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Isotopic and geochemical constraints for a Paleoproterozoic accretionary orogen in the Borborema Province,NE Brazil:Implications for reconstructing Nuna/Columbia

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Geoscience Frontiers 2022年第5期13卷 267-285页

作者： Lauro Cézar M.de Lira Santos Geysson A.Lages Fabrício A.Caxito Elton L.Dantas Peter A.Cawood Haroldo M.lima Felipe Jda Cruz lima departamento de Geologia Universidade Federal de PernambucoAv.da ArquiteturaCidade UniversitáriaRecifePEBrazil Serviço Geológico do Brasil-CPRM Av.SulAfogadosRecifePEBrazil CPMTC Instituto de GeociênciasUniversidade Federal de Minas GeraisAv.Pres.Antônio CarlosPampulhaBelo HorizonteMGBrazil Instituto de Geociências Universidade de BrasíliaCampus Universitário Darcy RibeiroAsa NorteBrasíliaDFBrazil School of Earth Atmosphere and EnvironmentMonash UniversityWellington RdClaytonVIC 3800Australia departamento de Geologia Universidade Federal do CearáCampus do PiciParquelândiaFortalezaCEBrazil

The Alto MoxotóTerrane of the Borborema Province presents a wide exposure of Paleoproterozoic crust,but unlike other continental blocks of South America,its orogenic history is strongly obliterated by late Neoproterozoic *** isotopic and geochemical studies were conducted in mafic-ultramafic(Fazenda Carmo Suite)and granitic-gneissic rocks(Riacho do Navio Suite)within the *** former present zircon U-Pb crystallization ages at ca.2.13 Ga,whereas Sm-Nd data suggests a juvenile origin via melting of early Paleoproterozoic to Archean peridotitic *** data for these rocks are compatible with tholeiitic magmas with some degree of crustal contamination and trace element distribution points to a continental-arc related setting interpreted as remnants of the early stages of *** contrast,the Riacho do Navio Suite was emplaced at ca.2.08 Ga and has highly negativeεNd(t)values indicating crustal *** suite displays calc-alkali to alkali-calcic and ferroan geochemical signatures compatible with Cordilleran *** addition,trace-element distribution as well as discriminant diagrams suggest that the precursor magmas were generated during the later stages of a continental arc or in a syn-collisional *** on our results,we suggest that the studied units might represent missing pieces of a Paleoproterozoic accretionary orogen that formed the crustal framework of the Alto MoxotóTerrane,and that this represents a block associated with assembly of the Nuna/Columbia supercontinent,which is now largely hidden within the Neoproterozoic orogenic belts of West Gondwana.

关键词： Paleoproterozoic accretionary-collisional event Early orogenic and syn-collisional magmatism Paleoproterozoic inlier within West Gondwana Nuna/Columbia Supercontinent

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Past,present and future of preserving and restoring function in the visual system:removing galectin-3 as a promising treatment

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Neural Regeneration Research 2017年第1期12卷 58-59页

作者： Silmara de lima Henrique Rocha Mendonca Camila Oliveira Goulart Ana M.Blanco Martinez Laboratories for Neuroscience Research in Neurosurgery and F.M.Kirby Neurobiology Center Children's Hospital BostonDepartmentsof Surgery and Ophthalmology and Program in NeuroscienceHarvard Medical SchoolBostonMAUSA Laboratorio de Neurodegeneracao e Reparo-departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Polo Universitairio Macae UFRJMacaeRJBrazil

Great advances in retinal ganglion cells survival（RGCs）,optic nerve preservation and regeneration have been made in the past ***,we know that RGCs are capable of regenerating the full length of the optic nerve,cross... 详细信息

关键词： RGCs preserving regeneration preservation galectin removing optic capable ganglion microglia

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Existence and Multiplicity Results for a Class of Nonlinear Schrödinger Equations with Magnetic Potential Involving Sign-Changing Nonlinearity

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Analysis in Theory and Applications 2022年第2期38卷 148-177页

作者： Francisco Odair de Paiva Sandra Machado de Souza lima Olimpio Hiroshi Miyagaki departamento de Matematica UFSCarSao CarlosSP13560-970 Brazil departamento de Ciencias Exatas Biologicas e da TerraINFES-UFFSanto Antonio de Padua-RJ28470-000Brazil

