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RIPK1 plays a crucial role in maintaining regulatory T-Cell homeostasis by inhibiting both RIPK3-and FADD-mediated cell death

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Cellular & Molecular Immunology 2024年第1期21卷 80-90页

作者： Xiaoxue Deng Lingxia Wang Yunze zhai Qiuyue Liu Fengxue Du Yu Zhang Wenxing Zhao Tingtao Wu Yiwen Tao Jie Deng Yongbing Cao Pei Hao Jiazi ren Yunli Shen Zuoren Yu Yuejuan Zheng Haibing Zhang Haikun Wang State Key Laboratory of Cardiology Shanghai East HospitalTongji University School of MedicineShanghai200120China CAS Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and InfectionChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200031China The Research Center for Traditional Chinese Medicine Shanghai Institute of Infectious Diseases and BiosecurityShanghai University of Traditional Chinese MedicineShanghai201203China Institute of Vascular Disease Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200433China

Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological ***,the mechanisms underlying T_(reg)homeostasis remain incompletely ***,we report that RIPK1 is crucial for T_(reg) cell survival and *** generated mice with T_(reg) cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell *** conventional T cells,Treg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent ***,simultaneous removal of both Fadd and Ripk3 completely restored the homeostasis of Ripk1-deficient Treg cells by blocking two cell death ***,our study highlights the critical role of RIPK1 in regulating Treg cell homeostasis by controlling both apoptosis and necroptosis,thereby providing novel insights into the mechanisms of Treg cell homeostasis.

关键词： Treg cell Homeostasis Apoptosis Necroptosis

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Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 765-779页

作者： Zi-Yuan Zou Tian-Yi ren Jia-Qi Li Ting-Ying Jiao Meng-Yu Wang Lei-Jie Huang shuang-Zhe Lin Yuan-Yang Wang Xiao-Zhen Guo Ye-Yu Song Rui-Xu Yang Cen Xie Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Human Phenome Institute School of Life SciencesFudan UniversityShanghaiChina Department of Gastroenterology Ningbo No.2 HospitalNingboZhejiangChina Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition ShanghaiChina

Background and Aims:Metabolic dysfunction-associated steatotic liver disease(MASLD)and its more advanced form,metabolic dysfunction-associated steatohepatitis,have emerged as the most prevalent liver diseases ***,lifestyle modification is the foremost guidelinerecommended management strategy for ***,it remains unclear which detrimental signals persist in MASLD even after disease ***,we aimed to examine the persistent changes in liver transcriptomic profiles following this ***:Male C57BL/6J mice were divided into three groups:Western diet(WD)feeding,chow diet(CD)feeding,or diet reversal from WD to *** 16 weeks of feeding,RNA sequencing was performed on the mice’s livers to identify persistent alterations characteristic of ***,RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were ***:WD-induced MASLD triggered persistent activation of the DNA damage response(DDR)and its primary transcription factor,P53,long after the resolution of the hepatic phenotype through dietary *** levels of P53 might promote apoptosis,thereby exacerbating metabolic dysfunction-associated steatohepatitis,as they strongly correlated with hepatocyte ballooning,an indicator of apoptosis ***,P53 knockout in mice led to downregulated expression of apoptosis signaling in the ***,P53 may regulate apoptosis by transcriptionally activating the expression of apoptosis-enhancing nuclease(AEN).Consistently,P53,AEN,and the apoptosis process all exhibited persistently elevated expression and showed a strong inter-correlation in the liver following dietary ***:The liver demonstrated upregulation of DDR signaling and the P53-AEN-apoptosis axis both during and after exposure to *** findings provide new insights into the mechanisms of MASLD relapse,highlighting DDR signaling as a promising target to prevent MASLD recu

关键词： Apoptosis DNA Damage Metabolic dysfunction-associated steatotic liver disease RNA-Seq Tumor suppressor protein P53 Western Diets

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Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury

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Chinese Journal of Traumatology 2024年第2期27卷 97-106页

作者： Peng Qi Meng-Jie Huang Wei Wu Xue-Wen ren Yong-Zhi zhai Chen Qiu Hai-Yan Zhu Department of Emergency First Medical Center of Chinese PLA General HospitalBeijing100853China Department of Nephrology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Anesthesiology.First Medical Center of Chinese PLA General Hospital Beijing100853China Department of Orthopedics Fourth Medical Center of Chinese PLA General HospitalBeijing100853China

