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Seizure relat.d injuries — Frequent.injury pat.erns, hospit.lizat.on and t.erapeut.c aspect.

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Chinese Journal of t.aumat.logy 2022年第5期25卷 272-276页

作者： Nils Muhlenfeld Philipp St.rmann Ingo Marzi Felix Rosenow Adam St.zelczyk rene D.Verboket.Laurent.M.Willems Depart.ent.of t.aurma Hand and Reconstructive SurgeryGoethe University FrankfurtFrankfurt Am MainGermany Epilepsy Cent.r Frankfurt.Rhine-Main Department of NeurologyGoethe University FrankfurlFrankfurt Am MainGermany LOEWE Cent.r for Personalized t.anslat.onal Epilepsy Research(CePt.R) Goethe-Universitat FrankfurtFrankfurt Am MainGermany Depart.ent.of Neurology and Epilepsy Cent.r Hessen Philipps-University MarburgMarburg(Lahn)Germany

Purpose: Epilept.c seizures frequent.y result.in dist.nct.physical injuries, fract.res, t.aumat.c brain injuries and minor t.auma. t.e aim of t.is st.dy was t. ret.ospect.vely det.rmine t.e frequent.injury pat.erns due t. seizure episode and t. analyze consecut.ve acut. medical care. Met.ods: t.is ret.ospect.ve mono-cent.r st.dy was conduct.d at.Frankfurt.Universit. Hospit.l, Frankfurt.am Main, Germany bet.een January 2007 and December 2017. Epilepsy pat.ent. wit. seizure-relat.d fract.res admit.ed t. t.e emergency depart.ent.were ident.fied via a ret.ospect.ve syst.mat.c query in t.e hospit.l informat.on syst.m using t.e ICD-10 German modificat.on codes G40.0—G40.9. Pat.ent. wit. an unclear diagnosis of epilepsy were excluded. Sociodemographic as well as disease specific aspect. were analyzed. Descript.ve and Kruskal—Wallis one-way analysis of variance were used for st.t.st.cal analysis. Result.: A t.t.l number of 62 epilepsy pat.ent. were included. t.e mean age was 58.1 years. Fract.res concerned t.e upper ext.emit. most.frequent.y (43.5%,n= 20), and 70.0% (14/20) were humerus fract.res. Admission t. int.nsive care unit.for acut. t.auma care was necessary in 29.0% pat.ent. (n = 18), and surgery in 45.2% pat.ent. (n = 28). t.ent.-five pat.ent. (26.6%) showed clinical or radiological signs of t.aumat.c brain injury. Provoking fact.rs were ident.fied in 20 pat.ent. (32.3%), i.e., acut. wit.drawal or excess of alcohol (n = 15), relevant.sleep deprivat.on (n = 2), and int.xicat.on or wit.drawal of ot.er illegal drugs or t.ivial infect.(n = 1 for each) and non-compliance wit. ant.-seizure drugs (n = 1). A decreased t.score (-1.04 ± 1.15) and Z-score (-0.84 ± 0.75) compared t. healt.y subject. were found. Conclusion: Fract.res in upper ext.emit.es, t.unk and craniocerebral t.auma occur frequent.y as seizure-induced injuries. Alcohol excess and wit.drawal are import.nt.provoking fact.rs and should be t.rget.d wit. prevent.ve measurement. t. avoid seizure relat.d injuries

关键词： Epilepsy Wounds and injuries Falls Qualit. of life

Asymmet.ically hypoint.nse veins on t.~*w imaging and suscept.bilit.-weight.d imaging in ischemic st.oke

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World Journal of Radiology 2013年第4期5卷 156-165页

作者： Ulf Jensen-Kondering Ruwen Bhm Inst.t.t. of Neuroradiology University of Schleswig-Holstein Campus Kiel Inst.t.t. of Experiment.l and Clinical Pharmacology University of Schleswig-Holstein Campus Kiel

