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Association of Plasma Connective Tissue Growth Factor Levels with Hyperthyroid Heart Disease

Current Medical Science 2021年第2期41卷 348-355页

作者： Huan li ren-li zeng Yun-fei liAO Meng-fei FU Huan ZHANG lin-fang WANG Yu-ming li Deparment of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Clinical Research Center for Diabees and Metabolic Disorders Wuhan 430022China Deparment of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Hyperthyroid heart disease(HHD)is one of the most severe complications of overt hyperthyroidism and increases the risk of mortality in affected *** identification of patients at a higher risk of developing HHD can improve clinical outcomes through active surveillance and *** tissue growth factor(CTGF),a secreted extracellular protein,plays a significant role in cardiac remodeling and *** aimed to investigate the association between plasma CTGF level and the risk of HHD in this study.A total of 142 overt hyperthyroid patients without HHD and 99 patients with HHD were *** plasma CTGF levels were measured using EliSA *** clinical medical data and echocardiography parameters were recorded for *** plasma CTGF level was significantly higher in patients with HHD than in those without HHD(P=0.002).The plasma CTGF level was positively correlated with free triiodothyronin,tryrotropin receptor antibody,troponin I and lactate dehydrogenase levels and the left atrium diameters,right atrium diameters,and right ventricular end-diastolic diameters(all P<0.05).Logistic regression analysis showed that quartiles 3 and 4 of plasma CTGF levels were significantly associated with the increased risk of HHD(crude OR:2.529;95%CI:1.188-5.387).However,after adjustment for the potentially confounding variables,quartile 4 alone was significantly associated with the higher risk of HHD relative to quartile *** patients with HHD display higher plasma CTGF ***,CTGF is an independent risk factor for ***,the plasma CTGF level may be a potential biomarker for the risk of HHD.

关键词： connective tissue growth factor hyperthyroid heart thyroid hormone

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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-Xiao Yi Hui ren Woon Genevieve Saw li zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

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双塔精馏回收环己醇工艺模拟与优化

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现代化工 2017年第8期37卷 195-199页

作者：杨涛李肖宁阳坤任保增李涛郑州大学化工与能源学院河南郑州450001

针对双塔精馏回收环己醇工艺,采用Fenske-Underwood-Gilliland-Kirkbride方程和Rad Frac模块对双塔进行简捷设计和严格模拟,保证预分离塔条件不变,利用响应面优化法(RSM)对萃取精馏塔的设计参数进行实验设计,得到最终优化的操作条件:预... 详细信息

针对双塔精馏回收环己醇工艺,采用Fenske-Underwood-Gilliland-Kirkbride方程和Rad Frac模块对双塔进行简捷设计和严格模拟,保证预分离塔条件不变,利用响应面优化法(RSM)对萃取精馏塔的设计参数进行实验设计,得到最终优化的操作条件:预分离塔板数N1=28,环己醇进料流量F=440 kg/h,操作压力P1=-0.007 5 MPa,回流比R1=6.5;萃取精馏塔塔板数N2=22,操作压力P2=96.401 k Pa,回流比R2=2.49,萃取剂水质量分数为0.36。在最佳操作条件下,塔顶环己醇质量分数为95.9%,环己醇回收率为84.2%,投资成本5.34×10~6元,运行成本为2.19×10~6元,为环己醇回收工艺提供模型和数据基础。

关键词：环己醇回收萃取精馏 Aspen Plus模拟响应面法

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降钙素对兔骨关节炎关节软骨的保护作用

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中国矫形外科杂志 2006年第2期14卷 121-123,i0002页

作者：李任增张柳高晓增华北煤炭医学院附属医院骨科河北唐山063000

[目的]研究降钙素(calc iton in,CT)对骨关节炎关节软骨的保护作用。[方法]6个月龄新西兰大白兔20只,随机分为两组均行右膝关节前交叉韧带切断术。1周后实验组开始皮下注射降钙素5 IU/kg,每日1次;对照组注入等剂量生理盐水;术后6周处死... 详细信息

