检索结果-南通市图书馆

Insect Science 2016年第4期23卷 502-512页

作者： Chun-Yan Zhou Xing-Fu Zha Chun Liu Min-Jin Han Li-Ying Zhang Pan-Pan Shi He Wang ren-wen zheng Qing-You Xia State Key Laboratory of Silkworm Genome Biology Southwest University Chongqing China

The Multiprotein bridge factor 2 （MBF2） gene was first identified as a coactivator involved in BmFTZ-F 1-mediated activation of the Fushi tarazu gene. Herein, nine homologous genes of MBF2 gene are identified. Evolutionary analysis showed that this gene family is insect-specific and that the family members are closely related to response to pathogens （REPAT） genes. Tissue distribution analysis revealed that these genes could be expressed in a tissue-specific manner. Developmental profiles analysis showed that the MBF2 gene family members were highly expressed in the different stages. Analysis of the expression patterns of nine MBF2 family genes showed that Bacillus bombysepticus treatment induced the up-regulation of several MBF2 family genes, including MBF2-4, -7, -9, -8. Furthermore, we found the MBF2 family genes were modulated by starvation and the expression of these genes recovered upon re-feeding, except for MBF2-5, -9. These findings suggested roles for these proteins in insect defense against pathogens and nutrient metabolism, which has an important guiding significance for designing pest control strategies.

关键词： immunity nutrient metabolism physiology whole-genome scanning

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan ren Fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing ren Chenguang zheng Jiajia Yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

在线全文

学校读者我要写书评

暂无评论

不同土壤钾素淋溶特性的初步研究

土壤 2014年第2期46卷 225-231页

作者：董艳红王火焰周健民任正文土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 南京210008 中国科学院大学北京100049

通过室内土柱淋溶试验,研究降雨情况下不同土壤钾素的淋溶特性及其与土壤性质的关系,结果表明:未施钾的自然土壤,在降雨量较小时(87 mm),决定钾素淋溶状况的主要土壤因子是土壤质地,质地越轻,K+淋溶量越大;降雨量较大时(435 mm),决定钾... 详细信息

通过室内土柱淋溶试验,研究降雨情况下不同土壤钾素的淋溶特性及其与土壤性质的关系,结果表明:未施钾的自然土壤,在降雨量较小时(87 mm),决定钾素淋溶状况的主要土壤因子是土壤质地,质地越轻,K+淋溶量越大;降雨量较大时(435 mm),决定钾素淋溶状况的主要因子则为速效钾,田间速效钾含量愈大,淋溶风险愈大。外源钾施入土壤后,在降雨量较小时(87 mm),钾素淋溶状况主要受土壤粉粒和缓效钾的影响,粉粒含量和缓效钾越大,淋溶量越小;降雨量较大时(435 mm),钾素淋溶状况主要受全钾和缓效钾的影响,其值越大淋溶量越小。在降雨量充足、田间排水不畅的情况下,短时间内(2 h)土壤钾肥表观淋出率仅与粉粒含量呈显著负相关关系,土壤的质地是影响钾淋溶主要因子;长时间(24 h)淋溶后钾肥表观淋出率则与土壤pH、粉粒、全钾、缓效钾和长石含量均呈显著负相关关系,其中全钾和粉粒的影响作用最大。

关键词：钾淋溶降雨土壤性质质地

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao zheng Zilin ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-zheng Lan zheng Wu wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai Kang Li Qifeng zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

在线全文

学校读者我要写书评

暂无评论

钻孔灌注桩在直挖土质基坑围护中的应用

重庆建筑 2008年第10期31卷 35-37页

作者：任文正章青群杜凤菊浙江嘉宇工程管理有限公司浙江嘉兴314000

本工程处于市中心位置,距周围建筑物、道路管线设施非常近,环境极其复杂,施工作业空间狭小,基坑开挖对周围影响较大,本文通过钻孔灌注桩及内支撑支护的方法,阐述复杂环境条件下钻孔灌注桩在基坑支护中的应用,保证了周边建筑物、道路管... 详细信息

本工程处于市中心位置,距周围建筑物、道路管线设施非常近,环境极其复杂,施工作业空间狭小,基坑开挖对周围影响较大,本文通过钻孔灌注桩及内支撑支护的方法,阐述复杂环境条件下钻孔灌注桩在基坑支护中的应用,保证了周边建筑物、道路管线设施的安全,并减少对附近居民正常生活的影响。

关键词：钻孔灌注桩基坑支护复杂环境

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou Ying Mo Biao zheng Miaomiao Han Qin Zhong wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ru原子高Rydberg态研究

物理学报 1989年第10期38卷 1665-1672页

作者：许祥源唐建志李良权黄雯张连芳文克玲尚仁成赵文正陈瓞延清华大学现代应用物理系

本文描述用激光共振激发-场电离实验方法测定Ru原子的4d^7(~4F)ns(n=28—45)和4d^7(~4F)nd(n=26—48)系列Rydberg能级,并应用非线性拟合得到了Ru原子的第一电离阈值。采用相对论性自洽场方法对所得能级以及相应的量子亏损作了计算,理论... 详细信息

本文描述用激光共振激发-场电离实验方法测定Ru原子的4d^7(~4F)ns(n=28—45)和4d^7(~4F)nd(n=26—48)系列Rydberg能级,并应用非线性拟合得到了Ru原子的第一电离阈值。采用相对论性自洽场方法对所得能级以及相应的量子亏损作了计算,理论与实验结果符合得很好。此外还将本文所得的第一电离阈值与已有数据作了比较。

关键词： Ru 原子 Rydberg态