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World Journal of Gastroenterology 2005年第48期11卷 7690-7693页

作者： Ramón Peces Joost PH Drenth rene hm te morsche Pedro González Carlos Peces Section of Nephrology Department of Medicine Section of Digestive Hospital General La Mancha-Centro Computer Science Superior School

Polycystic liver disease (PLD) is characterized by the presence of multiple bile duct-derived epithelial cysts scattered in the liver parenchyma. PLD can manifest itself in patients with severe autosomal dominant polycystic kidney disease (ADPKD). Isolated autosomal dominant polycystic liver disease (ADPLD) is genetically distinct from PLD associated with ADPKD, although it may have similar pathogenesis and clinical ***, mutations in two causative genes for ADPLD,independently from ADPKD, have been identified. We report here a family (a mother and her daughter) with a severe form of ADPLD not associated with ADPKD produced by a novel missense protein kinase C substrate 80K-H (PRKCSH) mutation (R281W). This mutation causes a severe phenotype, since the two affected subjects manifested signs of portal hypertension. Doppler sonography, computed tomography (CT) and magnetic resonance (MR) imaging are effective in documenting the underlying lesions in a non-invasive way.

关键词： ADPLD Hepatic cysts Hepatocystin Inferior vena cava compression Polycystic liver disease Portal hypertension

COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk

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World Journal of Gastroenterology 2009年第36期15卷 4561-4565页

作者： Juliёt H Hoff rene hm te morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert hm Peters Department of Gastroenterology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands

AIM： TO determine the possible modulating effect of the COX-2 polymorphisms, -765G→C and -1195A→G, on the risk of colorectal cancer （CRC） in a Dutch population. METHODS： This case-control study includes 326 patients with CRC and 369 age- and gender-matched controls. Genotypes of the COX-2 polymorphisms -7dEG→C and -1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism. COX-2 genotypes and haplotypes were analyzed and odds ratios with 95% confidence intervals were estimated by logistic regression. RESULTS： The -765GG genotype was associated with an increased risk of developing CRC （OR, 1.45; 95% CI, 1.03-2.04）. No significant difference was observed in the genotype distribution of the -1195A→G polymorphism between patients and controls. The GG/AC haplotype was present significantly less often in patients than in controls （OR 0.44; 95% CI, 0.22-0.85）. When the AC, AG and GG haplotypes were investigated separately, the AC haplotype showed a tendency to be less frequent in patients than in controls （OR（AG/AC） 0.78; 95% CI, 0.57-1.06）. CONCLUSION： The -765GG genotype is associated with an increased risk of developing CRC and the G6/ AC haplotype seems to protect against CRC. These findings suggest a modulating role for the COX-2 polymorphisms -765G→C and -1195A→G in the development of CRC in a Dutch population.

关键词： Colorectal carcinoma Cyclooxygenase-2 Genetic polymorphism

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma

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World Journal of Gastroenterology 2009年第28期15卷 3493-3497页

作者： Jón O Kristinsson Paul van Westerveld rene hm te morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert hm Peters Department of Gastroenterolog Radboud University Nijmegen Medical Center PO Box 9106500 HB Nijmegen The Netherlands Department of Surgery Radboud UniversityNijmegen Medical Center PO Box 9101 6500 HB NijmegenThe Netherlands Department of Gastroenterology Hospital Gelderse Vallei PO Box 9025 6710 HN Ede The Netherlands Department of Gastroenterology Canisius Wilhelmina Hospital Weg door Jonkerbos 100 6532 SZ Nijmegen The Netherlands

AIM： TO determine whether -1195 A→G and/or -765 G→C polymorphisms in Cyclooxygenase-2 CCOX-2） may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS： Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios （OR） and 95% confidence intervals （CI） were estimated. RESULTS： The distribution of the -1195A→G polymorphism was significantly different in esophageal cancer patients compared to controls. The -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma （OR = 3.85, 95% CI： 1.45-10.3） compared with the -1195AA genotype as a reference. The -765 G→C genotype distribution was not different between the two groups. The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls （OR = 3.45, 95% CI： 1.24-9.58; with AG/AG as a reference）. The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance. CONCLUSION： Presence of the COX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.

