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Evaluation of the Genotoxicity of Polymeric Microparticles Containing Ametryn Herbicide

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 553-565页

作者： Renata de Lima Leandro O. Feitosa renato grillo Anderson E.S. Pereira Leonardo FernandesFraceto Department of Biotechnology University of Sorocaba Sorocaba 18023-000 Brazil Federal University of Sao Carlos Sorocaba 18052-780 Brazil Department of Environmental Engineering UNESP-Univ. Estadual Paulista Sorocaba 18087-180 Brazil Department of Biochemistry Institute of Biology UNICAMP Campinas 18083-862 Brazil

Agrochemicals have been used throughout the ages to eradicate weeds and pests. Use of agrochemicals is now commonplace, serving as an aid in farming procedures and contributing to greater agricultural production. However, the indiscriminate use of agrochemicals is a cause for concern because they can exert toxic effects on the environment and hence on living beings. This work involved a genotoxic analysis of controlled release formulations of the herbicide ametryn encapsulated in microspheres of poly(hydroxybutyrate) and poly(hydroxybutyrate-co-valerate). Genotoxicity was analyzed using cytogenetic, micronucleus, comet and Allium cepa assays, as well as molecular analysis. The results showed that the rate of chromosome breakdown caused by unencapsulated ametryn was much higher than that caused by ametryn encapsulated in the polymer microspheres (p < 0.05). This indicates that controlled release delivery systems employing the polymer formulations should be significantly safer for the environment and for living beings.

关键词：聚合物微粒遗传毒性莠灭净除草剂毒性评价羟基丁酸酯控释制剂细胞遗传学

Alpha-Klotho in Parkinson’s disease: a perspective on experimental evidence and potential clinical implications

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Neural Regeneration Research 2022年第12期17卷 2687-2688页

作者： Piergiorgio grillo Michele Basilicata Tommaso Schirinzi Unit of Neurology Department of Systems MedicineUniversity of Roma Tor VergataRomeItaly Department of Experimental Medicine and Surgery University of Roma Tor VergataRomeItaly

more than 20 years ago,and immediately emerged as a master regulator of aging-related processes,which basically operates as an anti-aging *** is expressed through the entire human body,representing the choroid plexus and the kidney as the most active sources at the central nervous system(CNS)and periphery level *** a lesser extent,also the parathyroid gland,the adipose tissue,and the liver express *** is a transmembrane protein serving as an essential co-receptor for fibroblast growth factor receptors,but,in general,it mediates a number of molecular pathways and biological functions at a multisystem *** fact,even a soluble form exists,originated by the extracellular domain cleavage,which circulates in human fluids,allowing a sort of systemic *** all the tissue-specific actions have not been completely clarified,there is solid evidence that KL regulates basic mineral homeostasis and internal metabolism pathways.

关键词： metabolism Klotho homeostasis

Gut microbiota,inflammatory bowel disease and colorectal cancer

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World Journal of Gastroenterology 2022年第30期28卷 4053-4060页

作者： Ana Elisa Valencise Quaglio Thais Gagno grillo Ellen Cristina Souza De Oliveira Luiz Claudio Di Stasi Ligia Yukie Sassaki Departament of Biophysics and Pharmacology Sao Paulo State University(Unesp)Institute of BiosciencesBotucatu 18618-689Sao Paulo StateBrazil Department of Internal Medicine Sao Paulo State University(Unesp)Medical SchoolBotucatu 18618-686Sao Paulo StateBrazil

The gut microbiota is a complex community of microorganisms that inhabit the digestive tracts of humans,living in symbiosis with the ***,characterized by an imbalance between the beneficial and opportunistic gut microbiota,is associated with several gastrointestinal disorders,such as irritable bowel syndrome(IBS);inflammatory bowel disease(IBD),represented by ulcerative colitis and Crohn’s disease;and colorectal cancer(CRC).Dysbiosis can disrupt the mucosal barrier,resulting in perpetuation of inflammation and *** increase in some specific groups of harmful bacteria,such as Escherichia coli(***)and enterotoxigenic Bacteroides fragilis(ETBF),has been associated with chronic tissue inflammation and the release of pro-inflammatory and carcinogenic mediators,increasing the chance of developing CRC,following the inflammationdysplasia-cancer sequence in IBD ***,the aim of the present review was to analyze the correlation between changes in the gut microbiota and the development and maintenance of IBD,CRC,and IBD-associated *** with IBD and CRC have shown reduced bacterial diversity and abundance compared to healthy individuals,with enrichment of Firmicute sand *** bacteria are also associated with the onset and progression of CRC,such as Fusobacterium nucleatum,***,Enterococcus faecalis,Streptococcus gallolyticus,and *** research can evaluate the advantages of modulating the gut microbiota as preventive measures in CRC high-risk patients,directly affecting the prognosis of the disease and the quality of life of patients.

