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Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： renee J Dufault Katherine m Adler David O Carpenter Steven G Gilbert Raquel A Crider College of Graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKGROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

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Psychiatric comorbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul madley-Dowd Harriet Forbes Jessica Rast Caichen Zhong renee m Gardner Christina Dalman Kristen Lyal cRAIG Newschaffer Torbjorn Tomson michael Lundberg Daniel Berglind Neil m Davies Brian K Lee Cecilia magnusson Dheeraj Rai Department of Global Public Health Karolinska InstitutetStockholmSweden medical Research Council Integrative Epidemiology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academic mental Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidemiology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism Institute Drexel UniversityPhiladelphiaPAUSA Department of Epidemiology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Human Development Pennsylvania State UniversityState CollegePAUSA Department of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidemiology and Community medicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidemiology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Department of Statistical Sciences University Cllge LondonLondonK NIHR Biomedical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric comorbidities are common in patients with *** for the co-occurrence of psychiatric conditions and epilepsy remain poorly *** We aimed to triangulate the relationship between epilepsy and psychiatric conditions to determine the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetime prevalence of psychiatric disorders in patients with *** then used summarydata from genome-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium score ***,we assessed the potential bidirectional relationships using two-sample mendelian *** In a cohort of 7628495 individuals,we found that almost half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetime(adjusted lifetime prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and some neurodevelopmental and psychiatric *** example,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pmore pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pm mendelian randomisation using common genetic variants did not support bidirectional effects between epilepsy and neurodevelopmental or psychiatric *** Psychiatric comorbidities are common in patients with *** correlations may partially explain some comorbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environmental factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetime

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较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)

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英国医学杂志中文版 2018年第11期21卷 676-676页

作者： renee m barendse Gijsbert D musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft Jeroen m Jansen A W marc van milligen de Wit George P van der Schelling Erik J Schoon matthijs P Schwartz Bas L A m Weusten marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组李佳宁(译) 吴东(校) 不详北京协和医院消化科

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较... 详细信息

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EmR与TEm的临床结局与成本效益。

关键词：随机对照试验显微手术切除术内镜黏膜肛门肠腺成本效益

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Preoperative prediction of lymph node metastasis using deep learning-based features

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 88-98页

作者： renee Cattell Jia Ying Lan Lei Jie Ding Shenglan Chen mario Serrano Sosa Chuan Huang Department of Biomedical Engineering Stony Brook UniversityNY 11794 Stony BrookUSA Department of Radiation Oncology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Program in Public Health Stony Brook MedicineStony BrookNY 11794USA Department of medicine Northside Hospital GwinnettGA 30046 LawrencevilleUSA Department of Radiation Oncology Medical College of WisconsinMilwaukeeWI 53226USA Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Department of Radiology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794US

Lymph node involvement increases the risk of breast cancer *** accurate non-invasive assessment of nodal involvement is valuable in cancer staging,surgical risk,and cost *** has been proposed to pre-operatively predict sentinel lymph node(SLN)status;however,radiomic models are known to be sensitive to acquisition *** purpose of this study was to develop a prediction model for preoperative prediction of SLN metastasis using deep learning-based(DLB)features and compare its predictive performance to state-of-the-art ***,this study aimed to compare the generalizability of radiomics vs DLB features in an independent test set with dissimilar *** contrast-enhancement images from 198 patients(67 positive SLNs)were used in this *** these subjects,163 had an in-plane resolution of 0.7×0.7 mm^(2),which were randomly divided into a training set(approximately 67%)and a validation set(approximately 33%).The remaining 35 subjects with a different in-plane resolution(0.78×0.78 mm^(2))were treated as independent testing set for *** methods were employed:(1)conventional radiomics(CR),and(2)DLB features which replaced hand-curated features with pre-trained VGG-16 *** threshold determined using the training set was applied to the independent validation and testing *** feature reduction,feature selection,model creation procedures were used for both *** the validation set(same resolution as training),the DLB model outperformed the CR model(accuracy 83%vs 80%).Furthermore,in the independent testing set of the dissimilar resolution,the DLB model performed markedly better than the CR model(accuracy 77%vs 71%).The predictive performance of the DLB model outperformed the CR model for this *** interestingly,these improvements were seen particularly in the independent testing set of dissimilar *** could indicate that DLB features can ultimately result in a mor