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2 详细信息

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈H_(A)^(1)(R^(N)),(P)with 2

关键词： Magnetic potential sign-changing weight functions Nehari manifold Fibering map

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Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

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World Journal of Gastroenterology 2020年第43期26卷 6795-6809页

作者： Michelle Liz de Souza Pessoa Leiliane Macena Oliveira Silva Maria Elaine Cristina Araruna Catarina Alves de lima Serafim Edvaldo Balbino Alves Junior Alessa Oliveira Silva Matheus Marley Bezerra Pessoa Hermes Diniz Neto Edeltrudes de Oliveira lima Leonia Maria Batista department of Pharmaceutical Sciences IPeFarMFederal University of ParaibaJoao Pessoa 58051-970ParaibaBrazil Health Sciences Center Federal University of ParaibaJoaoPessoa 58051-970ParaibaBrazil Postgraduate Program in Natural and Synthetic Bioactive Products Universidade Federal da ParaibaJoão Pessoa 58051-900Brazil

BACKGROUND(-)-Fenchone is a bicyclic monoterpene present in essential oils of plant species,such as Foeniculum vulgare and Peumus boldus,used to treatment of gastrointestinal *** studies report its anti-inflammatory,antioxidant,and antinociceptive *** To investigate antidiarrheal activity related to gastrointestinal motility,intestinal secretion and antimicrobial *** A castor oil-induced diarrhea model was used to evaluate antidiarrheal *** transit and gastric emptying protocols were used to assess a possible antimotility *** receptors,presynaptic α2-adrenergic and tissue adrenergic receptors,KATP channels,nitric oxide were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory *** antimicrobial activity was evaluated in the minimum inhibitory concentration model,the fractional inhibitory concentration index using the(-)-fenchone association method with standard antifungal ***(-)-Fenchone(75,150 and 300 mg/kg)showed antidiarrheal activity,with a significant decrease in the evacuation *** activity is possibly related to a percentage of reduced intestinal transit(75,150 and 300 mg/kg).The antimotility effect of(-)-fenchone decreased in the presence of pilocarpine,yohimbine,propranolol,L-NG-nitroarginine methyl ester or *** the enteropooling model,no reduction in intestinal fluid weight was observed.(-)-Fenchone did not show antibacterial activity;on the other hand,inhibits the growth of strains of fungi with a minimum fungicide concentration of 32μg/***,when it was associated with amphotericin B,no synergism was *** The antidiarrheal effect of(-)-fenchone in this study involves antimotility effect and not involve antisecretory mechanisms.(-)-Fenchone presents antifungal activity;however,it did not show antibacterial activity.

关键词： (-)-Fenchone Monoterpenes Diarrhea Motility Antifungal

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Post-mortem Microstructural Study of Aluminous Refractory Brick Used in Channels of Blast Furnaces

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China's Refractories 2023年第1期32卷 40-43页

作者： Ana Valéria de Sousa COSTA Belmira Benedita de lima-KUHN Antonio Renato BIGANSOLLI department of Chemical Engineering Technology InstituteFederal Rural University of Rio de JaneiroSeropédica 23851-970Brazil

Aluminous refractory materials with high alumina contents are widely used in the steel industry,and the higher the alumina content,the higher the working *** such as high refractoriness and thermal shock resistance lead these refractory materials to be used as channel linings of blast furnaces,where they are exposed to the attack by slag,molten steel,working cycles and sudden temperature changes between 25℃(room temperature)and 1520℃(the temperature of molten pig iron).In this work,microstructural changes in post-mortem aluminous refractory bricks were investigated by apparent porosity,X-ray diffraction analysis(XRD),Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy,and X-ray dispersion energy spectrometry(SEM/EDS).The results showed an increase in the apparent porosity and the bulk density and the presence of the phases mullite,sillimanite,alumina,and quartz in the post-mortem *** and magnesium were not detected in the microstructure of the post-mortem brick,indicating that slags did not corrode these refractory ***,the microstructural changes that occurred in the post-mortem bricks must be due to thermal *** the X-ray diffraction(XRD)test,mullite,sillimanite,quartz,andα-alumina phases were *** results indicate that the aluminous refractory was obtained from *** infrared spectroscopy(FTIR)it was possible to identify the vibration bands referring to the Si-O and Al-O *** increase in the porosity is a result of cracks caused by work cycles at high temperatures and the temperature gradient to which the refractory was subjected during *** the micrograph it was possible to identify the presence of acicular *** absence of magnesium and calcium in the microanalysis results by energy dispersed X-ray spectrometry(EDS)indicates that there was no infiltration by slag or liquid *** results indicate that the microstructural changes that occurred in t