[目的]研究降钙素(calc iton in,CT)对骨关节炎关节软骨的保护作用。[方法]6个月龄新西兰大白兔20只,随机分为两组均行右膝关节前交叉韧带切断术。1周后实验组开始皮下注射降钙素5 IU/kg,每日1次;对照组注入等剂量生理盐水;术后6周处死动物。取股骨内髁制成切片行HE、番红“O”和Ⅱ型胶原免疫组化染色。HE切片按照M ank in评分表评分。番红“O”染色和Ⅱ型胶原免疫组化染色切片用图像分析仪,测量平均灰度值。[结果](1)对照组术侧膝关节组织学M ank in评分结果、番红“O”染色和Ⅱ型胶原免疫组化染色平均灰度值测量结果高于健侧,(P<0.01)。(2)对照组手术膝关节组织学评分、番红“O”染色和Ⅱ型胶原免疫组化染色平均灰度值测量结果高于实验组手术膝关节,(P<0.05)。[结论]降钙素5 IU/kg每日1次皮下注射够明显减轻兔膝关节不稳定诱发的骨关节炎关节软骨的退变。降钙素可能通过提高软骨基质糖胺多糖(glycosam inoglycans,GAG)和Ⅱ型胶原含量保护关节软骨。

关键词：降钙素骨关节炎灰度值

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锁定板结合可吸收螺钉治疗肱骨头颈部粉碎骨折12例疗效分析

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中国实用医药 2009年第29期4卷 150-151页

作者：李任增河南省安阳市第一人民医院骨二科 455000

目的讨论锁定钢板结合可吸收螺钉治疗肱骨头颈部粉碎骨折的临床疗效。方法2005年7月至2007年7月,应用锁钉板结合可吸收螺钉治疗肱骨近端合并肱骨头粉碎骨折12例。结果经6～12个月随访,无内固定松动、断裂,全部骨折均愈合。肩关节功能恢... 详细信息

目的讨论锁定钢板结合可吸收螺钉治疗肱骨头颈部粉碎骨折的临床疗效。方法2005年7月至2007年7月,应用锁钉板结合可吸收螺钉治疗肱骨近端合并肱骨头粉碎骨折12例。结果经6～12个月随访,无内固定松动、断裂,全部骨折均愈合。肩关节功能恢复优良率91.7%。结论锁定钢板结合可吸收螺钉固定,是治疗肱骨近端合并肱骨头粉碎骨折的有效方法。

关键词：肱骨头颈部骨骨折锁定钢板可吸收螺钉内固定

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公路路面施工中裂缝产生的原因及控制对策

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交通标准化 2013年第17期41卷 97-99页

作者：李仁增邢台路桥建设总公司河北邢台054001

在公路路面施工中,由于原材料质量、混凝土品质等方面的原因,常常会导致裂缝的产生。路面裂缝不仅会影响工程质量,还会给车辆通行带来不利影响。为了有效控制公路路面施工中裂缝的产生,需要采取相应的对策,严格控制混凝土配合比设计,保... 详细信息

在公路路面施工中,由于原材料质量、混凝土品质等方面的原因,常常会导致裂缝的产生。路面裂缝不仅会影响工程质量,还会给车辆通行带来不利影响。为了有效控制公路路面施工中裂缝的产生,需要采取相应的对策,严格控制混凝土配合比设计,保证原材料质量合格,并做好施工质量控制工作。

关键词：公路路面施工裂缝混凝土配合比设计控制对策

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公路水泥稳定碎石施工质量控制措施探讨

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交通标准化 2013年第18期41卷 45-47页

作者：李仁增邢台路桥建设总公司河北邢台054001

公路水泥稳定碎石基层具有良好的板体性、水稳定性和抗冻性,但也存在着一些质量问题,主要表现为平整度差、厚度不够、压实度差、强度不够等。针对这些问题,结合实践经验,提出一系列公路水泥稳定碎石施工质量控制措施,以供同行参考。

关键词：水泥稳定碎石公路施工质量控制平整度压实度

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong liu Haorun li Yan Wang Xiaojun Gu Shanghong zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong li Faqin li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni li Haojie An Shiyi zeng Chunyan Wang li Yang Cheng Long School of life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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