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Influence of Al doping on the crystal structure,optical properties,and photodetecting performance of ZnO film

Progress in Natural Science:Materials International 2020年第1期30卷 28-34页

作者： Ni'matul Azizah Shibghatullah Muhammady Muhammad Abiyyu Kenichi Purbayanto eka Nurfani Toto Winata euis Sustini rena Widita Yudi Darma Department of Physics Faculty of Mathematics and Natural SciencesInstitut Teknologi Bandung Materials engineering Program Institut Teknologi SumateraTerusan RyacuduWay HuiJati Agung

The structural,optical,and electrical properties of undoped and Al-doped ZnO films deposited on p-Si(001)substrate were studied using DC-unbalanced magnetron *** study is motivated by the absence of detail reports concerning the orbital states inducing the optical bandgap(eg) ***,the influences of Al on the possible modification of point defect and the photodetecting performance are highlighted to offer guidelines for better development in ZnO-based *** was found that the Al doping reduced the grain *** doping increased the lattice parameters and slightly decreased the local-symmetry distortion at *** the absorbance spectra,the doping increased eg of ZnO film(3.28-3.36 eV),induced by the Burstein-Moss *** the density-functional calculation,the Burstein-Moss effect induced egfrom the valence band maximum(VBM) to Fermi level located above the lowest Zn 4s conduction *** the photoluminescence spectra,the undoped film showed the transitions from O vacancy,Zn interstitial,and free-exciton states to the *** doped film showed the transitions from Zn interstitial to O interstitial and few Zn vacancy states at the cost of O ***,the energy level of free-exciton states slightly ***,O interstitials increased the lattice *** the electrical properties,the doping enhanced the ultraviolet-region photo-to-dark-current ratio up to 3.044 V,leading to the photodetecting sensitivity *** study emphasizes the significant effect of Al doping on the optical absorbance,point-defect evolution,and photodetecting performance of ZnO film for low-voltage ultraviolet photodetector applications.

关键词： ZnO Optical properties Point defect Photodetecting Local-symmetry distortion

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New dragonflies (Insecta: Odonata: Gomphaeschnidae) from the Yixian Formation in Inner Mongolia, China

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Progress in Natural Science:Materials International 2008年第1期18卷 59-64页

作者： Binglan Zhang a ,Dong rena ,*,Hong Pang b aCollege of Life Science,Capital Normal University,Beijing 100037,China bState Key Laboratory of Biocontrol and Institute of entomology,Sun Yat-sen University,Guangzhou 510275,China College of Life Science Capital Normal University Beijing 100037 China State Key Laboratory of Biocontrol and Institute of entomology Sun Yat-sen University Guangzhou 510275 China

Two fossil dragonflies from the Upper Jurassic to Lower Cretaceous Yixian Formation in Liutiaogou Village,Ningcheng County, Inner Mongolia,China are described and *** are assigned to two new genera and species,i.e.,Sophoaeschna frigida gen. et *** Falsisophoaeschna generalis *** *** the family Gomphaeschnidae Tillyard&Fraser,*** is the first report of Odonata from Yixian Formation in Inner Mongolia and the second record of fossil Gomphaeschnidae from China.

关键词： Odonata New genus Upper Jurassic to Lower Cretaceous Yixian Formation China

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effects of carbohydrate supplements on exercise-induced menstrual dysfunction and ovarian subcellular structural changes in rats

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Journal of Sport and Health Science 2014年第3期3卷 189-195页

作者： Can Zhao Xiao-Li Liu Run-Xiao Hong He Li rena Li Ren-Wei Wang School of Kinesiology Shanghai University of Sport Department of Sport Hubei Minzu University College of Physical education Shanghai Normal University Center for Advance Hormone Science and education.Roskamp Institute

