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Addition of respiratory exercises to conventional rehabilitation for children and adolescents with cerebral palsy:a systematic review and meta-analysis

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World Journal of Pediatrics 2023年第4期19卷 340-355页

作者： Thálita Raysa de Lima Crispim Mansueto Gomes Neto Tafnes Rayane Lima Crispim renivaldo batista dias Maria Déborah Monteiro de Albuquerque Micheli Bernardone Saquetto Paulo André Freire Magalhães Research Group of Neonatal and Pediatric Physical Therapy Baby GrUPEPetrolinaPernambucoBrazil Postgraduate Program in Rehabilitation and Functional Performance PPGRDFUniversidade de PernambucoRodovia BR 203Km 2 S/N.Vila EduardoPetrolinaPernambuco56328-900Brazil Research Group of Physiotherapy Department of Physical TherapyUniversidade Federal da BahiaSalvadorBrazil Posgraduate Program in Medicine and Health SalvadorBahiaBrazil

Background Respiratory dysfunctions are an important cause of morbidity and death in cerebral palsy(CP)*** exercises in addition to conventional rehabilitation have been suggested to improve respiratory status in CP *** objective of this systematic review and meta-analysis was to verify the effects of the addition of respiratory exercises to conventional rehabilitation on pulmonary function,functional capacity,respiratory muscle strength,gross motor function and quality of life in children and adolescents with *** We searched for randomized controlled clinical trials in PubMed/Medline,Lilacs,SciELO,EMBASE and Physi-otheraphy Evidence(PEDro)from their inception until July 2022 without language *** that included respiratory exercises(breathing exercise program;feedback respiratory training;incentive spirometer exercise;inspiratory muscle training;and combination of respiratory exercises+incentive spirometer exercise)in combination with conventional rehabilitation for children and adolescents with CP were evaluated by two independent *** mean difference(MD)and 95%confidence interval(CI)were estimated by random effect *** Ten studies met the eligibility criteria,including 324 children aged from 6 to 16 *** meta-analysis showed an improvement in inspiratory muscle strength of 22.96 cmH2O(18.63-27.27,n=55)and pulmonary function of 0.60(0.38-0.82,n=98)for forced vital capacity(L);0.22(0.06-0.39,n=98)for forced expiratory volume at 1 second(L);and 0.50(0.05-0.04,n=98)for peak expiratory flow(L/min).Functional skills in daily living activities improved in the intervention ***'assistance of daily living activities,functional capacity,gross motor function and expiratory muscle strength showed a nonsignificant *** well-being and acceptance and functioning domains improved in only one *** Emerging data show significant enhancements in inspiratory muscle stren

关键词： Breathing exercises Cerebral palsy Inspiratory muscle training Pediatrics Rehabilitation Respiratory exercise

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Impact of microbial self-induced anaerobiosis fermentation(SIAF)on coffee quality

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Food Bioscience 2022年第3期47卷 421-430页

作者： Marcela Caroline batista da Mota Nádia Nara batista Disney Ribeiro dias Rosane Freitas Schwan Department of Biology Federal University of LavrasLavrasMGBrazil Food Science Department Federal University of LavrasLavrasMGBrazil

The fermentation of natural(NC)and pulped coffee(PC)was performed with a conventional method(platform)and under self-induced anaerobic fermentation(SIAF).Of the 12 samples analyzed during the fermentation process,the highest temperature was obtained by the SIAF method(30.5℃ for NC and 29.67℃ for PC)with 87 h of *** compounds(36 samples)were evaluated by high-performance liquid *** in the SIAF method contributed to the maximum amount of citric acid(2.534 mg/g)in pulped coffee and acetic acid(6.04 mg/g)and lactic acid(2.533 mg/g)in *** was the primary chemical class detected,followed by ketones and *** coffees(12 samples)were evaluated five times and classified as specialty coffees(>80 points)following Specialty Coffee Association(SCA)*** pulped coffee processed by the SIAF method showed a 2.83-point increase in the sensory score compared to the conventional ***,the SIAF method is accessible to producers,contributes to coffees with differentiated sensory profiles,and increases beverage quality.

关键词： Bioreactor Fermentative process Specialty coffee Anaerobic conditions Natural processing

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Remnant gastric cancer:An ordinary primary adenocarcinoma or a tumor with its own pattern?

