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Mechanisms and Associated Factors of Nocturia in Women Attending Two Urogynecology Clinics: A Cross-sectional study

Open Journal of Obstetrics and Gynecology 2023年第9期13卷 1547-1568页

作者： Ingrid Antunes da silva José Rodrigo de Moraes renato augusto moreira de sá Carlos augusto Faria school of Medicine Federal Fluminense University Niterói Brazil

Introduction: Nocturia has a multifactorial etiology, and its diagnostic approach involves, in addition to medical history and physical examination, the use of a bladder diary to define the pathophysiological mechanisms present in each case. Methods: This study investigated the prevalence of nocturia, its mechanisms, and associated factors in women with lower urinary tract symptoms attending two urogynecology clinics in the state of Rio de Janeiro, Brazil. Anamnesis, physical examination, and a 24-hour bladder diary were conducted. Two definitions of nocturia were considered: one or more nighttime voids and two or more nighttime voids. Mann-Whitney and Chi-square tests were used, with p-value ≤ 0.05 considered significant. Results: A total of 133 participants were included. The majority were aged 60 years or older (61.4%) and had three or more comorbidities (66.7%), with systemic arterial hypertension being the most prevalent (59.1%). Of the total participants, 54 (41.4%) completed the bladder diary. Among those with one or more nighttime voids (70.7%), the prevalence of nocturnal polyuria was 69.1%, reduced nocturnal bladder capacity was 17.3%, and global polyuria was 12.9%. Among participants with two or more nighttime voids (56.4%), the prevalences were respectively 68.2%, 19.1%, and 13.6%. Among the mechanisms, associations were found only with global polyuria, namely: use of insulin, body mass index and tobacco consumption. An association was also found between recurrent urinary tract infection and global polyuria in participants with two or more nighttime voids. Conclusions: The prevalence of nocturia was higher than that reported in general population studies and specialized services for lower urinary tract symptoms. Nocturnal polyuria was the most prevalent mechanism. Associations were observed between the use of insulin, body mass index, tobacco consumption, and recurrent urinary tract infection with global polyuria. No associations were found between any c

关键词： Nocturia Polyuria Lower Urinary Tract symptoms Women’s Health

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Prenatal Diagnosis of Proximal Femoral Focal deficiency Combining Ultrasound and Computer Tomography

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Advances in Computed Tomography 2013年第3期2卷 102-106页

作者： Erica stein Ciasca Fernando Maia Peixoto-Filho Pedro Daltro Heron Werner Adriana Viana renato augusto moreira de sá Clínica de Diagnóstico Por Imagem-CDPI Rio de Janeiro Brazil department of Obstetrics-Instituto Fernandes Figueira-IFF/FIOCRUZ Rio de Janeiro Brazil Instituto Fernandes Figueira-IFF/FIOCRUZ Rio de Janeiro Brazil Universidade Federal Fluminense-NEAsMI/PGCM Niterói Brazil

Four cases of proximal femoral focal deficiency (PFFD) in an otherwise healthy infant are described. Antenatal diagnosis was made at 27, 23, 23 and 18 weeks of gestation by routine ultrasound (Us) examination. Computer Tomography (CT) was performed after 30 weeks of gestation and confirmed the images obtained by Us. The diagnosis was confirmed after delivery. These cases illustrate the importance of combining Us and CT to improve accuracy of prenatal diagnosis of skeletal disorders.

关键词： Prenatal Diagnosis Ultrasonography Imaging Three-Dimensional Tomography X-Ray Computed Limb deformities Congenital

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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro moreira Roger Pocock development and stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： renato socodato João B.Relvas Institute of Research and Innovation in Health(i3s)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNs)and the immune *** exploration is particularly significant in understanding microglia,the CNs’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of southern Brazil

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World Journal of Gastroenterology 2013年第39期19卷 6598-6603页

作者： Luís Carlos moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha renato Borges Fagundes Programa de Pós-Graduao: Ciências em Gastroenterologia e Hepatologia - Universidade Federal do Rio Grande do sul Porto AlegreRio Grande do Sul 90035-003Brasil Hospital Universitário de santa Maria - Universidade Federal de santa Maria Santa MariaRio Grande do Sul 97119-900Brasil departamento de Clínica Médica - Universidade Federal de santa Maria Santa MariaRio Grande do Sul 97119-900Brasil

AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(EsCC)in southern ***:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with EsCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNsCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol ***-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin *** PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except *** took extreme care to prevent DNA contamination in sample collection,processing,and ***:The histological biopsies confirmed the diagnosis of EsCC in 52 samples(51 from EsCC group and 1 from the HNsCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the EsCC group,42 from the HNsCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNsCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with EsCC,3from patients with HNsCC and 2 from patients without *** 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those *** DNA was negative in all the 183 samples tested:52 with EsCC,9 with esophagitis and 122 with normal esophageal ***:There was no evidence of HP

关键词： Esophageal cancer Esophageal squamous cell carcinoma Human papillomavirus Head and neck cancer Polymerase chain reactions Nested-polymerase chain reaction

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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan serneels Julie D.de schutter Lies de Groef Lieve Moons steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

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soil respiration in a natural forest and a plantation during a dry period in the Philippines

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Journal of Forestry Research 2023年第6期34卷 1975-1983页