Background： exercise-associated menstrual dysfunction （eAMD） is a common health problem in female athletes as a part of female athlete triad （FAT）, a condition related to low energy availability. In this study, we explored the possibility that carbohydrate supplements can improve the status of eAMD and prevent exercise-induced ovarian injury in a FAT rat model. This research aimed to provide experimental evidence with regard to the relationship of energy intervention and eAMD. Methods： Forty-five female Sprague-Dawley rats （2 months old） were randomly divided into five experimental groups： control group （C）, 9-week exercise as model for eAMD （e）, post-eAMD recovery group （R）, oligosaccharide intervention group （O）, and glucose intervention group （G）. All rats were sacrificed at the end of 9 weeks. Serum samples were collected for measuring gonadotropin releasing hormone, follicle stimulating hormone, luteinizing hormone, 1713-estradiol and progesterone levels. The ovaries were taken for investigation of exercise- and carbohydrate-induced follicular subcellular structure changes. Results： exercise induced irregular menstrual cycles and ovary subcellular structural damages, such as swollenness of mitochondria in rats from groups e and R. Both glucose and oligosaccharide supplements restored well-differentiated mitochondria in the ovarian follicular cells, and a significant improvement of endoplasmic reticulum and Golgi in swollenness in theca cells in groups O and G compared to groups C, e, and R. There was no difference in mitochondria subcellular structural changes between groups O and G. Group e showed attenuation of serum levels of 17β-estradiol and progesterone compared to C. There were no differences of 17β-estradiol serum levels among groups O, G, and R, while group G showed a lower level of progesterone than C. Conclusion： Female adult rats with 9-week continuous exercise can cause menstrual dysregulation as a model for eAMD. Post-eAMD intervention with glucos

关键词： Carbohydrate supplement estradiol estrous cycle restrain Follicular subcellular injury Ovary Progesterone rats

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Optimum Reinforcement in Concrete Using Genetic Algorithms

Optimum Reinforcement in Concrete Using Genetic Algorithms

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The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational Mechanics

作者： rena C.Yu Gonzalo Ruiz Jacinto R.Carmona School of Civil engineering University of Castilla-La Mancha Avda.Camilo Jose Cela s/n Ciudad Real 13071 Spain School of Civil engineering University of Castilla-La Mancha Avda.Camilo Jose Cela s/n Ciudad Real 13071 Spain School of Civil engineering University of Castilla-La Mancha Avda.Camilo Jose Cela s/n Ciudad Real 13071 Spain

We tackle the problem of minimum reinforcement in concre te using Genetic Algorithms (GAs), the searching procedures based on the fundamental evolutionary principle: better individuals survive and reproduce more often than other individuals [1]. GAs work very well on mixed (continuous and discrete) combinatorial problems;they are less susceptible to getting "stuck" at local optima than other gradient search methods. But they nevertheless tend to be computationally expensive, since a "pool" of samples with variations is needed to start and evolve the searching pr ocess. If the fitness value has to be fed by a finite element method calculation, thousands or millions of calculations are needed before a near-optimum solution can be finally found;and this would render the usage unrealistic. In particular, in dealing with optimization in lightly-reinforced concrete beams, the peak and near post-peak in the load-displacement and its neighborhood are known to b e controlled by three factors: 1) the steel ratio;2) the bond-slip properties;and 3) the steel cover [2]. But how to adjust these three factors to obtain a global ductile response of the structure is only by trial-and-error both numerically and experimentally. In this paper, we adopt a cohesive crack model developed by Ruiz [3], which deals with the propagation of a cohesive crack crossing a reinforcement layer in a beam made out of a cohesive matrix and lightly reinforced with steel bars. This model accounts for the aforementioned three factors, but above all, it gives a fast numerical solution, which makes the use of GAs in this particular problem feasible. Specifically, the case of a reinforced prismatic beam loaded at three points is modeled. GAs are adopted to study carefully the influence of those three parameters, optimization process is carried out toward an objective function which is the ductile response of the beam structure, i.e. a linear elastic perfect -plastic response in the dimensionless load-displac

