检索结果-南通市图书馆

Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B

World Journal of Gastroenterology 2005年第19期11卷 2892-2899页

作者： PingLiu Yi-YangHu ChengLiu Lie-MingXu Cheng-HaiLiu Ke-WeiSun De-ChangHu You-KuanYin xia-QiuZhou Mo-BinWan XiongCai Zhi-QingZhang JUNYe ren-xingzhou JiaHe Bao-ZhangTang InstituteofLiverDisease ShanghaiUniversityofTraditionalChineseMedicineShanghai201203China ShanghaiSecondMilitaryMedicalUniversity Shanghai200233China theAffiliatedHospital YunnanCollegeofTCMYunnan650000KunmingProvinceChina theAffiliatedHospital HunanCollegeofTCMChangsha410000HunanProvinceChina ZhongshanHospital FudanUniversityShanghai200032.China RuijinHospital ShanghaiSecondMedicalUniversityShanghai200025China ChanghaiHospital Shanghai200423China ShanghaiChangzhengHospital Shanghai200236China the4thPeopleHospitalofHuaianCity Huaian232000JiangsuProvinceChina theCentralHospitalofPutuoDistrict Shanghai200062China ShanghaiModemTechniqueCo. LtdforTCMShanghai200037China

AIM: To study the efficacy and safety of Fuzhenghuayu capsule (FZHY capsule, a capsule for strengthening body resistance to remove blood stasis) against liver fibrosis due to chronic hepatitis B. METHODS: Multicenter, randomized, double blinded and parallel control experiment was conducted in patients (aged from 18 to 65 years) with liver fibrosis due to chronic hepatitis B. Hepatic histologic changes and HBV markers were examined at wk 0 and 24 during treatment. Serologic parameters (HA, LM, P-Ⅲ-P, Ⅳ-C) were determined and B ultrasound examination of the spleen and liver was performed at wk 0, 12 and 24. Liver function (liver function and serologic parameters for liver fibrosis) was observedat wk 0, 6, 12, 18 and 24. Blood and urine routine test, renal function and ECG were examined before and after treatment. RESULTS: There was no significant difference between experimental group (110 cases) and control group (106 cases) in demographic features, vital signs, course of illness, history for drug anaphylaxis and previous therapy, liver function, serologic parameters for liver fibrosis, liver histologic examination (99 cases in experimental group, 96 cases in control group), HBV markers, and renal function. According to the criteria for liver fibrosis staging, meanscore of fibrotic stage(s) in experimental group after treatment (1.80) decreased significantly compared to the previous treatment (2.33, P＜0.05), but there was no significant difference in mean score of fibrotic stage(s) (2.11 and 2.14 respectively). There was a significant difference in reverse rate between experimental group (52%) and control group (23.3%) in liver biopsy. With marked effect on decreasing the mean value of inflammatory activity and score of inflammation (P＜0.05), Fuzhenghuayu capsule had rather good effects on inhibiting inflammatory activity and was superior to that of Heluoshugan capsule. Compared to that of pretreatment, there was a significant decrease in HA, LM, P-Ⅲ-P and Ⅳ-C content

关键词： Chronic hepatitis B Fuzhenghuayu capsule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

引用

Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan Wang Zhenzhen Cai Jianghai Du Zhengyu Chen Junjie Wang xingzhou Peng State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering Hainan University Haikou 570228P.R.China Key Laboratory of Biomedical Engineering of Hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical University Hainan Medical University Haikou 571199P.R.China Engineering Research Center for Hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Triphenylamine-AIEgens photoactive materials for cancer theranostics

引用

Chinese Chemical Letters 2024年第6期35卷 86-94页

作者： Junjie Wang Yan Wang Zhengdong Li Changqiang Xie Musammir Khan xingzhou Peng Fabiao Yu State Key Laboratory of Digital Medical Engineering School of Biomedical EngineeringHainan UniversityHaikou 570228China Key Laboratory of Biomedical Engineering of Hainan Province One Health InstituteHainan UniversityHaikou 570228China Key Laboratory of Hainan Trauma and Disaster Rescue The First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikou 571199China Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and TraumaMinistry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Precision Medical Center Guangyuan City Centre hospitalGuangyuan 628099China School of Natural Sciences(SNS) National University of Science and Technology(NUST)H-12Islamabad 44000Pakistan

Triphenylamine(TPA)-based aggregation-induced emission luminogens(TPA-AIEgens),a type of photoactive material utilizing the typical TPA moiety,has recently attracted increasing attention for the diagnostics and treatment of tumors due to their remarkable chemo-physical performance in optoelectronic ***-AIEgens are distinguished from other photoactive agents by their strong fluorescence,good sensitivity,high signal-to-noise ratio,resistance to photobleaching,and lack of high concentration or aggregation-caused fluoresce quenching *** this review,we summarize the current advancements and the biomedical progress of TPA-AIEgens in tumor ***,the design principles of TPAAIEgens photoactive agents as well as the advanced targeting strategies for nuclei,cell membranes,cell organelle and tumors were introduced,***,the applications of TPA-AIEgens in tumor diagnosis and therapeutic techniques were ***,the challenges and prospects of TPA-AIEgens for cancer therapy were *** given landscape of the TPA-AIEgens hereby is meaningful for the further design and utilization of the novel photoactive material,which could be beneficial for the development of clinic applications.

