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Predictors of surgical complications in boys with hypospadias:data from an international registry

World Journal of Pediatric Surgery 2023年第4期6卷 217-223页

作者： Kathryn Scougall Jillian Bryce Federico Baronio Rachel L Boal Jose Roberto Castera Sebastián Castro Tim Cheetham Eduardo Correa Costa Feyza Darendeliler Justin H Davies Mirjam Dirlewanger Gabriella Gazdagh Evgenia Globa Gil Guerra-Junior Tulay Guran Gloria Herrmann Paul-Martin Holterhus Ahsen KaragözlüAkgül renata markosyan Kenneth McElreavey Marcio Lopes Miranda Anna Nordenstrom Stuart O’Toole Sukran Poyrazoglu Gianni Russo Valerie Schwitzgebel Marianna Stancampiano Michael Steigert S Faisal Ahmed Angela K Lucas-Herald University of Glasgow GlasgowUK IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola BolognaItaly Great North Children's Hospital Newcastle Upon TyneUK Hospital de Ninos Ricardo Gutiérrez Buenos AiresArgentina Hospital de Clinicas de Porto Alegre Porto AlegreBrazil Istanbul University IstanbulTurkey Southampton Children's Hospital SouthamptonUK University Hospital of Geneva GenevaSwitzerland Ukrainian Research Center of Endocrine Surgery Endocrine Organs and Tissue Transplantation KyivUkraine State University of Campinas CampinasBrazil Marmara University IstanbulTurkey University Medical Centre UlmGermany University Hospital of Schleswig-Holstein Campus Kiel/Christian-Albrechts-University of Kiel KielGermany Marmara University Faculty of Medicine IstanbulTurkey Yerevan State Medical University Endocrinology Clinic YerevanArmenia Institut Pasteur ParisFrance Karolinska University Hospital StockholmSweden Royal Hospital for Children GlasgowUK IRCCS Ospedale San Raffaele MilanoItaly Graubunden Cantonal Hospital ChurSwitzerland

Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their *** Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development(l-DSD)*** regressions,fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication *** Of the 551 eligible boys,data were available on 160(29%).Within the cohort,the median(range)External Masculinization Score(EMS)was 6(2,9).All presented with one or more additional genital malformation and 61(38%)presented with additional extragenital *** of androgen action,androgen synthesis and gonadal development were diagnosed in 28(18%),22(14%)and 9(6%)boys,*** remaining 101(62%)patients were diagnosedas having non-specific 46,XY Disorders of Sex ***(50%)boys had evidence of abnormal biochemistry,and gene variants were identified in 42(26%).Median age at first hypospadias surgery was 2 years(0,9),and median length of follow-up was 5 years(0,17).Postsurgical complications were noted in 102(64%)*** were no significant associations with postsurgical *** Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative *** clinical factors were significantly associated with complication *** complication rates with no observable cause suggest the involvement of other factors which need investigation.

关键词： complications surgical involvement

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Biological, chemical and mechanical factors regulating migration and homing of mesenchymal stem cells

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World Journal of Stem Cells 2021年第6期13卷 619-631页

作者： renata Szydlak Department of Medical Biochemistry Faculty of MedicineJagiellonian University Medical CollegeKraków 31-034Poland

Mesenchymal stem cells(MSCs)are a population of primary and non-specialized cells,which can be isolated from various ***,MSCs are key players in cellular therapy and regenerative ***,the possibility of using MSCs in the treatment of many diseases needs to be preceded,though,by indepth analysis of their properties,especially by determining the mechanism of tissue homing as well as the mechanism,due to which cells contribute to tissue *** review is intended to present information on recent findings regarding the mechanism of recruitment and tissue homing by MSCs and discuss current hypotheses for how MSCs can reach target tissues.

关键词： Mesenchymal stem cell Cell migration Regenerative medicine Mesenchymal stem cell-based therapy

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Mesenchymal stem cells in ischemic tissue regeneration

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World Journal of Stem Cells 2023年第2期15卷 16-30页

作者： renata Szydlak Medical Biochemistry Faculty of Medicine Jagiellonian UniversityMedical College Kraków 31-034 Poland

Diseases caused by ischemia are one of the leading causes of death in the *** therapies for treating acute myocardial infarction,ischemic stroke,and critical limb ischemia do not complete *** therapies opens new therapeutic strategy in the treatment of ischemic *** stem cells(MSCs)are the most promising option in the field of cell-based therapies,due to their secretory and immunomodulatory abilities,that contribute to ease inflammation and promote the regeneration of damaged *** review presents the current knowledge of the mechanisms of action of MSCs and their therapeutic effects in the treatment of ischemic diseases,described on the basis of data from in vitro experiments and preclinical animal studies,and also summarize the effects of using these cells in clinical trial *** the obtained therapeutic benefits are not always satisfactory,approaches aimed at enhancing the effect of MSCs in regenerative therapies are presented at the end.