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Bioengineered stem cells as an alternative for islet cell transplantation

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World Journal of Transplantation 2015年第1期5卷 1-10页

作者： Sarah J Moore Boris L Gala-Lopez Andrew R Pepper rena L Pawlick AM James Shapiro Alberta Diabetes Institute University of AlbertaEdmonton AB T6G 2E1 Canada Clinical Islet Transplant Program University of AlbertaEdmonton AB T6G 2C8 Canada

Type 1 diabetes is an autoimmune and increasingly prevalent condition caused by immunological destruction of beta cells. Insulin remains the mainstay of therapy. endeavours in islet transplantation have clearly demonstrated that type 1 diabetes is treatable by cellular replacement. Many challenges remain with this approach. The opportunity to use bioengineered embryonic or adult pluripotential stem cells, or islets derived from porcine xenograft sources could address future demands, but are still associated with considerable challenges. This detailed review outlines current progress in clinical islet transplantation, and places this in perspective for the remarkable scientific advances now occurring in stem cell and regenerative medicine approaches in the treatment of future curative treatment of diabetes.

关键词： Islet transplantation Hypoxia Stem cell Diabetes

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食管鳞癌组织中差异表达miR-17-92基因簇成员及其靶基因的筛选、生物学功能分析

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山东医药 2021年第15期61卷 1-5页

作者：邵毅沈艺牛琛阮晓莉 rena Nakyeyune 刘芬首都医科大学公共卫生学院北京市临床流行病学重点实验室北京100069

目的筛选食管鳞癌(eSCC)组织中差异表达的miR-17-92基因簇及其靶基因,分析靶基因的生物学功能,并探讨miR-17-92基因簇及其靶基因与患者临床病理特征、预后的关系。方法下载癌症基因组图谱(TCGA)数据库和基因表达综合(GeO)数据库(GSe4373... 详细信息

目的筛选食管鳞癌(eSCC)组织中差异表达的miR-17-92基因簇及其靶基因,分析靶基因的生物学功能,并探讨miR-17-92基因簇及其靶基因与患者临床病理特征、预后的关系。方法下载癌症基因组图谱(TCGA)数据库和基因表达综合(GeO)数据库(GSe43732数据集)中eSCC相关数据,分别采用edgeR包和GeO2R分析miR-17-92基因簇的表达情况。将eSCC组织、正常食管组织及癌旁组织中差异表达最显著(差异倍数>2倍,校正后PetScan 7.2及miRTarBase 8.0在线网站预测关键miRNAs的靶基因,经蛋白互作网络分析及差异表达分析确定关键靶基因。对关键靶基因进行KeGG信号通路和GO功能富集分析。采用独立样本t检验或Mann-Whitney U检验分析关键miRNAs及其关键靶基因与eSCC临床病理学特征间的关系,采用生存分析评价关键miRNAs及其关键靶基因与eSCC患者预后的关系。结果相对于正常食管组织及癌旁组织,eSCC组织中miR-17-92基因簇表达均上调,其中上调的关键miRNAs是miR-17-5p、miR-18a-5p。筛选出14个差异表达的关键靶基因,分别为CNOT6L、CTDSPL、ATM、FBXL5、NHLRC3、FeM1C、HIF1A、UBe2G1、CeNPQ、CNOT7、RHOC、NR3C1、RUNX1、e2F3。关键靶基因主要富集于信号传导、转录调控、癌症通路、细胞周期等肿瘤相关生物学过程或通路。miR-17-5p、miR-18a-5p和关键靶基因CTDSPL在不同eSCC分化程度间存在差异表达(P均eSCC不同T分期间存在差异表达(P均e2G1在eSCC不同N分期间存在差异表达(P=0.03)。生存分析结果表明,关键靶基因ATM的表达水平与eSCC患者的预后相关(PeSCC组织中miR-17-92基因簇表达上调,关键miRNAs为miR-17-5p、miR-18a-5p,关键靶基因为CNOT6L、CTDSPL、ATM、UBe2G1等14个。关键靶基因主要富集于信号传导、转录调控、癌症通路等肿瘤相关生物学过程或通路。CTDSPL、ATM、NHLRC、UBe2G1与eSCC患者临床病理特征有关,ATM的低表达与eSCC患者的预后差有关。