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World Journal of Gastrointestinal Surgery 2021年第4期13卷 366-378页

作者： Marcus Fernando Kodama Pertille Ramos Marina Alessandra Pereira Andre Roncon dias Anna Carolina batista Dantas Daniel Jose Szor Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão PauloSão Paulo 01249000Brazil

BACKGROUND Remnant gastric cancer(RGC)is defined as a tumor that develops in the stomach after a previous gastrectomy and is generally associated with a worse ***,there little information available regarding RGCs and their prognostic factors and *** To evaluate the clinicopathological characteristics and prognosis of RGC after previous gastrectomy for benign *** Patients who underwent curative resection for primary gastric cancer(GC)at our institute between 2009 and 2019 were retrospectively *** RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in this *** proximal GC(PGC)who underwent total gastrectomy was selected as the comparison *** and pathological data were collected from a prospective medical *** A total of 41 patients with RGC and 120 PGC were *** age(P=0.001),lower body mass index(P=0.006),hemoglobin level(P<0.001),and number of resected lymph nodes resected(LN)(P<0.001)were associated with the RGC *** type,pathological tumor-node-metastasis,and perioperative morbimortality were similar between RGC and *** was no difference in disease-free survival(P=0.592)and overall survival(P=0.930)between *** status was the only independent factor related to *** RGC had similar clinicopathological characteristics to *** the lower number of resected LN,RGC had a similar prognosis.

关键词： Stomach neoplasms Gastric remnant Gastric cancer Remnant gastric cancer Peptic ulcer Gastric stump

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Study of a Photodegradant Polymeric Composite Containing TiO_(2) and Glass Residue

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Open Journal of Civil Engineering 2017年第4期7卷 553-560页

作者： Pedro de Almeida Carisio Jose Anceloann Lago Grande Martins Geraldo batista de Melo Joao Fernando dias Civil Engineering Postgraduate Program of Federal University of Uberlandia Federal University of UberlandiaUberlandiaBrazil Institute of Biomedical Sciences of Federal University of Uberlandia Federal University of UberlandiaUberlandiaBrazil

Photodegradation or photocatalysis is a chemical degradation process that occurs when an inorganic semiconductor is exposed to ultraviolet (UV) light. UV light (wavelength 320 - 400 nm) has enough energy to detach an electron from the last layer of the semiconductor, leading to the conduction band, leaving a hole in the valence band. In these bands, chemical reduction and oxidation reactions occur, respectively. These reactions degrade diverse surface dirt, dissociating them into simpler and less offensive substances such as CO2 and H2O. In this work, we studied the potential of photocatalysis of a composite based on a semiconductor encapsulated in epoxy resin, in the degradation of Staphylococcus aureus, pathogen with a high degree of hospital contamination, in order to apply it to the construction in hospital facilities. The experiments were carried out with a fabrication of only epoxy resin tablets and tablets with the composite, at various concentrations of the semiconductor and glass powder. Through contamination of these tablets and their exposure to sunlight and the ambient light, contamination on their surfaces was verified. The results indicated potential photodegradation capacity of the composite.

关键词： Photodegradation Semiconductor Epoxy Resin Composite

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Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

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Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： Marcos Antonio Costa de Albuquerque Danielle Menezes dias Lucas Teixeira Vieira Carlos Anselmo Lima Angela Maria da Silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

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Breast Cancer Cutaneous Metastasis after Scalp Cooling for Alopecia Prevention

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Journal of Cancer Therapy 2020年第11期11卷 745-748页

作者： Elimar Elias Gomes Maria C. C. Ferreira Amanda B. Karani Marcelo Sato-Sano Mariana N. Meireles Carlos E. Bacchi Mariana dias batista Fernando C. Maluf Oncology Center Beneficencia Portuguesa de Sao Paulo Sao Paulo Brazil Department of Dermatology Federal University of Sao Paulo Sao Paulo Brazil Laboratorio Bacchi Botucatu Brazil

Scalp cooling is a widely used method to prevent chemotherapy-induced transient alopecia. Although the success rates in maintaining hair can be high, authors have expressed their concerns regarding the risk of scalp metastasis after scalp cooling. We report a case of breast cancer scalp metastasis in a patient submitted to scalp cooling for alopecia prevention and discuss the physiopathology, risks and benefits of this treatment for patients under this treatment.

关键词： Skin Metastasis Scalp Cooling Chemotherapy-Induced Alopecia

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Impact of a physical activity program on plasma concentrations of adiponectin, leptin and ghrelin in overweight and obese schoolchildren: A randomized controlled trial

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Health 2013年第11期5卷 1819-1828页

作者： Andre Everton de Freitas Joel Alves Lamounier Danusa dias Soares Thiago Henrique de Oliveira Debora Romualdo Lacerda Joyce batista Andrade Flavia Komatsuzaki Leida Maria Botion Adaliene Versiani Matos Ferreira Camilo Adalto Mariano da Silva Dilermando Fazito Rezende Graduate Program in Child and Teenager Health Medicine SchoolFederal University of Minas GeraisBelo HorizonteBrazil Faculty of Health and Human Ecology Medicine SchoolVespasianoBrazil Graduate Program in Health Sciences Medicine SchoolFederal University of Sao Joao Del ReiCampus MidwestDivinopolisBrazil Laboratory of Exercise Physiology Federal University of Minas GeraisBelo HorizonteBrazil Laboratory of Metabolism Federal University of Minas GeraisBelo HorizonteBrazil School of Nursing Federal University of Minas GeraisBelo HorizonteBrazil School of Nutrition Federal University of Ouro PretoOuro PretoBrazil Faculty of Medicine Barbacena BarbacenaBrazil

