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Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria

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International Journal of Oral Science 2011年第1期3卷 13-20页

作者： Chu-hong Hu Jian He Randal Eckert Xiao-yang Wu Li-na Li Yan Tian renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet Bauer Maxwell H. Anderson Wen-yuan Shi School of Dentistry University of California Los Angeles USA C3 Jian Inc Inglewood USA UCLA School of Nursing University of California Los Angeles USA

Dental caries （tooth decay） is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineraI in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound （Glycyrrhizol A）, from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops （twice a day for ten days） led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods.

关键词： antimicrobial therapy licorice Streptococcus mutans

Induction of the AOX1D Isoform of Alternative Oxidase in A. thaliana T-DNA Insertion Lines Lacking Isoform AOX1A Is Insufficient to Optimize Photosynthesis when Treated with Antimycin A

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Molecular Plant 2009年第2期2卷 284-297页

作者： Inga Strodtkotter Kollipara Padmasree Challabathula Dinakar Birgit Speth Pamela S. Niazi Joanna Wojtera Ingo Voss Phuc Thi Do Adriano Nunes-Nesi Alisdair R. Fernie Vera Linke Agepati S. Raghavendra renate Scheibe Department of Plant Physiology FBS University of Osnabrueck 49069 Osnabrueck Germany Department of Plant Sciences School of Life Sciences University of Hyderabad Hyderabad 500 046 India Max Planck Institute for Molecular Plant Physiology Am Muhlenberg-1 14476 Potsdam-Golm Germany

Plant respiration is characterized by two pathways for electron transfer to O2, namely the cytochrome pathway （CP） that is linked to ATP production, and the alternative pathway （AP）, where electrons from ubiquinol are directly transferred to O2 via an alternative oxidase （AOX） without concomitant ATP production. This latter pathway is well suited to dispose of excess electrons in the light, leading to optimized photosynthetic performance. We have characterized T- DNA-insertion mutant lines of Arabidopsis thaliana that do not express the major isoform, AOXIA. In standard growth conditions, these plants did not show any phenotype, but restriction of electron flow through CP by antimycin A, which induces AOXIA expression in the wild-type, led to an increased expression of AOXID in leaves of the aoxla-knockout mutant. Despite the increased presence of the AOX1D isoform in the mutant, antimycin A caused inhibition of photosyn- thesis, increased ROS, and ultimately resulted in amplified membrane leakage and necrosis when compared to the wild- type, which was only marginally affected by the inhibitor. It thus appears that AOX1 D was unable to fully compensate for the loss of AOXIA when electron flow via the CP is restricted. A combination of inhibition studies, coupled to metabolite profiling and targeted expression analysis of the P-protein of glycine decarboxylase complex （GDC）, suggests that the aoxla mutants attempt to increase their capacity for photorespiration. However, given their deficiency, it is intriguing that increase in expression neither of AOX1D nor of GDC could fully compensate for the lack of AOXIA to optimize pho- tosynthesis when treated with antimycin A. We suggest that the aoxla mutants can further be used to substantiate the current models concerning the influence of mitochondrial redox on photosynthetic performance and gene expression.

关键词： abiotic/environmental stress acclimation--physiological alternative electron transport photorespiration photosynthesis mitochondria T-DNA insertion line.

Ethylene resistance in flowering ornamental plants – improvements and future perspectives

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Horticulture Research 2015年第1期2卷 134-142页

作者： Andreas Olsen Henrik Lütken Josefine Nymark Hegelund renate Müller Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenHøjbakkegård Alle 9-13Taastrup2630Denmark

Various strategies of plant breeding have been attempted in order to improve the ethylene resistance of flowering ornamental plants. These approaches span from conventional techniques such as simple cross-pollination to new breeding techniques which modify the plants genetically such as precise genome-editing. The main strategies target the ethylene pathway directly;others focus on changing the ethylene pathway indirectly via pathways that are known to be antagonistic to the ethylene pathway, e.g. increasing cytokinin levels. Many of the known elements of the ethylene pathway have been addressed experimentally with the aim of modulating the overall response of the plant to ethylene. Elements of the ethylene pathway that appear particularly promising in this respect include ethylene receptors as ETR1, and transcription factors such as EIN3. Both direct and indirect approaches seem to be successful, nevertheless, although genetic transformation using recombinant DNA has the ability to save much time in the breeding process, they are not readily used by breeders yet. This is primarily due to legislative issues, economic issues, difficulties of implementing this technology in some ornamental plants, as well as how these techniques are publically perceived, particularly in Europe. Recently, newer and more precise genome-editing techniques have become available and they are already being implemented in some crops. New breeding techniques may help change the current situation and pave the way toward a legal and public acceptance if products of these technologies are indistinguishable from plants obtained by conventional techniques.