关键词： miR-17-92基因 miR-17-92靶基因食管癌食管鳞状细胞癌

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HPLC法测定榆叶合叶子中绣线菊苷、金丝桃苷、芦丁、槲皮素

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中成药 2013年第8期35卷 1714-1717页

作者：王艳张芳姚军张行热娜李新霞新疆医科大学药学院新疆乌鲁木齐830011

目的用高效液相法同时测定榆叶合叶子中绣线菊苷、金丝桃苷、芦丁、槲皮素的量。方法使用Agilent e-clipse XDB-C18色谱柱(250 mm×4.6 mm,5μm);流动相A为乙腈,B为1 000 mL水+55 mL乙腈+20 mL醋酸溶液,梯度洗脱;体积流量为1.0 mL/min;... 详细信息

目的用高效液相法同时测定榆叶合叶子中绣线菊苷、金丝桃苷、芦丁、槲皮素的量。方法使用Agilent e-clipse XDB-C18色谱柱(250 mm×4.6 mm,5μm);流动相A为乙腈,B为1 000 mL水+55 mL乙腈+20 mL醋酸溶液,梯度洗脱;体积流量为1.0 mL/min;检测波长360 nm;柱温35℃。结果绣线菊苷、金丝桃苷、芦丁和槲皮素分别在15.54～155.4μg/mL(r=0.999 0),5.18～51.8μg/mL(r=0.999 1),10.22～102.2μg/mL(r=0.999 3),9.8～98μg/mL(r=0.9993)范围内线性关系良好,平均回收率分别为99.84%、97.18%、98.73%、97.73%。结论建立的方法简便易行,准确性、重复性好,可作为榆叶合叶子中4种黄酮成分的定量测定方法。

关键词：榆叶合叶子绣线菊苷金丝桃苷芦丁槲皮素

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牙齿发育过程中Pax9和Msx1对BMP4转录调控作用的研究

牙齿发育过程中Pax9和Msx1对BMP4转录调控作用的研究

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全国第八次牙体牙髓病学学术会议

作者：孔辉王莹朱庆林余擎 Gabriele Mues rena N.D'Souza 第四军医大学口腔医院牙体牙髓科美国德州A&M大学贝勒牙学院

目的:研究牙齿早期发育阶段,BMP4基因启动子转录起始位点上游6kb的区域内Pax9和Msx1的结合位点。方法:利用染色质免疫共沉淀(ChIP)技术。取e14.5的CD1小鼠牙胚,在1%多聚甲醛的作用下将染色质与蛋白质交联,经酶消化法将染色质断裂成小片... 详细信息

目的:研究牙齿早期发育阶段,BMP4基因启动子转录起始位点上游6kb的区域内Pax9和Msx1的结合位点。方法:利用染色质免疫共沉淀(ChIP)技术。取e14.5的CD1小鼠牙胚,在1%多聚甲醛的作用下将染色质与蛋白质交联,经酶消化法将染色质断裂成小片段DNA,利用Pax9和Msx1的抗体分别收集蛋白/DNA复合物,与Pax9结合的DNA片段和与Msx1结合的DNA片段分别经过纯化后,利用BMP4启动子区域的特异性引物进行PCR扩增分析。结果:在e14.5的小鼠牙胚中,BMP4启动子转录起始位点上游6kb和4.6kb的区域有Pax9的结合位点。在BMP4转录起始位点上游6kb的区域内,没有Msx1的结合位点。结论:BMP4启动子区存在Pax9的结合位点,提示Pax9直接介导了BMP4的基因表达调控,而在6kb的区域内没有发现Msx1的结合位点,表明Msx1对BMP4转录调控的作用有可能是间接的。