关键词： aluminous refractories steel industry microstructural blast furnace

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3D Printing in Fiber-device Technology

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Advanced Fiber Materials 2021年第2期3卷 1-17页

作者： Louis van der Elst Camila Faccini de lima Meve Gokce Kurtoglu Veda Narayana Koraganji Mengxin Zheng Alexander Gumennik department of Intelligent Systems Engineering Luddy School of InformaticsComputing and EngineeringIndiana University Bloomington700 North Woodlawn AvenueBloomingtonIN 47408USA Fibers and Additive Manufacturing Enabled Systems Laboratory 2425 North Milo B Sampson LaneBloomingtonIN 47408USA

Recent advances in additive manufacturing enable redesigning material morphology on nano-,micro-,and meso-scale,for achieving an enhanced functionality on the *** non-planar and flexible electronic circuits,through biomechanically realistic surgical models,to shoe soles individualized for the user comfort,multiple scientific and technological areas undergo material-property redesign and enhancement enabled by 3D ***-device technology is currently entering such a *** this paper,we review the recent advances in adopting 3D printing for direct digital manufacturing of fiber preforms with complex cross-sectional architectures designed for the desired thermally drawn fiber-device ***,taking a recursive manufacturing approach,such fibers can serve as a raw material for 3D printing,resulting in macroscopic objects with enhanced functionalities,from optoelectronic to bio-functional,imparted by the fiber-devices properties.

关键词： Recursive manufacturing 3D printing Fibers Optical fibers Pervasive sensing

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Conocarpus erectus L., a plant with a high content of structural sugars, ions and phenolic compounds, shows antioxidant and antimicrobial properties promoted by different organic fractions

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 463-470页

作者： Dayane Kelly Dias do Nascimento Santos Weslley Henrique de Oliveira Melo Anastassia Mariáh Nunes de Oliveira lima Iranildo Joseda Cruz Filho Glaucia Manoella de Souza lima Tulio Diego da Silva Maiara Celine de Moura Marcia Silva do Nascimento Ana Maria Souto Maior Thiago Henrique Napoleao Cristiane Moutinho Lagos de Melo department of Biochemistry Biosciences Centre Federal University of Pernambuco department of Antibiotics Biosciences Centre Federal University of Pernambuco Center of Strategic Technologies of the Northeast

Objective: To evaluate the structural and chemical composition of plant and the antioxidant and antimicrobial activities promoted by hexanic, ethanolic and ethyl acetate fractions obtained from leaves of Conocarpus ***: Organic fractions were characterized through UPLC-MS and *** potential was performed through DPPH and molybdenum phosphate *** and antifungal assays were performed in accordance with Clinical and Laboratory Standards Institute ***: The obtained biomass of Conocarpus erectus leaves showed the high presence of glucose(0.45 g/L), cellulose(28.69%), Na(55.126 μg/L) and K(31.163 μg/L).We identified seven compounds in the hexanic and ethyl acetate fractions, and eight compounds in ethanolic ***, phenolic compounds are prevalent in all organic fractions with values of(10.04 ± 0.24),(221.26 ± 1.84),(340.53 ± 0.84) mg/g GAE to hexanic, ethyl acetate and ethanolic fraction, *** results showed a high potential in ethyl acetate fraction(71.82 ± 6.87)% and(10.89 ± 0.05)% in DPPH and molybdenum phosphate techniques, *** ethanolic fraction showed moderate bacteriostatic and bactericidal activity against Staphylococcus aureus and presented a high fungistatic potential for all Candida species ***: Organic fractions obtained from leaves of Conocarpus erectus present antimicrobial and antioxidant properties, and these findings contribute to scientific information for the effectiveness on use of this plant in the development of a phytotherapic compound.