Purpose:Acute kidney injury(AKI)is one of the most common functional injuries observed in trauma ***,certain trauma medications may exacerbate renal ***,the early detection of trauma-related AKI holds paramount importance in improving trauma ***:Qualified datasets were selected from public databases,and common differentially expressed genes related to trauma-induced AKI and hub genes were identified through enrichment analysis and the establishment of protein-protein interaction(PPI)***,the specificity of these hub genes was investigated using the sepsis dataset and conducted a comprehensive literature review to assess their *** raw data from both datasets were downloaded using R software(version 4.2.1)and processed with the"affy"package19 for correction and ***:Our analysis revealed 585 upregulated and 629 downregulated differentially expressed genes in the AKI dataset,along with 586 upregulated and 948 downregulated differentially expressed genes in the trauma ***,the establishment of the PPI network and subsequent topological analysis highlighted key hub genes,including CD44,CD163,TIMP metallopeptidase inhibitor 1,cytochrome b-245 beta chain,versican,membrane spanning 4-domains A4A,mitogen-activated protein kinase 14,and early growth response ***,their receiver operating characteristic curves displayed areas exceeding 75%,indicating good diagnostic ***,our findings postulated a unique molecular mechanism underlying trauma-related ***:This study presents an alternative strategy for the early diagnosis and treatment of trauma-related AKI,based on the identification of potential biomarkers and therapeutic ***,this study provides theoretical references for elucidating the mechanisms of trauma-related AKI.

关键词： Trauma Acutekidney injury Bioinformatic analysis Differentially expressed genes Biomarker

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Effect of Chinese Medicine in Patients with COVID-19: A Multi-center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第11期30卷 974-983页

作者： ZHAO Guo-zhen YAN Shi-yan LI Bo GUO Yu-hong SONG shuang HU Ya-hui GUO Shi-qi HU Jing DU Yuan LU Hai-tian YE Hao-ran ren Zhi-ying ZHU Ling-fei XU Xiao-long SU Rui LIU Qing-quan Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine School of Clinical Medicine Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Integrated Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness and safety of Chinese medicine(CM) in the treatment of coronavirus disease 2019(COVID-19) in China. Methods: A multi-center retrospective cohort study was carried out, with cumulative CM treatment period of 3 days during hospitalization as exposure. Data came from consecutive inpatients from December 19, 2019 to May 16, 2020 in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting(IPTW), and the Cox proportional hazards regression model was used for statistical analysis. Results:A total of 2,272 COVID-19 patients were included. There were 1,684 patients in the CM group and 588 patients in the control group. Compared with the control group, the hazard ratio(HR) for the deterioration rate in the CM group was 0.52 [95% confidence interval(CI): 0.41 to 0.64, Prenal function in the CM group was smaller. Conclusion: This real-world study indicates that the combination of a full-course CM therapy on the basic conventional treatment, may safely reduce the deterioration rate and all-cause mortality of COVID-19patients. This result can provide the new evidence to support the current treatment of COVID-19. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific CM interventions.(Registration No. ChiCTR2200062917)

关键词： Chinese medicine all-cause mortality cohort study coronavirus disease 2019 deterioration rate

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Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

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Biosafety and Health 2024年第1期6卷 12-20页

作者： shuang Zhao Amelia Siqi Huang Weibo Zhang Lili ren Hexiang Wang Jianbin Wang Xinyang Shao Guanbo Wang Institute of Agri-Food Processing and Nutrition Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBejing 100097China Bejing Key Laboratory of Fruits and Vegetable Storage and Processing Key Laboratory of Vegetable Postharvest ProcessingMinistry of AgricultureBejing 100097China Dalton Academy The Affliated High School of Peking UniversityBeijing 100190China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory National Institute of Pathogen BiologyBejing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China College of Biological Sciences China Agricultural UniversityBejing 100193China School of Life Sciences Tsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518132China

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health *** addition to physical preventative measures,pharmaceutical intervention is also *** natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other *** this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral *** this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction *** assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in *** charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue *** findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

关键词： Medicinal fungi Natural products Antiviral activity COVID‐19 Polysaccharides

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前交叉韧带断裂及重建术后步态生物力学特征研究现状

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北京大学学报（自然科学版） 2024年第2期60卷 377-392页

作者：陆逸群吴悦刘振龙任爽北京大学第三医院运动医学科北京大学运动医学研究所运动医学关节伤病北京市重点实验室运动创伤治疗技术与器械教育部工程研究中心北京100191 天津体育学院天津301617

对前交叉韧带(ACL)断裂及重建术后躯干、髋、膝和踝关节在不同运动平面的步态生物力学特征及康复治疗措施的研究现状进行综述,得到如下结论。ACL断裂及重建术后各关节步态的生物力学出现异常,其中膝关节步态生物力学异常在3个运动平面... 详细信息

对前交叉韧带(ACL)断裂及重建术后躯干、髋、膝和踝关节在不同运动平面的步态生物力学特征及康复治疗措施的研究现状进行综述,得到如下结论。ACL断裂及重建术后各关节步态的生物力学出现异常,其中膝关节步态生物力学异常在3个运动平面均有体现,踝关节的异常集中在矢状面,髋关节及躯干的异常多见于冠状面。根据各关节生物力学特征及ACL断裂和术后时期的不同,需制定针对性且长期的康复治疗方案;目前常规的康复训练不能完全恢复ACL断裂重建患者的正常步态,还需加入神经肌肉控制训练和躯干-髋-膝-踝的整体康复训练。

