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Chinese Chemical Letters 2006年第10期17卷 1365-1368页

作者： Jian XU Zhi Lan LIU ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel biodegradable copolymer poly（CC-co-EEP） was synthesized by ring-opening copolymerization of cyclic carbonate 9-phenyl-2, 4, 8, 10-tetraoxaspiro-[5, 5]undcane-3-one （CC） and ethylene ethyl phosphate （EEP）. The obtained poly （CC-co-EEP）s were characterized by FTIR, ^1H NMR, ^13C NMR and gel permeation chromatography （GPC）. In vitro hydrolytic degradation of the copolymers were investigated in phosphate buffer solution （pH=7.4）. Hydrophilic phosphate units apparently improved the degradability of poly（carbonate-phosphate）.

关键词： Poly(carbonate-phosphate) ring-opening copolymerization biodegradable polymers.

Synthesis and Properties of IPN Hydrogels Based on Konjac Glucomannan and Poly(acrylic acid)

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Chinese Chemical Letters 2006年第10期17卷 1377-1380页

作者： Bing LIU Zhi Lan LIU ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel interpenetrating polymer network （IPN） hydrogels based on konjac glucomannan （KGM） and poly（acrylic acid）（PAA） were prepared by polymerization and cross-linking of acrylic acid （AA） in the pre-fabricated KGM gel. The IPN gel was analyzed by FF-IR. The studies on the equilibrium swelling ratio of IPN hydrogels revealed their sensitive response to environmental pH value. The results of in vitro degradation showed that the IPN hydrogels retain the enzymatic degradation character of KGM.

关键词： Hydrogel interpenetrating polymer network pH-sensitivity konjac glucomannan poly(acrylic acid).

Synthesis and Characterization of Amphiphific Block Copolymer Containing PVP and Poly（5-benzyloxytrimethylene carbonate）

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Chinese Chemical Letters 2006年第2期17卷 239-242页

作者： Ying xia WANG Feng HE ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Amphiphilic copolymer of 5-benzyloxytrimethylene carbonate （BTMC） with poly （vinyl pyrrolidone）（PVP） was successfully synthesized using immobilized porcine pancreas lipase （IPPL） or SnOct2 as catalyst. Hydroxyl terminated PVP, synthesized with 2-mercaptoethanol as a chain transfer reagent, was employed as a rnacroinitiator. The resulting copolymers were characterized by GPC, ^1H NMR and IR. Increasing the BTMC/PVP-OH feed ratio （[B]/[P]） resulted in the increase of Mn of corresponding copolymers and the decrease of Mw/Mn. Immobilized enzyme has comparable catalytic activity to SnOct2 for the copolymerization.

关键词： Amphiphilic copolymer end-functionalized PVP 5-benzyloxytrimethylene carbonate,immobilized enzyme ring-opening polymerization macroinitiator.

A BIOREDUCIBLE POLYPEPTIDE FOR EFFICIENT GENE TRANSFECTION BOTH IN VITRO AND IN VIVO

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Chinese Journal of Polymer Science 2013年第5期31卷 713-713,714-718页

作者： Wei Qu Si Chen Shan ren Xue-jun Jiang ren-xi zhuo 张先正 Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Department of Cardiology Renmin Hospital of Wuhan University

A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obtained PolyK6-Rs was 9：1, and PolyK6-R8 could combine DNA compactly when weight ratio reached 5. Through in vitro investigation, it was found that PolyK6-R8 was an efficient gene vector with low cytotoxicity for delivering DNA in both COS-7 and HeLa cells. Cellular uptake of DNA mediated by PolyK6-R8/DNA complexes was promoted after incubation for 4 h. Moreover, by examining the histological sections of hindlimb ischemia rats through immunohistochemistry, PolyK6- R8/VEGF complexes were proved to be effective in both VEGF protein expression and succeeding vessel formation. The results indicated that polypeptide-based PolyK6-R8 is a promising gene vector for the limb ischemia treatment.

关键词： Gene vector Polypeptide Angiogenesis Limb ischemia.

Multi-drug loaded vitamin E-TPGS nanoparticles for synergistic drug delivery to overcome drug resistance in tumor treatment

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Science Bulletin 2016年第15期61卷 552-560页

作者： Bo-Ya Liu Cong Wu xiao-Yan He ren-xi zhuo Si-Xue Cheng Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University

A facile self-assembly strategy to labricate vitamin E-tocopheryl polyethylene glycol succinate （TPGS） based nanoparticles with a high drug loading level for co-delivery of multiple drugs was developed. To overcome multi-drug resistance, a chemotherapeutic agent （paclitaxel, PTX） and a drug resistance inhibitor （tariq- uidar, TQR） were co-loaded in the vitamin E-TPGS based nanoparticle to obtain TPGS/PTX/TQR nanoparticles. The sizes of mono-drug loaded TPGS/PTX nanoparticles and dual-drug loaded TPGS/PTX/TQR nanoparticles were below 150 nm with relatively narrow size distributions. The efficiencies of the drug delivery systems on tumor cells inhibition and reversal of drug resistance were evaluated in drug resistant cancer cells （MCF-7/ADR） as compared with nonresistant cells （HeLa）. Due to the effective inhibition of the P-gp efflux by TQR, the dual-drug loaded nanoparticles exhibited significantly improved tumor cell inhibitory efficiency. To study the immunostimulatory effect, the effect of the drug delivery system on the production of IL- 10, a cytokine related to tumor development, in the drug resistant cells was determined. After the treatment by the drug delivery systems, the concentration of IL-10 in the cell supernatant decreased. The multi-drug loaded vitamin E-TPGS nanoparticles for synergistic drug delivery have promising applications in reversal of drug resistance in tumor treatments.