Introduction: Child obesity has important consequences on the child’s health and is related to the risk of developing chronic diseases. That brings up the need for research assessing the impact of obesity-and overweight-reduction programs with close attention to methodology aspects and precise indicators of the impact of such programs. Goal: Assessing the impact of a physical activity program on the plasma concentrations of adiponectin, leptin, and ghrelin in overweight and obese schoolchildren. Methods: Randomized controlled trial, double-blind, with 6-to 9-year-old overweight and obese school-children. A sample of 79 schoolchildren randomly distributed into control and intervention groups was subjected to a physical activity program. The levels of adiponectin, leptin, ghrelin, body mass index, body fat percentage, anthropometry, lipid profile and glycemia were evaluated. The program’s impact was assessed through multivariate linear regression models. Result: When comparing the groups, a significant difference was found for adiponectin, which shows an increase in the proportion of subjects with higher adiponectin concentrations for the intervention group and a reduction in body mass index and body fat percentage. Conclusion: The impact of the intervention program was positive in increasing adiponectin levels associated with a reduction in body mass index and body fat percentage.

关键词： Obesity Overweight Schoolchildren Physical Activity Adipocitokines

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Novel Immunogenic Epitopes in the NaPi-IIb Protein: Production of Monospecific Antibodies Using Synthetic Peptides Outlined on Isoform Specific Regions of the Type IIb Sodium-Dependent Phosphate Transporter (NaPi-IIb)

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Journal of Cancer Therapy 2016年第2期7卷 129-151页

作者： Ângela Alice Amadeu Megale Jorge Mário da Costa Ferreira Júnior Letícia batista Azevedo Rangel Maria Del Pilar Estevez Diz Max Senna Mano Paulo Marcelo Gehm Hoff Priscila Hess Lopes Roberto Jun Arai Wilmar dias da Silva Laboratório de Imunoquímica Instituto Butantan S&atildeo Paulo Brazil Departamento de Ciências Farmacêuticas Universidade Federal do Espírito Santo Espírito Santo Brazil Departamento de Pesquisa Clínica Instituto do C&acircncer do Estado de S&atildeo Paulo S&atildeo Paulo Brazil

NaPi-IIb is a multiple passage protein membrane which is primarily responsible for phosphate uptake in the kidney and in the small intestine. Beyond its physiological functions, their involvement with carcinogenesis was initially described in mid-2003, due to its distinct level of expression in normal and tumor cells of the ovary. Although less common than cervical cancer, epithelial ovarian cancer is considered the most lethal gynecologic malignancy, which is mainly due to diagnosis in the advanced stages as a result of the absence of symptoms during the onset of the disease and the lack of tools for early detection. Here, we produce antibodies that are anti-synthetic peptides that are derived from the regions of second extracellular loop of NaPi-IIb, which is a non-overlapping portion of MX35 epitope. These two 15 distinct amino acid residue peptides, designated as Let#1 and Let#2, are engineered in a very thorough way to detect specific sites only in this isoform, thus excluding cross-reactivity with other carriers of the same family. The lack of immunogenicity of small peptides is surpassed by the conjugation with carrier proteins. Using immunochemical methods, we demonstrate that polyclonal antibodies that are mono-specific for the Let#1 and Let#2 peptides recognize proteins that express similar amino acid sequences during blood circulation. Additionally, using flow cytometry, we identify NaPi-IIb in NIH:OVCAR-3 cells. The clear identification of two shorter peptides on the extracellular loop of NaPi-IIb, which are far from the monoclonal antibody MX35-recognizing epitopes, adds new promising tools for ovarian cancer follow-up and staging.

关键词： NaPi2b Peptides Antibodies Ovarian Cancer

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Comparison between the Energy Required for Production of PV Module and the Output Energy Througout the Product Life Time

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Journal of Energy and Power Engineering 2015年第6期9卷 592-597页

作者： Lea Beatriz Dai Pra Joao batista dias Amanda Goncalves Kieling Laboratorio de Energias Renovaveis UNISINOS (Universidade do Vale do Rio dos Sinos) Sao Leopoldo 93.022-000 Brazil

Electrical energy consumption is growing and is necessary to improve the technologies related to energy production. We have carried out a pilot study about environmental impacts during the manufacturing process of PV (photovoltaic) modules and compared between the energy requirement for the production of PV cells and modules and generation throughout the life time of the finished good that is PV module. It was taken into account the generation of environmental aspects and impacts in the manufacture of monocrystalline silicon PV modules (consisting of three components: silicon cell, flat tempered glass and aluminum frame), and an analysis of a grid-connected PV system using an energetic alternative in residences was considered. Results show that, this kind of renewable energy is really clean and can be considered as a way to change the energy technology.

关键词：生产技术光伏组件输出能量产品寿命可再生能源制造过程电能消耗环境影响

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