关键词： Deep learning Radiomics Prediction model Lymph node metastasis Breast cancer

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Two fully automated data-driven 3D whole-breast segmentation strategies in mRI for mR-based breast density using image registration and U-Net with a focus on reproducibility

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Visual Computing for Industry,Biomedicine,and Art 2022年第1期5卷 303-314页

作者： Jia Ying renee Cattell Tianyun Zhao Lan Lei Zhao Jiang Shahid m.Hussain Yi Gao H‑H.Sherry Chow Alison T.Stopeck Patricia A.Thompson Chuan Huang Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Radiation Oncology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of medicine Northside Hospital GwinnettLawrencevilleGA 30046USA Program of Public Health Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Radiology Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Department of Biomedical Informatics Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China University of Arizona Cancer Center TucsonAZ 85719USA Department of medicine Renaissance School of MedicineStony Brook UniversityStony BrookNY 11794USA Stony Brook Cancer Center Stony Brook UniversityStony BrookNY 11794USA Department of medicine Cedar Sinai CancerCedars Sinai Medical CenterLos AngelesCA 90048USA

Presence of higher breast density(BD)and persistence over time are risk factors for breast cancer.A quantitatively accurate and highly reproducible BD measure that relies on precise and reproducible whole-breast segmentation is *** this study,we aimed to develop a highly reproducible and accurate whole-breast segmentation algorithm for the generation of reproducible BD *** datasets of volunteers from two clinical trials were *** mR images were acquired on 3T Siemens Biograph mmR,Prisma,and Skyra using 3D Cartesian six-echo GRE sequences with a fat-water separation *** whole-breast segmentation strategies,utiliz-ing image registration and 3D U-Net,were *** segmentation was performed.A task-based analysis was performed:a previously developed mR-based BD measure,magDensity,was calculated and assessed using automated and manual *** mean squared error(mSE)and intraclass correlation coefficient(ICC)between magDensity were evaluated using the manual segmentation as a *** test-retest reproducibility of magDensity derived from different breast segmentation methods was assessed using the difference between the test and retest measures(Δ_(2-1)),mSE,and *** results showed that magDensity derived by the registration and deep learning segmentation methods exhibited high concordance with manual segmentation,with ICCs of 0.986(95%CI:0.974-0.993)and 0.983(95%CI:0.961-0.992),*** test-retest analysis,magDensity derived using the regis-tration algorithm achieved the smallest mSE of 0.370 and highest ICC of 0.993(95%CI:0.982-0.997)when compared to other segmentation *** conclusion,the proposed registration and deep learning whole-breast segmentation methods are accurate and reliable for estimating *** methods outperformed a previously developed algorithm and manual segmentation in the test-retest assessment,with the registration exhibiting superior performance for highly reproducibl

关键词： Breast cancer Breast density Breast segmentation Image registration Deep learning

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Robustness of radiomic features in magnetic resonance imaging: review and a phantom study

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Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 176-191页

作者： renee Cattell Shenglan Chen Chuan Huang Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA Department of Radiology Stony Brook MedicineStony BrookNY 11794USA Department of Psychiatry Stony Brook MedicineStony BrookNY 11794USA

Radiomic analysis has exponentially increased the amount of quantitative data that can be extracted from a single *** imaging biomarkers can aid in the generation of prediction models aimed to further personalized ***,the generalizability of the model is dependent on the robustness of these *** purpose of this study is to review the current literature regarding robustness of radiomic features on magnetic resonance ***,a phantom study is performed to systematically evaluate the behavior of radiomic features under various conditions(signal to noise ratio,region of interest delineation,voxel size change and normalization methods)using intraclass correlation *** features extracted in this phantom study include first order,shape,gray level cooccurrence matrix and gray level run length *** features are found to be non-robust to changing *** robustness assessment prior to feature selection,especially in the case of combining multi-institutional data,may be *** investigation is needed in this area of research.

