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Dietary sanguinarine supplementation recovers the decrease in muscle quality and nutrient composition induced by high-fat diets of grass carp(Ctenopharyngodon idella)

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Animal Nutrition 2024年第2期17卷 208-219页

作者： Yong shi Lei Zhong Yuanxiang Liu Shude xu Jihong Dai Yaozhengtai Zhang Yi Hu Fisheries College Hunan Agricultural University Hunan Engineering Research Center for Utilization of Characteristics of Aquatic Resources Hunan Agricultural University Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture Institute of Hydrobiology Chinese Academy of Sciences

The intake of high-fat diets(HFD) has been shown to diminish the muscle quality of aquatic ***, as an excellent additive, exhibits the capability to reduce fat deposition and alleviate inflammation. However, its role in the muscle quality reduction caused by HFD remains unclear. An eight-week trial was conducted to investigate the impacts of dietary supplementation of sanguinarine at1200 μg/kg(HFDS; crude fat = 10%) on the muscle quality of grass carp(Ctenopharyngodon idellus) in comparison to a basic diet(CON, crude fat = 5%). Each group had 3 replicates, with 40 fish per *** experiment employed one-way ANOVA and Duncan's multiple comparisons of the means. The results showed that the HFD exhibited lower growth performance, reduced protein deposition, myofiber diameter, and muscle hardness, coupled with higher levels of fat deposition and inflammation when compared with the CON. However, HFDS improved growth performance(P < 0.05), fat metabolism(ppara( P = 0.001), lpl(P < 0.001), atgl(P < 0.001), and cpt1(P = 0.001) expression exhibited a significant elevation), protein deposition(the protein and m RNA levels of AKT(P = 0.004), PI3K(P = 0.027),TOR(P = 0.005), and P70S6K(P = 0.007) demonstrated a marked increase), myofiber diameter, muscle hardness, and the total content of eicosapentaenoic acid and docosahexaenoic acid. Furthermore, the HFDS reduced oxidative damage caused by fat deposition by significantly downregulating nf-κb(P <0.001), il-1β(P < 0.001), il-6(P < 0.001), il-8(P = 0.003), and tnf-a(P < 0.001) expression and markedly upregulated nrf2(P < 0.001), gpx4(P < 0.001), cat(P < 0.001), sod(P < 0.001), and gr(P = 0.003)expression. The findings from this study suggest that sanguinarine has the potential to alleviate the adverse effects of HFD on growth and muscle quality, providing a theoretical foundation for its practical implementation.

关键词： Plant extract Muscle feature Myofiber characteristics Muscular texture Protein metabolism

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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian xu Ding-qiao YUE shi-jun FU Rui-jia TANG Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

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Mirizzi syndrome:Problems and strategies

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 234-240页

作者： Jun Wu Shuang-Yong Cai xu-Liang Chen Zhi-Tao Chen Shao-Hua shi Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Jiulongpo DistrictChongqing 400050China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310003China

Mirizzi syndrome is a serious complication of gallstone *** is caused by the impacted stones in the gallbladder neck or cystic *** of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot’s *** our clinical practice,bile duct,branches of right hepatic artery and right portal vein clinging to gallbladder infundibulum are often observed due to gallbladder infundibulum adhered to right hepatic *** intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct,all of which are hidden pitfalls for *** resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)are the preferable tools for the diagnosis of Mirizzi *** cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic *** cholecystectomy is an easy,safe and definitive approach to Mirizzi *** combined with the application of ERCP,a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and *** objective of this review was to highlight its existing problems:(1)low preoperative diagnostic rate,(2)easy to damage bile duct and branches of right hepatic artery,and(3)high concomitant gallbladder ***,the review aimed to discuss the possible therapeutic strategies:(1)to enhance its preoperative recognition by imaging findings,and(2)to avoid potential pitfalls during surgery.

