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FP-Zernike:An Open-source Structural Database Construction Toolkit for Fast Structure Retrieval

Genomics, Proteomics & Bioinformatics 2024年第1期22卷 111-119页

作者： Junhai Qi Chenjie Feng Yulin Shi Jianyi Yang Fa Zhang Guojun Li renmin Han Research Center for Mathematics and Interdisciplinary Sciences Shandong UniversityQingdao 266237China BioMap Research Menlo ParkCA 94025USA College of Medical Information and Engineering Ningxia Medical UniversityYinchuan 750004China Institute of Engineering Medicine Beijing Institute of TechnologyBeijing 100081China

The release of AlphaFold2 has sparked a rapid expansion in protein model *** protein structure retrieval is crucial for the analysis of structure models,while measuring the similarity between structures is the key challenge in structural *** existing structure alignment algorithms can address this challenge,they are often ***,the state-of-the-art approach involves converting protein structures into three-dimensional(3.)Zernike descriptors and assessing similarity using Euclidean ***,the methods for computing 3. Zernike descriptors mainly rely on structural surfaces and are predominantly web-based,thus limiting their application in studying custom *** overcome this limitation,we developed FP-Zernike,a user-friendly toolkit for computing different types of Zernike descriptors based on feature *** simply need to enter a single line of command to calculate the Zernike descriptors of all structures in customized ***-Zernike outperforms the leading method in terms of retrieval accuracy and binary classification accuracy across diverse benchmark *** addition,we showed the application of FP-Zernike in the construction of the descriptor database and the protocol used for the Protein Data Bank(PDB)dataset to facilitate the local deployment of this tool for interested *** demonstration contained 590,685 structures,and at this scale,our system required only 4-9 s to complete a *** experiments confirmed that it achieved the state-of-the-art accuracy ***-Zernike is an open-source toolkit,with the source code and related data accessible at https://***/biocode/tools/BT0073.5/releases/0.1,as well as through a webserver at http://***/.

关键词： Zernike descriptor Structure alignment PDB dataset Open-source Retrieval system

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Generating barcodes for nanopore sequencing data with PRO

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Fundamental Research 2024年第4期4卷 785-794页

作者： Ting Yu Zitong Ren Xin Gao Guojun Li renmin Han Research Center for Mathematics and Interdisciplinary Sciences Frontiers Science Center for Nonlinear Expectations(Ministry of Education)Shandong UniversityShandong 266000China Computer Electrical and Mathematical Sciences and Engineering Division&Computational Bioscience Research CenterKing Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia

DNA barcodes,short and unique DNA sequences,play a crucial role in sample identification when processing many samples simultaneously,which helps reduce experimental ***,the low quality of long-read sequencing makes it difficult to identify barcodes accurately,which poses significant challenges for the design of barcodes for large numbers of samples in a single sequencing ***,we present a comprehensive study of the generation of barcodes and develop a tool,PRO,that can be used for selecting optimal barcode sets and *** formulate the barcode design problem as a combinatorial problem and prove that finding the optimal largest barcode set in a given DNA sequence space in which all sequences have the same length is theoretically *** practical applications,we developed the novel method PRO by introducing the probability divergence between two DNA sequences to expand the capacity of barcode kits while ensuring demultiplexing ***,the maximum size of the barcode kits designed by PRO is 2,292,which keeps the length of barcodes the same as that of the official ones used by Oxford Nanopore Technologies(ONT).We validated the performance of PRO on a simulated nanopore dataset with high error *** demultiplexing accuracy of PRO reached 98.29%for a barcode kit of size 2,922,4.3.%higher than that of Guppy,the official demultiplexing *** the size of the barcode kit generated by PRO is the same as the official size provided by ONT,both tools show superior and comparable demultiplexing accuracy.

关键词： Third-generation sequencing Nanopore sequencing DNA barcode Farthest point sampling algorithm High throughput

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中国政治经济学年度发展报告（2023.（下）

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政治经济学评论 2024年第3期 90+207-208页

作者： Center for Studies of Contemporary Political Economy,Research Institute for 21st-Century Marxism,Nankai University·University of Chinese Academy of Social Science Center for Teaching and Research on Capital,renmin University of china National Institute of Socialist Political Economy with Chinese Characteristics,renmin University of china 南开大学·中国社会科学院大学21世纪马克思主义研究院当代政治经济学研究中心中国人民大学《资本论》教学与研究中心中国人民大学全国中国特色社会主义政治经济学研究中心

编者按2023.，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，...

