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Comparison of neutron energy spectrum unfolding methods and evaluation of rationality criteria

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Nuclear Science and Techniques 2022年第12期33卷 159-172页

作者： Jun‑Kai Yang Ping‑Quan wang Zhong‑Guo ren ren‑sheng wang Hui Zhang Jian Zhang National Institute of Metrology Beijing 100029China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang 621900China School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China

The neutron energy spectrum was measured using a Bonner sphere spectrometer at six locations inside the containment vessel of a nuclear reactor at the Qinshan nuclear power plant. The structures of the neutron spectra obtained by the maximum entropy, iteration, and genetic algorithm methods were consistent with one another and could be interpreted as the spectral superposition of different energy regions. The characteristic parameters of the neutron spectrum, including the fluence rate,average energy, and neutron ambient dose equivalent rate H^(*)(10), were in good agreement among the three methods. In addition, an LB6411 neutron ambient dose equivalent meter was employed to obtain the H^(*)(10) directly for *** findings indicate that neutron spectrum unfolding methods can be used to overcome the problems associated with the response functions of dosimeters to provide more accurate H^(*)(10) values. In this study, the following three evaluation criteria were systematically addressed to ensure the accuracy of the unfolded spectra: count rates of the inverse solutions,neutron spectrum structures, and comparison of key parameters.

关键词： Neutron spectrum ̇H∗(10) Nuclear power plant Evaluation criteria

Performance of a plastic scintillation fiber dosimeter based on different photoelectric devices

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Nuclear Science and Techniques 2021年第11期32卷 25-31页

作者： Yue Yang Cui-Ping Yang Jie Xin Hai-Feng Chen Zhong-Xu Xing Wei-Wei Qu Liang Hu Xin-Jian Chen ren-sheng wang State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China renji Hospital Affiliated with the Shanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Ninth People’s Hospital Affiliated with the Shanghai Jiao Tong University School of MedicineShanghai 200127China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou 215123China

The photoelectric device of a scintillation dosimeter converts photons produced by radiation into an electrical *** features directly determine the overall performance of the *** a plastic scintillation fiber dosimeter(PSFD)with a current readout mode,systematic studies of the stability and light-dose response were performed for the photomultiplier tube(PMT),silicon photomultiplier(SiPM),avalanche photodiode(APD),and photodiode(PD).The temperature stability,long-term stability,repeatability,signal-to-noise ratio(SNR),and current dose response of the PSFD with the abovementioned photoelectric devices were studied using a pulsed LED light source and the Small Animal Radiation Therapy *** exponential relationship between the dark/ne current and temperature was obtained for all the devices.I is shown that the APD is the most sensitive device to temperature,with a current dependence on temperature reaching 6.5%C^(-1)at room temperature,whereas for the other devices this dependence is alwaysrent of PD can change by up to 4%when working continuously for 8 h and 2%when working intermittently for 32 h,whereas for the other devices,the changes are allrent readout mode,the performance of the PMT and SiPM is concluded to be better than that of the other devices in the *** particular,the SiPM,which has a compact size,low bias voltage,and antimagnetic interference,has great advantages for further applications.

关键词： Photoelectric device Plastic scintillation fiber dosimeter(PSFD) Current readout Dose response

MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu Shen Yong Zhang Fang Wu Mei-Zhen Shen Jun-Lin Liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li ren-sheng wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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欧洲中世纪体育的价值断层与意识绵延

体育文化导刊 2018年第3期 139-143页

作者：刘仁盛王冬悦辽宁师范大学体育学院辽宁大连116029

从柏格森生命哲学中"绵延"理念视角,对中世纪体育及其价值进行剖析。认为:早期政治与文化思潮的出现,致使欧洲中世纪体育观发生了转变,从古希腊传承下来的自然价值、人本价值和社会价值出现断层,而以骑士体育为主、市民体育以及教士体... 详细信息

从柏格森生命哲学中"绵延"理念视角,对中世纪体育及其价值进行剖析。认为:早期政治与文化思潮的出现,致使欧洲中世纪体育观发生了转变,从古希腊传承下来的自然价值、人本价值和社会价值出现断层,而以骑士体育为主、市民体育以及教士体育为辅的多元化体育的出现,又证明体育意识在断层中维系着某种意识绵延。这揭示出,无论宗教还是政治等外在的强制控制与干扰,都不能泯灭人们内在体育意识的绵延,这种绵延是与生俱来的需求,是体育内在的根本动力,寻求意识绵延的冲动和内在需求的满足,便是寻求体育之于人的价值。

关键词：体育史体育价值体育意识中世纪欧洲

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

原发性高血压患者血清C-反应蛋白与心功能的关系

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中国实用内科杂志 2007年第S1期27卷 210-211页

