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新乡师范高等专科学校学报 2004年第4期18卷 52-55页

作者：任太增李刘艳河南师范大学经济管理学院河南新乡453007

从产品销售收入、市场占有率、全员劳动生产率等几个方面．对河南省制造业的现状进行了分析，并对河南省制造业竞争力如何提升提出了一些建议。

关键词：制造业竞争力提升河南市场占有率

帕瑞昔布钠联合右美托咪定对鼻内镜手术苏醒期躁动的影响

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罕少疾病杂志 2023年第2期30卷 24-25页

作者：刘俊波李任增马向阳安阳市第三人民医院麻醉科河南安阳455000

目的探讨帕瑞昔布钠联合右美托咪定对鼻内镜手术苏醒期躁动的影响。方法收集2019年4月至2021年10月在我院进行鼻内镜手术患者98例,采用随机数字表法进行分组,即对照组、观察组,均49例。对照组仅静脉注射右美托咪定(0.5μg/kg),观察组静... 详细信息

目的探讨帕瑞昔布钠联合右美托咪定对鼻内镜手术苏醒期躁动的影响。方法收集2019年4月至2021年10月在我院进行鼻内镜手术患者98例,采用随机数字表法进行分组,即对照组、观察组,均49例。对照组仅静脉注射右美托咪定(0.5μg/kg),观察组静脉注射帕瑞昔布钠(40mg)联合右美托咪定(0.5μg/kg)。对比两组麻醉方案对患者苏醒期躁动的影响。结果两组患者出室时间比较,差异具有统计学意义(P0.05)。两组RSAS评分在T_(1)、T_(2)点比较,差异均无统计学意义(P>0.05),两组VAS评分、VAS评分在术后2h、4h、8h比较,差异具有统计学意义(P0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论帕瑞昔布钠联合右美托咪定应用于鼻内镜手术患者,可以有效降低RSAS评分,且术后早期镇痛效果更优。

关键词：鼻内镜帕瑞昔布钠右美托咪定苏醒期躁动安全性

Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Removal of Methyl Violet from aqueous solutions using poly (acrylic acid-co-acrylamide)/attapulgite composite

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Journal of Environmental Sciences 2010年第1期22卷 7-14页

作者： YongshengWang li zeng Xuefeng ren Hai Song Aiqin Wang Key Laboratory of Resources and Environment Chemistry of West China Hexi University Zhangye 734000 China Center of Eco-Material and Green Chemistry Lanzhou Institute of Chemical PhysicsChinese Academy of Sciences Lanzhou 730000 China

The adsorption of Methyl Violet （MV） cationic dye from aqueous solution was carried out by using crosslinked poly （acrylic acid-coacrylamide）/attapulgite （Poly（AA-co-AM）/ATP） composite as adsorbent. The factors influencing adsorption capacity of the composite such as pH, concentration of the dye, temperature, contact time, adsorbent dosage, ionic strength and surfactant were systematically investigated. The equilibrium data fitted very well to the Langmuir isotherm and the maximum adsorption capacity reached 1194 mg/g at 30℃. The thermodynamic parameters including △G0, △H0 and △S0 for the adsorption processes of MV on the composite were also calculated, and the negative △H0 and △G0 confirmed that the adsorption process was exothermicand spontaneous. The kinetic studies showed that the adsorption process was consistent with the pseudo second-order kinetic model and the desorption studies revealed that the regeneration of the composite adsorbent can be easily achieved.

关键词： composite Methyl Violet adsorption kinetics isotherm

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红霉素对支气管扩张症患者呼吸道细菌的影响

中国现代医学杂志 2017年第17期27卷 119-124页

作者：武文娟张国俊胡俊祥牛安林李任增李国涛朱莎莎河南省安阳市第三人民医院呼吸内科河南安阳455000 郑州大学第一附属医院呼吸与危重症科河南郑州456400

目的观察长期口服小剂量红霉素对稳定期支气管扩张症患者细菌耐药性的影响,以及呼吸道微生物群构成的变化。方法采取双盲、对照方法进行为期6个月的观察,纳入患者既往1年内有2次急性加重史,治疗组口服红霉素250 mg/次,2次/d,评估治疗前... 详细信息