关键词：前交叉韧带(ACL) 步态生物力学康复训练

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数字乡村建设对浙江省山区26县林业产业发展升级的影响

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林业科学 2024年第5期60卷 67-88页

作者：徐彩瑶任燕翟郡孔凡斌浙江农林大学浙江省乡村振兴研究院/“千万工程”研究院杭州311300 浙江农林大学经济管理学院杭州311300 南京林业大学数字林业与绿色发展研究院/经济管理学院南京210037

[目的]在加快推进数字经济与实体经济深度融合赋能现代产业体系的背景下,研究数字乡村建设对林业产业发展升级的影响机制,为森林资源富集地区制定数字赋能林业产业高质量发展的政策策略提供科学依据。[方法]基于浙江省山区26县2001—202... 详细信息

[目的]在加快推进数字经济与实体经济深度融合赋能现代产业体系的背景下,研究数字乡村建设对林业产业发展升级的影响机制,为森林资源富集地区制定数字赋能林业产业高质量发展的政策策略提供科学依据。[方法]基于浙江省山区26县2001—2021年面板数据,构建县域数字乡村建设水平评价指标体系测度数字乡村建设水平,采用双向固定效应模型、中介效应模型、门槛效应模型和空间杜宾模型等量化分析数字乡村建设对林业产业发展升级的影响及其作用机制。[结果]1) 2001—2021年浙江省山区26县数字乡村建设水平呈增长态势,其中跨越发展县的数字乡村建设水平高于生态发展县;林业产业发展规模不断扩大,但区域间差异明显且两极分化较严重;林业产业结构合理化程度小幅上升,林业产业结构高级化程度波动上升。2)数字乡村建设能够促进林业产业发展升级,即数字乡村建设对林业产业发展规模、林业产业结构合理化和林业产业高级化均产生显著正向影响;数字乡村建设对林业产业结构合理化和林业产业结构高级化的影响存在门槛效应。3)数字乡村建设能够通过技术赋能、劳动力赋能和治理赋能等路径促进林业产业发展升级。4)数字乡村建设对林业产业发展升级存在正向空间溢出效应;数字乡村建设能够显著促进本地区林业产业发展规模、林业产业结构合理化和林业产业结构高级化,同时对邻近地区的林业产业发展规模、林业产业结构合理化和林业产业结构高级化产生显著正向影响。[结论]2001—2021年浙江省山区26县数字乡村建设水平不断提高,林业产业发展升级状况向好,技术应用水平、人力资本水平和森林生态产品价值实现效率等因素在不同程度上影响数字乡村建设、促进林业产业发展。各县域单元需加快推进数字乡村建设,从创新技术运用、大力引进人才、提升林业部门生态治理能力和林业企业经营管理水平以及培育林业龙头企业并发挥辐射带动作用等方面发力,因地制宜,分类施策,推动山区县林业产业发展升级,打造数字赋能现代林业产业高质量发展的示范样板。

关键词：数字乡村建设林业产业发展产业结构合理化产业结构高级化浙江省

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半干旱草原露天矿区生态累积效应:评估模型与应用

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煤炭学报 2024年第7期49卷 3199-3215页

作者：梁佳欣李晶殷守强任河蒋斋中国矿业大学(北京)地球科学与测绘工程学院北京100083

为揭示半干旱草原露天矿区生态环境质量状况,分离矿区人类活动生态累积效应并识别其演变态势,在厘清矿区生态累积效应概念的基础上,构建适用于半干旱草原的露天矿区生态环境质量评估指数(Surface Mining Areas Eco-environmental Evalua... 详细信息

