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The Probability Density Function Related to Shallow Cumulus Entrainment Rate and Its Influencing Factors in a Large-Eddy Simulation

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Advances in Atmospheric Sciences 2024年第1期41卷 173-187页

作者： Lei ZHU Chunsong LU Xiaoqi xu Xin HE Junjun LI shi LUO Yuan WANG Fan WANG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)and Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science and TechnologyNanjing 210044China Nanjing Joint Institute for Atmospheric Sciences Nanjing 210019China College of Aviation Meteorology Civil Aviation Flight University of ChinaGuanghan 618307China Collaborative Innovation Center for Western Ecological Safety Lanzhou UniversityLanzhou 730000China Department of Geography Hong Kong Baptist UniversityHong Kong SAR 999077China

The process of entrainment-mixing between cumulus clouds and the ambient air is important for the development of cumulus *** obtaining the entrainment rate(λ)is particularly important for its parameterization within the overall cumulus parameterization *** this study,an improved bulk-plume method is proposed by solving the equations of two conserved variables simultaneously to calculateλof cumulus clouds in a large-eddy *** results demonstrate that the improved bulk-plume method is more reliable than the traditional bulk-plume method,becauseλ,as calculated from the improved method,falls within the range ofλvalues obtained from the traditional method using different conserved *** probability density functions ofλfor all data,different times,and different heights can be well-fitted by a log-normal distribution,which supports the assumed stochastic entrainment process in previous *** analysis demonstrate that the relationship betweenλand the vertical velocity is better than other thermodynamic/dynamical properties;thus,the vertical velocity is recommended as the primary influencing factor for the parameterization ofλin the *** results of this study enhance the theoretical understanding ofλand its influencing factors and shed new light on the development ofλparameterization.

关键词： large-eddy simulation cumulus clouds entrainment rate probability density functions spatial and temporal distribution

Improving RSW nugget diameter prediction method:unleashing the power of multi-fidelity neural networks and transfer learning

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Advances in Manufacturing 2024年第3期12卷 409-427页

作者： Zhong-Jie Yue Qiu-ren Chen Zu-Guo Bao Li Huang Guo-Bi Tan Ze-Hong Hou Mu-shi Li shi-Yao Huang Hai-Long Zhao Jing-Yu Kong Jia Wang Qing Liu Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing210009People’s Republic of China School of Advanced Technology Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuPeople’s Republic of China Material Academy JITRISuzhou215100JiangsuPeople’s Republic of China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China

This research presents an innovative approach to accurately predict the nugget diameter in resistance spot welding(RSW)by leveraging machine learning and transfer learning ***,low-fidelity(LF)data were obtained through finite element numerical simulation and design of experiments(DOEs)to train the LF machine learning ***,high-fidelity(HF)data were collected from RSW process experiments and used to fine-tune the LF model by transfer learning *** accuracy and generalization performance of the models were thoroughly *** results demonstrated that combining different fidelity datasets and employing transfer learning could significantly improve the prediction accuracy while minimize the costs associated with experimental trials,and provide an effective and valuable method for predicting critical process parameters in RSW.

关键词： Resistance spot welding(RSW) Nugget diameter prediction Multi-fidelity neural networks Transfer learning

A Novel Algorithm for Streamlining Diagnosis of Advanced Liver Fibrosis in CHB Patients with Concurrent Hepatic Steatosis

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 222-226页

作者： Xiaoming xu Fajuan Rui Wenjing Ni Chao Wu Junping shi Jie Li Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Department of Infectious and Hepatology Diseases The Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiangChina

Citation of this article:xu X,Rui F,Ni W,Wu C,shi J,Li J.A Novel Algorithm for Streamlining Diagnosis of Advanced Liver Fibrosis in CHB Patients with Concurrent Hepatic Steatosis.J Clin Transl Hepatol 2024;12(2):222–***:10.14218/*** hepatitis B(CHB)with concurrent hepatic steatosis(HS)is a growing challenge for public health globally.

关键词： Hepatic Patients Liver

Prognostic significance and relationship of SMAD3 phosphoisoforms and VEGFR-1 in gastric cancer:A clinicopathological study

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 118-132页

作者： shi-Lin Lv Pei Guo Jun-Rong Zou ren-Sheng Chen Ling-Yu Luo De-Qiang Huang Hospital of Gastroenterology Institute of Digestive DiseasesThe First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Pathology Shenzhen Hospital of Southern Medical UniversityShenzhen 518000Guangdong ProvinceChina Institute of Urology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Pathology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles in gastric cancer ***3 phosphorylation is a crucial prognostic marker in gastric *** To determine the prognostic value and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric *** This was a single-center observational study which enrolled 98 gastric cancer patients and 82 adjacent normal gastric tissues from patients aged 32-84 years(median age 65)between July 2006 and April *** were followed up until death or the study ended(median follow-up duration of 28.5 mo).The samples were used to generate tissue microarrays(TMAs)for immunohistochemical(IHC)*** expressions of TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 in gastric cancer(GC)tumor tissue and normal tissue were measured by IHC staining using TMAs obtained from 98 GC *** and survival information of the patients was recorded by Outdo Biotech from May 2007 to July *** relationship between TGF-β1,pSMAD3C(S423/425),pSMAD3L(S204),and VEGFR-1 protein expression levels was analyzed using Pearson's correlation *** relationship between protein expression levels and clinicopathological parameters was analyzed using the Chi-squared test.A survival curve was generated using the Kaplan-Meier survival *** TGFβ-1 and VEGFR-1 expression was significantly upregulated in gastric cancer tissue compared to adjacent noncancerous *** positive expression of phosphorylated isoforms of Smad3 varied depending on the phosphorylation site[pSMAD3C(S423/425):51.0%and pSMAD3L(S204):31.6%].High expression of pSMAD-3L(S204)was significantly correlated with larger tumors(P=0.038)and later N stages(P=0.035).Additionally,high expression of VEGFR-1 was closely correlated with tumor size(P=0.015)and pathological grading(P=0.013).High expression of both pSMAD3L(S204)and VEGFR-1 was associated with unfavorable outcomes in terms of overall survival(OS).Multiva

关键词： Gastric cancer pSMAD3L(S204) pSMAD3C(S423/425) Survival Transforming growth factor-β1 VEGFR-1

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： ren-Yong Wang Jia-Ling Yang Ning xu Jia xu Shao-Hua Yang Dao-Ming Liang Jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

Candidate genes conferring ethylene-response in cultivated peanuts determined by BSA-seq and fine-mapping

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The Crop Journal 2024年第3期12卷 856-865页

作者： Yanyan Tang Zhong Huang Shaohui xu Wenjie Zhou Jianjun ren Fuxin Yu Jingshan Wang Wujun Ma Lixian Qiao College of Agronomy Qingdao Agricultural UniversityQingdao 266109ShandongChina Murdoch University Food Futures InstitutePerthWA 6150Australia The Characteristic Laboratory of Crop Germplasm Innovation and Application Provincial Department of EducationCollege of AgronomyQingdao Agricultural UniversityQingdao 266109ShandongChina Academy of Dongying Efficient Agricultural Technology and Industry on Saline and Alkaline Land in Collaboration with Qingdao Agricultural University Dongying 257347ShandongChina

Ethylene plays essential roles in plant growth,development and stress *** ethylene signaling pathway and molecular mechanism have been studied extensively in Arabidopsis and rice but limited in ***,we established a sand-culture method to screen pingyangmycin mutagenized peanut lines based on their specific response to ethylene(“triple response”).An ethylene-insensitive mutant,inhibition of peanut hypocotyl elongation 1(iph1),was identified that showed reduced sensitivity to ethylene in both hypocotyl elongation and root *** bulked segregant analysis sequencing,a major gene related to iph1,named AhIPH1,was preliminarily mapped at the chromosome Arahy.01,and further narrowed to a 450-kb genomic region through substitution mapping strategy.A total of 7014 genes were differentially expressed among the ACC treatment through RNA-seq analysis,of which only the Arahy.5BLU0Q gene in the candidate mapping interval was differentially expressed between WT and mutant *** sequence variations,functional annotation and transcriptome analysis revealed that a predicated gene,Arahy.5BLU0Q,encoding SNF1 protein kinase,may be the candidate gene for *** gene contained two single-nucleotide polymorphisms at promoter region and was more highly expressed in iph1 than *** findings reveal a novel ethylene-responsive gene,which provides a theoretical foundation and new genetic resources for the mechanism of ethylene signaling in peanuts.

关键词： Ethylene-insensitive Hypocotyl elongation AhIPH1 Candidate gene Genetic resources

Dielectric polymer grafted electrodes enhanced aqueous supercapacitors

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Nano Research 2024年第3期17卷 1525-1534页

作者： shian Dong Kunming shi Jie Chen Yingke Zhu Hongfei Li Weihang Gao Zhenli xu Qinglei Liu Xingyi Huang Shanghai Key Laboratory of Electrical Insulation and Thermal Aging Department of Polymer Science and EngineeringState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China School of Mathematical Sciences Institute of Natural Sciences and MOE−LSCShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China

Supercapacitors(SCs)have become increasingly important in electrical energy storage and delivery owing to their high power densities and long *** SCs are promising for large-scale engineering applications because of their low cost and ***,the low operating voltage and low energy density of aqueous SCs severely limit their practical *** this study,a nanoscale dielectric layer is grafted onto a graphene electrode to achieve both a high operating voltage and enhanced *** with an SC without dielectric grafting,a dielectric-enhanced SC(DESC)shows a higher capacitance by 2200%.The mechanism of the capacitance enhancement can be attributed to three factors:the dielectric polarization,the ions desolvation by the dielectric,and the enhanced quantum capacitance from charge transfer and ion adsorption in the polymer *** addition,a 2.5 V pouch DESC with a 1 M KCl electrolyte is confirmed to cycle up to 50,000 times with a capacitance retention of 87.5%.The DESC presents the optimal electrochemical properties after it is grafted with a 5 nm dielectric *** study provides new insights into the design of high-voltage and high-energy-density aqueous SCs.

关键词： supercapacitors dielectric polymer high voltage capacitance enhancement

Plasmon-enhanced self-powered GaN/ZnTe core/shell nanopillar array photodetector

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Nano Research 2024年第6期17卷 5569-5577页

作者： Jianqi Dong Dongqi Zhang Yi Ma Daotong You Jinping Chen Bin Liu Xingfu Wang Zengliang shi Chunxiang xu State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials National Laboratory of Solid State MicrostructuresSchool of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Photonics Technology Jinan UniversityGuangzhou 510632China Guangdong Engineering Research Center of Optoelectronic Functional Materials and Devices Institute of SemiconductorsSouth China Normal UniversityGuangzhou 510631China

Nanostructure photodetectors,as the core component of optoelectronic devices,are mainly focused on the precise preparation of mixed-component nano-heterostructures and the realization of zero power consumption ***,we successfully fabricated n-GaN/p-ZnTe core/shell nanopillar array and realized self-power ultraviolet/violet *** radial heterojunction nanodevice reveals high light-dark current ratio of 104 at 0 V bias,indicating effective carriers’*** more,by integrating plasmonic effect,the responsivity and detectivity of the Au nanoparticles decorated device are increased from 3.85 to 148.83 mA/W and 4.45×1011 to 2.33×1012 Jones under 325 nm UV light *** the rise and the fall time are decreased 1.3 times and 6.8 times under 520 nm visible light irradiation at 0 V *** high photocurrent gain is derived from that the oscillating high-energy hot electrons in Au nanoparticles spontaneously inject into the ZnTe conduction band to involve the photodetection *** work presents an effective route to prepare high-performance self-power photodetector and provides a promising blueprint to realize different functional photoelectronic devices based on core/shell nanostructure.

关键词： GaN/ZnTe core/shell nanopillar array self-power ultraviolet/visible photodetector plasmonic effect

Contrasting response of rice rhizosphere microbiomes to in situ cadmium-contaminated soil remediation

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Soil Ecology Letters 2024年第2期6卷 149-162页

作者： Zhongyi Cheng Qinyu Han Yan He Jiachun shi Laosheng Wu Jianming xu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Institute of Soil and Water Resources and Environmental ScienceCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou310058China Key Laboratory of Environment Remediation and Ecological Health Ministry of EducationHangzhou310058China Department of Environmental Sciences University of CaliforniaRiversideCA92521USA

Changes in soil properties and microbial communities regulated rhizosphere protistan assemblages. • Bacterial community was more sensitive to soil amendments than protists and fungi. • Soil amendments trigger the role of specific protistan taxa Cercozoa on microbial interactions. Understanding the responses of different rhizosphere microbial lineages to soil amendments during in situ remediation of Cd-contaminated soil is of great importance in the assessment of the restoration and crop health. Here, we evaluated the effects of lime (LM), biochar (BC), pig manure (PM), and a commercial Mg-Ca-Si conditioner (CMC) on the rice rhizosphere soil physicochemical properties and community assembly of bacteria, fungi, and protists in a six-year consecutive application of soil amendments field trial. Our results indicated that among the four amendments, the BC and CMC had the best efficiency in increasing soil pH, which were 5.2% and 16.2%, respectively. Despite the differences in soil Cd concentrations is not noticeable, all the soil amendment treatments significantly decreased the proportion of available Cd in total Cd compared to the control. Soil amendments significantly altered the diversity of bacterial community, while they had no effect on fungal and protistan communities. Linear discriminant analysis effect size (LEfSe) showed that the bacteria was more sensitive to soil amendment-induced changes. For protists, treatments with LM and BC changed the groups of protistan consumers, while treatments with PM and CMC significantly increased the relative abundances of protistan phototrophs. Co-occurrence network analysis revealed that soil amendments increased microbial network complexity and triggered the role of protists, especially for the predatory protists Cercozoa, on microbial trophic interactions. Further variation partitioning analysis revealed that edaphic properties, bacterial and fungal communities compositions together explained the 77% of the total variation i

关键词： cadmium soil amendments soil protist community microbial interactions