目的观察长期口服小剂量红霉素对稳定期支气管扩张症患者细菌耐药性的影响,以及呼吸道微生物群构成的变化。方法采取双盲、对照方法进行为期6个月的观察,纳入患者既往1年内有2次急性加重史,治疗组口服红霉素250 mg/次,2次/d,评估治疗前后两组急性加重次数的不同、呼吸道定植菌的耐药率变化,以及细菌构成的变化。结果 176例患者随机分组,治疗组90例,对照组86例;与对照组相比较,铜绿假单胞菌定植亚组的急性加重次数减少,但非铜绿定植亚组无变化;治疗组呼吸道革兰阴性菌群耐药率无变化,而革兰阳性菌群耐药率升高,尤其是对大环内酯类药物;治疗组较对照组痰菌负荷减少,微生物构成发生变化,但铜绿假单胞菌定植亚组患者微生物构成变化不大,非铜绿假单胞菌定植亚组微生物构成变化大,流感嗜血杆菌定植率降低,但耐大环内酯类药物细菌包括铜绿假单胞菌定植率升高。结论长期小剂量红霉素治疗造成支气管扩张症患者呼吸道革兰阳性菌群耐药率升高,尤其是对大环内酯类药物;呼吸道微生物群构成发生变化,在非铜绿假单胞菌定植亚组,急性加重次数并没有减少,而红霉素治疗使其流感嗜血杆菌定植率降低,但铜绿假单胞菌、金黄色葡萄球菌等对大环内酯类药物耐药的细菌定植率升高,该类患者尚需进一步寻找更好的治疗方案。

关键词：红霉素支气管扩张症耐药性微生物构成

A comprehensive understanding of grain selection in spiral grain selector during directional solidification

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Journal of Materials Science & Technology 2022年第7期102卷 204-212页

作者： Binqiang Wang Long zeng Neng ren Mingxu Xia Jianguo li School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

It is of great importance to further investigate grain selection mechanism for the production of single crystal(SX) turbine blade because a single crystal with optimized crystal orientation will enhance service performance of the blade *** this paper,single crystals with different deviation angles,i.e.6°,12° and 29°, were obtained using directional solidification under the same casting *** has been found that the grain selection in spiral selector is a coupling process where high order dendrites branch in the front side and primary dendrites disappear in the back side based on the metallographic analysis and electron back scatter diffraction(EBSD).Considering the development of liquid/solid interface by numerical simulation,a combination effect with space expansion,geometrical restriction and grain competition was proposed for spiral grain *** space expansion mechanism dominates the process as it provides growth space and driving force for high order dendrites ***,the smaller the take-off angle(θ) is,the larger space and the stronger driving force high order dendrites will get,and the higher efficient the selector will be. The competitive growth between the secondary dendrites plays more contribution than that of primary dendrites,*** with preferred secondary dendrites instead of preferred primary dendrites could outcompete during grain selection,and this is the reason why spiral grain selector cannot optimize the orientation of the primary *** findings provide experimental evidence for spatial control of SX growth,and benefit the sophistic casting fields such as turbine blade casting for improved yield.

关键词： Ni-based superalloy Spiral grain selector Space expansion Geometrical restriction Grain competition

Simplified quantitative analysis method and its application in the insitu synthesized copper-based azide chips

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Defence Technology（防务技术） 2024年第2期32卷 309-316页

作者： Jie ren Yunfeng li Mingyu li Xingyu Wu Jiabao Wang Qingxuan zeng State Key Laboratory of Explosion and Technology Beijing Institute of TechnologyBeijing 100081China

Copper-based azide(Cu(N_(3))2 or CuN_(3),CA)chips synthesized by in-situ azide reaction and utilized in miniaturized explosive systems has become a hot research topic in recent ***,the advantages of in-situ synthesis method,including small size and low dosage,bring about difficulties in quantitative analysis and differences in ignition capabilities of CA *** aim of present work is to develop a simplified quantitative analysis method for accurate and safe analysis of components in CA chips to evaluate and investigate the corresponding ignition *** this work,Cu(N_(3))2 and CuN_(3)components in CA chips were separated through dissolution and distillation by utilizing the difference in solubility and corresponding content was obtained by measuring N_(3)-concentration through *** spectrophotometry method was optimized by studying influencing factors and the recovery rate of different separation methods was studied,ensuring the accuracy and reproducibility of test *** optimized method is linear in range from 1.0-25.0 mg/L,with a correlation coefficient R^(2)=0.9998,which meets the requirements of CA chips with a milligram-level content *** with the existing ICP method,component analysis results of CA chips obtained by spectrophotometry are closer to real component content in samples and have satisfactory ***,as its application in miniaturized explosive systems,the ignition ability of CA chips with different component contents for direct ink writing CL-20 and the corresponding mechanism was *** study provided a basis and idea for the design and performance evaluation of CA chips in miniaturized explosive systems.

