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FGFR3 alterations in bladder cancer:Sensitivity and resistance to targeted therapies

Cancer Communications 2024年第10期44卷 1189-1208页

作者： Maxim Noeraparast Katarina Krajina renate pichler Dora Nieders-Beke Shahrokh F Shariat Viktor Grünwald Sascha Ahyai Martin pichler Translational Oncology II.Med Clinics Hematology and OncologyAugsburgGermany Department of Urology Medical University of InnsbruckInnsbruckAustria Department of Hematology and Oncology Clinics OttakringViennaAustria Department of Urology Medical University of ViennaViennaAustria Interdisciplinary Genitourinary Oncology Clinic for UrologyClinic for Medical OncologyUniversity Hospital EssenHufelandstrase 55EssenGermany Department of Urology Medical University of GrazGrazAustria

In this review,we revisit the pivotal role of fibroblast growth factor receptor 3(FGFR3)in bladder cancer(BLCA),underscoring its prevalence in both nonmuscle-invasive and muscle-invasive forms of the ***3 mutations in up to half of BLCAs play a well-established role in tumorigenesis,shaping distinct tumor initiation patterns and impacting the tumor microenvironment(TME).Emphasizing the importance of considering epithelial-mesenchymal transition profile and TME status,we revisit their relevance in predicting responses to immune checkpoint inhibitors in FGFR3-mutated *** writing highlights the initially promising yet transient efficacy of the FGFR inhibitor Erdafitinib on FGFR3-mutated BLCA,stressing the pressing need to unravel resistance mechanisms and identify co-targets for future combinatorial studies.A thorough analysis of recent preclinical and clinical evidence reveals resistance mechanisms,including secondarymutations,epigenetic alterations in pathway effectors,phenotypic heterogeneity,and population-specific variations within FGFR3 mutational ***,we discuss the potential of combinatorial treatments and concepts like synthetic lethality for discovering more effective targeted therapies against FGFR3-mutated BLCA.

关键词： Bladder Cancer Erdafitinib FGFR inhibition FGFR3 mutations Resistance to Erdafitinib Tumor Microenvironment

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THERMOCHROMIC EFFECTS OF LEUCO DYES STUDIED IN POLYPROPYLENE

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Chinese Journal of Polymer Science 2006年第4期24卷 363-368页

作者： Arno Seeboth Detlef L(o|¨)tzsch Elvira Potechius renate Vetter Fraunhofer Institute for Applied Polymer Research

A series of thermochromic polypropylene foils were prepared by embedding various leuco dye-developer-solvent systems in the polymer matrix. Bisphenol A, laurylgallate, ethylgallate and p-hydroxybenzoic acid methyl ester were used as developers, crystal violet lactone and 3,3-bis-（1-n-butyl-2-methyl-3-indolyl）-phthalide as dyes and l-octanoic acid methyl ester as solvent. The molar ratio between the three components of the investigated leuco dye-developer-solvent systems was kept constant. All obtained polypropylene foils exhibit an excellent thermochromic behavior. The foils, prepared by extrusion technology, switch from color to colorless with increasing temperature. The influence of molecular structure of the developer on the intensity of the colored state and the influence of a developer-surfactant complex on the resulting thermochromic properties were investigated. The results are presented and discussed in detail according to a molecular model suggesting that the ring-opening process of the leuco dye is triggered by the formation of dye-developer complexes via H-bondings.

关键词： Thermochromism Dyes Extrusion UV-Vis spectroscopy.

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德语语法大全

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作者： renate·Luscher

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Interaction Dynamics in AEC Global Teamwork

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Tsinghua Science and Technology 2008年第S1期13卷 145-150页

作者： renate Fruchter Shubashri Swaminathan Naohiro Matsumura Yukio Ohsawa Department of Civil and Environmental Engineering Stanford University Graduate School of Economics Osaka University Faculty of Engineering The University of Tokyo

Architecture, engineering, and construction (AEC) global project teamwork is communication intensive and relies heavily on synchronous and asynchronous information and collaboration technologies (ICT). We explore in this paper how an asynchronous ICT, called ThinkTank, reshaped the work practice of design-construction global teams, and how the interaction with this ICT reshaped the purpose and benefits of its use. ThinkTank is a web-based asynchronous collaboration and discussion forum. We introduce the influence diffusion model (IDM) that formalizes the process of identifying the influence of people, messages, and terms mathematically. Discovering who the influence leaders in project teams are can be beneficial and critical from a corporate management perspective, since they can guide or motivate the team towards successful actions and outcomes. We present the ThinkTank-IDM integrated system and its validation with a testbed of 53 AEC global team project archived in ThinkTank over 8 years.

