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Astrocytes dynamically regulate the blood-brain barrier in the healthy brain

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Neural Regeneration Research 2024年第4期19卷 709-710页

作者： AgnėPociūtė Augustas Pivoriūnas Alexei Verkhratsky Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Centre for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

The blood-brain barrier(BBB)(discovered and defined by Max Lewandowsky and Lina Stern,and not,as it is universally,and yet erroneously believed,by Paul Ehrlich(Verkhratsky and Pivoriunas,2023))that separates the nervous system from the circulation is evolutionarily conserved from arthropods to *** primeval BBB of the invertebrates and some early vertebrates was made solely by glial cells and secured(in invertebrates)by septate junctions.

关键词： Ehrlich barrier blood

Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： renan Dal-Fabbro Minzhi Yu Ling Mei Hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(Pdownregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

Random vibration analysis of FGM plates subjected to moving load using a refined stochastic finite element method

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Defence Technology（防务技术） 2024年第4期34卷 42-56页

作者： Ngoc-Tu do Trung Thanh Tran Faculty of Mechanical Engineering Hanoi University of IndustryHanoiViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam

The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving *** advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving ***, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.

关键词： FGM Moving load R-FSDT Q4 element Monte Carlo simulation Random vibration

Relationship between land use and user’s behavior along the street:A case study of Da Nang City,Viet Nam

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Frontiers of Architectural Research 2024年第1期13卷 144-163页

作者： Duy Thinh do Duy Thao do Faculty of Civil Engineering Ho Chi Minh City University of Technology and Education(HCMUTE)Ho Chi Minh City 71307Viet Nam School of Computing Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Human activities on street spaces are affected by both physical and non-physical settings on *** two aspects are primarily impacted by land use which results in the uneven distribution of different activities on *** research investigates land use patterns and their characteristics in association to user’s *** using mixed qualitative and quantitative research methods,e.g.,place-centered behavioral map,observation,visual encounter surveys,machine learning,the relationship between user’s behavior and land use characteristics along the street is *** user behaviors along both types of streets were classified into six main categories,with 26 *** observation results show that the residential use of land along the street was transformed into the commercial use for various types of shophouses based on the resident’s *** is a great correlation between land use and user’s *** findings give support to authorities to manage urban streets and develop a sustainable policy for improving street ***,this research contributes useful information to urban designers and planners in creating a successful street space that is appropriate for the Vietnam Community.

关键词： Land use pattern User’s behavior Da Nang Street space Data mining

Study on the tunnel shape and soil-lining interaction influencing the lining behavior under seismic loading

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 845-862页

作者： Van Vi Pham Ngoc Anh do Piotr Osinski Ngoc Thai do Daniel Dias Sustainable Development in Underground Engineering Research Team Hanoi University of Mining and GeologyHanoiVietnam Department of Underground and Mining Construction Faculty of Civil EngineeringHanoi University of Mining and GeologyHanoiVietnam Department of Geotechnical Engineering Institute of Civil EngineeringWarsaw University of Life Sciences-SGGWWarszawaPoland Laboratory 3SR Grenoble Alpes UniversityGrenoble 38400France

The response of tunnels subjected to seismic loading is a complex mechanism and depends not only on the seismic nature but also on tunnel structure and surrounding soil *** individual behavior of circular,rectangular,and sub-rectangular tunnels subjected to seismic loadings has already been studied in the *** the present research,two case scenarios of circular,rectangular tunnels and four sub-rectangular shaped tunnels,with similar cross-section areas,were adopted to perform a comprehensive numerical *** purpose of the study was to determine the mechanical behavior of tunnels of different shapes,depending upon seismic *** were performed by considering the influence of soil-lining interaction,soil parameters,and lining thickness,as well as lining *** were performed for no-slip and full-slip *** results indicate that the tunnel shape design is of great importance when regarding the mechanical behavior of the surrounding *** concerns no-slip as well as full-slip soil-lining interaction,especially when the lining is subjected to seismic ***,it is shown that changes in incremental bending moments for circular,rectangular and sub-rectangular tunnels that depend upon the soil-lining interaction conditions differ significantly.

关键词： tunnel shape soil-lining interaction seismic loading internal forces numerical analysis

Velocity equation for grenades while impacting on dry sand media

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Defence Technology（防务技术） 2024年第5期35卷 168-173页

作者： Martin Macko Xuan Son Bui Kongsathit Phanthavong Duc Hung Pham Van Gion do Van Minh do Jiri Skala University of Defence BrnoCzech Republic Le Quy don Technical University Ha NoiViet Nam

This paper deals with the collision of sphere shape grenades with sand *** central issue of the article is the establishing of an empirical velocity equation of the grenade while impacting on sand that is used to solve motion equations of the mechanical mechanism inside the impact grenade *** paper focuses on impact velocities that are lower than 5 m s^(-1).An experiment was conducted to study the velocity of the grenade while impacting on dry sand.A high-speed camera video was used to capture the grenade *** grenade velocity in the impact process was generated from these video *** types of fitting curves are used to regress the velocity equation of the grenade while interacting with the sand media and the best-fitting model is *** result shows the regression curve has a high correlation with the experiment data for grenade velocities below 5 m s^(-1).The received regression equation is useful for analyzing the working ability of the inertial mechanism inside the impact grenade or analyzing and choosing the appropriate parameters of each part in the inertial mechanism to meet the required characteristics of the mechanism.