作者：曹桂秋任生生王贵鹏新疆医科大学第五附属医院心内科新疆乌鲁木齐830011 新疆医科大学第五附属医院老年病科新疆乌鲁木齐830011

目的探讨血清C-反应蛋白(CRP)与高血压病心功能改变的关系。方法选择2006年3月至2006年10月在新疆医科大学第五附属医院心内科门诊、干部病房门诊或住院的原发性高血压病患者68例,根据心功能情况分为高血压病无心功能障碍组26例、高血... 详细信息

目的探讨血清C-反应蛋白(CRP)与高血压病心功能改变的关系。方法选择2006年3月至2006年10月在新疆医科大学第五附属医院心内科门诊、干部病房门诊或住院的原发性高血压病患者68例,根据心功能情况分为高血压病无心功能障碍组26例、高血压病轻度心功能障碍组22例,及高血压病重度心功能障碍组20例,以免疫比浊法分别测定血清 CRP,同时行心脏彩超测定左室射血分数(LVEF)。选取同期正常健康人30名作为对照。结果高血压病各组 CRP 均较正常对照组增高,其中高血压病重度心功能障碍组血清 CRP 质量浓度较高血压无或轻度心功能障碍组相比增高更为明显(P<0.05)。结论血清 CRP 与高血压病及心功能障碍的发生和程度密切相关。

关键词：高血压 C 反应蛋白心功能障碍

Anatomy of Large Animal Spines and its Comparison to the Human Spine:A Systematic Review

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Anatomy of Large Animal Spines and its Comparison to the Hum...

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

2009年浙江省骨科学学术年会

作者： Department of Orthopaedic Surgery,Second Affiliated Hospital of Wenzhou Medical College Sun-ren sheng Xiang-Yang wang PhD Hua-Zi Xu Wenzhou Medical College Guo-qing Zhu Yi-Fei Zhou

Animal models have been commonly used for in vivo and in vitro spinal ***,the extent to which animal models resemble the human spine has not been well *** conducted a systematic review to compare the morphometric feat...

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： Ling-Long Tang Yu-Pei Chen Chuan-Ben Chen Ming-Yuan Chen Nian-Yong Chen Xiao-Zhong Chen Xiao-Jing Du Wen-Feng Fang Mei Feng Jin Gao Fei Han Xia He Chao-Su Hu De-sheng Hu Guang-Yuan Hu Hao Jiang Wei Jiang Feng Jin Jin-Yi Lang Jin-Gao Li Shao-Jun Lin Xu Liu Qiu-Fang Liu Lin Ma Hai-Qiang Mai Ji-Yong Qin Liang-Fang Shen Ying Sun Pei-Guo wang ren-sheng wang Ruo-Zheng wang Xiao-Shen wang Ying wang Hui Wu Yun-Fei Xia Shao-Wen Xiao Kun-Yu Yang Jun-Lin Yi Xiao-Dong Zhu Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China Department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China Department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China Department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in China and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

东北民猪和长白猪的胴体品质与内脏器官的特点及其遗传方式与杂种优势的研究 Ⅱ.遗传方式与杂种优势

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畜牧兽医学报 1981年第3期 55-62页

作者：许振英陈润生王性善汪嘉燮东北农学院红兴隆农场局科研所

在研究东北民猪和长白猪的胴体性状与内脏器官的品种特征的同时,研究了这两个亲本品种的正、反交杂种一代后裔,以及正、反交杂种一代母猪分别与长白公猪回交所得回交后裔的相应性状,以期查明胴体性状和内脏器官的遗传方式与杂种优势的... 详细信息

在研究东北民猪和长白猪的胴体性状与内脏器官的品种特征的同时,研究了这两个亲本品种的正、反交杂种一代后裔,以及正、反交杂种一代母猪分别与长白公猪回交所得回交后裔的相应性状,以期查明胴体性状和内脏器官的遗传方式与杂种优势的表现。结果表明,东北民猪背膘厚、板油、腹外脂肪和总脂肪的相对重量等标志产脂力的性状呈显性或超显性遗传。杂种后裔在这些性状上呈现高度显著的杂种优势,突破了国外有关文献认为猪胴体性状呈中间型遗传,杂交时不表现杂种优势的结论。研究表明,肉身长、肋骨数和皮肤厚度呈典型的传遗中间型。眼肌面积、腿臀部比例、骨骼和皮肤相对重量基本呈中间型遗传,有时倾向于小值亲本。屠宰率、胸椎数、颈肩胸部和腰部比例、水油相对重量基本呈中间型遗传,有时倾向大值亲本。与脂肪呈强负相关的肌肉相对重量,则始终倾向民猪(小值亲本)该性状的显性遗传。所考察的内脏器官性状基本呈中间遗传,不表现杂种优势。本文是探讨板油等性状的遗传与杂种优势的表现问题。

关键词：杂种优势率东北民猪长白猪兰德瑞斯猪中间型遗传内脏器官遗传方式胴体品质