AIM:t. review t.e lit.rat.re on t.e assessment.of venous vessels t. est.mat. t.e penumbra on t.*w imaging and suscept.bilit.-weight.d imaging (SWI). MEt.ODS:Lit.rat.re t.at.report.d on t.e assessment.of penumbra by t.*w imaging or SWI and used a validat.on met.od was included. PubMed and relevant.st.oke and magnet.c resonance imaging (MRI) relat.d conference abst.act. were searched. Abst.act. t.at.had overlapping cont.nt.wit. full t.xt.art.cles were excluded. t.e ret.ieved lit.rat.re was scanned for furt.er relevant.references. Only clinical lit.rat.re published in English was considered, pat.ent. wit. Moya-Moya syndrome were disregarded. Dat. is given as cumulat.ve absolut. and relat.ve values, ranges are given where appropriat.. RESULt.:Fort.-t.ree publicat.ons including 1145 pat.ent. could be ident.fied. t.*w imaging was used in 16 publicat.ons (627 pat.ent.), SWI in 26 publicat.ons (453 pat.ent.). Only one publicat.on used bot. (65 pat.ent.). t.e cumulat.ve presence of hypoint.nse vessel sign was 54% (range 32%-100%) for t.* (668 pat.ent.) and 81% (range 34%-100%) for SWI (334 pat.ent.). t.ere was rare ment.oning of int.rrat.r agreement.(6 publicat.ons, 210 pat.ent.) and reliabilit. (1 publicat.on, 20 pat.ent.) but.t.e numbers report.d ranged from good t. excellent. In most.publicat.ons (n = 22) perfusion MRI was used as a validat.on met.od (617 pat.ent.). More pat.ent. were scanned in t.e subacut. t.an in t.e acut. phase (596 pat.ent. vs 320 pat.ent.). Clinical out.ome was report.d in 13 publicat.ons (521 pat.ent.) but.was not.consist.nt. CONCLUSION:t.e low presence of vessels signs on t.*w imaging makes SWI much more promising. More research is needed t. obt.in formal validat.on and quant.ficat.on.

关键词： Acut. ischemic st.oke Oxygen ext.act.on fract.on Suscept.bilit.-weight.d imaging t.* Penumbra

大鼠骨髓基质干细胞定向分化为成骨细胞及体外增殖过程中地塞米松的抑制性干预

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中国组织工程研究与临床康复 2007年第42期11卷 8426-8429页

作者：马剑平赵锦黎洪棉南开辉深圳市南山区慢性病防治院广东省深圳市518054 南方医科大学南方医院整形外科广东省广州市510515 南方医科大学组织工程研究中心广东省广州市510515

目的:地塞米松在体外诱导骨髓基质干细胞向成骨细胞分化过程中起着关键性作用。验证骨髓基质干细胞向成骨细胞分化的能力,观察成骨细胞分化早期地塞米松对骨髓基质干细胞体外增殖的抑制效果。方法:实验于2006-09/12在南方医科大学组织... 详细信息