关键词： Dynamic response Impact velocity Impact grenade Low-velocity impact

Integrated strategies on cobalt phosphides-based electrocatalysts for efficient hydrogen evolution reaction

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Tungsten 2024年第3期6卷 488-503页

作者： Thanh Dam Mai Ha Huu do Faculty of Mechanical Engineering and Technology Ho Chi Minh City University of Industry and Trade VKTech Research Center NTT Hi-Tech Institute Nguyen Tat Thanh University

The development of cost-effective and durable hydrogen evolution reaction(HER) electrocatalysts plays a vital role in dealing with the issues related to carbon dioxide *** phosphide-based nanomaterials are evaluated as promising advocates for HER due to high catalytic activities,good stability,and rich *** review commences with an exploration of the synthetic pathways of CoP,including solid-phase,solution-phase along with electrochemical ***,the mechanism of hydrogen formation is expressed thoroughly,after which various integrated strategies of morphology engineering with doping,assisted highly conductive materials,and construction of heterostructure were introduced for ***,burdensome tasks and possible guidance for the advancement of CoP-based nanomaterials were discussed for hydrogen production.

关键词： Cobalt phosphides Nanomaterials Electrocatalysts Hydrogen evolution reaction

A New Framework for Software Vulnerability Detection Based on an Advanced Computing

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Computers, Materials & Continua 2024年第6期79卷 3699-3723页

作者： Bui Van Cong Cho do Xuan Department of Information Technology University of Economics and Technical IndustriesHanoi100000Vietnam Faculty of Information Security Posts and Telecommunications Institute of TechnologyHanoi100000Vietnam

The detection of software vulnerabilities written in C and C++languages takes a lot of attention and interest *** paper proposes a new framework called DrCSE to improve software vulnerability *** uses an intelligent computation technique based on the combination of two methods:Rebalancing data and representation learning to analyze and evaluate the code property graph(CPG)of the source code for detecting abnormal behavior of software *** do that,DrCSE performs a combination of 3 main processing techniques:(i)building the source code feature profiles,(ii)rebalancing data,and(iii)contrastive *** which,the method(i)extracts the source code’s features based on the vertices and edges of the *** method of rebalancing data has the function of supporting the training process by balancing the experimental ***,contrastive learning techniques learn the important features of the source code by finding and pulling similar ones together while pushing the outliers *** experiment part of this paper demonstrates the superiority of the DrCSE Framework for detecting source code security vulnerabilities using the Verum *** a result,the method proposed in the article has brought a pretty good performance in all metrics,especially the Precision and Recall scores of 39.35%and 69.07%,respectively,proving the efficiency of the DrCSE *** performs better than other approaches,with a 5%boost in Precision and a 5%boost in ***,this is considered the best research result for the software vulnerability detection problem using the Verum dataset according to our survey to date.

关键词： Source code vulnerability source code vulnerability detection code property graph feature profile contrastive learning data rebalancing

Pinus sylvestris and Picea abies canopy effects on deposition of air pollutants

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Journal of Forestry Research 2024年第4期 38-50页

作者： Valentinas ?erniauskas Iveta Varnagiryt?-Kaba?inskien? Valda Araminien? Vidas Stak?nas Lithuanian Research Centre for Agriculture and Forestry Instituto Av.1

Tree canopies influence atmospheric pollutant depositions depending on type,ecosystem characteristics,and local climatic *** study investigated the impact of Pinus sylvestris *** Picea abies （L.） ***.,and a mixture of both,on the chemical composition of *** permanent plots within the ICP forest level II monitoring network in Lithuania were selected to illustrate typical hemiboreal coniferous *** study analysed（1） the concentrations of NO2,NH3and SO2in the ambient air;（2） the concentrations of SO42-,NO3-,NH4+,Na+,K+,Ca2+and Cl–in throughfall beneath canopies and in precipitation collected in an adjacent field,and （3） S and total N,Na+,K+,Ca2+and Cl-depositions in throughfall and precipitation over 2006–*** show a significant decrease in SO2emissions in the ambient air;NO2and NH3emissions also *** canopies reduced the acidity of throughfall,although they led to notably higher concentrations of SO42-,NO3-,Na+,and particularly K+.During the study,low variability in NO3–deposition and a decrease in NH4+deposition *** loads increased by 20–30% when precipitation passed through the *** cumulative deposition of S,Cl,Na,K,Ca,and N was greater under *** than under ***,K deposition in throughfall was considerably lower under *** compared to the *** or mixed *** S depositions declined across all three coniferous ***,there was no specific effect of tree species on throughfall chemistry.

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