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International Journal of Sediment Research 2021年第2期36卷 317-327页

作者： Michel Michaelovitch de Mahiques Samara Cazzoli y Goya Maria Carolina da silva Nogueira de Matos Rodrigo Augusto Udenal de Oliveira Bianca Sung Mi Kim Paulo Alves de Lima ferreira Rubens Cesar Lopes Figueira Marcia Caruso Bícego Oceanographic Institute University of S?o Paulo Pra?a do Oceanográfico Institute of Energy and Environment University of S?o Paulo Avenida Professor Luciano Gualberto

The current study aims to do a comparative analysis of the results obtained with two End-Member(EM)grain-size modeling techniques(Analy Size and Bas EMMA) and the Environmental Sensitive Grain-Size(ESGS) modeling for sediment samples collected in the mudbelts of the southern Brazilian shelf. The methods were compared using grain-size data from the south Brazilian shelf, and the results are discussed here. It is the first time that the concept of ESGS, in its present form, is utilized outside China. The results show that despite its relative ease of use, the ESGS is not fully comparable to the EM analyses, and only two grain-size ESGS classes were recognized as analogous to EMs. The comparison of the Analy Size and Bas EMMA procedures also revealed significant differences between the techniques. A comparative analysis between the two EM techniques revealed advantages in the Bas EMMA, especially in the better correlation of the end-members with the original grain size distribution. The analysis of the geographical distribution of the EM abundances allowed point sources of sandy populations to be recognized as well as the contribution of the Rio de la Plata as a source of silty sediments to be inferred.

关键词： Grain-size End-member Environmentally sensitive Mudbelt Continental shelf

Sublethal Doses of Insecticides Affect the Fecundity and Fertility of the <i>Chrysodeixis includens</i>?

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American Journal of Plant Sciences 2018年第3期9卷 483-494页

作者： Raimundo Henrique ferreira Rodrigues Luciana Barboza da silva Thiago ferreira Rodrigues Gleidyane Novais Lopes Eliane Carneiro Bruno Ettore Pavan Post-Graduation Program in Plant Science Agronomy Universidade Federal do Piauí Bom Jesus Brazil Faculty of Engineering UNESP Ilha Solteira Universidade Estadual Paulista Ilha Solteira Brazil

The objective was to determine lethal concentrations and to evaluate the effects of sublethal doses of insecticides on Chrysodeixis includens under laboratory conditions. The standard population of C. includens was kept on artificial diet under controlled conditions (25°C ± 5°C, 60% ± 10 RU, 12:12 h). The active principles used were B. thuringiensis, Indoxacarb and Teflubenzuron. The CL25 and LC50 obtained from dose response curve (estimated from eight concentrations of each active principle) were diluted in water and applied to the back of third instar caterpillars and compared to the control (water). The insecticides used showed lethal and sublethal effects in C. includens. Bacillus thuringiensis was 6.21 and 2.79 times more toxic to soybean looper when compared to the products Indoxacarb and Teflubenzuron, respectively. Insecticides applied to the caterpillars reduced survival and affected the biomass gain with increased larvae and pupae longevity, with a significant reduction in fertility (40%) and fecundity (94.97%) in adults. In the present study it was observed that both survival and larval biomass gain have a direct effect on fecundity and fertility, respectively. Therefore the active ingredients Indoxacarb, Teflubenzuron and B. thuringiensis can be used in rotation as a tool in the C. includens.

关键词： Bacillus thuringiensis Chemical Control Indoxacarb Soybean Looper Teflubenzuron

In Silico Approach for the Identification of Potential Targets and Specific Antimicrobials for Streptococcus mutans

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Advances in Bioscience and Biotechnology 2014年第4期5卷 373-385页

作者： Andrea Cristina Barbosa da silva Diego Romario da silva Sabrina Avelar de Macedo ferreira Gustavo Gomes Agripino Allan Reis Albuquerque Thais Gaudencio do Rego Center for Science Technology and HealthState University of ParaibaArarunaBrazil Center for Health Sciences Federal University of ParaíbaJoao PessoaBrazil Center for Informatics Federal University of ParaibaJoao PessoaBrazil

Tooth decay affects most of the population in developed countries. The multifactorial etiology of the disease includes multiple bacterial species, S. mutans is the main pathogen associated with the disease. This bacterium adheres to the tooth surface and allows the colonization of other microorganisms resulting in dental biofilm. Several therapeutic agents are available to treat or prevent tooth decay, but none, with the exception of fluoride, has significantly influenced the disease’s global burden. Moreover, the probable development of resistance of microorganisms to existing antibacterial agents and the scarcity of good antimicrobial agents motivates this effort for innovation. The detailed knowledge obtained in recent years on the S. mutans allowed the identification of potential targets in this microorganism, enabling the development of specific drugs to combat tooth decay. Thus, the identification of potential targets in these pathogens is the first step in the discovery process of new therapeutic agents. Currently, the experimental assays used for this purpose are expensive and time consuming. In contrast, bioinformatics methods to predict drug targets are cheap, quick and workaday in the biotechnology. This article will review the potential drug targets in S. mutans, as well as the bioinformatics methods used to identify these targets and effective drugs for specific pharmacological treatment of dental caries.