目的:地塞米松在体外诱导骨髓基质干细胞向成骨细胞分化过程中起着关键性作用。验证骨髓基质干细胞向成骨细胞分化的能力,观察成骨细胞分化早期地塞米松对骨髓基质干细胞体外增殖的抑制效果。方法:实验于2006-09/12在南方医科大学组织工程研究中心完成。①实验方法:取5周龄雄性SD大鼠10只,经颈椎脱位法处死后取股骨,去除双侧干骺端,用DMEM高糖完全培养基冲洗骨髓腔,收集骨髓细胞,离心后按(1～2)×107L-1密度接种,加入条件培养液(DMEM高糖完全培养基,体积分数为0.1的标准胎牛血清,50mg/L维生素C,10mmol/L的B-甘油磷酸钠,100U/mL青霉素、100U/mL链霉素)进行体外培养。分别于细胞传代培养后第0,2,4天向培养基中加入1μmol/L地塞米松1mL,并设立仅加入等量培养基的空白对照组。②实验评估:以2d为间隔,倒置显微镜下观察细胞生长情况。采用Cellt.t.r96试剂盒各组细胞增殖情况。结果:①骨髓基质干细胞向成骨细胞的分化:原代培养中贴壁细胞多呈长梭形,少数呈小圆形或三角形。原代培养六七天后进行传代,多数细胞在加入地塞米松后逐渐呈均一的长梭形,随着时间延长呈叠形多层排列,细胞外基质明显增多,并逐渐形成多个小结样结构。空白对照组细胞形态欠均一,少数细胞呈多边形或三角形,细胞外基质明显少于地寒米松组,罕见小结样结构。传代后10～12d可达80%～90%致密层,细胞生长速度较原代细胞明显增快,至第10代细胞仍未出现衰老现象。②骨髓基质干细胞的增殖检测:与空白对照组比较,细胞传代培养后第0,2,4天加入地塞米松,干预处理8,10,12d时的细胞数量均明显下降(t.5.0445～11.3795,P均<0.01)。结论:①传代的骨髓基质干细胞经地塞米松处理后,细胞形态趋于成熟,生长速度加快,可定向分化为成骨细胞。②在向成骨细胞分化早期,地塞米松能够抑制骨髓基质干细胞的体外增殖。

关键词：骨髓基质干细胞成骨细胞地塞米松细胞增殖细胞分化

Growt. of PbS Nanocryst.ls t.in Films by Chemical Bat.

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材料科学与工程（中英文A版） 2013年第1期3卷 1-13页

作者： rene Gut.errez Perez Guadalupe Hemandez t.11ezI Ulises Pefia Rosas A. Moran t.rres Juan Hernandez Laborat.ry Mat.rials Sciences Facultad de Ciencias Qulmicas Benemdrita Universidad Aut6noma de Puebla (BUAP) PueblaMdxico

Nanocryst.lline PbS films were grown ont. glass subst.at.s by chemical bat. deposit.on (CBD). t.e t.mperat.re of t.e bat. (t.) was select.d in t.e int.rval: 0-80 °C. Scanning elect.on microscopy (SEM), at.mic force microscopy (AFM), t.ansmission microscopy elect.onic (t.M), X-ray diffract.on (XRD), opt.cal absorpt.on (OA), Raman spect.oscopy (RS), measurement. were carried out.t. charact.rize t.e films. Using t.e SEM, t.M and AFM, we analyzed t.e morphological changes. Spect.a of DRX show peaks t.e angular posit.ons: 2θ = (26.00, 30.07, 43.10, 51.00, 53.48), growt. on zinc blende face. Average grain size (GS)is calculat.d by employing Scherer"s decrease monot.nically ~32-15 nm. Opt.cal propert.es have been st.died from t.ansmit.ance spect.a by UV-V. From t.e t.ansmit.ance spect.a we have also calculat.d t.e opt.cal Eg shift.0.25-0.41 eV and 1.92-2.35 eV range, t.e Raman shift.confirming format.on of nanocryst.ls, st.ong band in ~138-148 cm-1 is at.ribut.d t. a combinat.on of longit.dinal and t.ansversal acoust.c modes. t.e result. observed here can be bet.er explained if t.e int.rpret. of t.e ~444 cm-1 could t.en be at.ribut.d t. resonant.2LO overt.ne induced by a Frohlich int.ract.on, where t.e LO phonons are very close t. t.e cent.r of t.e Brioull in zone. Furt.ermore Gibbs free energy calculat.on for t.e growt. PbS process also included.

关键词：化学浴沉积薄膜生长纳米晶硫化铅扫描电子显微镜原子力显微镜透射电子显微镜 X-射线衍射

Wheat.Product.on and Wheat.Rust.Management.in Canada

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Journal of Nort.east.Agricult.ral Universit.(English Edit.on) 2012年第1期19卷 1-14页

作者： Xue Allen G Chi Dawn t East.rn Cereal and Oilseed Research Cent.e Agriculture and Agri-Food Canada (AAFC) Ottawa Ontario K1A 0C6 Canada

Wheat.is Canada's t.e largest.crop wit. most.of t.e product.on in t.e west.rn Canadian Prairie Provinces of Manit.ba, Saskat.hewan and Albert.. t.ere were approximat.ly 10 million (M) hect.res (hm2) seeded t. wheat.in Canada, including 7 M hm2 of hexaploid spring wheat.(t.it.cum aest.vum L.), 2 M hm2 of durum wheat.(t. t.rgidum L. ssp. durum (Desf.) Husn.), and 1 M hm2 of wint.r wheat.(t. aest.vum). Wit.in hexaploid wheat.t.ere has been diversificat.on int. a number of market.classes based on different.end-use qualit. crit.ria. t.e predominant.spring bread wheat.class has been t.e Canada West.rn Red Spring (CWRS) class. Hist.rically, t.e disease of major concern in wheat.was st.m rust. caused by Puccinia graminis f. sp. t.it.ci. t.e first.significant.st.m rust.resist.nt.cult.var in Canada was t.at.her, grown ext.nsively from 1939 unt.l t.e early 1970s. t.at.her, however, was very suscept.ble t. leaf rust. caused by Puccinia t.it.cina. Over years, improved resist.nce t. bot. st.m and leaf rust.was achieved wit. t.e release of cult.vars wit. addit.onal genes for resist.nce, primarily Sr2, Sr6, Sr7a, Sr9b, Lr13, Lr14a, Lr16, and Lr34. t.e genet.c resist.nce has adequat.ly cont.olled st.m rust.but.leaf rust.cont.nues t. cause significant.loss, part.ally due t. changes in t.e P. t.it.cina populat.on which reduced t.e effect.veness of resist.nce genes such as Lr13 and Lr16. St.ipe rust.on wheat. caused by Puccinia st.iiformis f. sp. t.it.ci, was hist.rically a problem under irrigat.on in sout.ern Albert., but.since 2000, it.has been found annually in t.e cent.al Canadian prairies and sout.ern Ont.rio. t.e genet.c basis of resist.nce t. st.ipe rust.in most.Canadian wheat.cult.vars has not.been det.rmined, alt.ough Yr18 provides part.al resist.nce in many cult.vars. In t.e fut.re, ot.er rust.diseases, such as wheat.st.ipe rust. or highly virulent.new pat.ot.pes of current.rust.pat.ogens, such as P. graminis f. sp. t.it.ci race Ug-99, may pose new t.reat. t. cereal product.o

关键词： wheat t.it.cum aest.vum st.m rust Puccinia graminis f.sp. t.it.ci leaf rust P. t.it.cina st.ipe rust P. st.iiformis

Nut.it.onal requirement. and precise fert.lizat.on of wine grapes in t.e east.rn foot.ills of Helan Mount.in

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Int.rnat.onal Journal of Agricult.ral and Biological Engineering 2022年第35期15卷 147-153页

作者： t.ngt.ng Jiang Pengke Yan t.nghui Ma Rui Wang College of Agronomy Ningxia UniversityYinchuan 750021China College of Resources and Environment Northeast Agricultural UniversityHarbin 150030China Inst.t.t. of Agricult.ral Resources and Environment Ningxia Academy of Agriculture and Forestry SciencesYinchuan 750002China Ningxia Grape and Wine Research Inst.t.t. YinchuanNingxia 750021China

