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分子氧氧化法合成ε-己内酯的研究进展

中国科学：化学 2020年第2期50卷 245-258页

作者：袁浩然汪玲瑶杜仁峰姚加李浩然浙江大学化学系杭州310027

内酯化合物在医药、高分子等领域都有重要的应用.其中ε-己内酯是生物可降解材料聚己内酯(poly(ε-caprolactone))的单体以及聚酯的改性剂,目前年产量近10万吨,未来前景广阔.本文主要介绍了本课题组在分子氧氧化法合成内酯化合物特别是... 详细信息

内酯化合物在医药、高分子等领域都有重要的应用.其中ε-己内酯是生物可降解材料聚己内酯(poly(ε-caprolactone))的单体以及聚酯的改性剂,目前年产量近10万吨,未来前景广阔.本文主要介绍了本课题组在分子氧氧化法合成内酯化合物特别是ε-己内酯方面所做的工作,以及国内外关于内酯化合物合成的研究进展以及展望.本课题组在传统的Baeyer-Villiger氧化环酮化合物制备内酯产物的研究基础上加以改进,分别从环己酮、K/A油(环己酮和环己醇的混合物)、环己烷出发,以氧气为氧化剂,一步反应得到ε-己内酯,较传统Baeyer-Villiger氧化法更加简单、高效、绿色环保,具有潜在的工业发展前景.

关键词：氧气氧化内酯化合物环己酮 K/A油环己烷

胶质细胞介导的神经炎性反应与神经病理性疼痛研究进展

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疑难病杂志 2018年第1期17卷 91-94,100页

作者：杜仁峰郭朝晖李永男哈尔滨医科大学附属第四医院神经内科 150001

神经病理性疼痛(NP)是最常见的慢性疼痛,由于其病因多样、发病机制复杂且尚不明确,而成为神经科学领域的一大难题。近年来研究发现,神经病理性疼痛的发生及发展与神经炎性反应密切相关,而胶质细胞(小胶质细胞和星形胶质细胞)的激活在其... 详细信息

神经病理性疼痛(NP)是最常见的慢性疼痛,由于其病因多样、发病机制复杂且尚不明确,而成为神经科学领域的一大难题。近年来研究发现,神经病理性疼痛的发生及发展与神经炎性反应密切相关,而胶质细胞(小胶质细胞和星形胶质细胞)的激活在其中扮演重要角色。该文就胶质细胞释放的促炎性细胞因子(肿瘤坏死因子-α、白细胞介素-1β、白细胞介素-18、白细胞介素-6)在神经病理性疼痛调控中的作用及机制做一综述。

关键词：神经病理性疼痛胶质细胞神经炎性反应促炎性细胞因子

High surface area biocarbon monoliths for methane storage

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Green Energy & Environment 2023年第5期8卷 1308-1324页

作者： Elizabeth Michaelis renfeng Nie Douglas Austin Yanfeng Yue Department of Chemistry Delaware State UniversityDoverDE 19901United States College of Chemical Engineering Zhengzhou UniversityZhengzhouHenan450001China

New energy sources that reduce the volume of harmful gases such as SO_(x)and NO_(x)released into the atmosphere are in constant *** gas,primarily made up of methane,is being widely used as one reliable energy source for heating and electricity generation due to its high combustion ***,natural gas accounts for a large portion of electricity generation and chemical feedstock in manufacturing plastics and other commercially important organic *** the near future,natural gas will be widely used as a fuel for ***,a practical storage device for its storage and transportation is very beneficial to the deployment of natural gas as an energy source for new *** this tutorial review,biomaterials-based carbon monoliths(CMs),one kind of carbonaceous material,was reviewed as an adsorbent for natural gas(methane)adsorption and storage.