关键词： Pax9 Msx1 BMP4 转录调控 ChIP

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Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(english edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia e.Cabrera Paulita Pamela P.Astudillo Rolando enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan e.Aguilar Gabrielle S.evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim rena Ivy Bascuna rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pe from the Visayas(Ped on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

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非淀粉多糖复合酶对肉仔鸡生产性能和排泄物中含氮物含量的影响

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动物营养学报 2014年第5期26卷 1370-1378页

作者：孙春阳何科林萨仁娜张宏福高杰仝永娟中国农业科学院北京畜牧兽医研究所动物营养学国家重点实验室北京100193

本试验旨在研究饲粮中添加非淀粉多糖（ NSP ）复合酶对肉仔鸡生产性能和排泄物中含氮物含量的影响。试验采取单因子完全随机设计，选用208只1日龄爱拨益加肉仔鸡公雏，随机分成4组，每组4个重复，每个重复13只。分别饲喂玉米-豆粕型饲... 详细信息

本试验旨在研究饲粮中添加非淀粉多糖（ NSP ）复合酶对肉仔鸡生产性能和排泄物中含氮物含量的影响。试验采取单因子完全随机设计，选用208只1日龄爱拨益加肉仔鸡公雏，随机分成4组，每组4个重复，每个重复13只。分别饲喂玉米-豆粕型饲粮（ C组）、玉米-豆粕型饲粮＋NSP复合酶（ C＋e 组）、小麦-豆粕型饲粮（ W 组）和小麦-豆粕型饲粮＋NSP复合酶（W＋e组）。 NSP复合酶由木聚糖酶、β-葡聚糖酶、纤维素酶、果胶酶、β-甘露聚糖酶组成，酶谱组合为体外试验筛选后获得最适宜添加量。试验期42 d。结果表明：1）试验1～21 d，W＋e组平均日增重（ADG）显著高于W组（P＜0.05），料重比（F/G）显著低于W组（P＜0.05）；与C组相比，C＋e组F/G有降低趋势（0.05＜P＜0.10），ADG无显著差异（P＞0.05）。试验22～42 d，与W组相比，W＋e组F/G显著降低（ P＜0.05），ADG有提高的趋势（0.05＜P＜0.10），C＋e组ADG和F/G与C组相比无显著差异（P＞0.05）。2）试验第14、21、28、35、42天，C组和C＋e组排泄物中氨气含量极显著高于W组和W＋e组（ P＜0.01）；第21天时，C＋e组排泄物中氨气含量极显著低于C组（P＜0.01），W＋e组排泄物中氨气含量与W组无显著差异（P＞0.05）。3）试验第21、28、35、42天，C组和C＋e组排泄物中尿酸含量极显著高于W组和W＋e组（P＜0.01），W组和W＋e组之间与C组和C＋e组之间排泄物中尿酸含量均无显著差异（P＞0.05）。4）试验第14、21、28、35、42天，C组和C＋e组与 W 组和W＋e组相比，排泄物中尿素含量有增高的趋势（P＞0.05），除第14、35天外，W组和W＋e组之间与C组和C＋e组之间排泄物中尿素含量均无显著差异（P＞0.05）。综上所述，小麦-豆粕型饲粮和玉米-豆粕型饲粮添加NSP复合酶可有效改善肉仔鸡生产性能；小麦-豆粕型饲粮添加NSP复合酶可替代玉米-豆粕型饲粮，生产性能可达到玉米-豆粕型饲粮水平。玉米-豆粕型饲粮使肉仔鸡排泄物中氨气、尿素和尿酸含量高于小麦-豆粕型饲粮，小麦-豆粕型饲粮添加NSP复合酶后可降低排泄物中氨气含量。

关键词：非淀粉多糖复合酶生产性能氨气尿酸肉仔鸡

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