings.

关键词： Antioxidative Enzymes 28-Homobrassinolide Brassinosteroids Temperature Stress Lipid Peroxidation Guaiacol Peroxidase Catalase

Inhibition of H2O2-induced DNA damage in single cell gel electrophoresis assay (comet assay) by castasterone isolated from leaves of centella asiatica

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Health 2010年第6期2卷 595-602页

作者： Nishi Sondhi renu Bhardwaj Satwinderjeet Kaur Madhu Chandel Neeraj Kumar Bikram Singh 不详

Brassinosteroids (BRs) are a large group of polyhydroxy steroids, which regulate numerous aspects of plant growth and development, including stem elongation, leaf bending, tracheary element differentiation, stress protection and photomorphogenesis. Recent studies indicate antigenotoxic and anticancerous activities of these compounds. The role of natural BRs in H2O2 (hydrogen peroxide) -induced DNA damage in human lymphocytes is still unknown. The present study reports the presence of Castasterone from leaves of Centella asiatica, an important medicinal herb commonly used as a memory enhancer and immunomodulator. CA50 fraction isolated from Centella asiatica was characterized as Castasterone by electrospray ionization mass spectral data with standard Castasterone. An attempt has been made to study antigenotoxic activity of the isolated Castasterone against H2O2 -induced DNA damage in human blood lymphocytes using Single cell gel electrophoresis assay (Comet Assay). Castasterone at 10–9 M concentration proved to be effective in diminishing the DNA damage by 89.42 %.

关键词： Brassinosteroids Castasterone Comet Assay Hydrogen Peroxide

Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics

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Genes & Diseases 2023年第3期10卷 960-989页

作者： Hafiza Padinharayil Jinsu Varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex George Jubilee Centre for Medical Research Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India PG&Research Department of Zoology St.Thomas CollegeKozhencheryPathanamthittaKerala 689641India Department of Medical Oncology Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India School of Biotechnology National Institute of TechnologyCalicutKerala 673601India Canterbury Christ Church University Natural Applied SciencesLife Sciences Industry Liaison LabDiscovery ParkSandwich CT139FFUnited Kingdom Centre of Molecular Medicine and Diagnostics(COMManD) Department of BiochemistrySaveetha Dental College&HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil Nadu 600077India Department of Pharmaceutical Technology Jadavpur UniversityKolkataWest Bengal 700032India Department of Botany Bhairab Ganguly CollegeFeeder RoadBelghoriaKolkataWest Bengal 700056India Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biomedical Sciences School of Bio-Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance.

关键词： Biomarker Clinical trial Epidemiology Histology Liquid biopsy NSCLC Targeted therapy

Prevalence of HIV in a Tertiary Care Centre in Delhi: A Five-Year ICTC Based Study

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World Journal of AIDS 2015年第1期5卷 1-9页

作者： Banke Lal Sherwal Poonam Gupta Rojalin Nayak Sanjib Gogoi Sarika Suri renu Dutta Department of Microbiology Lady Hardinge Medical College New Delhi India

Objective: The purpose of this study is to estimate the prevalence of HIV infection among the clients attending ICTC, LHMC of New Delhi, for a period of five years, i.e., from 2008 to 2012. Material & Method: A total of 25,413 clients attended ICTC, LHMC from the year 2008 to 2012. Serum samples were collected after taking informed consent and pre-test counseling. In India for all ICTCs, NACO (National AIDS Control Organization), a national guidelines has been followed for HIV testing, reporting and release of results with post test counseling. Results: Out of the total 25,413 clients tested for HIV infection, 963 (3.78%) were found to be HIV-1 seropositive. Seropositivity was higher in male clients i.e. 625 (64.4%) than female i.e. 336 (34.8%) followed by transgender (TG), i.e., 2 (0.2%). Heterosexual route of transmission was the major route seen in 676 clients (70.1%). Maximum HIV seropositivity was in the age group of 25 - 34 years (35.4%). No HIV-2 case was found among the studied population. Conclusion: HIV prevalence of 3.78% among the clients attending ICTC, LHMC, New Delhi, puts light on the burden on HIV in this part of the country and suggests the need for the scaling up of focused prevention efforts in high-risk groups.

关键词： HIV Seropositivity ICTC Heterosexual Transgender

Role of intraluminal brachytherapy in palliation of biliary obstruction in cholangiocarcinoma:A brief review

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World Journal of Gastrointestinal Endoscopy 2022年第3期14卷 106-112页

作者： Divya Khosla Samreen Zaheer Rahul Gupta renu Madan Shikha Goyal Narendra Kumar Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Educa Department of Gastroenterology and Hepatology Shalby Multispeciality HospitalMohali 160062PunjabIndiation and ResearchChandigarh 160012U.T.India

Surgery is the only curative treatment for cholangiocarcinoma. However, mostpatients present with advanced disease, and hence are unresectable. Thus, theintent of treatment shifts from curative to palliative in the majority of *** drainage with intraluminal brachytherapy is an effective means ofrelieving the malignant biliary obstruction. In this review, we discuss the role ofbrachytherapy in the palliation of obstructive symptoms in extrahepatic cholangiocarcinoma.

关键词： Biliary tract Cholangiocarcinoma Extrahepatic Intraluminal brachytherapy