关键词： Mirizzi syndrome Bile duct injury Artery injury Surgical treatment Subtotal cholecystectomy

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Membrane vesicles derived from Streptococcus suis serotype 2 induce cell pyroptosis in endothelial cells via the NLRP3/Caspase-1/GSDMD pathway

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Journal of Integrative Agriculture 2024年第4期23卷 1338-1353页

作者： Keda shi Yan Li Minsheng xu Kunli Zhang Hongchao Gou Chunling Li Shaolun Zhai Institute of Animal Health Guangdong Academy of Agricultural Sciences/Key Laboratory of Livestock Disease Prevention ofGuangdong Province/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of GuangdongProvinceMinistry of Agriculture and Rural AffairsGuangzhou 510640China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000China College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhou 510225China

Streptococcus suis serotype 2(*** 2)is a zoonotic pathogen that clinically causes severe swine and human infections(such as meningitis,endocarditis,and septicemia).In order to cause widespread diseases in different organs,*** 2 must colonize the host,break the blood barrier,and cause exaggerated *** the last few years,most studies have focused on a single virulence factor and its influences on the *** vesicles(MVs)can be actively secreted into the extracellular environment contributing to bacteria-host ***-negative bacteria-derived outer membrane vesicles(OMVs)were recently shown to activate host Caspase-11-mediated non-canonical inflammasome pathway via deliverance of OMV-bound lipopolysaccharide(LPS),causing host cell ***,little is known about the effect of the MVs from *** 2(Gram-positive bacteria without LPS)on cell ***,we investigated the molecular mechanism by which *** 2 MVs participate in endothelial cell *** this study,we used proteomics,electron scanning microscopy,fluorescence microscope,Western blotting,and bioassays,to investigate the MVs secreted by *** ***,we demonstrated that *** 2 secreted MVs with an average diameter of 72.04 nm,and 200 proteins in MVs were ***,we showed that MVs were transported to cells via mainly dynamin-dependent *** *** 2 MVs activated NLRP3/Caspase-1/GSDMD canonical inflammasome signaling pathway,resulting in cell pyroptosis,but it did not activate the Caspase-4/-5 *** importantly,endothelial cells produce large amounts of reactive oxygen species(ROS)and lost their mitochondrial membrane potential under induction by *** 2 *** results in this study suggest for the first time that MVs from *** 2 were internalized by endothelial cells via mainly dynamin-dependent endocytosis and might promote NLRP3/Caspase-1/GSDMD pathway by mitochondrial damage,which produced mtDNA and ROS under induction,

关键词： Streptococcus suis serotype 2 membrane vesicles endocytosis pyroptosis NLRP3 inflammasomes mitochondrial damage endothelial cell

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Nanophase separated,grafted alternate copolymer styrene-maleic anhydride as an efficient room temperature solid state lithium ion conductor

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Chinese Chemical Letters 2024年第7期35卷 491-496页

作者： Qian Wang Ting Gao Xiwen Lu Hangchao Wang Minggui xu Longtao ren Zheng Chang Wen Liu Institute of Science and Technology China Three Gorges CorporationBeijing 100038China State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029China

All solid-state lithium metal batteries(ASSLMBs)based on polymer solid electrolyte and lithium metal anode have attracted much attention due to their high energy density and intrinsic ***,the low ionic conductivity at room temperature and poor mechanical properties of the solid polymer electrolyte result in increased polarization and poor cycling stability of the Li metal *** order to improve the ionic conductivity at room temperature while maintaining mechanical strength,we combine the conductivity of short chain polyethylene oxide(PEO)and strength of styrene-maleic anhydride copolymer(SMA)to obtain a grafted block copolymer with nanophase separation structure,which has room temperature ionic conductivity up to 1.14×10^(-4)S/cm and tensile strength up to 1.4 ***||Li symmetric cell can work stably for more than 1500 h under the condition of 0.1 mA/cm^(2).Li||LiFePO_(4)full cells can deliver a high capacity of 151.4 mAh/g at 25℃and 0.2 C/0.2 C charge/discharge conditions,showing 85.6%capacity retention after 400 ***,the all solid state Li||LiFePO_(4)pouch cell shows excellent safety performance under different abuse *** results demonstrate that the nanophase separated,grafted alternate copolymer electrolyte has huge potential for application in Li metal batteries.