关键词： Activated carbon Carbon monolith Methane storage High surface area Activation agent

缺血性脑卒中血脑屏障受损及修复的神经炎性机制研究进展

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华西医学 2022年第4期37卷 622-626页

作者：杜仁峰余波潘丹红蔺雁萍王清华李永男侯双兴上海市浦东医院复旦大学附属浦东医院神经内科上海201399 上海市浦东医院复旦大学附属浦东医院血管外科上海201399 哈尔滨医科大学附属第四医院神经内科哈尔滨150001

缺血性脑卒中(ischemic stroke,IS)是目前威胁人类健康的重要疾病之一,IS的发生发展过程可触发一系列复杂的病理生理改变,包括血脑屏障受损、离子失衡、氧化应激、线粒体损伤等,最终导致缺血区神经细胞的凋亡及坏死。其中,血脑屏障受损... 详细信息

缺血性脑卒中(ischemic stroke,IS)是目前威胁人类健康的重要疾病之一,IS的发生发展过程可触发一系列复杂的病理生理改变,包括血脑屏障受损、离子失衡、氧化应激、线粒体损伤等,最终导致缺血区神经细胞的凋亡及坏死。其中,血脑屏障受损是IS患者出现脑水肿、出血转化及预后不良的关键因素,而神经炎性反应在血脑屏障受损及修复过程中发挥重要作用。该文主要围绕胶质细胞、促炎性细胞因子及基质金属蛋白酶介导的神经炎性反应与IS血脑屏障受损及修复的相关机制进行综述,以期为IS的治疗提供新方向。

关键词：缺血性脑卒中血脑屏障神经炎性胶质细胞

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Numerical Simulation of the Mixing and Hydrodynamics of Asphalt and Rubber in a Stirred Tank

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Fluid Dynamics & Materials Processing 2021年第2期17卷 397-412页

作者： Zechen Yao renfeng Yang Haichao An School of Construction Machinery Chang’an UniversityXi’an710064China School of Transportation and Logistics Taiyuan University of Science and TechnologyTaiyuan030024China

Computational fluid dynamics(CFD)has been used to analyze the mixing process of Asphalt and Rubber(AR)in a stirred tank with a six flat-blade disc turbine(Rushton),a down-pumping 45°pitched-blade turbine(PBTD-6)and a down-pumping propeller(TXL).The two-phase(solid-liquid)flow in the considered stirred tank has been modelled in the framework of an Eulerian-Eulerian approach,a laminar-flow assumption and a multi-reference frame *** following effects have been investigated:The influence of the impeller speed,impeller type,crumb rubber(CR)particle diameter and initial CR particle loading on the quality of the CR particle’s *** outcomes of the numerical simulations have been found to be in good agreement with the experimental *** most important findings can be summarized as *** flow velocity on the lower part of the stirred tank,induced by the Rushton impeller,is the highest for the three considered mixing systems at the same impeller *** suspension quality of CR particles increases with the impeller speed.A larger particle diameter and a higher initial CR particle loading lead to an uneven distribution of *** degree of homogeneity in the Rushton impeller system is better than that of the PBTD-6 impeller system and the TXL impeller system at the same impeller speed,while the suspension uniformity of the TXL impeller system is the best possible one for the same power consumption.

关键词： Mixing suspension quality CR particles asphalt-Rubber CFD

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

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Nano-Micro Letters 2020年第1期12卷 124-142页

作者： Jiajia Wang renfeng Dong Huiying Wu Yuepeng Cai Biye Ren School of Chemistry and Environment Guangzhou Key Laboratory of Materials for Energy Conversion and StorageGuangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and StorageSouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Materials Science and Engineering South China University of TechnologyGuangzhou 510640People’s Republic of China

Micro/nanomotors have been extensively explored for efficient cancer diagnosis and therapy,as evidenced by significant breakthroughs in the design of micro/nanomotors-based intelligent and comprehensive biomedical ***,we demonstrate the recent advances of micro/nanomotors in the field of cancer-targeted delivery,diagnosis,and imaging-guided therapy,as well as the challenges and problems faced by micro/nanomotors in clinical *** outlook for the future development of micro/nanomotors toward clinical applications is also *** hope to highlight these new advances in micro/nanomotors in the field of cancer diagnosis and therapy,with the ultimate goal of stimulating the successful exploration of intelligent micro/nanomotors for future clinical applications.

