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Effect of ions on the activity of brain acetylcholinesterase from tropical ifsh

Journal of Coastal Life Medicine 2015年第7期 505-514页

作者： Caio Rodrigo Dias Assis Amanda Guedes Linhares Vagne Melo Oliveira renata cristina penha franca Juliana Ferreira Santos Elba Verônica Matoso Maciel Carvalho Ranilson Souza Bezerra Luiz Bezerra Carvalho Jr Laboratory of Enzymology-LABENZ Biochemistry Department and Laboratory of Immunopathology Keizo AsamiFederal University of PernambucoRecife-PEBrazil Academic Unit of Serra Talhada Federal Rural University of PernambucoSerra Talhada-PEBrazil Laboratory of Glycoproteins Biochemistry DepartmentFederal University of PernambucoRecife-PEBrazil

Objective:To investigate the effect of ions on brain acetylcholinesterase(AChE;EC 3.***.1.7)activities from economic important fish[pirarucu,Arapaima gigas;tambaqui,Colossoma macropomum;cobia,Rachycentron canadum(***)and Nile tilapia,Oreochromis niloticus(***)]comparing with a commercial enzyme from electric eel[Electrophorus electricus(***)].Methods:Thein vitro exposure was performed at concentrations ranging from 0.001 to 10 mmol/L(except for ethylene diamine tetraacetic acid;up to 150 mmol/L).Inhibition kinetics *** *** were also observed through four methods(Michaelis-Menten,Lineweaver-Burk,Dixon and Cornish-Bowden plots)in order to investigate the type of inhibition produced by some ***:Hg^(2+),As^(3+),Cu^(2+),Zn^(2+),Cd^(2+)caused inhibition in all the species under ***^(2+),Mg^(2+)and Mn^(2+)induced slight activation *** enzyme while Pb^(2+),Ba^(2+),Fe^(2+),Li+inhibited the AChE from some of the analyzed *** lowest IC50 and Ki values were estimated *** AChE in presence of Hg^(2+),Pb^(2+),Zn^(2+).Under our experimental conditions,the results *** ***,As^(3+),Cu^(2+),Cd^(2+),Pb^(2+)and Zn^(2+)showed a non-competitive/mixed-type inhibition,while Hg^(2+)inhibited the enzyme in a mixed/competitive-like ***:*** AChE activity was affected by ten of fifteen ions under study showing that this enzyme could undergo interference by these ions when used as pesticide biosensor in environmental *** hindrance would be less relevant for the crude extracts.

关键词： Ions Acetylcholinesterase Biomarkers Fish

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Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles

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Neural Regeneration Research 2022年第7期17卷 1503-1504页

作者： cristina Agliardi franca R.Guerini Mario Meloni Mario Clerici IRCCS Fondazione Don Carlo Gnocchi MilanItaly Department of Pathophysiology and Transplantation University of MilanMilanItaly

The prevalence of Parkinson’s disease(PD)is rapidly increasing,and more than 12 million people are expected to suffer from PD by *** is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars *** main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies.

关键词： degeneration Alpha prevalence

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Design and criteria of electrospun fibrous scaffolds for the treatment of spinal cord injury

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Neural Regeneration Research 2017年第11期12卷 1786-1790页

作者： Barbara Vigani Silvia Rossi Giuseppina Sandri Maria cristina Bonferoni franca Ferrari Department of Drug Sciences University of PaviaViale TaramelliPaviaItaly

The complex pathophysiology of spinal cord injury may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. Many efforts have been performed to design and develop suitable scaffolds for spinal cord regeneration, keeping in mind that the reconstruction of a pro-regenerative environment is the key challenge for an effective neurogenesis. The aim of this review is to outline the main features of an ideal scaffold, based on biomaterials, produced by the electrospinning technique and intended for the spinal cord regeneration. An overview of the poly- mers more investigated in the production of neural fibrous scaffolds is also provided.