关键词： Ischemia Mesenchymal stem cells Regenerative medicine Stem cell therapy Clinical applications

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Science as the Basis for Public Health Decisions in Nutrition and Food Safety in Asia

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Biomedical and Environmental Sciences 2001年第1期14卷 1-13页

作者： KRAISID TONTISIRIN renata CLARKE Director Food and Nutrition DivisionNutrition OfficerFood Quality and Consumer Protection GroupFood and Nutrition DivisionFood and Agriculture Organization of the United NationsRomeItaly

Worldwide,great advances have been made in public health protection over the last *** this is most cogently illustrated by the improvements in life experctancy that have been achieved in countries throughout the ***,the average life expectancy at birth from 1950 to 1955 was 46.1 years.^[1]Forty years later,this statistic increased to 64.3 *** this global average masks important differences between less and more developed countries,for all countries at all stages of development,substantial increases in life expectancy at birth have been *** Asia,the average life expectancy increased from 56.3 years to 64.5years in the two decades between 1975 and 1995,While there remains much to be done to further improve public health and well-being of the people,the achievements are *** increase in the duration and quality of life has been largely attributable to advances in science and the sensible application of these scientific and medical advances in public health services,Developments in a wide range of scientific domains continue to abound and policy makers realize that it is necessary to develop processes and procedures that reliably utilize available acientific achivements to arrive at appropriate polity decisions in nutrition and food safety.

关键词： Science as the Basis for Public Health Decisions in Nutrition and Food Safety in Asia

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The influence of environmental factors on the carbon dioxide flux across the water–air interface of reservoirs in south-eastern Poland

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Journal of Environmental Sciences 2017年第6期29卷 290-299页

作者： renata Gruca-Rokosz Lilianna Bartoszek Piotr Koszelnik Faculty of Civil and Environmental Engineering and Architecture Rzeszdw University of TechnologyRzeszowPoland

Studies concerning the emission of carbon dioxide （CO2） were carried out in 2009-2012 for six reservoirs located in four provinces of south-eastern Poland. The CO2 flux across the water-air interface was measured using the ＂static chamber＂ method. The measured fluxes of CO2 （FCO2） ranged from -30.64 to 183.78 mmol/m2/day, and the average values varied in the range from -3.52 to 82.11 mmol/m2/day. In most of the cases, emission of CO2 to the atmosphere was observed. The obtained values of CO2 fluxes were comparable to values typical for other temperate reservoirs. Analysis of the influence of selected envi- ronmental factors on the FCO2 showed that it depends on parameters characterizing both the sediments and surface water. The CO2 flux at the water-air interface was positively correlated with parameters of bottom sediments such as porosity, content of organic carbon and total nitrogen; and negatively with pH value and 51℃ of organic carbon. In the case of the parameters characterizing surface water, positive dependences on the concen- trations of nitrate and total nitrogen, and negative relationships with water temperature and chlorophyll a concentrations, were found.

关键词： Carbon dioxideGreenhouse gasesReservoirSediment

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Luminescence intensification of lanthanide complexes by silver nanoparticles incorporated in sol-gel matrix

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Journal of Rare Earths 2009年第4期27卷 544-549页

作者： renata Reisfeld Marek Pietraszkiewicz Tsiala Saraidarov Viktoria Levchenko Inorganic Chemistry Department The Hebrew University of Jerusalem Givat-Ram 91940 Jerusalem Israel Institute of Physical Chemistry Polish Academy of Sciences 01-224 Warsaw Kasprzaka 44/52 Poland

We present how the luminescence of europium RR-2-P-oxides complexes can be increased by interaction of electronic levels of the complex with the radiation field of silver nanoparticles （NPs）. The procedure by which silver NPs are formed in a sol-gel polyurethane matrix precursor was elaborated. The formed Ag NPs were combined with Eu complex incorporated in ormocer matrix. The emission spectra of the complexes without silver NPs were compared with spectra of the same complexes with addition of silver NPs. As the result of the interaction of the electronic levels of lanthaaide ligands with silver plasmons, dramatic increase of luminescence was observed.