关键词： Radiomics Robustness magnetic resonance imaging Imaging biomarker Phantom study

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Clinical factors associated with hepatitis B screening andvaccination in high-risk adults

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World Journal of Hepatology 2019年第1期11卷 86-98页

作者： Rotimi Ayoola Sebastian Larion David m Poppers renee Williams Department of medicine Division of Gastroenterology Howard University Department of medicine Augusta University Department of medicine Division of Gastroenterology New York University Langone Health

BACKGROUND Hepatitis B virus is a viral infection that can lead to acute and/or chronic liver disease, and hepatocellular carcinoma(HCC). Hepatitis B vaccination is 95% effective in preventing infection and the development of chronic liver disease and HCC due to hepatitis B. In 2011, the Centers for Disease Control updated their guidelines recommending that adults at high-risk for hepatitis B infection be vaccinated against hepatitis B including those with diabetes mellitus(Dm). We hypothesize that adults at high-risk for hepatitis B infection are not being adequately screened and/or vaccinated for hepatitis B in a large urban healthcare *** To investigate clinical factors associated with Hepatitis B screening and vaccination in patients at high-risk for Hepatitis B *** We conducted a retrospective review of 999 patients presenting at a large urban healthcare system from 2012-2017 at high-risk for hepatitis B infection. Patients were considered high-risk for hepatitis B infection based on hepatitis B practice recommendations from the Center for Disease Control. medical history including hepatitis B serology, concomitant medical diagnoses, demographics, insurance status and social history were extracted from electronic health *** logistic regression was used to identify clinical risk factors independently associated with hepatitis B screening and *** Among the 999 patients, 556(55.7%) patients were screened for hepatitis B. Of those who were screened, only 242(43.5%) patients were vaccinated against hepatitis B. multivariate regression analysis revealed end-stage renal disease[odds ratio(OR): 5.122; 2.766-9.483], alcoholic hepatitis(OR: 3.064; 1.020-9.206),and cirrhosis or end-stage liver disease(OR: 1.909; 1.095-3.329); all P m(OR: 0.518; 0.364-0.737), and human immunodeficiency v

关键词： Health prevention Vaccination Hepatitis B virus Screening Diabetes mellitus Cirrhosis End-stage renal disease Human immunodeficiency virus Intravenous drug users

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The balancing act of AKT in T cells

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Frontiers in Biology 2013年第2期8卷 160-174页

作者： mary Catherine renee~ Francesc mARTI Department of microbiology Immunology and Molecular Genetics University of Kentucky College of MedicineLexington KY 40536 USA

Abstract The serine/threonine-specific protein kinase AKT is gaining recognition as a major crossroad in numerous cellular signaling pathways through its ability to regulate cell differentiation, proliferation, survival and metabolism. This review focuses on the recent advances in AKT signaling and downstream events in T cells, emphasizing its contrasting role in conventional and regulatory （Treg） T cell populations. Activation of AKT has been known for many years to be critical in the development and function of conventional T cells. However, it has just recently been uncovered that AKT exerts an inhibitory effect on Treg generation and suppressor function. These studies have placed AKT at the nexus of Treg development and function, thus opening novel avenues for therapeutic manipulation.

关键词： AKT Tregs T cell signaling T cell differentiation

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The Role of T Lymphocytes in Bone Remodeling

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Open Journal of Orthopedics 2023年第4期13卷 131-146页

作者： Jaymes L. Fuller renee E. Samuel Jason J. Abraham Dina Gad Dana m. Padilla Jessica A. Cottrell Department of Biological Sciences Seton Hall University South Orange USA

Bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain bone function. Bone remodeling involves the synchronized differentiation and activity of bone-related cell types including bone matrix-depositing osteoblasts, bone matrix-resorbing osteoclasts, collagen/extracellular matrix-producing chondrocytes, and the progenitors of these cell types. T and B cells are adaptive immune cells that can influence bone remodeling by directly regulating the function of bone-related cells under normal and pathophysiological conditions. The specific mechanisms through which T cells control remodeling are not well defined. Here, we review the impact and influence of T cells and their products on the differentiation and function of bone cells during bone remodeling. Synthesizing new connections and highlighting potential mechanisms may promote additional avenues of study to elucidate the full role that immune cells play in regulating bone homeostasis.

关键词： Osteoimmunology Bone Homeostasis Fracture T Cells B Cells Osteoblasts Osteoclasts Chondrocytes

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The practical guide to finance and accounting

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2001年

作者： Susan m. Drake renee G. Dingler

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