关键词： spinal cord injury biomaterials electrospun fibers conductive scaffolds morphological properties biodegradability

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Method for grinding and delaminating muscovite

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Mining Science and Technology 2011年第1期21卷 7-10页

作者： Shirleny Fontes Santos Silvia cristina Alves franca Tsuneharu Ogasawara Metallurgical and Materials Department Centre for Mineral Technology

A method of dry grinding muscovite based on the use of knife-mills is *** was possible to produce mica with a particle size below 100 and 45μ*** grinding,the samples were submitted to sonication treatment,which promoted delamination of the *** particle size distribution shows that sonicated mica has more particles in the size range 10-50μm than does non-sonicated mica have. This also indicates a decrease in the average particle *** of the treated muscovite by scanning electron microscopy revealed a highly delaminated material with a plate-like *** products were characterized by chemical analysis and X-ray diffraction,*** mica has already been used for the synthesis of pearlescent pigments.

关键词： Muscovite Grinding Ultrasound treatment Mineral processing

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Implementation of a High-Risk Outpatient Clinic for Children with Complex Congenital Heart Disease in a Reference Service in Brazil

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Congenital Heart Disease 2023年第6期18卷 649-656页

作者： Gustavo Foronda Vanessa Ferreira Amorim de Melo Claudia Regina Pinheiro de Castro Grau Ingrid Magatti Piva Glaucia Maria penha Tavares Ana cristina Sayuri Tanaka Nana Miura Department of Pediatric Cardiology and Adult Congenital Heart Diseases Heart Institute of the University of São PauloSão PauloBrazil Foronda Clinic São PauloBrazil Institute of Orthopedics and Traumatology University of São PauloSão PauloBrazil Department of Echocardiography Heart Institute of the University of São PauloSão PauloBrazil

Background:Children with congenital heart disease(CHD),even after surgical approaches,and especially those who undergo staged procedures in theﬁrst months of life,remain vulnerable to readmissions and complications,requiring very close monitoring and differentiated intervention ***:Descriptive and exploratory study,of the experience report type,which presents the process of building the high-risk outpatient clinic for complex congenital heart diseases(AAR)at the Instituto do Coração(InCor).Results:Report of the path taken to structure the AAR,demonstrating the organization,interface with the multidisciplinary team,admission and discharge criteria,training,and patient proﬁ*** theseﬁve years of care,275 patients were treated,59.65%with biventricular interstage physiology,followed by univentricular interstage physiology(34.55%),residual defects after surgical procedures(3.63%),tumors with risk of mechanical obstruction(1.45%)and patients with an intrauterine approach(0.72%).The signiﬁcant number of critical patients who were successfully discharged from hospital(44.72%),the low mortality rate due to sudden deaths at home and the high adherence to follow-up cor-roborate the impact of this specialized ***:Despite the limitations of the study,this experi-ence report showed that with few resources,there is the possibility of organizing an AAR with differentiated care,with the objective of early detection and treatment of residual injuries,identiﬁcation of early interventions,edu-cation of parents for follow-up of their children,resulting in individualized treatment,promoting a better quality of life for this population.

关键词： Congenital heart defects ambulatory care heart defects

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Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics

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Congenital Heart Disease 2022年第3期17卷 351-363页

作者： Eloisa Sassa Carvalho Maria Francilene SSouza Kelly cristina O.Abud Claudia R.P.Castro Juliano G.penha Ana Maria Thomaz Vanessa A.Guimaraes Antonio Augusto Lopes Heart Institute(InCor) University of Sao Paulo School of MedicineSão PauloBrazil

Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac *** patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up ***:We analyzed a prospective cohort of 52 pediatric patients(age 3 to 35 months)looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery,defined as a systolic pressure greater than 30 mmHg by transthoracic *** corresponds to a mean pulmonary arterial pressure of>20 ***,echocardiographic and hemodynamic parameters were *** hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling *** postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio(PAP/SAP)obtained per patient during the first 6 h of postoperative ***:Among the factors that were investigated as possible predictors,perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis(p0.35 was 76%sensitive and 74%specific at predicting a systolic pulmonary arterial pressure of>30 mmHg 6 months after surgery(hazard ratio with 95%CI 8.972[2.428–33.158],p=0.002).Conclusion:The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome,and it was char

关键词： Pulmonary hypertension congenital heart disease Down syndrome pediatric cardiac surgery

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Preliminary Tests of a Kerma-Area Product (KAP) Meter to Be Used as a Monitor Chamber in a Conventional Diagnostic X Ray System

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Journal of Modern Physics 2015年第4期6卷 483-489页

作者： Eduardo Correa Regina Medeiros Maria da penha Potiens Vitor Vivolo Nathalia Costa Camila Murata cristina Kikuti Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN) Universityof Sao Paulo (USP) Sao Paulo Brazil Federal University of Sao Paulo (UNIFESP) Sao Paulo Brazil

