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Chinese Journal of Polymer Science 2019年第12期37卷 1305-1318,I0009页

作者： T Sajini renjith thomas Beena Mathew Research&Post Graduate Department of Chemistry St.Berchmans College(Autonomous)Affiliated to Mahatma Gandhi UniversityChanganassery School of Chemical Sciences Mahatma Gandhi UniversityPriyadarsini Hills P O.Kottayan 686560India

Computational strategies have been employed to investigate the influence of the nature of monomers and cross-linker in order to design three dimensional imprinted polymers with selective recognition sites for L-phenylalanine benzyl ester(L-PABE)***,computational chemistry methods were applied to screen the molar quantity of functional monomers that interact with one mole of the template *** of the nature of functional monomer,cross-linker,and molar ratio were determined computationally using density functional calculations with B3LYP functional and generic 6-31G basis *** acid(MAA)and ethylene glycol dimethacrylate(EGDMA)were used as the functional monomer and crosslinking agent,respectively.L-PABE imprinted polymer layered on multiwalled carbon nanotube(MWCNT)and conventional bulk MIP were synthesised and characterized as *** investigate the influence of pre-organization of binding sites on the selectivity of L-PABE,respective non-imprinted polymers were also ***-MIPs and MIPs exhibited the highest adsorption capacity towards *** synthesized polymers revealed characteristic adsorption features and selectivity towards L-PABE in comparison with those of its enantiomer analogues.

关键词： Molecular imprinting L-phenylalanine benzyl ester Density functional theory Monomer Cross-linker Selectivity

Micro-textures in plagioclase from 1994-1995 eruption, Barren Island Volcano: Evidence of dynamic magma plumbing system in the Andaman subduction zone

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Geoscience Frontiers 2014年第1期5卷 113-126页

作者： M.L.renjith Marine and Coastal Survey Division Geological Survey of India 4th Floor C-Block Kendriya Bhavan Kakkanadu CochinKerala 682037 India

A systematic account of micro-textures and a few compositional profiles of plagioclase from high-alumina basaltic aa lava erupted during the year 1994-1995, from Barren Island Volcano, NE India ocean, are presented for the first time. The identified micro-textures can be grouped into two categories：（i） Growth related textures in the form of coarse/fine-sieve morphology, fine-scale oscillatory zoning and resorption surfaces resulted when the equilibrium at the crystal-melt interface was fluctuated due to change in temperature or H20 or pressure or composition of the crystallizing melt; and （ii） morphological texture, like glomerocryst, synneusis, swallow-tailed crystal, microlite and broken crystals, formed by the influence of dynamic behavior of the crystallizing magma （convection, turbulence, degassing, etc.）. Each micro-texture has developed in a specific magmatic environment, accordingly, a first order magma plumbing model and crystallization dynamics are envisaged for the studied lava unit. Magma generated has undergone extensive fractional crystallization of An-rich plagioclase in stable magmatic environment at a deeper depth. Subsequently they ascend to a shallow chamber where the newly brought crystals and pre-existing crystals have undergone dynamic crystallization via dissolution-regrowth processes in a convective self- mixing environment. Such repeated recharge-recycling processes have produced various populations of plagioclase with different micro-textural stratigraphy in the studied lava unit. Intermittent degassing and eruption related decompression have also played a major role in the final stage of crystallization dynamics.

关键词： Micro-texture Plagioclase Magma chamber process Barren Island Volcano Andaman subduction zone

Cytoprotective,antihyperglycemic and phytochemical properties of Cocos nucifera(L.) inflorescence

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Asian Pacific Journal of Tropical Medicine 2013年第10期6卷 804-810页

作者： RS renjith AM Chikku T Rajamohan Department of Biochemistry University of KeralaThiruvananthapuram-695581KeralaIndia

Objective:To analyze the eytoproteetive and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocas nucifera belonging to the Arecaceae ***:The phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera *** free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay ***:The phytochemical analyses on inflorescence showed the presence of phenolic compounds,*** and *** macronutrient analyses,on the other hand,showed the presence of carbohydrate,proteins and *** of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in *** cytoprotective property of coconut inflorescence was evidenced from the acute toxicological *** levels of serum aspartate aminotransferase,alanine aminotransferase,and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control ***:The results obtained from the present study apparently proved the non-toxic nature and the eytoproteetive and antihyperglycemic properties of coconut inflorescence.