关键词： breeding resistance precise

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沙丘掠影

数码摄影 2014年第12期 176-177页

作者： renate Reichert

比拉沙丘位于法国波尔多市西南的大西洋海岸,它是欧洲最大的沙丘,宽度大概在500米,高度130多米,长度大概有3千米,沙丘的西面坡度不大朝向大海,东面的斜坡坡度较大,朝向松树林,经过一条陡峭的楼梯才可到达。它有逐步移动的倾向,科学家担... 详细信息

比拉沙丘位于法国波尔多市西南的大西洋海岸,它是欧洲最大的沙丘,宽度大概在500米,高度130多米,长度大概有3千米,沙丘的西面坡度不大朝向大海,东面的斜坡坡度较大,朝向松树林,经过一条陡峭的楼梯才可到达。它有逐步移动的倾向,科学家担心总有一天会覆盖更多的森林和道路。木制的围栏折射在沙丘上得到一个硬朗的黑白艺术图形,对于来此进行拍摄创作的人来说,沙丘上的阴影算是这里最有特色的画面。

关键词：斜坡坡度法国波尔多市天会松树林

供水系统的现代化改造新的控制系统实现了供水系统的改造

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流程工业 2011年第15期 28-29页

作者： renate Kleber-Klingemann Wago Kontakttechnik公司

瑞士的一个乡镇为全村居民提供自来水的给水供水设施已经太老。现代化改造方案中，给水设备自给自足的主控系统和泵站电力控制方案和能够便捷地获取所有数据的控制方案得到了他们的高度重视。

关键词：现代化改造供水系统控制系统控制方案给水设备供水设施改造方案主控系统

呼吸运动适应参数对磁共振冠状动脉成像质量的影响

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中国医学影像技术 2010年第9期26卷 1775-1778页

作者：梁红琴朱立强张笑春金利新李长英 renate Jerecic 王新王健第三军医大学附属西南医院放射科重庆400038 第三军医大学统计教研室重庆400038 西门子(中国)有限公司医疗系统集团上海201318

目的探讨在全心对比增强磁共振冠状动脉成像中,呼吸运动适应(resp ***)参数的使用与否对呼吸平稳患者成像质量的影响。方法应用3.0T磁共振扫描仪对34名志愿者进行全心对比增强检查,其中26名志愿者成功完成检查。应用序贯抽样方案分为A和... 详细信息

目的探讨在全心对比增强磁共振冠状动脉成像中,呼吸运动适应(resp ***)参数的使用与否对呼吸平稳患者成像质量的影响。方法应用3.0T磁共振扫描仪对34名志愿者进行全心对比增强检查,其中26名志愿者成功完成检查。应用序贯抽样方案分为A和B两组,每组13名志愿者。A组使用参数resp ***,B组不使用该参数。应用两样本U检验及χ2检验对比分析两种方法的成像质量及段落显示率。结果两组图像质量比较差异有统计学意义(U=46.00,P=0.034),右冠状动脉节段显示率差异有统计学意义(χ2=6.385,P=0.012),前降支节段显示率差异有统计学意义(χ2=5.764,P=0.016),回旋支节段显示率差异无统计学意义(χ2=2.229,P=0.135)。组间性别及年龄差异无统计学意义。结论在对比增强全心磁共振冠状动脉成像中,对于呼吸平稳的患者,不使用resp ***参数成像的效果优于使用该参数。

关键词：呼吸运动适应参数磁共振血管造影术

智能监控：污水净化设备中的以太网监控器和I／O—IPC的应用

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流程工业 2012年第8期 26-27页

作者： renate Klebe-Klingemann

在污水净化过程的自动化和热能回收再利用中，瑞士的污水净化公司SIG Services Industriels de Geneve使用了Wago公司研发生产的以太网监控器和I／O-IPC工业控制计算机，获得了创新性的解决方案。

关键词：污水净化设备监控器以太网智能监控 IPC I/O Services 工业控制计算机

Effective Young’s modulus measurement of plasma-polymerized allylamine films under humidity ambient

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Effective Young’s modulus measurement of plasma-polymerized...