关键词： Solid polymer electrolyte All solid-state battery Li metal battery Copolymers Nanophase separation

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An improved plant prime editor for efficient generation of multiple-nucleotide variations and structural variations in rice

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Plant Communications 2024年第9期5卷 21-24页

作者： Zhaohui Zhong Tingting Fan Yao He shishi Liu xuelian Zheng Yang xu Jingqi ren Hua Yuan Zhengyan xu Yong Zhang Department of Biotechnology School of Life Sciences and TechnologyCenter for Informational BiologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China Chongqing Key Laboratory of Plant Resource Conservation and Germplasm Innovation Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science CitySchool of Life SciencesSouthwest UniversityChongqing 400715China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Rice Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Dear Editor,The ability to manipulate single-nucleotide variations(SNVs),multiple-nucleotide variations(MNVs),and structural variations(SVs)in rice genomes is crucial for studying gene function and improving agricultural ***,these manipulations were achieved mainly through homology-directed repair,which has limited efficiency in plants.

关键词： structural editor nucleotide

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Casual associations between blood metabolites and colon cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1995-2005页

作者： Ke-Yue Hu Yi-Quan Cheng Zhi-Long shi Fu-Peng ren Gang-Feng Xiao Department of Hematology and Oncology Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina

BACKGROUND Limited knowledge exists regarding the casual associations linking blood metabolites and the risk of developing colorectal *** To investigate causal associations between blood metabolites and colon *** The study utilized a two-sample Mendelian randomization(MR)analysis to investigate the causal impact of 486 blood metabolites on colorectal *** primary method of analysis used was the inverse variance weighted *** further validate the results several sensitivity analyses were performed,including Cochran's Q test,MR-Egger intercept test,and MR robust adjusted profile *** additional analyses were conducted to ensure the reliability and robustness of the *** After rigorous selection for genetic variation,486 blood metabolites were included in the MR *** found Mannose[odds ratio(OR)=2.09(1.10-3.97),P=0.024],N-acetylglycine[OR=3.14(1.78-5.53),P=7.54×10^(-8)],X-11593-O-methylascorbate[OR=1.68(1.04-2.72),P=0.034],1-arachidonoylglycerophosphocholine[OR=4.23(2.51-7.12),P=6.35×10^(-8)]and 1-arachidonoylglycerophosphoethanolamine 4[OR=3.99(1.17-13.54),P=0.027]were positively causally associated with colorectal cancer,and we also found a negative causal relationship between Tyrosine[OR=0.08(0.01-0.63),P=0.014],Urate[OR=0.25(0.10-0.62),P=0.003],N-acetylglycine[0.73(0.54-0.98),P=0.033],X-12092[OR=0.89(0.81-0.99),P=0.028],Succinylcarnitine[OR=0.48(0.27-0.84),P=0.09]with colorectal cancer.A series of sensitivity analyses were performed to confirm the rigidity of the *** This study showed a causal relationship between 10 blood metabolites and colorectal cancer,of which 5 blood metabolites were found to be causal for the development of colorectal cancer and were confirmed as risk *** other five blood metabolites are protective factors.

关键词： Metabolites Colon cancer Mendelian randomization Genome-wide association studies Casual

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Synthesis of spherical nano-ZSM-5 zeolite with intergranular mesoporous for alkylation of ethylbenzene with ethanol to produce m-diethylbenzene

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Chinese Journal of Chemical Engineering 2024年第3期67卷 298-309页

作者： Siyue Wang Jinhong Li Qingxin xu Shengjie Song Yu'ni Jiang Lidong Chen Xin shi Weiguo Cheng Faculty of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 110629China Beijing Key Laboratory of Ionic Liquids Clean Process Key Laboratory of Green Process and EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Catalytic synthesis of m-diethylbenzene(m-DEB)through alkylation of ethylbenzene(EB)may be a promising alternative route in comparison with traditional rectification of mixed DEB,for which the top priority is to develop efficient and stable heterogeneous ***,the spherical nano-ZSM-5 zeolite with abundant intergranular mesoporous is synthesized by the seed-mediated growth method for alkylation of EB with ethanol to produce *** results show that the spherical nano-ZSM-5 zeolite exhibits better stability and higher alkylation activity at a lower temperature than those of commercial micropore *** then,the spherical nano-ZSM-5 is further modified by La_(2)O_(3) through acid treatment followed by immersion *** acid treatment causes nano-ZSM-5 to exhibit the increased pore size but decreased the acid sites,and subsequent La_(2)O_(3) loading reintroduces the weak acid *** a result,the HNO_(3)-La_(2)O_(3)-modified catalyst exhibits a slight increase in EB conversion and DEB yield in comparison with unmodified one,and meanwhile,it still maintains high m-DEB *** catalyst after acid treatment achieves higher catalytic stability besides maintaining the high alkylation activity of EB with *** present study on the spherical nano-HZSM-5 zeolite and its modification catalyst with excellent alkylation ability provides new insights into the production of mDEB.