关键词： Combretaceae Phenolic compounds Antimicrobial activity Antioxidant

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Brazilian biosafety law and the new breeding technologies

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： Alexandre lima NEPOMUCENO renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRAde FILHO Patricia Machado Bueno FERNANdeS Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao Paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

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A Survey of the Homotopy Properties of Inclusion of Certain Types of Configuration Spaces into the Cartesian Product

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Chinese Annals of Mathematics,Series B 2017年第6期38卷 1223-1246页

作者： Daciberg lima GONCALVES John GUASCHI departamento de Matematica IME-USPRua do Matao 1010CEP:05508-090Sao PauloSPBrazil Normandie Universite UNICAENLaboratoire de Mathematiques Nicolas Oresme UMR CNRS 6139CS 1403214032 Caen Cedex 5France

Let X be a topological *** this survey the authors consider several types of configuration spaces,namely,the classical(usual)configuration spaces F_n(X)and D_n(X),the orbit configuration spaces F_n^G(X)and F_n^G(X)/S_nwith respect to a free action of a group G on X,and the graph configuration spaces F_n~Γ(X)and F_n~Γ(X)/H,whereΓis a graph and H is a suitable subgroup of the symmetric group S_*** ordered configuration spaces F_n(X),F_n^G(X),F_n~Γ(X)are all subsets of the n-fold Cartesian product ∏_1~nX of X with itself,and satisfy F_n^G(X)?F_n(X)?F_n~Γ(X)?∏_1~*** A denotes one of these configuration spaces,the authors analyse the difference between A and ∏_1~nXfrom a topological and homotopical point of *** principal results known in the literature concern the usual configuration *** authors are particularly interested in the homomorphism on the level of the homotopy groups of the spaces induced by the inclusionι:A-→∏_1~nX,the homotopy type of the homotopy fibre I_ιof the mapιvia certain constructions on various spaces that depend on X,and the long exact sequence in homotopy of the fibration involving I_ιand arising from the inclusionι.In this respect,if X is either a surface without boundary,in particular if X is the 2-sphere or the real projective plane,or a space whose universal covering is contractible,or an orbit space S^k/Gof the k-dimensional sphere by a free action of a Lie group G,the authors present recent results obtained by themselves for the first case,and in collaboration with Golasi′nski for the second and third *** authors also briefly indicate some older results relative to the homotopy of these spaces that are related to the problems of *** order to motivate various questions,for the remaining types of configuration spaces,a few of their basic properties are described and proved.A list of open questions and problems is given at the end of the paper.

关键词： Configuration space Equivariant configuration space Fibration Homotopy fibre K(π,1)space Braid groups

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Mayaro fever:A brief review on the immune profile

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 95-100页

作者： Jean Moisés Ferreira Danielly Santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo Jose Luizde lima Filho Laboratório de Imunopatologia Keizo Asami-LIKA Centro de BiociênciasUniversidade Federal de Pernambuco(UFPE)50670-901RecifePernambucoBrazil Laboratório de Biologia Molecular e Expressao Genica-LABMEG Departamento de Ciências BiológicasUniversidade Federal de Alagoas(UFAL)Campus Arapiraca57300-970ArapiracaAlagoasBrazil

Mayaro virus is an emergent alphavirus that infects humans,leading to Mayaro *** fifty percent of infected patients develop arthritis symptoms in the recovery phase,a phase that can last up to a *** literature about Mayaro virus infection and its immune response is scarce,which may hamper the development of treatment *** summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients,and relate this molecular characterization with the immune *** and IL-12/p70 show pronounced changes in patients in the acute phase,suggesting the development of cellular immunity and Th1 ***-6,IL-7,CXCL8/IL-8,IL-13,IL-17,and IFN-γare elevated in patients with arthritis symptoms in the long-term recovery phase,which may be related to the continuous inflammatory process,a possible Th2 inhibiting and promoting Th17 *** few studies discuss the issue,with a small number of patients and different backgrounds,inflammatory and immune response and manifestations seem to be closely *** information may help to develop the appropriate treatment strategies in Mayaro virus ***,we analyzed and summarized data available in literature.

关键词： Emergent virus Mayaro virus Cytokines Chemokine Molecular characterization

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