关键词： Triphenylamine AIEgens Targeting Theranostics Phototherapy Immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A FAS approach for stabilization of generalized chained forms: part 1. Discontinuous control laws

引用

Science China(Information Sciences) 2024年第2期67卷 118-143页

作者： Guang-ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Center for Control Science and Technology Southern University of Science and Technology

In this paper, a type of general nonholonomic systems is proposed, which contains both the Brockett’s two example systems, and their extended n-dimensional chained forms, as special cases. For the stabilization of such systems, a stabilizing controller is proposed based on the fully actuated system(FAS)approach, which is discontinuous at the origin but time-invariant when the open-loop system is time-invariant,and drives the feasible trajectories of the system to the origin exponentially. Furthermore, the proposed FAS approach is also extended to the sub-normal system case and the time-delay system case.

关键词： nonholonomic systems feedback stabilization exponential convergence sub-fully actuated systems time-delay systems

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A FAS approach for stabilization of generalized chained forms: part 2. Continuous control laws

引用

Science China(Information Sciences) 2024年第3期67卷 114-135页

作者： Guang-ren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and Technology

In this paper, continuous time-varying stabilizing controllers for the type of general nonholonomic systems proposed and treated in part 1 are designed using the fully actuated system(FAS) approach. The key step is to differentiate the first scalar equation, and by control of the obtained second-order scalar system, a proportional plus integral feedback form for the first control variable is obtained. With the solution to this designed second-order scalar system, the rest equations in the nonholonomic system form an independent time-varying subsystem which is then handled by the FAS approach. The overall designed controller contains an almost arbitrarily chosen design parameter, and is proven to guarantee the uniformly and globally exponential stability of the closed-loop system. The proposed approach is simple and effective,and is demonstrated with a practical example of ship control.

关键词： nonholonomic systems feedback stabilization fully actuated systems Lyapunov stability continuous controllers

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

我国服务经济发展的总体特征与制度障碍

引用

科学发展 2010年第10期 13-32页

作者：任兴洲国务院发展研究中心 100010

目前,我国经济发展中已经出现一些与服务经济发展特征一致的发展趋势,东部地区和一些大型经济中心城市出现了加快向服务经济转型的势头,为我国服务经济的形成奠定了重要的基础。但我国经济社会发展距离服务经济形成还有一定差距。影响... 详细信息

目前,我国经济发展中已经出现一些与服务经济发展特征一致的发展趋势,东部地区和一些大型经济中心城市出现了加快向服务经济转型的势头,为我国服务经济的形成奠定了重要的基础。但我国经济社会发展距离服务经济形成还有一定差距。影响我国服务经济发展的主要制度障碍和问题是:服务领域多元化市场主体发育和企业制度建设滞后;要素和服务市场发展改革滞后,市场机制作用不强;监管体制和方式亟待改革创新;政府职能转变滞后;法治环境亟待完善;服务标准体系缺失或落后;促进服务业发展的机制和政策方式亟待改革创新等。

关键词：服务经济经济转型总体特征制度障碍

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Resilient control of flexible hypersonic vehicles against unmatched distributed faults

引用

Chinese Journal of Aeronautics 2024年第5期37卷 60-70页

作者： Dong ZHAO Wenjing ren School of Artificial Intelligence Anhui UniversityHefei 230601China Key Laboratory of System Control and Information Processing Ministry of EducationShanghai Jiao Tong UniversityShanghai 200240China School of Electrical Engineering and Automation Hefei University of TechnologyHefei 230009China

This paper studies a robust fault compensation and vibration suppression problem of flexible hypersonic *** controlled plant is represented by a cascade system composed of a nonlinear Ordinary Differential Equation(ODE)and an Euler-Bernoulli Beam Equation(EBBE),in which the vibration dynamics is coupled with the rigid dynamics and suffers from distributed faults.A state differential transformation is introduced to transfer distributed faults to an EBBE boundary and a longitudinal dynamics is refined by utilizing T-S fuzzy IF-THEN rules.A novel T-S fuzzy based fault-tolerant control algorithm is developed and related stability conditions are *** robust exponential stability and well-posedness are proved by using the modified l_(0)-semigroup based Lyapunov direct approach.A simulation study on the longitudinal dynamics of flexible hypersonic vehicles effectively verifies the validity of the developed theoretical results.

关键词： Flexible hypersonic vehicles ODE-EBBE cascade Robust exponential stability Unmatched distributed fault compensation Vibration suppression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in modeling and control of probe-and-drogue autonomous aerial refueling

引用

Chinese Journal of Aeronautics 2024年第5期37卷 6-26,I0001页

作者： Jinrui ren Quan QUAN School of Automation Xi’an University of Posts&TelecommunicationsXi'an 710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China

By refueling aircraft while they are in flight,aerial refueling is an efficient technique to extend their endurance and *** Aerial Refueling(AAR)is anticipated to be used to complete aerial refueling for unmanned *** are three aerial refueling methods:the Probe-and-Drogue Refueling(PDR)refueling method,the flying-boom refueling method,and the boom-drogue-adapter refueling *** paper considers the PDR approach,the most challenging of the three,because the flexible hose-drogue assembly has fast dynamics and is susceptible to various kinds of winds,which makes the probe docking with the drogue *** is divided into four phases,namely the rendezvous phase,joining phase,refueling phase,and reform phase,with the refueling phase being the most *** controller design faces the greatest challenge during the docking control of the refueling phase since it calls for a high level of safety,precision,and *** a result,the modeling and control issues encountered during the refueling phase are typical and *** fundamental idea of AAR is presented in the paper first,after which the characteristics and requirements of AAR are *** progress in modeling and control techniques for the AAR’s refueling phase is then systematically ***,potential future work for high safety,precision,and efficiency requirements is examined and suggested.

关键词： Aerial refueling Probe-and-drogue refueling Docking Flight controlsystems Unmanned Aerial Vehicles

来源：

维普期刊数据库

同方期刊数据库评论