关键词： Zeolite Modification Alkylation reaction m-diethylbenzene Catalyst Fixed-bed

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NH_(4)Cl-assisted synthesis of TaON nanoparticle applied to photocatalytic hydrogen and oxygen evolution from water

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Journal of Energy Chemistry 2024年第7期94卷 541-550页

作者： Yao xu Kaiwei Liu Jifang Zhang Boyang Zhang Jiaming Zhang Ke shi Haifeng Wang Guijun Ma School of Physical Science and Technology Shanghaitech UniversityShanghai 201210China

Oxynitride semiconductors are promising photocatalyst materials for visible light-driven water splitting,while the synthesis of well crystalized oxynitride still remains *** present work,narrow-bandgap TaON nanoparticles are synthesized via heating a vacuum-sealed mixture of KTaO_(3),Ta and NH_(4)*** method possesses multiple advantages in terms of lower calcination parameter,higher N conversion efficiency and superior photocatalytic activity in comparison with the traditional thermal ammonolysis using NH_(3) gas as a nitrogen *** the analysis of intermediates produced upon the elevation of heating temperature,a gas-solid-phase reaction between TaCl_(5) and Ta_(2)O_(5) is demonstrated as the final step,which is conducive to decreasing thermal energy barrier and accelerating nitridation *** control of preparation conditions,including calcination temperature and duration,allows for the regulation of surface O/N ratio of TaON particles to unity,resulting in optimized photocat-alytic *** assessment and intensity modulated photocurrent spectroscopy provide convincing evidence for improved charge transfer effciency of photoexcited holes at TaON surface.A Z-scheme overall water splitting is accomplished by employing the TaON as an effective oxygen evolution photocatalyst,SrTiO_(3):Rh as a hydrogen evolution photocatalyst,and reduced graphene oxide(rGO)as a solid-state electron *** work presents a promising strategy for the synthesis of high-quality oxynitride materials in application to photocatalytic water splitting.

关键词： TaON Oxynitride synthesis Photocatalyst Water splitting,Hydrogen Z-scheme

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Effect of Chinese Medicine in Patients with COVID-19: A Multi-center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第11期30卷 974-983页

作者： ZHAO Guo-zhen YAN shi-yan LI Bo GUO Yu-hong SONG Shuang HU Ya-hui GUO shi-qi HU Jing DU Yuan LU Hai-tian YE Hao-ran ren Zhi-ying ZHU Ling-fei xu Xiao-long SU Rui LIU Qing-quan Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine School of Clinical Medicine Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Integrated Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness and safety of Chinese medicine(CM) in the treatment of coronavirus disease 2019(COVID-19) in China. Methods: A multi-center retrospective cohort study was carried out, with cumulative CM treatment period of 3 days during hospitalization as exposure. Data came from consecutive inpatients from December 19, 2019 to May 16, 2020 in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting(IPTW), and the Cox proportional hazards regression model was used for statistical analysis. Results:A total of 2,272 COVID-19 patients were included. There were 1,684 patients in the CM group and 588 patients in the control group. Compared with the control group, the hazard ratio(HR) for the deterioration rate in the CM group was 0.52 [95% confidence interval(CI): 0.41 to 0.64, Prenal function in the CM group was smaller. Conclusion: This real-world study indicates that the combination of a full-course CM therapy on the basic conventional treatment, may safely reduce the deterioration rate and all-cause mortality of COVID-19patients. This result can provide the new evidence to support the current treatment of COVID-19. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific CM interventions.(Registration No. ChiCTR2200062917)

关键词： Chinese medicine all-cause mortality cohort study coronavirus disease 2019 deterioration rate

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