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Core value of laparoscopic colorectal surgery

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1295-1299页

作者： Xin-Xiang Li ren-jie wang Department of Colorectal Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University

Since laparoscopy was first used in cholecystectomy in 1987, it has developed quickly and has been used in most fields of traditional surgery. People have now accepted its advantages like small incision, quick recovery, light pain, beauty and short hospital stays. In early times, there are still controversies about the application of laparoscopy in malignant tumor treatments, especially about the problems of oncology efficacy, incision implantation and operation security. However, these concerns have been fully eliminated by evidences on the basis of evidence-basis medicine. In recent years, new minimally invasive technologies are appearing continually, but they still have challenges and may increase the difficulties of radical dissection and the risks of potential complications, so they are confined to benign or early malignant tumors. The core value of the laparoscopic technique is to ensure the high quality of tumor's radical resection and less complications. On the basis of this, it is allowed to pursue more minimally invasive techniques. Since the development of laparoscopic colorectal surgery is rapid and unceasing, we have reasons to believe that laparoscopic surgery will become gold standard for colorectal surgery in the near future.

关键词： Laparoscopy Minimally invasive surgery Core value

Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury

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Neural Regeneration Research 2021年第6期16卷 1068-1077页

作者： Jian Zhang ren-jie wang Miao Chen Xiao-Yin Liu Ke Ma Hui-You Xu Wu-Sheng Deng Yi-Chao Ye Wei-Xin Li Xu-Yi Chen Hong-Tao Sun Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjinChina Graduate School Logistics University of People’s Armed Police ForceTianjinChina Graduate School Affiliated Hospital of Traditional Chinese MedicineXinjiang Medical UniversityUrumqiXinjiang Uygur Autonomous RegionChina Graduate School Tianjin Medical UniversityTianjinChina

One reason for the poor therapeutic effects of stem cell transplantation in traumatic brain injury is that exogenous neural stem cells cannot effectively migrate to the local injury site,resulting in poor adhesion and proliferation of neural stem cells at the injured *** enhance the targeted delivery of exogenous stem cells to the injury site,cell therapy combined with neural tissue engineering technology is expected to become a new strategy for treating traumatic brain ***/heparan sulfate porous scaffolds,prepared using a freeze-drying method,have stable physical and chemical *** scaffolds also have good cell biocompatibility because of their high porosity,which is suitable for the proliferation and migration of neural stem *** the present study,collagen/heparan sulfate porous scaffolds loaded with neural stem cells were used to treat a rat model of traumatic brain injury,which was established using the controlled cortical impact *** 2 months after the implantation of collagen/heparan sulfate porous scaffolds loaded with neural stem cells,there was significantly improved regeneration of neurons,nerve fibers,synapses,and myelin sheaths in the injured brain ***,brain edema and cell apoptosis were significantly reduced,and rat motor and cognitive functions were markedly *** findings suggest that the novel collagen/heparan sulfate porous scaffold loaded with neural stem cells can improve neurological function in a rat model of traumatic brain *** study was approved by the Institutional Ethics Committee of Characteristic Medical Center of Chinese People’s Armed Police Force,China(approval No.2017-0007.2)on February 10,2019.

关键词： collagen heparan sulfate injury neural stem cells regeneration repair scaffold traumatic brain injury morris water maze motor evoked potential synapses myelin sheaths

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钨球正撞击下低碳钢板的极限贯穿厚度研究

北京理工大学学报 2017年第6期37卷 551-556页

作者：徐豫新任杰王树山北京理工大学爆炸科学与技术国家重点试验室北京100081

研究低碳钢板在钨球正撞击下的极限贯穿厚度.采用6射弹弹道极限试验数据处理方法通过试验获得Φ6.0mm(93W)、Φ7.0mm(93W)、Φ6.0mm(95W)和Φ7.5mm(95W)共4种钨球对6种不同厚度Q235A钢板正撞击下的弹道极限速度和极限贯穿厚度范围.采用A... 详细信息

研究低碳钢板在钨球正撞击下的极限贯穿厚度.采用6射弹弹道极限试验数据处理方法通过试验获得Φ6.0mm(93W)、Φ7.0mm(93W)、Φ6.0mm(95W)和Φ7.5mm(95W)共4种钨球对6种不同厚度Q235A钢板正撞击下的弹道极限速度和极限贯穿厚度范围.采用Autodyn软件进行了同试验条件下的数值仿真,仿真模型被验证后,通过仿真获得了极限贯穿厚度范围,同时分析了钨球正撞击侵彻过程中的能量转换规律.基于能量守恒,建立了钨球对低碳钢板正撞击下极限贯穿厚度的计算模型.采用所建立的计算模型计算得到:Φ6.0mm(93W)、Φ7.0mm(93W)、Φ6.0mm(95 W)和Φ7.5mm(95 W)4种钨球正撞击下Q235A钢板的极限贯穿厚度分别为16.95,19.17,17.30,21.50mm,计算结果与试验和数值仿真所获得范围误差不大于10%.研究结果为杀爆战斗部毁伤元的设计提供了基础数据以及方法支撑.