编者按2023.，高质量发展扎实推进，新质生产力加快形成，我国经济总体回升向好，圆满实现发展主要预期目标。为针对性地破解经济恢复发展中的难题，聚焦推进中国式现代化进程中的重点、难点问题，中国政治经济学界开展系统深入研究，取得系列代表性成果。为准确刻画学界研究进展和轨迹，推动中国经济学理论体系的构建和完善，本刊精选议题如期奉上《中国政治经济学年度发展报告（2023.》。自2010年起，本刊连续十四年发布《中国政治经济学年度发展报告》，“年度发展报告”专栏已成为本刊标志性特色栏目。2023.报告聚焦12个专题，分为（上）（下）两篇，其中专题1—6于报告（上）篇刊登，专题7—12由报告（下）篇刊登。2023.报告（下）选题如下：

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融合教育的价值意蕴与实践路径——基于卢曼社会系统理论的分析

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教育科学 2024年第2期40卷 52-59页

作者：史仁民王吉渤海大学教育科学学院辽宁锦州121013

融合教育是保证教育公平而有质量的关键要素,是解决教育发展中不平衡、不充分问题的有效路径。随着社会的进步与多元化发展,学者们日益关注如何有效实施融合教育以更好地满足不同学生的需求。融合教育的发展经历了隔离教育时期、部分融... 详细信息

融合教育是保证教育公平而有质量的关键要素,是解决教育发展中不平衡、不充分问题的有效路径。随着社会的进步与多元化发展,学者们日益关注如何有效实施融合教育以更好地满足不同学生的需求。融合教育的发展经历了隔离教育时期、部分融合时期和完全融合时期的演变过程,体现出社会对融合教育的理解与认可是逐渐深化的。融合教育涉及多样性、平等、质量、权利等相关概念,具有追求教育公平切实实现、尊重个体差异多元发展、促进社会发展深度融合的价值意蕴。卢曼的社会系统理论,从社会结构和功能分化角度出发,将教育作为现代社会系统的重要子系统,为融合教育提供了三方面实践路径,即增强共通性价值认同、建立包容性学习环境和提供个性化学习支持。

关键词：融合教育价值意蕴实践路径社会系统理论

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Ev Surge Illuminates Pathto Sustainable Mobility

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中印对话（英文版） 2024年第1期38卷 56-58页

作者： china-lndia Dialogue 不详

china's Booming NEVs zhang Yifan occupation:PhD student at the school of Philosophy,renmin University of china Birth Place:Panzhihua,Sichuan Current Residence:Lijiang,Yunnan Rapid advancements in technological innovation and energy transformation within the automotive industry in recent years have far exceeded *** market share of new energy vehicles(NEVs)in the automotive sector continues to grow,with globally recognized brands like Tesla and domestically acclaimed brands such as Xiaomi frequently capturing the public's attention.

关键词： Sustainable occupation globally

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On conformal measures for infinitely renormalizable quadratic polynomials

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Science china Mathematics 2005年第10期48卷 1411-1420页

作者： HUANG Zhiyong~1 JIANG Yunping~(2,3. & WANG Yuefei~3.1. School of Information,renmin University of china,Beijing 100872,china 2. Department of Mathematics,Queens College,City University of New York,NY 113.7,USA Department of Mathematics,Graduate School,City University of New York,New York,NY 10016,USA 3. Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing 100080,china 1. School of Information Renmin University of China 100872 Beijing China 2. Department of Mathematics Queens College City University of New York 11367 NY USA 3. Department of Mathematics Graduate School City University of New York 10016 New York NY USA 4. Academy of Mathematics and Systems Science Chinese Academy of Sciences 100080 Beijing China

We study a conformal measure for an infinitely renormalizable quadratic polynomial. We prove that the conformal measure is ergodic if the polynomial is unbranched and has complex bounds. The main technique we use in t... 详细信息

关键词： Julia set, conformal measure, three-dimensional puzzle, infinitely renormalizable quadratic polynomial.

