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Fe-catalyzed regioselective Friedel–Crafts hydroxyalkylation of N-substituted glyoxylamide with indoles

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Chinese Chemical Letters 2016年第1期27卷 41-46页

作者： Yang Zheng ren-jun li Zhen Zhan Yan Zhou li Hai Yong Wu Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry West China School of Pharmacy Sichuan University

An efficient regioselective Friedel-Crafts hydroxyalkylation of N-substituted glyoxylamide with various indoles catalyzed by Lewis acids was developed. The reactions proceeded smoothly at room temperature and the 2-hydroxy-2-（1H-indol-3-yl）-N-substituted acetamide resulted from the reactions catalyzed by FeSO4 were synthesized in excellent yields （up to 93%）. While the bisindole compounds were obtained when FeCl3 was used as a catalyst in excellent yields （up to 92%）. A possible mechanism was proposed.

关键词： Friedel-Crafts hydroxyalkylation N-substituted glyoxylamide Indole Lewis acid 2-Hydroxy-2-(1H-indol-3-yl)-N substituted acetamide Bisindole compounds

A DYNAMIC SPECTRUM ACCESS NETWORK BASED ON COGNITIVE RADIO

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Journal of Electronics(China) 2010年第5期27卷 577-610页

作者： ren Pinyi Wang jun li Shaoqian Department of Electronics and Information Engineering Xi＇an Jiaotong UniversityXi＇an 710049China

Dynamic spectrum access technologies based on Cognitive Radio(CR) is under intensive research carried out by the wireless communication society and is expected to solve the problem of spectrum ***,most enabling technologies related to dynamic spectrum access are con-sidered *** this paper,we consider these key technologies jointly and introduce a new implementation scheme for a Dynamic Spectrum Access Network Based on Cognitive Radio(DSAN-BCR).We start with a flexible hardware platform for DSAN-BCR,as well as a flexible protocol structure that dominates the operation of *** then focus on the state of the art of key technologies such as spectrum sensing,spectrum resources management,dynamic spectrum access,and routing that are below the network layer in DSAN-BCR,as well as the development of technologies related to higher *** but not the least,we analyze the challenges confronted by these men-tioned technologies in DSAN-BCR,and give the perspectives on the future development of these *** DSAN-BCR introduced is expected to provide a system level guidance to alleviate the problem of spectrum scarcity.

关键词： Cognitive Radio (CR) Dynamic Spectrum Access Network Based on Cognitive Radio (DSAN-BCR) Spectrum sensing Spectrum management Dynamic Spectrum Access (DSA) Cognitive routing

Low Correspondence of EGFR Mutations in Tumor Tissue And Paired Serum of Non-Small-Cell Lung Cancer Patients

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Chinese Journal of Cancer Research 2010年第1期22卷 27-31页

作者： Guo-hong Song,jun ren,li-jian Zhang,li-jun Di, Yan-hua Yuan,Jing Yu,jun Jia Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Oncology,Peking University School of Oncology,Beijing Cancer Hospital & Institute,Beijing 100142,China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Medical Oncology Peking University School of Oncology Beijing Cancer Hospital & Institute Beijing China

Objective： Epidermal growth factor receptor （EGFR） mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer （NSCLC） patients. The aim of this study was to evaluate the correspondence between EGFR mutations in non-small-cell lung cancer tissues and in circulating DNA. Methods： The research was conducted in 50 non-small-cell lung cancer patients who had undergone curative surgery, and in whom both serum and neoplastic tissues were available. Meanwhile sera of 33 cases of advanced NSCLC patients were also analyzed. DNA were extracted from each sample. Mutations of EGFR in exonl8-21 were examined by PCR amplification method and direct sequencing. Results： EGFR mutations were detected in 15 （30%） of 50 neoplastic tissue samples, 6 cases were in-frame deletion del E746-A750 in exonl9, 9 cases were substitution in exon 21 （all were L858R except one was L861Q）, but no mutated DNA resulted in paired serum circulating DNA samples of 50 resectable patients. As the 33 advanced NSCLC patients, EGFR mutations were detected in only 2 serum circulating DNA samples, all were L858R mutation in exon 21. Conclusion： These data indicated that it was difficult to identify EGFR mutations in circulating DNA of NSCLC patients. The use of EGFR mutation in serum as a clinical method for decision making of TKI therapy is unsatisfactory.

关键词： Circulating DNA Epidermal growth factor receptor (EGFR) Mutation Non-small-cell lung cancer (NSCLC)

Characteristics of the Activity of the lintong-Chang'an Fault in the Late Pleistocene

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Earthquake Research in China 2008年第1期22卷 62-72页

作者： Shi Yaqin Feng Xijie li Jin Dai Wangqiang ren jun li Xiaoni Earthquake Administration of Shaanxi Province Xi＇an 710068 China

Analysis of fault outcrops and trench sections indicates fault displacements of 0.2m～6.0 m on the bottom paleosol layer of the Epipleistocene with the maximum rate of 0.047 mm/a and an average displacement of 1.1 *** activity appears as fissures on the fault surface in the late Epipleistocene and there is no obvious *** fault activity is weak and the most active segment is the Bailuyuan segment.

