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Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

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Liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine Karvellas David L.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-LatAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of Laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(ALT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower ALT levels(P<0.001,0.007,and 0.031,respectively).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,<0.001,0.003,and 0.043,respectively)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,and<0.001,respectively).Levels of the pro-inflammatory cyto-kines,particularly interleukin(IL)-1β,IL-2,IL-4,IL-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue Liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

Palliative care with adequate pain relief challenges the need for euthanasia legislation

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History & Philosophy of Medicine 2024年第2期6卷 6-13页

作者： renald Blundell Martina cini Kimberley Blundell Department of Physiology and Biochemistry Faculty of Medicine and SurgeryUniversity of MaltaMsida MSD2080Malta Centre for Molecular Medicine and Biobanking University of MaltaMsida MSD2080Malta Faculty of Law University of MaltaMsida MSD2080Malta

Background:In today’s society the ongoing discussion about euthanasia triggers emotionally charged debates surrounding the delicate balance between valuing life and respecting an individual’s *** the persistence of this debate,there has been the emergence of the concept of the so-called alternative:palliative *** as a substitute for euthanasia,palliative care aims to alleviate suffering in terminally ill patients without engaging in the ethical dilemmas associated with ***:This paper explores the facets of palliative care highlighting its core objectives such as providing adequate pain relief as a compassionate alternative to ***:By examining palliative care as a comprehensive approach to end of life support,this study challenges the perceived necessity of euthanasia and advocates,for compassionate and dignified end of life ***:In conclusion,palliative care emerges as a viable and ethically sound alternative to euthanasia,emphasizing the importance of compassionate end-of-life care and pain management.

关键词： palliative care adequate pain relief euthanasia legislation end-of-life care patient-centered care policy development

算法如何重塑劳动力剥削:对平台经济中劳动不可见化过程的审视

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求是学刊 2024年第2期51卷 1-16页

作者： [爱]洛伦佐·西尼刘歆(译) 刘明明(译) 亓为康(译) 都柏林大学商学院《工作、就业和社会》编委会南开大学马克思主义学院天津300350

马克思认为,劳动力在劳动过程中的生产性消费是价值创造的主要来源。资本家试图掩盖并获得工人对生产过程的贡献,而工人力图使他们的贡献得到充分承认。因此,资本与劳动的对抗建立在无酬劳动时间的占有和剥削之上。在当代资本主义社会中... 详细信息

马克思认为,劳动力在劳动过程中的生产性消费是价值创造的主要来源。资本家试图掩盖并获得工人对生产过程的贡献,而工人力图使他们的贡献得到充分承认。因此,资本与劳动的对抗建立在无酬劳动时间的占有和剥削之上。在当代资本主义社会中,这种不可见化过程仍然是一种剩余价值获取的相关方式,尤其是在平台经济中,其特点在于通过算法进行远程但无处不在的控制。重新发现这种剩余价值获取方式及其在平台劳动中的表现,将有助于对工作过程转型和剩余价值创造之间的关系有一个新的认识。

关键词：资本劳动不可见化劳动力劳动时间占有平台工作价值

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抑郁症自杀行为发生机制及预测研究新进展

首都医科大学学报 2024年第1期45卷 88-96页

作者：任艳萍吴涵王雯金文青李人首都医科大学附属北京安定医院国家精神疾病医学中心国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室北京100088 人脑保护高精尖创新中心首都医科大学北京100069

自杀是个体蓄意或自愿采取各种手段结束自己生命的行为。全球年自杀病死率约为16/100000,即每年大约有703000人死于自杀,是人类死亡的首位原因。自杀多发生于精神疾病患者中,最常见的为抑郁症。研究抑郁症自杀行为发生的机制对于制定从... 详细信息

自杀是个体蓄意或自愿采取各种手段结束自己生命的行为。全球年自杀病死率约为16/100000,即每年大约有703000人死于自杀,是人类死亡的首位原因。自杀多发生于精神疾病患者中,最常见的为抑郁症。研究抑郁症自杀行为发生的机制对于制定从自杀意念到自杀行为的预防措施可提供重要的数据支持。自杀行为发生的相关因素包括社会、心理、生物遗传等多种相关因素,本文旨在针对抑郁症自杀行为的生物学机制包括与自杀行为相关的磁共振研究、与自杀行为相关的神经认知研究、机器学习、生态瞬时评价及数字表型研究进展进行综述,以期为开发自杀风险早期识别指标提供借鉴。

关键词：自杀行为抑郁机制

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Troubleshooting of reinterventions after stent-by-stent placement for malignant hilar biliary obstruction(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 500-502页

作者： Tadahisa Inoue rena Kitano Masashi Yoneda Department of Gastroenterology Aichi Medical University1-1 YazakokarimataNagakuteAichi 480-1195Japan

To the Editor:Biliary drainage is essential for controlling cholangitis and/or jaundice in patients with malignant hilar biliary obstruction,and endoscopy is the first choice of approach due to its less *** unresectable cases,placement of self-expandable metal stents(SEMSs)has been recommended over that of plastic stents due to their longer patency,and bilateral placement is also recommended to achieve higher clinical success and patency rates[1].

关键词： obstruction malignant stent

Correlation between betatrophin/angiogenin-likeprotein3/lipoprotein lipase pathway and severity of coronary artery disease in Kazakh patients with coronary heart disease

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World Journal of Clinical Cases 2022年第7期10卷 2095-2105页

作者： Lian Qin rena Rehemuding Aikeliyaer Ainiwaer Xiang Ma Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous regionChina

BACKGROUND The results of previous animal experiments and clinical studies have shown that there is a correlation between expression of betatrophin and blood lipid ***,there are still differences studies on the correlation and interaction mechanism between betatrophin,angiogenin-likeprotein3(ANGPTL3)and lipoprotein lipase(LPL).In our previous studies,we found an increase in serum ANGPTL3 Levels in Chinese patients with coronary heart disease(CHD).Therefore,we retrospectively studied Kazakh CHD *** To explore the correlation between the betatrophin/ANGPTL3/LPL pathway and severity of coronary artery disease(CAD)in patients with *** Nondiabetic patients diagnosed with CHD were selected as the case group;79 were of Kazakh descent and 72 were of Han *** control groups comprised of 61 Kazakh and 65 Han *** serum levels of betatrophin and LPL were detected by enzyme-linked immunosorbent assay(ELISA),and the double antibody sandwich ELISA was used to detect serum level of *** levels of triglycerides,total cholesterol,and fasting blood glucose in each group were determined by an automatic biochemical *** the same time,the clinical baseline data of patients in each group were *** Betatrophin,ANGPTL3 and LPL levels of Kazakh patients were significantly higher than those of Han patients(P=0.031,0.038,0.021 respectively).There was a positive correlation between the Gensini score and total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),betatrophin,and LPL in Kazakh patients(r=0.204,0.453,0.352,0.471,and 0.382 respectively),(P=0.043,0.009,0.048,0.001,and P<0.001 respectively).A positive correlation was found between the Gensini score and body mass index(BMI),TC,TG,LDL-C,LPL,betatrophin in Han patients(r=0.438,0.195,0.296,0.357,0.328,and 0.446 respectively),(P=0.044,0.026,0.003,0.20,0.004,and P<0.001).TG and betatrophin were the risk factors of coronary artery disease in Kaza

关键词： Betatrophin/angiogenin-likeprotein3/Lipoprotein lipase pathway Coronary heart disease Gensini integral Coronary artery disease

Establishment and development of the World Association for Sedimentation and Erosion Research

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International Journal of Sediment Research 2023年第6期38卷 901-909页

作者： Cheng Liu Zhaoyin Wang des E.Walling International Research and Training Center on Erosion and Sedimentation Department of Hydraulic Engineering Tsinghua University Geography Faculty of EnvironmentScience and EconomyUniversity of Exeter

Problems of soil erosion and sedimentation are issues of global *** the intensification of global change and the impacts of human activities,many countries are facing severe challenges from wideranging sediment-related *** prevention and control of sediment disasters and the rational use of soil and sediment resources are important requirements for the sustainable development strategies of all *** sediment problems are closely related to social,economic,and other human activities,the effective solution of sediment problems requires the concerted efforts of experts in different fields and thus an interdisciplinary approach is *** view of the increasing recognition of sediment as a topic of global significance and the need to promote interdisciplinary research in this field,the World Association for Sedimentation and Erosion Research(WASER) was inaugurated in *** this paper the history of the establishment of WASER is reviewed and its main activities are briefly *** series of International Symposia on River Sedimentation(ISRS) has served as the official symposium of WASER since *** triennial technical events have been held in China,Russia,Japan,South Africa,and Germany with about 2,000 *** addition to sponsoring the ISRS,WASER has to date also sponsored/organized or co-sponsored/co-organized over 30 other international conferences,workshops,training courses,and study tours besides sponsoring the *** adoption of the International Journal of Sediment Research(IJSR) as the official journal of WASER in 2004has also played an important role in increasing the exposure of the *** activities have served to raise WASER’s profile as well as promoting collaboration with agencies and other organizations working in the field of erosion and *** types of prizes and honors are awarded by *** include the International Qian Ning Prize for Erosion and Sedimentation Technolog

关键词： Erosion and sedimentation Association Symposia Journal

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala Kimberley Amanda K.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo Michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim rena Ivy Bascuna Rachel M.Ng Kevin B.Agsaoay Kris Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(P<0.02)and those from the Visayas(P<0.003).Based on the International Retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

NIHSS评分及肺部感染预测缺血性脑卒中晚期癫痫发作的价值评估

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脑与神经疾病杂志 2024年第8期32卷 518-522页

作者：焦腾飞肖书玲杨晶热娜·阿不都萨拉木韩登峰新疆医科大学第一附属医院神经内科乌鲁木齐830054 南阳市第二人民医院神经内科

目的分析缺血性脑卒中(IS)患者晚期癫痫发作的危险因素,并评估其预测价值。方法收集776例IS患者,根据是否出现晚期癫痫发作(LS),分为癫痫发作组28例(3.6%)和非癫痫发作组748例(96.4%),比较两组患者的一般临床信息资料、实验室检查及影... 详细信息

目的分析缺血性脑卒中(IS)患者晚期癫痫发作的危险因素,并评估其预测价值。方法收集776例IS患者,根据是否出现晚期癫痫发作(LS),分为癫痫发作组28例(3.6%)和非癫痫发作组748例(96.4%),比较两组患者的一般临床信息资料、实验室检查及影像学资料。采用单、多因素Logistic回归分析IS晚期癫痫发作的独立危险因素,并通过受试者工作曲线(ROC)评估其预测价值。结果776例IS患者的年龄为(62.0±13.6)岁;与非癫痫发作组相比,癫痫发作组患者的NIHSS评分、脑皮质受累、动脉循环受累、肺部感染、血钠水平方面,比较差异均有统计学意义(^(均)P6.5分是预测IS患者晚期癫痫发作的最佳临界值。结论NIHSS评分>6.5分和伴有肺部感染是IS患者晚期癫痫发作的独立危险因素,两项指标联合可较好的预测患者的晚期癫痫发作状况。

关键词：缺血性脑卒中晚期癫痫发作 NIHSS评分肺部感染联合指标