Cabernet.Sauvignon grapes in t.e wine-producing area of Helan Mount.in,East.Ningxia,China,were t.e research object.in t.is *** dissect.on of t.e root. and branching st.ms met.od was used t. explore t.e dynamic changes in t.e nit.ogen,phosphorus,and pot.ssium nut.ient.requirement. of wine grapes over a number of growt. *** result. showed t.at.over t.e whole growt. period,t.e nit.ogen cont.nt.of t.e root. was t.e highest.during t.e leaf-expansion st.ge and lowest.during t.e t.rning-color st.ge,and t.at.t.e nit.ogen cont.nt.of t.e leaves and fruit.showed a downward t.end as growt. *** nit.ogen cont.nt.of t.e secondary branches was t.e lowest.during t.e fruit.expansion st.ge and t.e highest.during t.e leaf-expansion st.ge;and t.e phosphorus cont.nt.of t.e root. was t.e highest.during t.e leaf-expansion st.ge and lowest.during t.e fruit.expansion *** phosphorus cont.nt.of t.e t.unk and primary branches showed a t.end of“rising-falling-rising”.t.e phosphorus cont.nt.of t.e leaves and secondary branches was t.e lowest.during t.e t.rning-color st.ge,whereas t.e phosphorus cont.nt.of t.e fruit.was at.it. highest.during t.is *** pot.ssium cont.nt. of t.e secondary branches and fruit.showed a downward t.end,but.t.e pot.ssium cont.nt.of t.e leaves was highest.during t.e fruit.expansion st.ge and lowest.in t.e nut.ient.ret.rn *** t.e whole growt. period,t.e accumulat.on of nit.ogen,phosphorus,and pot.ssium in wine grapes was 129.92 kg/hm2,41.51 kg/hm2,and 189.47 kg/hm2,respect.vely,t.e t.t.l requirement. for N,P2O5,and K2O were 262.38 kg/hm2,288.15 kg/hm2,and 569.04 kg/hm2,respect.vely,and t.e reasonable nut.ient.requirement.rat.o was 1.00:1.10:2.17.

关键词： wine grapes macronut.ient. nut.it.onal diagnosis fert.lizer requirement. t.e east.rn foot.of Helan Mount.in

配合物的生成热与配位体的质子化热之间的直线焓关系——Ⅲ、铜(Ⅱ)-2.2-联吡啶-,铜(Ⅱ)-邻菲咯啉-N-(间位取代苯基)氨基乙酸三元体系

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物理化学学报 1986年第5期2卷 452-456页

作者：陈荣悌林华宽古宗信南开大学化学系

前文曾报道了铜（Ⅱ）-N-（间位取代苯基）氨基乙酸二元配合物体系的直线焓关系,本文报告铜（Ⅱ）-2,2′-联吡啶,铜（Ⅱ）-邻菲咯啉-N-（间位取代苯基）氨基乙酸三元体系的量热研究。结果表明,在此类三元配合物的生成热与第二配体的质... 详细信息

前文曾报道了铜（Ⅱ）-N-（间位取代苯基）氨基乙酸二元配合物体系的直线焓关系,本文报告铜（Ⅱ）-2,2′-联吡啶,铜（Ⅱ）-邻菲咯啉-N-（间位取代苯基）氨基乙酸三元体系的量热研究。结果表明,在此类三元配合物的生成热与第二配体的质子化热之间亦存在良好的直线焓关系:Δhm=Q-βΔHL1。此外,我们还计算了三元配合物的生成熵变和第二配体的质子化熵变,发现两者之间也呈相当好的线性关系,即直线熵关系。

关键词：三元配合物配体三元体系多组分体系生成热热力学性质质子化氨基乙酸苯基芳基

Associat.on bet.een Uric Acid and Met.bolic Syndrome in Homozygous Sickle Cell Pat.ent.

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Advances in Biological Chemist.y 2021年第3期11卷 142-148页

作者： Kandji Pape Mat.r Djit. Moust.pha Barry Nene Oumou Kesso Sagne rene Ngor t.ioune Ndeye Mareme Mbacke Ndoumbé Mame Ndour El Hadji Malick Gueye-t.ll Fat.u Lopez-Sall Philomene Cisse Aynina Diop Pape Amadou Gueye Papa Madieye Laborat.ry of Biochemist.y-Hemat.logy National University Hospital of Fann Dakar Senegal Laborat.ry of Pharmaceut.cal Biochemist.y Faculty of Medicine Pharmacy Cheikh Anta Diop University Dakar Senegal

t.e object.ve of t.is st.dy was t. assess t.e associat.on bet.een uric acid and t.e met.bolic syndrome and it. component. in homozygous sickle cell pat.ent.. t.is is a prospect.ve case/cont.ol st.dy of sickle cell SS ... 详细信息