关键词：高速侵彻动力学极限贯穿厚度钨球低碳钢

Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying wang jie Liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

深部咸水层CO_2地质封存对地层压力环境的影响

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河海大学学报（自然科学版） 2016年第6期44卷 512-518页

作者：胡叶军王蔚任杰王媛河海大学土木与交通学院江苏南京210098 嘉兴市世纪交通设计有限公司浙江嘉兴314001 河海大学水利水电学院江苏南京210098 水文水资源与水利工程科学国家重点实验室江苏南京210098

针对深部咸水层CO_2地质封存过程中流体的运移和压力的传递现象,利用美国Frio地区的CO_2咸水层封存试验实测数据,建立二维多岩相结构模型,模拟分析CO_2地质封存中CO_2注入阶段岩石孔渗性能的变化特征、岩层压力增加的变化特征以及CO_2... 详细信息

针对深部咸水层CO_2地质封存过程中流体的运移和压力的传递现象,利用美国Frio地区的CO_2咸水层封存试验实测数据,建立二维多岩相结构模型,模拟分析CO_2地质封存中CO_2注入阶段岩石孔渗性能的变化特征、岩层压力增加的变化特征以及CO_2羽流的演化规律。结果表明,超临界CO_2在驱替咸水溶液的过程中形成类似漏斗状的扩散晕,蒸发作用产生的盐沉淀主要位于井附近的单气相区,随着盐沉淀的增加,井周围的渗透率降低、压力积聚;盖层渗透性提高避免了储层内部出现过大压力,但却增加了泄漏的可能性。

关键词：深部咸水层多岩相模型固体饱和度 CO2羽流盖层压力

干旱胁迫及复水对红松针叶和树皮绿色组织光合特性及抗氧化系统的影响

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生态学杂志 2016年第10期35卷 2606-2614页

作者：张丹任洁王慧梅东北林业大学森林植物生态学教育部重点实验室哈尔滨150040

以红松为材料,研究了干旱及复水对红松针叶和树皮绿色组织的光合特性和抗氧化酶活性等生理生化指标的影响。结果表明:干旱胁迫下,红松针叶和树皮绿色组织叶绿素总量和叶绿素a/b值均有显著下降,这样可以通过降低PSII天线捕获的光能,减少... 详细信息

以红松为材料,研究了干旱及复水对红松针叶和树皮绿色组织的光合特性和抗氧化酶活性等生理生化指标的影响。结果表明:干旱胁迫下,红松针叶和树皮绿色组织叶绿素总量和叶绿素a/b值均有显著下降,这样可以通过降低PSII天线捕获的光能,减少发生光抑制的危险;针叶净光合速率(Pn)下降主要由非气孔因素造成,树皮绿色组织Pn下降主要由气孔因素造成;红松针叶和树皮绿色组织非光化学猝灭(NPQ)均升高,表明热耗散是植株重要光保护机制;红松针叶和树皮绿色组织丙二醛(MDA)含量明显升高,发生了氧化胁迫,超氧化物歧化酶(SOD)等抗氧化酶活性的提高对红松的干旱胁迫起到了积极的防御作用;复水后,红松针叶和树皮绿色组织Pn恢复到对照水平,叶绿素荧光参数和抗氧化酶活性也表现出不同程度恢复。以上研究结果表明,干旱胁迫下红松针叶和树皮绿色组织均通过减少光捕获、热耗散和酶活性调节协同作用,稳定光合机构功能,复水后红松光合特性表现较好的恢复能力,红松对干旱具有较强的适应能力。

关键词：干旱复水针叶树皮绿色组织叶绿素荧光气体交换抗氧化酶

Platinum Drugs Selectively Downregulated the Frequency Myeloid-derived Suppressor Cells in Microenvironment of Bladder Cancer

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

第十三届全国免疫学学术大会

作者： Ke Wu ren-jie wang Zhi-xian Yao Zhong Zheng Zhi-hong Liu Shanghai General Hospital

Background: Bladder cancer(BC) remains the fifth most common cancer and the second most common genitourinary neoplasm in the United *** prevalence of bladder cancer is estimated at 1 million and is steadily ***-derived suppressor cells(MDSC) could inhibit the activation, proliferation and cytotoxic function of effector cells through various mechanisms, thus leading to the failure of antitumor immune *** Drugs are expected to become promising conditioning agents for the elimination of MDSC, but the mechanism is still not *** of study: In this study, T24 bladder cancer cell lines were divided into cisplatin, carboplatin and lobaplatin treated groups and control *** cells treated drug concentration was tested by CCK-8 *** proportion of MDSC from CD11 b+CD45+ immune cells was evaluated by flow cytometry *** BC cells apoptosis was evaluated by Hoechst dyeing *** apoptosis related protein expression was tested by flow cytometry ***: We have found that platinum drugs treatment can inhibit BC cells progression by enhancing *** treatment can also significantly decreased proportion of *** level of MDSC, especially granulocyte derived MDSC, is an important characteristic of BC immune *** can promote BC cells proliferation and inhibit apoptosis through various *** platinum drugs reasonable perhaps can kill BC cells directly and ***: Platinum drugs treatment can not only kill BC cells, but also decrease proportion of MDSC, which can improve prognosis of BC ulteriorly.

关键词： Platinum drugs MDSCs Bladder Cancer Microenvironment

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： jie wang Wei wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

Gemcitabine promoting CCL2 secretion by Bladder cancer cell recruited MDSCs into tumor microenvironment

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Gemcitabine promoting CCL2 secretion by Bladder cancer cell ...