关键词： Adenocarcinoma Cyclooxygenase-2 Esophagus Genetic polymorphism Squamous cellcarcinoma

Short mucin 6 alleles are associated with H pylori infection

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World Journal of Gastroenterology 2006年第37期12卷 6021-6025页

作者： Thai V Nguyen Marcel JR Janssen Paulien Gritters René hm te morsche Joost PH Drenth Henri van Asten Robert JF Laheij Jan BMJ Jansen Department of Gastroenterology Can Tho University of Medicine and Pharmacy Can Tho Viet Nam Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands Nijmegen Institute for International Health Radboud University Nijmegen Medical Centre Nijmegen The Netherlands

AIM： To investigate the relationship between mucin 6 （MUC6） VNTR length and Hpylori infection. METHODS： Blood samples were collected from patients visiting the Can Tho General Hospital for upper gastrointestinal endoscopy. DNA was isolated from whole blood, the repeated section was cut out using a restriction enzyme （Pvu 11） and the length of the allele fragments was determined by Southern blotting. Hpylori infection was diagnosed by ^14C urea breath test. For analysis, MUC6 allele fragment length was dichotomized as being either long （〉 13.5 kbp） or short （≤ 13.5 kbp） and patients were classified according to genotype [long- long （LL）, long-short （LS）, short-short （SS）]. RESULTS： 160 patients were studied （mean age 43 years, 36% were males, 58% H pylori positive）. MUC6 PvuⅡ-restricted allele fragment lengths ranged from 7 to 19 kbp. Of the patients with the LL, LS, SS MUC6 genotype, 43% （24/56）, 57% （25/58） and 76% （11/46） were infected with Hpylori, respectively （P = 0.003）. CONCLUSION： Short MUC6 alleles are associated with H pylori infection.

关键词： H pylori Mucin 6 Polymorphism Variable number of tandem repeats

CNB-001 reduces paraplegia in rabbits following spinal cord ischemia

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Neural Regeneration Research 2019年第12期14卷 2192-2198页

作者： Paul A. Lapchak Paul D. Boitano rene Bombien Daisy Chou Margot Knight Anja Muehle Mihaela te Winkel Ali Khoynezhad Neurocore LLC Pomona CA USA Department of Surgery Memorial Care Health System Long Beach CA USA

Spinal cord ischemia associated with trauma and surgical procedures including thoraco-abdominal aortic aneurysm repair and thoracic endovascular aortic repair results in devastating clinical deficits in patients. Because spinal cord ischemia is inadequately treated, we studied the effects of [4-((1 E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1 H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol)](CNB-001), a novel curcumin-based compound, in a rabbit SCI model. CNB-001 is known to inhibit human 5-lipoxygenase and 15-lipoxygenase and reduce the ischemia-induced inflammatory response. Moreover, CNB-001 can reduce the level of oxidative stress markers and potentiate brain-derived neurotrophic factor and brain-derived neurotrophic factor receptor signaling. The Tarlov scale and quantal analysis technique results revealed that CNB-001 administered as an intravenous dose(bolus) 30 minutes prior to spinal cord ischemia improved the behaviors of female New Zealand White rabbits. The improvements were similar to those produced by the uncompetitive N-methyl-D-aspartate receptor antagonist memantine. At 48 hours after aortic occlusion, there was a 42.7% increase(P ted ischemia duration(n = 14) for rabbits treated with CNB-001(n = 16), and a 72.3% increase for rabbits treated with the positive control memantine(P ted ischemic rabbits(n = 22). CNB-001 is a potential important novel treatment for spinal cord ischemia induced by aortic occlusion. All experiments were approved by the CSMC Institutional Animal Care and Use Committee(IACUC #4311) on November 1,2012.

关键词： curcumin analog spinal cord injury spinal cord ischemia thoraco-abdominal aortic aneurysm thoracic endovascular aortic repair motor function neuroprotection neurorepair

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考虑水转化过程的干旱区内陆河流域适宜灌溉规模

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农业工程学报 2024年第6期40卷 228-236页

作者：胡雪雪粟晓玲朱兴宇褚江东张特吴海江西北农林科技大学旱区农业水土工程教育部重点实验室杨凌712100 西北农林科技大学水利与建筑工程学院杨凌712100

农业适水发展是保障干旱区水土资源高效利用和生态健康的关键,其核心在于如何科学确定灌溉规模,进而控制农业灌溉用水量。该研究以石羊河流域为研究区,在明确非灌溉需水量的基础上,基于水均衡模型计算考虑水转化过程的不同水文年农业灌... 详细信息

农业适水发展是保障干旱区水土资源高效利用和生态健康的关键,其核心在于如何科学确定灌溉规模,进而控制农业灌溉用水量。该研究以石羊河流域为研究区,在明确非灌溉需水量的基础上,基于水均衡模型计算考虑水转化过程的不同水文年农业灌溉可用水量,并构建多目标种植结构优化模型对作物种植结构进行调整,最后改进水热平衡模型构建考虑水转化过程的旱区适宜灌溉规模计算模型,分析流域不同情景下的适宜灌溉规模。结果表明:地表水地下水联合调控下,石羊河流域丰、平、枯水年的灌溉可用水量分别为18.97亿~21.57亿、14.75亿~17.51亿、12.31亿~14.95亿m^(3);优化作物种植结构后能够以减少2.94%的经济效益实现14.13%的灌溉节水;构建的适宜灌溉规模计算模型在干旱区内陆河流域具有较好的适用性,采用该方法得到现状条件下石羊河流域丰、平、枯水年的适宜灌溉规模分别为27.73万~31.66万、21.55万~25.76万、18.01万~22.03万hm^(2),提高节水水平、调整种植结构后,流域的适宜灌溉规模有所增加。现状2020年(平水年)的实际灌溉面积高于当地水资源能够承载的临界适宜灌溉规模,需压减2.13万~6.34万hm^(2)。研究结果可在宏观层面上为决策者制定适水农业发展方案提供理论依据。