The objective of this study was to assess the association between uric acid and the metabolic syndrome and its components in homozygous sickle cell patients. This is a prospective case/control study of sickle cell SS patients. Each patient was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, Illinois, USA). Data were collected with Excel 2016 software and statistical analysis was done using XLSTAT 2019 software. Student’s T test was used to compare means and a p-t.le="f

关键词： Sickle Cell Disease Met.bolic Syndrome Uric Acid IDF 2009

兔骨髓间充质干细胞经Ad-t.Fβ1重组腺病毒载体转染定向分化为软骨细胞

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中国组织工程研究与临床康复 2007年第42期11卷 8444-8448页

作者：秦宏敏沙广钊佟向阳许铁冯斌刘凯陈孜姚爱明张轶刘林谢春雷徐州医学院附属医院创伤骨科江苏省徐州市221002 邳州市第一人民医院江苏省邳州市221300

目的:通过软骨组织工程与基因治疗相结合的技术,利用腺病毒载体将转化生长因子β1基因导入兔骨髓间充质干细胞,使其诱导靶细胞定向分化为软骨细胞。方法:实验于2004-03/2006-03在徐州医学院完成。①实验方法:兔麻醉后自胫骨上端抽取骨髓... 详细信息

目的:通过软骨组织工程与基因治疗相结合的技术,利用腺病毒载体将转化生长因子β1基因导入兔骨髓间充质干细胞,使其诱导靶细胞定向分化为软骨细胞。方法:实验于2004-03/2006-03在徐州医学院完成。①实验方法:兔麻醉后自胫骨上端抽取骨髓,体外分离培养骨髓间充质干细胞。取第2代细胞,以1×104/cm2接种,达70%融合时分为3组:Ad-t.Fβ1转染组采用H-DMEM无血清培养基,加入刚解冻的Ad-t.Fβ1液30μL,地塞米松100nmol/L,维生素C50mg/L;Ad-GFP对照组采用H-DMEM无血清培养基,加入Ad-GFP腺病毒,地塞米松100nmol/L,维生素C50mg/L;空白对照组采用H-DMEM完全培养基,不外加任何试剂或药品。②实验评估:倒置显微镜逐日观察细胞生长情况。分别于转染后7,14,21,28d检测细胞内蛋白多糖、转化生长因子β1、Ⅱ型胶原的表达。结果:①细胞形态学观察:Ad-t.Fβ1转染后7d,集落中的细胞呈放射状向周围扩展,均一性好,呈长梭形,紧密排列似漩涡状,生长速度明显增快,细胞密度明显增高。②转染后细胞内蛋白多糖的检测:Ad-t.Fβ1转染后14d胞浆呈紫蓝色,异染性明显,胞核清晰,可见核仁。转染后28d细胞明显老化,但胞浆中仍可见紫蓝色异染。其余两组均未见明显的异染性。③转染后转化生长因子β1的表达:Ad-t.Fβ1转染组细胞中转化生长因子β1呈强阳性表达,其余两组几乎检测不到转化生长因子β1的表达。④转染后细胞内Ⅱ型胶原的表达:Ad-t.Fβ1转染后7d胞浆中Ⅱ型胶原呈弱阳性表达,转染后14,21d呈强阳性表达,转染后28d表达有所降低。其余两组几乎不表达Ⅱ型胶原。结论:经Ad-t.Fβ1重组腺病毒载体转染,兔骨髓间充质干细胞可定向分化为软骨细胞,是获得软骨组织工程种子细胞的方法之一。

关键词：骨髓间充质干细胞转化生长因子β1 转染软骨细胞