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构建社会主义现代化强国的高水平市场经济体制

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改革 2024年第6期 30-39页

作者：中国人民大学经济学院课题组中国人民大学经济学院中国人民大学国家发展与战略研究院中国人民大学农业与农村发展学院

改革开放是决定当代中国命运、大踏步赶上时代的关键一招,更是推进中国式现代化、实现中华民族伟大复兴的关键一招。新形势下,面对国际国内诸多历史性挑战,只有坚定不移全面深化改革开放、建立现代化经济体系,才能破除体制机制障碍,激... 详细信息

改革开放是决定当代中国命运、大踏步赶上时代的关键一招,更是推进中国式现代化、实现中华民族伟大复兴的关键一招。新形势下,面对国际国内诸多历史性挑战,只有坚定不移全面深化改革开放、建立现代化经济体系,才能破除体制机制障碍,激发经济发展新动能,延续经济增长与追赶势头,为中国式现代化建设提供充满生机活力的制度保障。进一步全面深化改革的总目标是完善和发展中国特色社会主义制度,推进国家治理体系和治理能力现代化。建立支撑建设社会主义现代化强国的高水平社会主义市场经济体制,亟须聚焦基本经济制度、高标准市场体系、政府和市场关系、科技创新体制、数字经济发展机制、高水平开放型经济体制、共同富裕实现机制、城乡融合与乡村振兴体制八大重点领域,推动体制机制创新。在进一步全面深化改革中,寻求改革、发展与稳定之间的平衡,处理好政治与经济、增长与收缩、秩序和活力、体制转型与风险防范、发展和安全、中国和世界六大关系。

关键词：中国式现代化经济体制改革全面深化改革

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Hierarchical linear regression models for conditional quantiles

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Science china Mathematics 2006年第12期49卷 1800-1815页

作者： TIAN Maozai & CHEN Gemai School of Statistics, renmin University of china, Beijing 100872, china and Center for Applied Statistics, renmin University of china, Beijing 100872, china Department of Mathematics and Statistics, University of Calgary, Canada School of Statistics Renmin University of China Beijing 100872 China Department of Mathematics Statistics University of Calgary Canada Center for Applied Statistics Renmin University of China Beijing 100872 China

The quantile regression has several useful features and therefore is gradually developing into a comprehensive approach to the statistical analysis of linear and nonlinear response models,but it cannot deal effectively with the data with a hierarchical *** practice,the existence of such data hierarchies is neither accidental nor ignorable,it is a common *** ignore this hierarchical data structure risks overlooking the importance of group effects,and may also render many of the traditional statistical analysis techniques used for studying data relationships *** the other hand,the hierarchical models take a hierarchical data structure into account and have also many applications in statistics,ranging from overdispersion to constructing min-max ***,the hierarchical models are virtually the mean regression,therefore,they cannot be used to characterize the entire conditional distribution of a dependent variable given high-dimensional ***,the estimated coefficient vector (marginal effects)is sensitive to an outlier observation on the dependent *** this article,a new approach,which is based on the Gauss-Seidel iteration and taking a full advantage of the quantile regression and hierarchical models,is *** the theoretical front,we also consider the asymptotic properties of the new method,obtaining the simple conditions for an n1/2-convergence and an asymptotic *** also illustrate the use of the technique with the real educational data which is hierarchical and how the results can be explained.

关键词： hierarchical quantile regression models,EQ algorithm,fixed effects,random effects,regression quantile.

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Ruin probability of the renewal model with risky investment and large claims

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Science china Mathematics 2009年第7期52卷 1539-1545页

作者： WEI Li School of Finance,renmin University of china,Beijing 100872,china 1. School of Finance Renmin University of China Beijing 100872 China

The ruin probability of the renewal risk model with investment strategy for a capital market index is investigated in this *** claim sizes with common distribution of extended regular variation,we study the asymptotic behaviour of the ruin *** a corollary,we establish a simple asymptotic formula for the ruin probability for the case of Pareto-like claims.

关键词： asymptotics extended regular variation renewal risk model risky investment strategy ruin probability 60G70 60K3. 60K3.

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BLOW-UP PROBLEMS FOR NONLINEAR PARABOLIC EQUATIONS ON LOCALLY FINITE GRAPHS

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Acta Mathematica Scientia 2018年第3期38卷 843-856页

作者： Yong LIN Yiting WU Department of Mathematics renmin University of china Department of Mathematics Renmin University of China

Let G =（V, E） be a locally finite connected weighted graph, and ？ be the usual graph Laplacian. In this article, we study blow-up problems for the nonlinear parabolic equation ut = ？u ＋ f（u） on G. The blow-up phenomenons for ut = ？u ＋ f（u） are discussed in terms of two cases：（i） an initial condition is given;（ii） a Dirichlet boundary condition is given. We prove that if f satisfies appropriate conditions, then the corresponding solutions will blow up in a finite time.

关键词： Blow-up parabolic equations locally finite graphs differential inequalities

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