为揭示半干旱草原露天矿区生态环境质量状况,分离矿区人类活动生态累积效应并识别其演变态势,在厘清矿区生态累积效应概念的基础上,构建适用于半干旱草原的露天矿区生态环境质量评估指数(Surface Mining Areas Eco-environmental Evaluation Index,SMAEEI)以及矿区生态累积效应定量评估模型。选取内蒙古胜利矿区为研究区,量化分析1986—2020年区域生态环境质量和生态累积效应的时空分布规律,以及主要人类活动的生态累积效应差异。结果表明:①SMAEEI适用于半干旱草原露天矿区,能客观呈现各地类生态环境质量高低顺序。35 a间研究区生态环境质量呈极显著下降趋势,且其空间差异显著减弱。露天矿场、城镇扩张区、锡林河湿地及北侧草地生态环境质量出现极显著、显著的退化趋势。②半干旱草原露天矿区生态累积效应定量评估模型能剔除气候因素对生态系统的耦合影响,分离并量化人类活动对矿区生态系统的累积效应,揭示累积的方向、程度和空间范围。35 a间研究区生态服务价值累积量(Change of Ecosystem Service Value Cumulant,COESVC)共减少1186157.03万元,出现负向生态累积效应,生态系统服务功能下降。高度、中度负向累积区集中在湿地和草地退化区、城镇区、露天矿场。③露天开采、城镇建设造成的单位面积负向生态累积效应最明显,前者在单位时间内带来的负向累积变化最剧烈,后者负向累积效应的局部影响程度和偏离度最大;放牧活动引起的负向生态累积效应影响范围最广、总量最大,但局部影响程度最小,生态系统服务功能较其余人类活动更稳定。研究成果可将矿区人类活动引起的生态环境实物量变动转化为价值量描述,为采用货币形式测算矿区生产生活行为的环境损害成本提供可行方法。

关键词：生态累积效应半干旱草原露天矿区生态环境质量评估指数生态服务价值内蒙古胜利矿区

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OsPRMT6a-mediated arginine methylation of OsJAZ1 regulates jasmonate signaling and spikelet development in rice

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Molecular Plant 2024年第6期17卷 900-919页

作者： Kun Dong Fuqing Wu Siqi Cheng Shuai Li Feng Zhang Xinxin Xing Xin Jin Sheng Luo Miao Feng Rong Miao Yanqi Chang shuang Zhang Xiaoman You Peiran Wang Xin Zhang Cailin Lei Yulong ren Shanshan Zhu Xiuping Guo Chuanyin Wu Dong-Lei Yang Qibing Lin Zhijun Cheng Jianmin Wan State Key Laboratory of Crop Gene Resources and Breeding National Key Facility for Crop Gene Resources and Genetic ImprovementInstitute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory for Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095China

Although both protein arginine methylation(PRMT)and jasmonate(JA)signaling are crucial for regulating plant development,the relationship between these processes in the control of spikelet development remains *** this study,we used the CRISPR/Cas9 technology to generate two OsPRMT6a loss-of-function mutants that exhibit various abnormal spikelet ***,we found that OsPRMT6a can methylate arginine residues in JA signal repressors OsJAZ1 and *** showed that arginine methylation of OsJAZ1 enhances the binding affinity of OsJAZ1 with the JA receptors OsCOI1a and OsCOI1b in the presence of JAs,thereby promoting the ubiquitination of OsJAZ1 by the SCF^(OsCOI1a/OsCOI1b) complex and degradation via the 26S *** process ultimately releases OsMYC2,a core transcriptional regulator in the JA signaling pathway,to activate or repress JA-responsive genes,thereby maintaining normal plant(spikelet)***,in the osprmt6a-1 mutant,reduced arginine methylation of OsJAZ1 impaires the interaction between OsJAZ1 and OsCOI1a/OsCOI1b in the presence of *** a result,OsJAZ1 proteins become more stable,repressing JA responses,thus causing the formation of abnormal spikelet ***,we discovered that JA signaling reduces the OsPRMT6a mRNA level in an OsMYC2-dependent manner,thereby establishing a negative feedback loop to balance JA *** further found that OsPRMT6a-mediated arginine methylation of OsJAZ1 likely serves as a switch to tune JA signaling to maintain normal spikelet development under harsh environmental conditions such as high ***,our study establishes a direct molecular link between arginine methylation and JA signaling in rice.

关键词： protein arginine methylation jasmonate signaling negative feedback loop spikelet development adaptation to heat stress rice

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教师社会情感能力评估研究述评

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中国考试 2024年第3期 63-71页

作者：黄爽翟鑫宇王可意首都师范大学北京100048

教师社会情感能力是影响学校社会情感学习的关键因素,如何有效评估教师的社会情感能力是教师教育中的重要问题。通过对国内外有关教师社会情感能力评估的研究进行梳理分析发现,教师社会情感能力的评估模型主要以国外的概念框架和理论模... 详细信息

教师社会情感能力是影响学校社会情感学习的关键因素,如何有效评估教师的社会情感能力是教师教育中的重要问题。通过对国内外有关教师社会情感能力评估的研究进行梳理分析发现,教师社会情感能力的评估模型主要以国外的概念框架和理论模型为基础,主要包括情绪智力模型、情绪调节模型和CASEL模型三大类别;评估工具可分为情绪智力的评估工具、社会情感能力的专门评估工具和组合的评估工具;评估方法可分为自我报告、表现测量和情境判断测验三种。未来应注重推动教师社会情感能力本土化评估模型的构建,加强情境判断测验的研究,拓展教师社会情感能力评估工具的应用研究。

关键词：教师社会情感能力社会情感学习教师评估教育评价改革

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