关键词： luminescence intensification Eu RR-2-P-oxides complexes silver nanoparticles silica-polyurethane zirconia-glymo particles size distribution rare earths

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Probing behavior of aposymbiotic green peach aphid persicae） on susceptible Solanum tuberosum and resistant Solanum stoloniferum plants

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Insect Science 2018年第1期25卷 127-136页

作者： Cristina renata Machado-Assefh Adriana Elisabet Alvarez Catedra de Quimica Biologica Facultad de Ciencias Naturales Universidad Nacional de Salta Avda Bolivia 5150 A4408FVY Salta Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) CCT Salta Avda Bolivia 5150 A4408FVY Salta Argentina

The green peach aphid, Myzuspersicae Sulzer （Hemiptera： Aphididae） is one of the potato important pests; it is the most efficient vector of potato viruses. Myzuspersicae harbors the endosymbiotic bacteria Buchnera aphidicola which supplements their diet. There is increasing evidence that B. aphidicola is involved in plant-aphid interactions and we previously demonstrated that B. aphidieola disruption （aposymbiosis） affected the probing behavior ofM. persicae on radish plants, delaying host plant acceptance. In this work, we evaluated the effect of aposymbiosis on the probing behavior of M. persicae on 2 Solanum species with different compatibility with M. persieae, Solanum tuberosum （susceptible） and Solanum stoloniferum （resistant） with the electrical penetration graph technique （EPG）. To disrupt B. aphidicola, rifampicin was administered to aphids through artificial diets. Aposymbiotic aphids, on both plant species, showed increased pathway activities, mechanical problems with the stylets, and delayed salivation in the phloem. The extended time in derailed stylet mechanics affected the occurrence of most other probing activities; it delayed the time to the first phloem phase and prevented ingestion from the phloem. The effect of aposymbiosis was more evident in the compatible interaction of M. persicae-S, tuberosum, than in the incompatible interaction with S. stoloniferum, which generated the M. persicae--S, tuberosum interaction to become incompatible. These results confirm that B. aphidicola is involved in the plant-aphid interaction in relation to plant acceptance, presumably through a role in stylets penetration in the plant.

关键词： aphid artificial diets Buchnera aphidicola EPG technique potato

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Fluidized and vibrofluidized shallow beds of fresh leaves

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Particuology 2011年第2期9卷 139-147页

作者： renata de Aquino Brito Lima Maria do Carmo Ferreira Drying Center of Pastes Suspensions and SeedsChemical Engineering DepartmentFederal University of S o Carlos

The fluid dynamics behavior of shallow fluidized and vibrofluidized beds operating with fresh leaves was investigated with the aim of exploring drying applications in a modified conveyor belt （MCB） system, which may be operated in a fixed- or fluidized-bed mode. Leaves of the specimens Duranta repens, Schinus molle, Coleus barbatus, Buxus sempervirens, and Bougainvillea spectabilis were tested with a range of sphericities from 0.063 to 0.213, bulk densities from 0.038 to 0.251 g/cm3, apparent densities from 0.52 to 0.97 g/cm3 and ratios of total surface area to volume from 21 to 224 cm-1. Fluidization characteristic curves were obtained by measuring pressure drops versus air velocity in a rectangular column of 0.20 m - 0.11 m cross section. It was not possible to reach real fluidized regimes with the leaves due to strongly non-homogeneous beds. Nevertheless, the characteristic curves allowed for the identification of a transition regime from fixed- to expanded-beds, and parameters such as air velocity and pressure drop obtained from the experimental data at the transition were reproducible for specimens with lower surface area or lower specific gravity （i.e., Duranta repens, Schinus molle, and Bougainvillea spectabilis）. The transition velocity and pressure drop could not be predicted by the literature developed for estimat- ing minimum fluidization conditions. The use of vibration at dimensionless vibration parameters （Γ） of 0.5 and 1.0 helped to reduce channeling and decrease the transition velocities from fixed to expanded regimes although it did not affect the pressure drops after the bed expansion. The results suggest that drying fresh leaves using the MCB dryer operating in a fluidized mode would not be feasible because none of the materials investigated attained a high-quality fluidization. Operation of the MCB dryer may be pos- sible by alternating between the fixed and vibrofluidized modes. For the specimens tested, the drying should be performed in a range

关键词： LeavesLow-sphericity particlesPressure dropsFluidizationVibration

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A new concept to forecast the process of suspended sediment accumulation in the bottom sediment of small reservoirs

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International Journal of Sediment Research 2023年第4期38卷 556-565页

作者： Maksymilian Cie?la renata Gruca-Rokosz Lilianna Bartoszek Department of Environmental and Chemistry Engineering Faculty of Civil and Environmental Engineering and Architecture Rzeszow University of Technology

The new concept presented for forecasting the rate of accumulation of suspended sediment in reservoir water in the bottom sediment allows reasonable estimates of the siltation process globally, regionally, or locally, to be obtained without the need for costly research. The method draws on three key parameters,i.e., the concentration of suspended sediments(SS), and its organic matter(OMSS) content, as well as the storage capacity(VR)(i.e., the water storage in the reservoir). All of these parameters easy to determine,with information on them, in fact, made widely available by most agencies managing reservoirs in different parts of the world. In practice, the proposed method can represent a missing link in the precise determination of a reservoirs rate of siltation(and hence, losses of storage capacity).

关键词： Sediment accumulation Suspended sediment Organic matter Storage reservoirs Siltation rates Water resources

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Diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele Di Stefano Silvia Giordani renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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