关键词：水资源灌溉模型水转化适宜规模种植结构优化石羊河流域

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IL－2对NOD鼠糖尿病的影响

中华微生物学和免疫学杂志 1994年第3期14卷 168-172页

作者：张志利 Geor.,hm 山西医学院第一附属医院

ＮＯＤ鼠是人类胰岛素依赖型糖尿病的动物模型，其发病与自身免疫有关。环磷酰胺（ＣＰ）可以加速这一过程，使ＮＯＤ鼠糖尿病的发病率提高或提前。一些研究表明：ＮＯＤ鼠的淋巴细胞在淋巴细胞混合反应中（ＭＬＲ），在有或无刺激物的... 详细信息

ＮＯＤ鼠是人类胰岛素依赖型糖尿病的动物模型，其发病与自身免疫有关。环磷酰胺（ＣＰ）可以加速这一过程，使ＮＯＤ鼠糖尿病的发病率提高或提前。一些研究表明：ＮＯＤ鼠的淋巴细胞在淋巴细胞混合反应中（ＭＬＲ），在有或无刺激物的存在下，白细胞介素２（ＩＬ－２）的产量均明显低于正常鼠的淋巴细胞。该实验对注射了一次大剂量的ＣＰ（３００ｍｇ／ｋｇ体重）后的ＮＯＤ鼠试用了ＩＬ－２治疗。结果显示：对于年幼的ＮＯＤ鼠ＩＬ－２治疗１４无可以明显减轻注射ＣＰ后的胰岛破坏加速。病理检查显示三组胰岛炎严重程度积分分别为２９；８１；８８。ＩＬ－２处理组明显低于ＣｏｎＡ处理组与对照组。这个研究还显示，对于１２周龄的ＮＯＤ鼠，经１４天的ＩＬ－２治疗，可以完全预防ＣＰ诱导的糖尿病的发生。糖尿病发病率在ＩＬ－２组为０／１２；对照组为７／１２。但对已发病的ＮＯＤ鼠自发性糖尿病ＩＬ－２不能使其缓解。

关键词：白细胞介素2 NOD 糖尿病

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<i>STAT</i>1 gene mutation is not implicated in upper aerodigestive cancers

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Open Journal of Gastroenterology 2012年第2期2卷 68-71页

作者： Polat Dura rene H. M. te morsche Martin Lacko Mihai G. Netea Jos W. M. van der Meer Joost P. H. Drenth Wilbert H. M. Peters Department of Otorhinolaryngology Maastricht University Medical Center Maastricht the Netherlands Departments of Gastroenterology and Internal Medicine Radboud University Nijmegen Medical Center Nijmegen the Netherlands

Autosomal Dominant Chronic Mucocutaneous Candidiasis (AD-CMC) is characterized by defective T cell immunity, leading to fungal infections limited to mucosal surfaces. Recently it was discovered that mutations in the coiled-coil (CC) domain of STAT1 are the cause of AD-CMC. STAT1 deficiency has been implicated in experimental models of oesophageal cancer (EC) and head and neck carcinoma (HNC). Both carcinoma types are prevalent among CMC patients. Consequently, we postulated that the same mutation in the STAT1 gene triggering AD-CMC, could also be involved in oesophageal- or head and neck carcinogenesis. However we failed to identify the c.820C>T mutation in the STAT1 CC domain in 3 cohorts of Dutch Caucasian origin: being 351 EC patients, 325 HNC patients and 309 controls. Although it seems valuable to investigate the relationship between AD-CMC and upper aerodigestive neo- plasms, the c.820C>T mutation in the STAT1 gene does not seem implicated in EC and HNC aetiology.