关键词： Copper-based azide chips Spectrophotometry Separation method Quantitative analysis Ignition ability

外侧髌旁切口膝关节半伸直位关节外髓内钉技术治疗胫骨干骨折的临床疗效分析

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创伤外科杂志 2016年第2期18卷 103-104页

作者：李国强李任增张永飞王军李逸群安阳市第三人民医院骨科二病区河南455000

目的探讨分析外侧髌旁切口膝关节半伸直位关节外髓内钉技术治疗胫骨干骨折的临床疗效。方法笔者回顾性分析2012年6月-2013年9月收治的胫骨干骨折患者24例，男性15例，女性9例；年龄17—63岁，平均40岁。其中胫骨上1／4骨折17例，胫骨... 详细信息

目的探讨分析外侧髌旁切口膝关节半伸直位关节外髓内钉技术治疗胫骨干骨折的临床疗效。方法笔者回顾性分析2012年6月-2013年9月收治的胫骨干骨折患者24例，男性15例，女性9例；年龄17—63岁，平均40岁。其中胫骨上1／4骨折17例，胫骨干骨折合并髌骨前皮肤软组织挫伤7例；均符合髓内钉固定治疗。24例患者均采取经外侧髌腱旁入路，关节外髓内钉植入技术，并得到了12个月以上的随访。随访期间，采用视觉模拟评分法（VAS），客观的活动度评分和功能障碍评分来反映膝前痛程度、关节的活动度。结果7例胫骨干骨折合并髌骨前皮肤软组织挫伤的患者由于采用了髌旁外侧切口，切口均良好愈合。所有24例患者在术后3～6周的随访期间，80．16％的患者有膝前疼痛；但术后3个月的随访显示79．6％的患者膝前疼痛均消失，膝关节的屈伸功能及活动度均较满意。根据VAS评分及活动度评分，优15例，良7例，差2例，总优良率为91．66％。各年龄阶段无明显差异。结论外侧髌旁切口膝关节半伸直位关节外髓内钉技术，尤其对于合并髌骨前皮肤软组织挫伤者，可以大大减少切口感染及皮肤坏死的概率，而且手术复位操作简便，影像学透视优势明显。术后膝关节膝前痛的发生率低，关节功能恢复良好，尤其适用于胫骨上1／4骨折及胫骨干骨折合并髌骨前皮肤软组织挫伤的患者。

关键词：胫骨干骨折髌旁切口膝关节髓内钉

Kinetic model of chromium release from argon oxygen decarburisation(AOD)slag in a neutral leachate

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Journal of Iron and Steel Research International 2020年第11期27卷 1303-1310页

作者： Ya-nan zeng Qian-qian ren Bao liu Jun-guo li School of Metallurgy and Energy North China University of Science and TechnologyTangshan 063200HebeiChina

Valorisation of argon oxygen decarburisation(AOD)slag,a suitable recycling resource,is limited by the release of a notable amount of heavy metals,such as *** mineralogical component of AOD slag was characterised by X-ray diffraction and scanning electron microscopy-energy-dispersive X-ray *** explore the release kinetics of chromium from AOD slag,neutral leaching tests were performed at various *** results indicated the existence of two leaching stages:quick and slow leaching *** 2 h,the chromium release fraction increased sharply as the leaching time *** the leaching time in creased,the chromium release rate gradually *** on the shrinking core model,chromium release kinetic models for the quick and slow leaching stages from the AOD slag were independently *** chromium release was controlled by solid product diffusion during the quick leaching stage and a complicated process in the slow leaching *** activation energy of chromium leaching was calculated based on the Arrhenius *** product diffusion was the velocity-determining step during the 2 h leaching *** the slow leaching stage,chromium release was controlled by complicated hybrid control dominated by solid product diffusion.

关键词： Kinetic model Chromium release Shrinking core model-AOD slag

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

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World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen li liu Fang-Zhen lin Hai-Min zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-lin Wang Bin Chen De-Le liu Yun liu Zheng-Zheng li Xin-Xing zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder