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Relationship with spatial memory in diabetic rats and protein kinase Cγ,caveolin-1 in the hippocampus and neuroprotective effect of catalpol

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Chinese Medical Journal 2014年第5期127卷 916-923页

作者： Zhou Haicheng Liu Jing ren Liyuan Liu wei xing Qian Men Lili Song Guirong Du Jianling Department of Endocrinology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China

Background The mechanisms underlying diabetic encephalopathy are largely unknown,and no effective treatments are *** has received much attention due to its numerous biological effects,especially in neuroprotective *** aim of this study was to investigate the effects of catalpol on cognitive functions in diabetic rats and the underlying *** A rat model of diabetes was established by streptozotocin injection,followed by intraperitoneal infusion of catalpol after 10 *** weeks later,the Morris water maze was used to test the spatial learning *** staining was performed to evaluate the morphological changes in the *** of protein kinase Cy （PKCy） and caveolin-1 （Cav-1） in the hippocampus were assessed by reverse transcription PCR and Western *** of anti-oxidative enzymes such as glutathione （GSH）,superoxide dismutase （SOD） and catalase （CAT） and levels of malonaldehyde （MDA） were measured using commercial *** Significant hippocampal neuronal injury was observed in rats with streptozotocin-induced ***,cognitive dysfunction was associated with markedly increased oxidative stress in the *** treatment significantly attenuated cognitive deficits,neuronal damage,and oxidative stress in the brain of diabetic *** analyses showed that catalpol reversed the down-regulation of PKCγ and Cav-1 expression in the diabetic *** Spatial memory in diabetic rats is associated with the expression of PKCy and *** treatment markedly attenuated oxidative stress,reversed the alteration of PKCy,Cav-1 and spatial memory deficits.

关键词： catalpol diabetic encephalopathy protein kinase Cγ caveolin-1

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： xing Wang wei Pi Sheng Hu Haifeng Bao Na Yao wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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技术创新的域、势、能

自然辩证法研究 2007年第3期23卷 88-91页

作者：魏仁兴朱宝荣福建商业高等专科学校福建福州350012 复旦大学哲学系上海200433

技术创新是特定域内的一种科学和技术的涌现,这种涌现取决于技术创新所在域内的势与能,域是创新的根基,具有边界有形性、区隔性和分层性等特征;势是域内创新的事物充满张力的局态,体现为吸附性和凝聚性;能则是域内创新的事物所具有的潜... 详细信息

技术创新是特定域内的一种科学和技术的涌现,这种涌现取决于技术创新所在域内的势与能,域是创新的根基,具有边界有形性、区隔性和分层性等特征;势是域内创新的事物充满张力的局态,体现为吸附性和凝聚性;能则是域内创新的事物所具有的潜在能量与动力,体现为动力本源性和持续性。国家或地区的技术创新通过一定的域,形成一定的势,对外吸附外在资源,对内聚集资源,最终以持续的技术创新来促进国家或地区的经济、文化、政治的跨越性发展。

关键词：技术创新域势能

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会展策划与管理专业人才培养模式初探

福建商业高等专科学校学报 2016年第5期 70-77页

作者：魏仁兴福建商学院旅游系福建福州350012

根据"一带一路"的政策沟通、道路连通、贸易畅通、货币流通、民心相通的"五通"与会展产业之间的关系,以及会展产业高速发展和主题活动业态的变化,针对会展策划与管理专业知识体系所具有的项目化、综合性强专业特征,经过多年的教学改革探... 详细信息

根据"一带一路"的政策沟通、道路连通、贸易畅通、货币流通、民心相通的"五通"与会展产业之间的关系,以及会展产业高速发展和主题活动业态的变化,针对会展策划与管理专业知识体系所具有的项目化、综合性强专业特征,经过多年的教学改革探索,课程设计调整,提出"一库一平台",互联网+融合;二类师资协同,校企联动;三法兼容,项目驱动;四核并重,系统开发;五层实训,无缝接轨;项目个性化、成果可视化等方式的人才培养模式。

关键词：会展策划与管理人才培养模式项目化

Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review

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World Journal of Gastroenterology 2025年第2期31卷 27-41页

作者： Jing Ye Jian-Guo Wang Rong-Qiang Liu Qiao Shi wei-xing Wang Department of General Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pancreatic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent *** prevalence of IPFD is relatively high and associated with factors such as obesity,age,and ***,the pathophysiological mechanisms underlying IPFD remain unclear,with several potential contributing factors,including oxida-tive stress,alterations in the gut microbiota,and hormonal *** was found to be highly correlated with the occurrence and prognosis of exocrine pan-creatic *** imaging techniques remain the primary diagnostic approach for IPFD,an expanding array of biomarkers and clinical scoring systems have been identified for screening ***,effective treatments for IPFD are not available;however,existing medications,such as glucagon-like peptide-1 receptor agonists,and new therapeutic approaches explored in animal models have shown considerable potential for managing this *** paper reviews the pathogenesis of IPFD,its association with exocrine pancreatic disea-ses,and recent advancements in its diagnosis and treatment,emphasizing the significant clinical relevance of IPFD.

关键词： Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease Pancreatitis Pancreatic cancer

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展会复杂域探讨

嘉应学院学报 2013年第9期31卷 44-48页

作者：魏仁兴福建商业高等专科学校福州350012

展会在特定的场域内聚集着组织、人、物、信息等,是复杂的多系统交织的社会活动,其形成依靠本地产业根植性,并形成特定的流动性,而其中运作机制需要生成、涌现、切近,从而产生大量的商机、品牌传播等社会现象。尽管展会是一种市场行为... 详细信息

展会在特定的场域内聚集着组织、人、物、信息等,是复杂的多系统交织的社会活动,其形成依靠本地产业根植性,并形成特定的流动性,而其中运作机制需要生成、涌现、切近,从而产生大量的商机、品牌传播等社会现象。尽管展会是一种市场行为的自组织,但是需要进行适当的控制,需要从吸引子的依托性营造,自上而下的规则制定,自下而上的创新,还需要各组织的自律控制。

关键词：展会复杂域涌现生成