关键词： global teamwork asynchronous collaboration technology interaction dynamics influence leader influence topic

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Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms

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Journal of Environmental Sciences 2017年第12期29卷 133-137页

作者： renate Kopp Irene Ozáez Martínez Jessica Legradi Juliette Legler Institute for Environmental Studies(IVM) VU University Amsterdam1081HVThe Netherlands. Biology and Environmental Toxicology Group Faculty of SciencesNational Distance Education University28015 MadridSpain Institute for Environment Health and SocietiesCollege of Health and Life SciencesBrunel University LondonUxbridgeUB8 3PHUnited Kingdom

A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds（EDCs）, including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease.

关键词： zebrafish adiposity tributyltin flame retardants clock genes

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RESPONSE OF WHEAT COMPOSITE CROSS POPULATIONS TO DISEASE AND CLIMATE VARIATION OVER 13 GENERATIONS

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Frontiers of Agricultural Science and Engineering 2021年第3期8卷 400-415页

作者： Odette Denise WEEDON Maria renate FINCKH Faculty of Organic Agricultural Sciences Department of Ecological Plant ProtectionUniversity of KasselNordbahnhofstr.1aWitzenhausenD-37213Germany

Since the F_(5)(2005),three winter wheat composite cross populations(CCPs)based on germplasm specifically suitable for low-input conditions were subjected to natural selection under organic and conventional *** the F_(6),each CCP was divided into two parallel populations(12 CCPs in total)and maintained continuously until *** used modern cultivars with different disease susceptibilities were grown alongside to assess the agronomic performance of the *** organically managed CCPs were comparable in yield and foliar disease resistance to two continuously used reference cultivars,Achat and *** contrast,under conventional management the *** outyielded the CCPs(Achat was not tested),highlighting the importance of parental cultivar choice for specific management *** CCPs were found to be moderately resistant to brown rust and even to the newly emerged stripe rust races prevalent in Europe since *** between the CCPs were mainly due to parental genetic background and were significant in the first five generations,but were no longer so in the last five *** addition,these differences tended to vary depending on the experimental year and the environmental stresses *** conclusion,the CCPs despite being derived from older cultivars are able to compete with more recently released reference cultivars under organic farming practices and represent a dynamic germplasm resource.

关键词： evolutionary breeding heterogeneous crop population management system

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Stochastic Runge-Kutta–Munthe-Kaas Methods in the Modelling of Perturbed Rigid Bodies

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Advances in Applied Mathematics and Mechanics 2022年第2期14卷 528-538页

作者： Michelle Muniz Matthias Ehrhardt Michael Günther renate Winkler Institute of Mathematical Modelling Analysis and Computational Mathematics(IMACM)Applied Mathematics and Numerical AnalysisBergische Universität WuppertalGaußstraße 2042119 WuppertalGermany

In this paper we present how nonlinear stochastic Itˆo differential equations arising in the modelling of perturbed rigid bodies can be solved numerically in such a way that the solution evolves on the correct *** this end,we formulate an approach based on Runge-Kutta–Munthe-Kaas(RKMK)schemes for ordinary differ-ential equations on ***,we provide a proof of the mean-square convergence of this stochastic version of the RKMK schemes applied to the rigid body problem and illustrate the effectiveness of our proposed schemes by demonstrating the structure preservation of the stochastic RKMK schemes in contrast to the stochastic Runge-Kutta methods.