关键词： Gut microbiota Dysbiosis Ulcerative colitis Crohn’s disease Inflammatory bowel disease Colorectal cancer

Yield stress measurements and microstructure of colloidal kaolin powders clusterized and dispersed in different liquids

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Particuology 2009年第6期7卷 438-444页

作者： Dario T.Beruto Alberto Lagazzo Rodolfo Botter Roberto grillo Department of Civil Environmental and Architectural Engineering (DICAT)University of GenoaP.le Kennedy (Fiera del Mare)Pad. D16129-GenoaItaly Artigo S.p.A. loc.Carpeneto17014-Cairo Montenotte (SV)Italy

Rheologicat measurements of four colloidal kaolin powders dispersed in water, paraffinic oil and liquid rubber have been done at solid concentration （9 （VS/VL） in the range 8-33%. In quasi-static conditions the yield stress τ° values were derived. An S-shaped relationship between τ° and （9 exists, that allows to evaluate the percolation threshold θc values. In water θc ranges between 29% and 33%, while it is between 17% and 21% in oil and in liquid rubber. In water the microstructure units, i.e. the primary clusters among kaolin crystallites, are denser and bigger than the ones in the two other liquids. Furthermore, in quasistatic condition, the aqueous microstructure units have less tendency to cling together to form a network that can span all over the liquid phase. The different kaolin dispersions at θ equal to 22% are characterized by yield stress ranging between 7.S Pa and 59 Pa in water, 66-250 Pa in oil and 230-770 Pa in liquid rubber. It has been found that for any kaolin types the log τ°/ θ evaluated near to the percolation threshold is a conservative parameter of the three different liquids. These results are useful to design colloidal dispersions with selected microstructure.

关键词： Yield stress Colloid Dispersions Microstructure units Cluster Kaolin Rheology

Gastric inflammatory myofibroblastic tumor, a rare mesenchymalneoplasm: A case report

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2657-2662页

作者： Manuel Fernandez Rodriguez Pedro Joaquin Artuñedo Pe Alejandro Callejas Diaz Gala Silvestre Egea Cristián grillo Marín Eva Iglesias Garcia Jose Luis Lucena de La Poza Department of General and Digestive Surgery Hospital Universitario Puerta de HierroMajadahondaMadrid 28222Spain Department of Internal Medicine Hospital Universitario Puerta de HierroMajadahondaMadrid 28222Spain Department of Pathologycal Anatomy Hospital Universitario Puerta de HierroMajadahondaMadrid 28222Spain

BACKGROUND The inflammatory myofibroblastic tumor(IMT)is a rare mesenquimal tumor of doubtful biological ***’s characterised for affecting mainly children and young adults,although it can appear at any age,being the lungs the primary affected organ(in children it represents 20%of all primary pulmonary tumors).CASE SUMMARY We present the case of a 45 year old woman,with a computed tomography(CT)finding of injury on the anterior surface of the fundus/gastric body and a solid perigastric injury of 12 mm in the *** case is presented in the tumor committee deciding to perform a laparoscopic wedge *** histological diagnosis was a *** diagnosis is based on imaging tests like the abdominal CT,abdominal ecography and the ecoendoscopy but to confirm the diagnosis a pathological study is *** Due to the unpredictable nature of this tumor,surgical resection is the best therapeutic option.

关键词： Inflammatory myofibroblastic tumor Gastric Wedge resection ALK-mutation Case report

Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease:A review of the literature

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World Journal of Cardiology 2023年第5期15卷 217-228页

作者： Thais Gagno grillo Caroline Ferreira da Silva Mazeto Pupo Silveira Ana Elisa Valencise Quaglio Renata de Medeiros Dutra Julio Pinheiro Baima Silmeia Garcia Zanati Bazan Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatuBotucatu 18618686Brazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatuBotucatu 18618689Brazil

Tumor necrosis factor inhibitors(anti-TNFs)are widely used therapies for the treatment of inflammatory bowel diseases(IBD);however,their administration is not *** failure(HF),although rare,is a potential adverse event related to administration of these ***,the exact mechanism of development of HF remains ***αis found in both healthy and damaged *** effects are concentration-and receptor-dependent,promoting either cardio-protection or cardiomyocyte *** rat models with TNFαreceptor knockout showed increased survival rates,less reactive oxygen species formation,and improved diastolic left ventricle ***,clinical trials employing anti-TNF therapy to treat HF had disappointing results,suggesting abolishment of the cardioprotective properties of TNFα,making cardiomyocytes susceptible to apoptosis and ***,patients with IBD who have risk factors should be screened for HF before initiating anti-TNF *** review aims to discuss adverse events associated with the administration of anti-TNF therapy,with a focus on HF,and propose some approaches to avoid cardiac adverse events in patients with IBD.