关键词： Micro/nanomotors Cancer Drug delivery Diagnosis Imaging

Dye-Enhanced Self-Electrophoretic Propulsion of Light-Driven TiO_2–Au Janus Micromotors

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Nano-Micro Letters 2017年第3期9卷 60-71页

作者： Yefei Wu renfeng Dong Qilu Zhang Biye Ren School of Materials Science and Engineering South China University of Technology School of Chemistry and Environment South China Normal University

Light-driven synthetic micro-/nanomotors have attracted considerable attention in recent years due to their unique performances and potential applications. We herein demonstrate the dye-enhanced self-electrophoretic propulsion of light-driven Ti O_2–Au Janus micromotors in aqueous dye solutions. Compared to the velocities of these micromotors in pure water, 1.7, 1.5, and 1.4 times accelerated motions were observed for them in aqueous solutions of methyl blue(10-5g L^(-1)), cresol red(10^(-4)g L^(-1)),and methyl orange(10^(-4)g L^(-1)), respectively. We determined that the micromotor speed changes depending on thetype of dyes, due to variations in their photodegradation rates. In addition, following the deposition of a paramagnetic Ni layer between the Au and Ti O_2 layers, the micromotor can be precisely navigated under an external magnetic field. Such magnetic micromotors not only facilitate the recycling of micromotors, but also allow reusability in the context of dye detection and *** general, such photocatalytic micro-/nanomotors provide considerable potential for the rapid detection and ‘‘on-thefly'' degradation of dye pollutants in aqueous environments.

关键词： TiO2–Au Janus micromotor Selfelectrophoresis Light-driven Motion control Dye pollution Environmental remediation

Recent Advances in One‑Dimensional Micro/Nanomotors:Fabrication,Propulsion and Application

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Nano-Micro Letters 2023年第2期15卷 114-142页

作者： Yuhong Zheng He Zhao Yuepeng Cai Beatriz Jurado‑Sanchez renfeng Dong School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Department of Analytical Chemistry Physical Chemistryand Chemical EngineeringUniversidad de Alcala28871 Alcala de HenaresMadridSpain Chemical Research Institute“Andres M.del Rio” University of Alcala28871 Alcala de HenaresMadridSpain

due to their tiny size,autonomous motion and functionalize modifications,micro/nanomotors have shown great potential for environmental remediation,biomedicine and micro/***-dimensional(1D)micro/nanomotors combine the characteristics of anisotropy and large aspect ratio of 1D materials with the advantages of functionalization and autonomous motion of micro/nanomotors for revolutionary *** this review,we discuss current research progress on 1D micro/nanomotors,including the fabrication methods,driving mechanisms,and recent advances in environmental remediation and biomedical applications,as well as discuss current challenges and possible *** continuous attention and innovation,the advancement of 1D micro/nanomotors will pave the way for the continued development of the micro/nanomotor field.

关键词： 1D micro/nanomotors Fabrication methods Driving mechanisms Applications

Advances in ablative treatment for human papillomavirus related cervical pre-cancer lesions

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Gynecology and Obstetrics Clinical Medicine 2023年第4期3卷 213-219页

作者： Lili Xu Yanming Jiang renfeng Zhao Department of Gynecology The People's Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanning530021China

HPV infection is the primary cause of cervical intraepithelial neoplasia(CIN),with persistent high-risk HPV infection being the leading factor in the development of cervical *** addition to the application of large loop excision of the transformation zone(LLETZ)for the treatment of cervical pre-cancerous lesions,various ablative techniques,including thermal ablation,cryotherapy,carbon dioxide(CO_(2))laser therapy,and focused ultrasound therapy also play significant roles in the management of cervical intraepithelial *** review presents a comprehensive overview of the pathophysiology of cervical HPV infection and discusses the ablative methods commonly used in clinical practice,along with their indication and contradiction,especially in women with high-grade squamous intraepithelial *** aim is to identify safe and effective treatment strategies for treating cervical intraepithelial neoplasia,thereby avoiding under-or over-treatment,which may reduce the incidenceandprogr ssion of cervical cancer through timely diagnosis and treatment.

关键词： Ablative treatment Thermal ablation Cryotherapy Cervical intraepithelial neoplasia Human papillomavirus