关键词： Bioinformatics Antimicrobial Targets S.mutans

Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease:A review of the literature

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World Journal of Cardiology 2023年第5期15卷 217-228页

作者： Thais Gagno Grillo Caroline ferreira da silva Mazeto Pupo Silveira Ana Elisa Valencise Quaglio Renata de Medeiros Dutra Julio Pinheiro Baima Silmeia Garcia Zanati Bazan Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatuBotucatu 18618686Brazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatuBotucatu 18618689Brazil

Tumor necrosis factor inhibitors(anti-TNFs)are widely used therapies for the treatment of inflammatory bowel diseases(IBD);however,their administration is not *** failure(HF),although rare,is a potential adverse event related to administration of these ***,the exact mechanism of development of HF remains ***αis found in both healthy and damaged *** effects are concentration-and receptor-dependent,promoting either cardio-protection or cardiomyocyte *** rat models with TNFαreceptor knockout showed increased survival rates,less reactive oxygen species formation,and improved diastolic left ventricle ***,clinical trials employing anti-TNF therapy to treat HF had disappointing results,suggesting abolishment of the cardioprotective properties of TNFα,making cardiomyocytes susceptible to apoptosis and ***,patients with IBD who have risk factors should be screened for HF before initiating anti-TNF *** review aims to discuss adverse events associated with the administration of anti-TNF therapy,with a focus on HF,and propose some approaches to avoid cardiac adverse events in patients with IBD.

关键词： Tumor necrosis factor inhibitors Inflammatory bowel disease Heart failure Adverse event TNFαreceptor

Demand Charge under Nonsinusoidal Conditions

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Journal of Energy and Power Engineering 2013年第2期7卷 375-380页

作者： Eduardo da Costa Sousa Ezequiel Junio de Lima Augusto Wohlgemuth Fleury Veloso da Silveira Sergio ferreira de Paula silva School of Electrical Engineering Brazilian Federal University of U-berlandia Uberldndia 38408-100 Minas Gerais Brazil

This paper aims to present a new point of view about the active power measurement, for billing purposes, measured at the PCC （point of common coupling） between the utility and the consumer when harmonic distortions are involved. Depending on theorigin of it, the active power can result in higher or lower values in comparison to the fundamental component. The consequences are higher costs for the consumer or losses for the electric utility. Using computational simulations and theoretical analysis, these aspects are evaluated and compared.

关键词： Harmonic distortions demand charge power quality active power harmonic direction.

Risk Factors for Cervical Cancer in a Sample Comprising Three Generations of Brazilian Women

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Journal of Cancer Therapy 2017年第1期8卷 12-25页

作者： Ilce ferreira da silva Rosalina Jorge Koifman Virgilio Augusto Gomes Parreira Simone Soares Sergio Koifman Instituto Fernandes Figueira Fundacao Oswaldo Cruz Rio de Janeiro Brazil Escola Nacional de Saúde Pública Fundacao Oswaldo Cruz Rio de Janeiro Brazil Hospital do Cancer-II Instituto Nacional do Cancer Rio de Janeiro Brazil

Background: Cervical cancer is the main cause of cancer deaths in some developing countries. Age-related cervical cancer incidence has been fundamental for understanding the different stages of carcinogenesis concepts. No Brazilian study explored the environmental risk factors involved on cervical cancer, according to age groups taking 70’s sexual revolution in Brazil as reference. Aim: To determine the prevalence of epidemiological and clinical aspects related to cervical cancer development in a sample of three age groups of Brazilian women based on 70’s sexual revolution. Methods: A cross-section study was proceeded in a hospital-based cohort of women with altered Pap-test refereed to the National Cancer Institute for Colposcopy and treatment from October 2004 to May 2006. Two register nurses interviewed all patients ascertaining risk factors and clinical characteristics. Biopsy, partial ablation were used for CIN-1, and conization was the treatment for CIN-2/3. Results: From 318 women included in the study, 42.8% were 18 - 30 years old (born after 1975), 43.4% were 31 - 49 years old (born 1955-1975), and 13.8% were 50 - 68 years old (born 1936-1954). Pregnancies (OR = 1.16;CI95%: 1.01 - 1.34) and menarche under 12 years old (OR = 1.95;CI95%: 1.17 - 3.25) were independently associated to CIN2- 3/cancer in 18 - 30 age group;menopause age (OR = 1.21;CI95%: 1.04 - 1.41) and current smoking habit (OR = 1.37;CI95%: 1.10 - 1.70) were associated to CIN2- 3/cancer in 31 - 49 age group;no statistical significance was observed for 50 - 68 age group. Conclusion: Brazilian women present distinct risk for cervical cancer according to the generation they belong, when taking the Brazilian sexual revolution on 70’s as a reference.