关键词： lintong-Chang'an fault zone Fault outcrop Trenching The Late Pleistocene

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乙醇脱水分壁式萃取精馏工艺研究

现代化工 2014年第7期34卷 145-148页

作者：任军利浙江工业大学化学工程学院浙江杭州310014

利用Aspen Plus过程模拟软件,采用乙二醇作萃取剂,模拟研究了分壁式萃取精馏对摩尔分数为82%乙醇溶液脱水的分离过程。建立了分壁式萃取精馏模型,得到了优化的工艺参数,主塔理论板数为11块,精馏段理论板数为5块,回流比为0.10;副塔原料... 详细信息

利用Aspen Plus过程模拟软件,采用乙二醇作萃取剂,模拟研究了分壁式萃取精馏对摩尔分数为82%乙醇溶液脱水的分离过程。建立了分壁式萃取精馏模型,得到了优化的工艺参数,主塔理论板数为11块,精馏段理论板数为5块,回流比为0.10;副塔原料进料位置为第14块板,萃取剂进料位置为第4块板,隔板在副塔第18块板底端,萃取精馏段回流比为0.419,溶剂比为1.1。比较了分壁式萃取精馏和常规双塔2种流程下的能耗。模拟结果表明,采用分壁式萃取精馏,再沸器能耗降低了15%,节能效果明显。

关键词：无水乙醇分壁式萃取精 Aspen Plus 流程模拟

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锁定效应与资源型区域产业投资结构变迁研究

山西大学学报(哲学社会科学版) 2015年第3期38卷 119-123页

作者：杨军任力军山西大学经济与管理学院山西大学晋商学研究所

从资源产品价值锁定、供求锁定和资源产业优势锁定三个方面分析了锁定效应与资源型区域产业投资结构变迁之间的关系,指出资源型区域产业投资结构变迁因锁定效应的存在,会经历初级均衡变迁阶段、非均衡变迁阶段和高级均衡变迁阶段,并以... 详细信息

从资源产品价值锁定、供求锁定和资源产业优势锁定三个方面分析了锁定效应与资源型区域产业投资结构变迁之间的关系,指出资源型区域产业投资结构变迁因锁定效应的存在,会经历初级均衡变迁阶段、非均衡变迁阶段和高级均衡变迁阶段,并以山西省为例进行实证分析。

关键词：锁定效应资源价值锁定资源供求锁定产业投资结构变迁

The Study of Paleoearthquakes on the Weihe Fault Zone

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Earthquake Research in China 2008年第4期22卷 470-480页

作者： Shi Yaqin Feng Xijie Dai Wangqiang ren jun li Xiaoni Dou Mali Earthquake Administration of Shaanxi Province Xi＇an 710068 China

It is indicated by historical records and the exploratory trench on the Weihe fault that the Yaodian-Zhangjiawan segment of the Weihe fault zone has experienced a historical earthquake and 3 paleoearthquake events in the past 9110a. The historical earthquake, namely, event Ⅳ, occurred between 1487 and 1568 AD. The date of paleoseismic event Ⅰ is （9110 ＋ 90） a, and the ages of events Ⅱ and Ⅲ are unknown. The coseismic vertical displacement of events Ⅰ, Ⅱ and Ⅲ is 0.5m, 0.5m and 0.2m, respectively. The exploratory trench also indicates that the Yaodian-Zhangjiawan segment of the Weihe fault was active in the Holocene.

关键词： Weihe fault zone Paleoearthquake Coseismic displacement Exploratory trench Bilicun Village

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会展理论研究综述与前沿问题探讨

商业研究 2008年第1期 50-53页

作者：任丽君河北大学经济学院河北保定071002

会展经济在我国方兴未艾,会展理论研究正处起步阶段。国外会展发达国家已开始向我国实施战略转移。基于以上背景,系统分析国内外会展理论,提出会展理论研究的前沿问题,将在经济全球一体化趋势中,为我国会展经济健康发展提供理论支撑。

关键词：会展经济产业链前沿问题

海港货运列车用联接件表面纳米镀层的耐海洋大气腐蚀性能

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电镀与环保 2018年第2期38卷 48-50页

作者：任俊利中车唐山机车车辆有限公司河北唐山063000

以海港货运列车联接件使用的材料35CrMo钢为基体,在其表面制备了Ni-Al_2O_3纳米镀层。通过周期性浸润腐蚀试验模拟海洋大气腐蚀,分别研究了纳米镀层和基体的耐海洋大气腐蚀性能,得到了各自的腐蚀失重曲线、自腐蚀电位及自腐蚀电流密度... 详细信息

以海港货运列车联接件使用的材料35CrMo钢为基体,在其表面制备了Ni-Al_2O_3纳米镀层。通过周期性浸润腐蚀试验模拟海洋大气腐蚀,分别研究了纳米镀层和基体的耐海洋大气腐蚀性能,得到了各自的腐蚀失重曲线、自腐蚀电位及自腐蚀电流密度。与基体相比,相同实验条件下纳米镀层的腐蚀失重更低,周期性浸润腐蚀试验后的总腐蚀失重为3.76×10^(-2) mg/mm^2。纳米镀层的自腐蚀电位为-212mV,比基体的自腐蚀电位正移了45mV;自腐蚀电流密度为3.25×10^(-5)A/cm^2,比基体的自腐蚀电流密度下降了21.5%。纳米镀层表面腐蚀比较均匀,表现出比基体更好的耐海洋大气腐蚀性能。

关键词：耐海洋大气腐蚀性能纳米镀层 35CrMo钢腐蚀失重自腐蚀电位自腐蚀电流密度