关键词： STAT1 Signal Transducers and Activators of Transcription Chronic Mucocutaneous Candidiasis Genetic Mutation Esophageal Carcinoma Head and Neck Carcinoma

鄂尔多斯高原北部一年两季燕麦种植模式生产性能评价

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草业学报 2024年第1期33卷 159-168页

作者：李文龙李峰张仲鹃王殿清王欢靳慧卿特木热胡志玲陶雅中国农业科学院草原研究所农业农村部饲草高效生产模式创新重点实验室内蒙古呼和浩特010010 黑龙江飞鹤乳业有限公司创新中心北京100015 呼和浩特市农牧技术推广中心内蒙古呼和浩特010010 巴彦淖尔市农牧局内蒙古巴彦淖尔015000 赤峰市宁城县农牧局内蒙古赤峰024200

为了筛选出适宜鄂尔多斯高原北部一年两季种植的优良燕麦品种,优化种植模式,以提高土地利用效率,增加经济效益,本研究分别对鄂尔多斯高原北部第一、二季种植的6个国内外燕麦品种的产量性状和营养品质进行了监测分析,并应用灰色关联度法... 详细信息

为了筛选出适宜鄂尔多斯高原北部一年两季种植的优良燕麦品种,优化种植模式,以提高土地利用效率,增加经济效益,本研究分别对鄂尔多斯高原北部第一、二季种植的6个国内外燕麦品种的产量性状和营养品质进行了监测分析,并应用灰色关联度法对不同品种燕麦在该地区的生产性能进行了综合评价。结果表明,第一、二季不同燕麦品种的株高、干草产量、粗蛋白(CP)、中性洗涤纤维(NDF)、酸性洗涤纤维(ADF)、钾(K)以及相对饲草质量(RFQ)的变化范围分别是96.77~121.77 cm、8426.38~14287.07 kg·hm^(-2)、8.19%~9.29%DM、51.47%~59.90%DM、30.00%~35.83%DM、1.23%~1.87%、117.88~161.41和68.73~97.20 cm、4927.07~7082.58 kg·hm^(-2)、12.12%~16.34%DM、39.60%~46.61%DM、19.49%~24.26%DM、1.67%~1.94%、206.09~262.64;除第一季燕麦粗蛋白含量外,各评价指标在不同品种间存在显著差异(P<0.05),其中第一季中品种太阳神的株高、NDF及ADF含量均高于其他品种,但其RFQ低于其他品种,而品种领袖的干草产量最大且K含量最低;第二季中品种青引1号的株高和干草产量均位列第一,其NDF、ADF含量居最高,贝勒的CP含量高于其他品种,青燕1号的K含量低于其他品种;株高及干、鲜草产量与CP、K、RFQ呈显著(P<0.05)或极显著(P<0.01或P<0.001)负相关,与NDF、ADF呈极显著正相关(P<0.001)。灰色关联度分析结果表明,各指标中NDF和RFQ的权重系数位列前二位,为该地区燕麦生产性能评价的重要指标;最适宜在鄂尔多斯高原北部地区作为第一季春播生产和第二季复种的燕麦品种分别为领袖和青燕1号,第一季春播领袖+第二季复种青燕1号的种植模式可在该地区以及同类型区域作为主推模式推广种植。

关键词：鄂尔多斯高原一年两季饲用燕麦生产力营养成分

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Long-term assist device patients admitted to ICU: Tips and pitfalls

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Journal of Intensive Medicine 2023年第2期3卷 81-88页

作者： Michiel Morshuis Hendrik Fox Volker Lauenroth rene Schramm Heart and Diabetes Center North Rhine-Westphalia Bad Oeynhausen 32545Germany

Left ventricular assist device(LVAD)therapy is well-established in the treatment of end-stage cardiac *** are bridge to transplant(BTT),bridge to candidacy(BTC),bridge to recovery(BTR),and destination therapy(DT).The durability and adverse event(AE)rate of LVADs have improved over the ***,due to donor shortage,the duration of support in the BTT population has increased tremendously;similarly,DT patients are on the device for a long ***,the number of readmissions of long-term LVAD patients has *** cases of severe AEs,intensive care unit(ICU)treatment can be *** complications are the most common ***,embolic or hemorrhagic strokes can occur due to foreign surfaces,acquired von Willebrand syndrome,and anticoagulation *** consequence of the coagulative status,in combination with the continuous flow,are gastrointestinal bleeding ***,in most patients,an isolated LVAD is implanted,and this involves the risk of late right heart *** of pump speed and optimization of the volume status can help solve this *** arrhythmias,pre-existing or de novo after LVAD implantation,can be a life-threatening *** medical therapy or ablation are potential treatment *** for specific LVADs,the Medtronic HeartWare TM ventricular assist device(HVAD)is not manufactured and distributed currently;however,4000 patients are still on the *** thrombosis can occur,wherein thrombolytic therapy is the first-line treatment ***,the HVAD can fail to restart after controller exchange due to technical issues,and precautions must be *** Momentum 3 trial showed superior survival without pump exchange or disabling stroke in patients treated with the HeartMate 3■(hm3;Abbott,Abbott Park,IL,USA)device in comparison to the HeartMate II(hmII).However,in a few cases,a twisted graft or bio debris formation between the outflow graft and bend reli

关键词： Heart failure Left ventricular assist device(LVAD)therapy Adverse events