作者： renato s.Pacaldo Mirac Aydin Forestry department College of Forestry and Environmental StudiesMindanao State University9700 Marawi CityPhilippines Faculty of Forestry Kastamonu UniversityKastamonu 37210Türkiye

Climate change is forecast to increase the frequency of extreme hot temperatures and dryer days and is anticipated to have profound impacts on the global carbon *** are expected to alter soil respiration(R_(s))rates,but the scarcity of data preclude a reliable estimate of this response and its future trajectory.A field experiment using an automated soil respiration machinery(LI-8100A)was conducted in a natural forest and a plantation during a dry period in the Philippines,with the goal of quantifying Rsrates and their relationship with soil temperature and moisture,and air *** natural forest(5.81μmol m^(-2)s^(-1))exhibited significantly higher Rsrates(ps^(-1))and control(3.23μmol m^(-2)s^(-1)).Rsrates showed significant negative relationships with air(-0.71)and soil temperatures(-0.62),indicating that as temperatures increase,the R_(s)rates *** contrast,the R_(s)rates exhibited a significant positive relationship with soil moisture(0.65).Although the low R_(s)rates in the plantation and high Rsrates in the natural forest are indicators of sensitivities of these two types of tropical forests to warm,dry soil,this observation is only conclusive during the dry period,but not necessarily during wet *** studies are needed to determine the trend of Rsrates during wet periods,considering different site conditions and types of vegetation.

关键词： Climate change Carbon Air and soil temperatures soil moisture Tropical stands

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Is there a window of opportunity to optimize trastuzumab cardiac monitoring?

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World Journal of Cardiology 2022年第7期14卷 403-410页

作者： Bruno Henrique Rala de Paula Maria Eduarda Teixeira Ferro Costa Carlos augusto moreira de sousa JoséBines sarah Cannon Research Institute London W1G 6ADUnited Kingdom department of Cardiology Hospital do Câncer III-Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil departamento de Tecnologias da Informação e Educação em saúde(DTIEs) da Faculdade de Ciências Médicas(FCM)na Universidade do Estado do Rio de Janeiro(UERJ)Rio de Janeiro 20550-170Brazil department of Medical Oncology Instituto Nacional de CâncerRio de Janeiro 20560-121Brazil

BACKGROUND It remains unclear whether the current arbitrary screening recommendations of trastuzumab-related cardiotoxicity provides an adequate balance between preventing heart damage and curtailing a curative *** To determine the incidence rate and consequences of trastuzumab-induced cardiotoxicity as adjuvant treatment in a real-world *** We present a retrospective analysis of cardiac function measured by echocardiogram at baseline and every 3 mo during trastuzumab *** was defined as a drop in left ventricular ejection fraction(LVEF)≥10%from baseline and/or any dropsULTs Between January 2011 and december 2014,407 patients were ***(93.6%)were treated with an anthracycline followed by a taxane-based regimen and trastuzumab for 12 *** patients(9.8%)had *** of them were symptomatic,and 28(72.5%)completely recovered *** happened early as shown by LVEF measured on echocardiogram 2 to 4 as compared to 5 to 7(odds ratio=2.47,95%confidence interval:1.09,5.63,P=0.024).There were 54 deaths(13.3%)during the 70-mo follow-up period;1(0.2%)was attributed to late cardiotoxicity(4 years after treatment).The absence of symptomatic cardiotoxicity during trastuzumab treatment and moreover the early occurrence on the treatment period may translate into a strategy to evaluate less *** We observed a 10%rate of asymptomatic cardiotoxicity,which mirrors the results from the large adjuvant *** being transient,an LVEF drop led to frequent treatment delays and *** remains unclear whether LVEF decline is predictive of late cardiotoxicity,and treatment efficacy is compromised.

关键词： Cardiac toxicity Ventricular Dysfunction Heart failure Trastuzumab Breast cancer

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Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

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World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana Andréa Moura Aryana Isabelle de Almeida Neves siqueira College of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil College of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(sLI)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of sLI is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in sLI,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding sLI *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress Inflammation Microbiota sepsis-associated liver injury

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Arbuscular mycorrhizal fungal community assembly in the Brazilian tropical seasonal dry forest

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Ecological Processes 2017年第1期6卷 9-18页

作者： Tancredo augusto Feitosa de souza Helena Freitas Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal

Introduction:Here,we compare the arbuscular mycorrhizal fungal(AMF)community composition in soils from the root zone of the exotic invasive species Prosopis juliflora(EXO soils)and soils from the root zone of the native species Mimosa tenuiflora(NAT soils)from five locations in the Brazilian tropical seasonal dry forest,Paraíba,Brazil,using morphological ***:AMF community composition in EXO and NAT soils were *** phosphorus,diversity index,spore abundance,and species richness were the main factors differing between the EXO and NAT *** general,the most dominant order present in the soils were Glomerales(44.8%)and Gigasporales(41.4%).The most abundant AMF genus in all studied soils was ***:Differences in AMF community composition were associated with(1)differences in the dominant plant species(*** ***)and(2)changes in soil chemical factors(soil,pH,total organic carbon,total nitrogen,and available P)in EXO *** results contribute to a deeper view of the AMF communities in exotic soils and open new perspectives for ecological processes involving AMF species and exotic plant species in the Brazilian tropical seasonal dry forest.

关键词： Glomeromycota AMF community AMF diversity Native plant species Exotic plant species Caatinga

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