关键词： Multi-drug resistance Drug delivery Paclitaxel Tariquidar TPGS

Enzymatic Synthesis and Characterization of Novel Polycarbonates Derived from 5-Allyloxy-1, 3-dioxan-2-one and 5, 5-Dimethvl-1.3-dioxan-2-one

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Chinese Chemical Letters 2006年第10期17卷 1385-1387页

作者： Yan Ping WANG Feng HE Gang LIU ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel polycarbonates from 5-allyloxy-1, 3-dioxan-2-one （ATMC） with 5, 5-dimethyl- 1, 3-dioxan-2-one （DTC） were successfully synthesized for the first time using immobilized porcine pancreas lipase （IPPL） as catalyst. The resulting copolymers were characterized by IR, ^1H NMR, ^13C NMR and GPC. The molecular weight （Mn） of the copolymer with molar feed ratio of 10：90 （ATMC：DTC） was 9300 and the polydispersity was 1.31, while the Mn increased to 14300 and polydispersity of 1.25 with the feed ratio of 50：50. Moreover, the composition of the copolymers agreed well with the monomer feed.

关键词： 5-Allyloxy-1 3-dioxan-2-one 5 5-dimethyl-1 3-dioxan-2-one enzyme-catalyzed ring opening polymerization polycarbonates.

Enzymatic Synthesis and Characterization of Novel Amphiphilic Triblock Copolymer Poly(p-dioxanone-co-5-benzyloxytrimethylene carbonate)-block-poly(ethylene glycol)

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Chinese Chemical Letters 2006年第8期17卷 1113-1116页

作者： Hua Li JIA Feng HE Jun FENG ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

Novel amphiphilic triblock copolymer poly（p-dioxanone-co-5-benzyloxytrimethylene carbonate）-block-poly（ethylene glycol）-block-poly（p-dioxanone-co-5-benzyloxytrimethylene carbonate）（p（PDO-co-BTMC）-b-PEG-b-p（PDO-co-BTMC）） was successfully synthesized using immobilized porcine pancreas lipase on porous silica particles （IPPL） as the catalyst for the fLrSt time. 1H NMR, 13C NMR and GPC analysis were used to confirm the structures of resulting copolymers. The molecular weight （Mn） of the copolymer with feed ratio of 69：20：11 （BTMC： PDO： PEG ） was 31300 g/mol and the polydispersity was 1.85, while the Mn decreased to 25000 g/mol and polydispersity of 1.93 with the feed ratio of 50：40：10.

关键词： Amphiphilic copolymer poly(ethylene glycol) 5-benzyloxytrimethylene carbonate,p-dioxanone enzymatic polymerization.

Metal-free synthesis of amphiphilic functional polycarbonates

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Chinese Chemical Letters 2007年第12期18卷 1528-1530页

作者： Ying xia Wang Jun Feng Feng He ren xi zhuo Key Laboratory of Eco-textiles （Jiangnan University） Ministry of Education Wuxi 214122 China Department of Chemistry Key Laboratory of Biomedical Polymers of Ministry of Education Wuhan University Wuhan 430072 China

Amphiphilic block copolymers of poly（5-benzyloxy trimethylene carbonate）（PBTMC） and poly（ethylene glycol）（PEG） were synthesized through enzymatic polymerization using immobilized porcine pancreas lipase （IPPL）. The obtained copolymers with different compositions were characterized by GPC and IH NMR. The copolymer composition was in agreement with the feed ratio. The molecular weight of the copolymers showed an increasing trend with the decrease of PEG contents. MiceUes of the copolymers were formed by dialysis procedure, and characterized by transmission electron microscopy （TEM）.

关键词： Amphiphilic block copolymer Enzymatic polymerization Polycarbonate

The Cycloaddition Reaction of Lawesson's Reagent with 1,3-Dienes

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Chinese Chemical Letters 1997年第8期8卷 655-656页

作者： Liang Nian HE ren xi zhuo(Department of Chemistry,Wuhan University,Wuhan, 430072) Department of Chemistry Wuhan University Wuhan 430072 China

Lawesson's reagent undergoes [2 + 4] cycloaddition reaction with 2-methyl-1, 3-butadiene,cyclopentadiene to yield heterocycles 4 and 5, respectively.

关键词： meta OCH The Cycloaddition Reaction of Lawesson’s Reagent with 1,3-Dienes

Synthesis and Characterization of Novel Aliphatic Polycarbonates Bearing Pendant Allyl Ether Groups

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Chinese Chemical Letters 2006年第1期17卷 137-139页

作者： Gang LIU Feng HE Yah Ping WANG Jun FENG ren xi zhuo Key Laboratory of Biomedical Polymers of Ministry of Education Department of Chemistry Wuhan University Wuhan 430072

A new six-membered cyclic carbonate monomer, 5-allyloxytrimethylene carbonate （ATMC）, was synthesized starting from glycerol, and the corresponding polycarbonates, poly（5-allyloxytrimethylene carbonate）（PATMC） were further synthesized by ring-opening polymerization in bulk at 150℃ using stannous octanoate as an initiator. The structures of the monomer and the polymers were confirmed by IR, IH-NMR, 13C-NMR, and GPC analysis.

关键词： 5-Allyloxytrmethylene carbonate poly(5-allyloxytrimethylene carbonate) ring-opening polymerization polycarbonate allyl ether.