关键词： Tumor necrosis factor inhibitors Inflammatory bowel disease Heart failure Adverse event TNFαreceptor

Role of Arabidopsis UV RESISTANCE LOCUS 8 in Plant Growth Reduction under Osmotic Stress and Low Levels of UV-B

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Molecular Plant 2014年第5期7卷 773-791页

作者： Rossella Fasano Nathalie Gonzalez Alessandra Tosco Fabrizio Dal Piaz Teresa Docimo Ramon Serrano Stefania grillo Antonella Leone Dirk Inze Department of Pharmacy University of Salerno Fisciano Italy Department of Plant Systems Biology VIB 9052 Ghent Belgium Department of Plant Biotechnology and Bioinformatics Ghent University 9052 Gent Belgium Max Planck Institute for Chemical Ecology Jena Germany Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia CSIC Valencia Spain National Research Council of Italy Institute of Plant Genetics Res. Div. Portici Portici Italy

In high-light environments, plants are exposed to different types of stresses, such as an excess of UV-B, but also drought stress which triggers a common morphogenic adaptive response resulting in a general reduction of plant growth. Here, we report that the Arabidopsis thaliana UVRESISTANCE LOCUS 8 （UVR8） gene, a known regulator of the UV-B morphogenic response, was able to complement a Saccharomyces cerevisiae osmo-sensitive mutant and its expression was induced after osmotic or salt stress in Arabidopsis plants. Under low levels of UV-B, plants overexpressing UVR8 are dwarfed with a reduced root development and accumulate more flavonoids compared to control plants. The growth defects are mainly due to the inhibition of cell expansion. The growth inhibition triggered by UVR8 overexpression in plants under low levels of UV-B was exacerbated by mannitol-induced osmotic stress, but it was not significantly affected by ionic stress. In contrast, uvr8-6 mutant plants do not differ from wild-type plants under standard conditions, but they show an increased shoot growth under high-salt stress. Our data suggest that UVR8-mediated accumulation of flavonoid and possibly changes in auxin homeostasis are the underlying mechanism of the observed growth phenotypes and that UVR8 might have an important role for integrating plant growth and stress signals.

关键词： osmotic stress growth reduction cell expansion flavonoid auxin.

Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2459-2462页

作者： Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari Giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce Centro Cardiologico Monzino IRCCSMilanoItaly Dompéfarmaceutici S.p.A. L’AquilaItaly Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani RomaItaly Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research CouncilNaplesItaly EXSCALATE DompéFarmaceutici S.p.ANapoliItaly Takis S.r.l. RomeItaly National Institute on Drug Abuse Intramural Research Program Baltimore21224MDUSA Johns Hopkins School of Medicine BaltimoreMDUSA Atreius S.a.s. L’AquilaItaly

Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by *** inflammation/dysfunction,platelet hyper-reactivity,generation of neutro... 详细信息

关键词： organs infection acute

MicroRNA expression in inflammatory bowel disease-associated colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 995-1016页

作者： Thais Gagno grillo Ana Elisa Valencise Quaglio Rodrigo Fedatto Beraldo Talles Bazeia Lima Julio Pinheiro Baima Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology São Paulo State University(Unesp)Institute of BiosciencesBotucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs)are non-coding RNA molecules composed of 19–25 nucleotides that regulate gene expression and play a central role in the regulation of several immune-mediated disorders,including inflammatory bowel diseases(IBD).IBD,represented by ulcerative colitis and Crohn’s disease,is characterized by chronic intestinal inflammation associated with an increased risk of colorectal cancer(CRC).CRC is one of the most prevalent tumors in the world,and its main risk factors are obesity,physical inactivity,smoking,alcoholism,advanced age,and some eating habits,in addition to chronic intestinal inflammatory processes and the use of immunosuppressants administered to IBD *** studies have identified miRNAs associated with an increased risk of developing CRC in this *** identification of miRNAs involved in this tumorigenic process could be useful to stratify cancer risk development for patients with IBD and to monitor and assess ***,the present review aimed to summarize the role of miRNAs as biomarkers for the diagnosis and prognosis of IBD-associated *** the future,therapies based on miRNA modulation could be used both in clinical practice to achieve remission of the disease and restore the quality of life for patients with IBD,and to identify the patients with IBD at high risk for tumor development.

关键词： MicroRNA Colorectal cancer Inflammatory bowel disease Crohn's disease Ulcerative colitis Cancer Diagnosis Prognosis Targets