关键词： Antihyperglycemic Coconut inflorescence Cytoprotective property Phenolic compound Phytochemical Stroptozotocin

Simultaneous pharmacokinetic assessment of cefadroxil and clavulanic acid in human plasma by LC-MS and its application to bioequivalence studies

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Journal of Pharmaceutical Analysis 2013年第4期3卷 285-291页

作者： Janaki Sankarachari Krishnan Nagarajan Chandran Sathish Vimal renjith George Anil Dubala Department of Pharmaceutical Analysis J.S.S. College of Pharmacy

A simple, rapid and selective liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry （LC-APCI-MS） assay method has been developed and fully validated for the simultaneous quantification of cefadroxil （CF） and clavulanic acid （CA） in human plasma. Analytes and internal standard （IS） were extracted from human plasma by solid- phase extraction （SPE） technique using Sam prep （3 mL, 100 mg） extraction cartridge. The extracted samples were chromatographed on a reverse phase Cls column using a mixture of methanol： acetonitrile： 2 mM ammonium acetate （pH 3.5）（25：25：50, v/v/v） as the mobile phase at a flow rate of 0.8 mL/min. Quantification of the analytes and IS were carried out using single quadrupole LC-APCI-MS through selected-ion monitoring （SIM） at m/z 362 and m/z 198, for CF and CA, respectively. Method validation was performed as per the FDA guidelines and the results met the acceptance criteria. Plasma concentration of CF and CA followed by the oral administration of CF/CA （500/125 mg） pill to healthy male volunteers （n= 12） was measured. Area under plasma concentration-time curve from 0 to 12 h （AUC0-12 h） and 0 h extrapolated to infinity （AUC0-∞） were calculated. The ratio of AUC0-12 h/AUC0-∞ was found to be 〉 85% for all the subjects, as recommended by the FDA guidelines.

关键词： Cefadroxil Clavulanic acid LC-MS A_PCI Pharmacokinetics Bioequivalence

Grain to outcrop-scale frozen moments of dynamic magma mixing in the syenite magma chamber,Yelagiri Alkaline Complex,South India

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Geoscience Frontiers 2014年第6期5卷 801-820页

作者： M.L.renjith S.N.Charan D.V.Subbarao E.V.S.S.K.Babu V.B.Rajashekhar Marine and Coastal Survey Division Geological Survey of IndiaCochin 682037India Geochemistry Division CSIR-National Geophysical Research InstituteHyderabad 500007India New Zealand Petroleum and Minerals Wellington 6037New Zealand

Magma mixing process is unusual in the petrogenesis of felsic rocks associated with alkaline complex worldwide. Here we present a rare example of magma mixing in syenite from the Yelagiri Alkaline Complex, South India. Yelagiri syenite is a reversely zoned massif with shoshonitic (Na2O t K2O?5e 10 wt.%, Na2O/K2O ? 0.5e2, TiO2<0.7 wt.%) and metaluminous character. Systematic modal variation of plagioclase (An11e16 Ab82e88), K-feldspar (Or27e95 Ab5e61), diopside (En34e40Fs11e18Wo46e49), biotite, and Ca-amphibole (edenite) build up three syenite facies within it and imply the role of in-situ fractional crystallization (FC). Evidences such as (1) disequilibrium micro-textures in feldspars, (2) microgranular mafic enclaves (MME) and (3) synplutonic dykes signify mixing of shoshonitic mafic magma (MgO ? 4e 5 wt.%, SiO2 ? 54e59 wt.%, K2O/Na2O ? 0.4e0.9) with syenite. Molecular-scale mixing of mafic magma resulted disequilibrium growth of feldspars in syenite. Physical entity of mafic magma preserved as MME due to high thermal-rheological contrast with syenite magma show various hybridization through chemical exchange, mechanical dilution enhanced by chaotic advection and phenocryst migration. In synplutonic dykes, disaggregation and mixing of mafic magma was confined within the conduit of injec-tion. Major-oxides mass balance test quantified that approximately 0.6 portions of mafic magma had interacted with most evolved syenite magma and generated most hybridized MME and dyke samples. It is unique that all the rock types (syenite, MME and synplutonic dykes) share similar shoshonitic and met-aluminous character;mineral chemistry, REE content, coherent geochemical variation in Harker diagram suggest that mixing of magma between similar composition. Outcrop-scale features of crystal accumu-lation and flow fabrics also significant along with MME and synplutonic dykes in syenite suggesting that Yelagiri syenite magma chamber had evolved through multiple physical processes like