关键词： Stochastic Runge-Kutta method Runge-Kutta–Munthe-Kaas scheme nonlinear Itˆo SDEs rigid body problem

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ANTIOXIDANT DEPLETION AND OIT VALUES OF HIGH IMPACT PP STRANDS

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Chinese Journal of Polymer Science 2009年第3期27卷 435-445页

作者： Werner W.Müller Ines Jakob Chunshan Li renate Tatzky-Gerth Federal Institute for Materials Research and Testing(BAM) D-12200 BerlinGermany

The service life of a polyolefin product depends to large extent on the type and amount of the antioxidants added. During the manufacturing,storage and use of the product the antioxidants are depleted by physical processes and chemical degradation,and this impairs its long-term *** initial and in-use oxidation stability is often characterized and monitored by the measurement of the oxidative induction time(OIT),and service life predictions are based on the rate of decrease of the OIT *** study the correlation between the OIT value and the actual antioxidant concentration,eight random arrays of high-impact polypropylene(PP)strands stabilized using six different antioxidant packages(composed of Irgafos 168,Irganox 1010 and 1330,Chimassorb 944)were immersed in hot water(80℃and 90℃)and oven aged in air (80℃)for more than two years,and the change of OIT values and antioxidant concentrations was *** phosphitic and phenolic stabilizers water immersion is generally a more critical aging condition than oven aging in air,while for the hindered amine stabilizers(HAS)the opposite was *** expected,a linear correlation between OIT values and concentrations was found for the'classical'package of phosphitic and phenolic *** the case of Irganox 1330,the change of the OIT values during aging was considerably slower than the change of *** when zero concentration was reached according to the vanishing peak height in the chromatogram,a considerable OIT value was still *** may be due to unidentified degradation products of Irganox 1330 which still act as antioxidants in the long *** of HAS(Chimassorb 944)seems to enhance the initial OIT of stabilized phenolic samples and the long-term effectiveness of the phenolic stabilization under air oven aging ***,the marked long-term effectiveness of the HAS itself and the slow change with time of the concentration were not detectable by OIT measurements

关键词： Polypropylene Stabilizers Oxidative resistance Antioxidant depletion Oxidative induction time

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Ethylene resistance in flowering ornamental plants – improvements and future perspectives

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Horticulture Research 2015年第1期2卷 134-142页

作者： Andreas Olsen Henrik Lütken Josefine Nymark Hegelund renate Müller Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenHøjbakkegård Alle 9-13Taastrup2630Denmark

Various strategies of plant breeding have been attempted in order to improve the ethylene resistance of flowering ornamental plants. These approaches span from conventional techniques such as simple cross-pollination to new breeding techniques which modify the plants genetically such as precise genome-editing. The main strategies target the ethylene pathway directly;others focus on changing the ethylene pathway indirectly via pathways that are known to be antagonistic to the ethylene pathway, e.g. increasing cytokinin levels. Many of the known elements of the ethylene pathway have been addressed experimentally with the aim of modulating the overall response of the plant to ethylene. Elements of the ethylene pathway that appear particularly promising in this respect include ethylene receptors as ETR1, and transcription factors such as EIN3. Both direct and indirect approaches seem to be successful, nevertheless, although genetic transformation using recombinant DNA has the ability to save much time in the breeding process, they are not readily used by breeders yet. This is primarily due to legislative issues, economic issues, difficulties of implementing this technology in some ornamental plants, as well as how these techniques are publically perceived, particularly in Europe. Recently, newer and more precise genome-editing techniques have become available and they are already being implemented in some crops. New breeding techniques may help change the current situation and pave the way toward a legal and public acceptance if products of these technologies are indistinguishable from plants obtained by conventional techniques.

关键词： breeding resistance precise

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Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer

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World Journal of Gastroenterology 2017年第34期23卷 6212-6219页

作者： renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater Division of Medical Diagnostics Department of Laboratory MedicineRegion Jonkoping County Division of Drug Research Department of Medicine and Health SciencesFaculty of Medicine and Health SciencesLinkoping University Division of Medical Diagnostics Department of Clinical PhysiologyRegion Jonkoping County Department of Surgery Region Jonkoping County Department of Clinical and Experimental Medicine Faculty of Medicine and Health SciencesLinkoping University Department of Natural Science and Biomedicine School of Health and WelfareJonkoping University

AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with *** Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total *** Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for *** High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis.

关键词： Colorectal cancer Inflammation Cytokines Plasma Prognosis Mortality

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