关键词： Cervical Cancer Cross-Section Study Epidemiology Sexual Revolution Brazil

Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2017年第2期9卷 78-86页

作者： Gilmar ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael dale Cotrim Guerreiro da silva Jaques Waisberg Department of Surgery - Escola Paulista de Medicina Federal University of Sao Paulo Genetic Laboratory Basics Health Sciences Department Medical School of Federal University of Mato Grosso Tropical Medicine Division Medical School of Brasilia University Campus Darcy Ribeiro University Laboratory of Genetics of Morphology and Genetics Department Federal University of Sao Paulo Laboratory of Clinical Analysis ABC Medical School avenida Príncipe de Gales Laboratory of Molecular Gynecology Department of Gynecology Federal University of Sao Paulo rua Pedro de Toledo

AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with spora

关键词： Colorectal cancer Genetic polymorphisms Vascular endothelial growth factor-A Colorectal surgery Genetic variation

超声波与人工智能在现场绝缘诊断中的应用(英文)

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高电压技术 2012年第8期38卷 1842-1847页

作者： ferreira T V Germano A D silva K M Costa E G Department of Electrical Engineering Federal University of Campina GrandeCampina Grande Institute for High Voltage Technology and Power Transmission Technische Universitt München Department of Electrical Engineering University of Brasília

This work studies the feasibility of implementing a system for diagnosis of electrical insulation in the field based on ultrasonic noise and artificial neural *** system,proved functional under laboratory conditions,extracts spectral information from the ultrasonic noise emitted by the corona discharges in electric equipments,and correlates it with previously defined degrees of *** achieve this classification,artificial neural networks are *** results show the viability of the method in the site;nevertheless they also show that its reliability is proportional to the size and diversity of the available database.

关键词：局部放电射频信号放电量高电压技术

Prognostic Factors, Incidence and Management for Acute Variceal Bleeding in the Liver Transplantation Era

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Surgical Science 2011年第4期2卷 198-203页

作者： élio Rodrigues da silva Ilka de Fátima Santana ferreira Boin Eurípedes Soares Filho Patrícia Alexsandra Nunes Barros Rodrgiues Benedito Borges da silva 不详

Background: Gastroesophageal varices are the most common and clinically important part of the portosys-temic collaterals due to their tendency to rupture and cause massive gastrointestinal bleeding. Objective The aim of this work was to evaluate retrospectively the incidence and the factors of prediction for the treatment of bleeding by gastroesophageal varices in the patients attended in the Emergency Room of the Hospital State University of Campinas (Brazil) from the last ten years. Methods: The method used here consisted of a descriptive and retrospective study carried out from the analyses of the medical records of 769 patients with upper gastrointestinal bleeding of which 220 were admitted because of upper gastrointestinal bleeding caused by gastroesophageal varices during this same period. Results: The results showed that the gastroe-sophageal varices appeared in 28.6% of the patients and they were the second most common cause of upper gastrointestinal bleeding. While evaluating factors such as age, sex and the common individual records, it was proved that this disease occurs mainly among people between the third and the fifth decade of life, with the great majority of cases occurring in the fourth decade (29.2%), of which 76.8% were male. There was an association of hematemesis and melena in the admission of 57.7% of the patients and even ascites was a common diagnosis in 48.2% of them. Most of these patients (40%) were classified as Child class B at admis-sion. The early endoscopic exam was used for 96.8% of them and showed the presence of F3 varices in 38.5%, CB varices in 25.1% and RCS varices in 12.6%. Most of these varices (41.5%) were situated in the distal third of the esophagus. The most used pharmacological treatment was based on octreotide in 45.9% of the patients. They received 0.05 mg of intravenous octreotide and a maintenance dose of 1 mg per day in 98.6% of the cases, with efficacy in 74.2% of the patients. The tamponade with Sengstaken-Blakemo

关键词： Liver Transplantation Portal Vein Thrombosis Surgical Technique

Drainage and Preliminary Risk of Flooding in an Urban Zone of Eastern Amazon

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Journal of Geoscience and Environment Protection 2023年第5期11卷 1-16页

作者： Taís silva Sousa Clezio Júnior Teixeira Viegas Helenilza ferreira Albuquerque Cunha Alan Cavalcanti da Cunha Graduate Program in Environmental Sciences Federal University of Amapá Macapá Brazil Graduate Program in Tropical Biodiversity Federal University of Amapá Macapá Brazil Graduate Program in Biotechnology Federal University of Amapá Macapá Brazil

Drainage system is a poorly investigated basic sanitation and urban planning issue in the Amazon, which is often related to flooding processes and public health. The aim of the present research is to correlate Preliminary Risk of Flooding (PRF) to independent variables, based on the following methodology: 1) identifying and classifying risk areas by using the Geographic Information System (GIS) and 2) statistically correlating risk to sanitary and environmental variables. Results have shown that preliminary risk is correlated to, at least, seven sanitary and environmental variables, depending on flood influence area;and there are significant correlations observed in the rainy season interval [probability or significance (p) 0.05]. In conclusion, PRF is higher in the rainy season, but it is spatially influenced by the elevation of terrain, number of flooding points, drainage typology and Environmental Salubrity Index (ESI) of neighborhoods, which directly affect the water quality in nearby groundwater wells (Total Coliforms, nitrate (NO3) and ammonia (NH3)). However, this influence can eventually significantly change in the dry season.

关键词： Drainage System Environmental Salubrity Index Groundwater GIS