关键词： Magma mixing Disequilibrium textures Petrology Synplutonic dykes Geodynamics

Petrogenesis of carbonatitic lamproitic dykes from Sidhi gneissic complex,Central India

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Geoscience Frontiers 2018年第2期9卷 531-547页

作者： M.Satyanarayanan D.V.Subba Rao M.L.renjith S.P.Singh E.V.S.S.K.Babu M.M.Korakoppa CSIR-National Geophysical Research Institute Hyderabad 500007India Geological Survey of India Hyderabad 500068India Department of Geology Bundelkhand UniversityJhansi 284128India NCEGR Geological Survey of IndiaBengaluru 560070India

Petrographic, mineral chemical and whole-rock geochemical characteristics of two newly discovered lamproitic dykes(Dyke 1 and Dyke 2) from the Sidhi Gneissic Complex(SGC), Central India are presented here. Both these dykes have almost similar sequence of mineral-textural patterns indicative of:(1) an early cumulate forming event in a deeper magma chamber where megacrystic/large size phenocrysts of phlogopites have crystallized along with subordinate amount of olivine and clinopyroxene;(2) crystallization at shallow crustal levels promoted fine-grained phlogopite, K-feldspar, calcite and Fe-Ti oxides in the groundmass;(3) dyke emplacement related quench texture(plumose K-feldspar, acicular phlogopites) and finally(4) post emplacement autometasomatism by hydrothermal fluids which percolated as micro-veins and altered the mafic phases. Phlogopite phenocrysts often display resorption textures together with growth zoning indicating that during their crystallization equilibrium at the crystal-melt interface fluctuated multiple times probably due to incremental addition or chaotic dynamic self mixing of the lamproitic magma. Carbonate aggregates as late stage melt segregation are common in both these dykes, however their micro-xenolithic forms suggest that assimilation with a plutonic carbonatite body also played a key role in enhancing the carbonatitic nature of these dykes. Geochemically both dykes are ultrapotassic(K_2 O/Na_2 O: 3.0-9.4) with low CaO, Al_2 O_3 and Na_2 O content and high SiO_2(53.3-55.6 wt.%)and K_2 O/Al_2 O_3 ratio(0.51-0.89) characterizing them as high-silica lamproites. Inspite of these similarities, many other features indicate that both these dykes have evolved independently from two distinct magmas. In dyke 1, phlogopite composition has evolved towards the minette trend(Al-enrichment) from a differentiated parental magma having low MgO, Ni and Cr content; whereas in dyke 2, phlogopite composition shows an evolutionary affinity towards the lamproit

关键词： Lamproite Phlogopite Carbonate aggregates Metasomatized mantle Sidhi Gneissic Complex Central India

Acetylcholinesterase inhibitors in cognitive impairment in Huntington's disease: A brief review

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World Journal of Psychiatry 2013年第3期3卷 62-64页

作者： Joe John Vattakatuchery renjith Kurien 5 Boroughs Partnership NHS Foundation Trust Warrington WA28WAUnited Kingdom

Huntington's disease(HD) is a neurodegenerative disease associated with cognitive deficits. Cognitive dysfunction may be present in the early stages of the disease, even before the onset of motor symptoms. The cognitive dysfunction includes executive dysfunction, psychomotor symptoms, visuospatial deficits, perceptual deficits, memory loss and difficulty learning new skills. Acetylcholinesterase inhibitors have shown good effect in the treatment of other types of dementia and it is postulated that it might delay cognitive decline in HD. We reviewed the evidence for Acetylcholinesterase inhibitors in the treatment of cognitive decline and dementia associated with Huntington's disease. We identified 6 articles that investigated the role of Acetylcholinesterase inhibitors for treatment of cognitive deficits in Huntington's disease. Following the review, the authors concluded that there is limited evidence for the use of Acetylcholinesterase inhibitors for cognitive impairment in HD.

关键词： Huntington’s disease Huntington’s dementia Cognitive deficits Acetylcholinesterase inhibitors Donepezil Rivastigmine Galantamine