This study presents the results of the preliminary tests performed using a kerma-area product (KAP) meter in order to verify its usefulness as a monitor chamber in a clinical X ray system, which will be used in ionization chambers’ quality control program. The tests performed were repeatability, surface measurement uniformity, linearity with tube current, measurement variation changing the distance and field size, KAP chamber radiation attenuation, and energy dependence. The KAP meter has presented a good repeatability (a maximum variation of 0.4%);its surface has a homogeneous response (a maximum variation of 1.0% among the different irradiated regions);the response is linear with the tube current and the variation of the PKA along the distance is less than 3.43%. On the other hand, the results obtained for chamber attenuation and energy dependence show that some corrections must be applied when the measurements are made. The results have shown a good performance of the KAP meter, confirming that it is possible to use this instrument as a monitor chamber. However, it is important to highlight that some correction factors for energy dependence and chamber radiation attenuation must be considered.

关键词： KAP Meter Quality Control Diagnostic Radiology Monitor Chamber

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Synthesis and Characterization of a New Compound of Cobalt Ⅱ with Isonicotinamide and Evaluation of the Bactericidal Potential

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Open Journal of Inorganic Chemistry 2019年第2期9卷 11-22页

作者： Anderson Dourado Galvao Fabricio Tarso de Moraes Claudia cristina de Sousa Katia Meirelles Duarte de Sousa Patricia Gelli Feres de Marchi Adenilda cristina Honorio franca Eduardo Luzia franca Wagner Batista dos Santos Federal University of Mato Grosso—Barra do Garcas/MT Brazil

In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H2O)(isn)3](BF4)2, was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H2O)(isn)3](BF4)2, CoCl2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.

关键词： Cobalt Isonicotinamide Spectroscopy Infrared TG/DTG and TG/DTA Bactericidal Activity

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Qi Gong and Heart Rate Variability: A Systematic Review

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Journal of Biosciences and Medicines 2017年第3期5卷 120-127页

作者： Carla cristina Ramos Elias de franca Thatiana Lacerda Nobre Jeferson Oliveira Santana Diana Madureira Cesar Augustus Sousa Zocoler Bruno Rodrigues Ronaldo VTSantos Iris Calado Sanches Erico Caperuto Gepame-Human Movement Laboratory Sao Judas Tadeu UniversitySao PauloBrazil Unifesp-Campus Santos Sao PauloBrazil

Qì Gōng is a type of exercise that involves meditation and is used for health. With a background from the martial arts, it is known also as an auto healing exercise with three main elements according to Traditional Chinese Medicine (TCM): body focus (posture and movement), breathing and mind focus (meditative elements). Heart rate variability is a tool that allows us to measure the autonomic system velocity to detect and respond to unexpected stimuli. So our goal was to build a systematic review of Qi Gong and Heart rate variability. PUBMED, EBSCO and Science Direct data bases were searched. Key terms (MeSH) were Heart Rate Variability and Ch’i Kung OR Qi Gong with a 10-year filter. Four independent reviewers analyzed all articles and excluded duplicated articles, articles in Chinese and articles with no adherence to the subject. The end result was 5 studies selected. Our results showed no significant improvements in HRV with the practice of Qì Gōng, probably because of data heterogeneity. We found 5 types of Qì Gōng, 3 different instruments and different time intervals to measure HRV and 2 different age groups in the studies. We can conclude that there is evidence that Qì Gōng can improve HRV but studies that would use the same parameters are needed to further confirm that.

关键词： Qi Gong Heart Rate Variability Meditation Exercises Exercise Physiology

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Evolution of sequential bortezomib-dexamethasone treatment followed by autologous hematopoietic stem cell transplantation in hemodialysis treatment

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Chinese Medical Journal 2013年第9期126卷 1795-1795页

作者： Li Cavoli Gioacchino Zagarrigo Carmela Servillo franca Coglitore Mario Schillaci Onofrio Tralongo Angelo Rotolo Ugo Nephrology and Dialysis Civic and Di Cristina Hospital Palermo Italy

T0 the editor： We read with interest the article of Zheng et al1 on sequential treatment with bortezomib plusdexamethasone followed by autologous hematopoietic stem cell transplantation （ASCT） in patients with mult...

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