检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

大断面绞车房掘进分部分次施工工艺探讨

科技创新与生产力 2014年第8期 71-73页

作者：任兆海太原煤气化炉峪口煤矿山西太原030024

介绍了采用传统炮掘施工工艺,在现有条件基础上,运用分部施工法进行大断面岩石工程施工,成功解决了掘进、支护、排矸等问题,提高了工效、降低了生产成本,最终顺利完成施工要求。

关键词：提大断面掘进施工工艺

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei zhao Wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

On the consistency of two-phase local/nonlocal piezoelectric integral model

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2021年第11期42卷 1581-1598页

作者： Yanming ren hai QING State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In this paper,we propose general strain-and stress-driven two-phase local/nonlocal piezoelectric integral models,which can distinguish the difference of nonlocal effects on the elastic and piezoelectric behaviors of *** nonlocal piezoelectric model is transformed from integral to an equivalent differential form with four constitutive boundary conditions due to the difficulty in solving intergro-differential equations *** nonlocal piezoelectric integral models are used to model the static bending of the Euler-Bernoulli piezoelectric beam on the assumption that the nonlocal elastic and piezoelectric parameters are coincident with each *** governing differential equations as well as constitutive and standard boundary conditions are *** is found that purely strain-and stress-driven nonlocal piezoelectric integral models are ill-posed,because the total number of differential orders for governing equations is less than that of boundary ***,the traditional nonlocal piezoelectric differential model would lead to inconsistent bending response for Euler-Bernoulli piezoelectric beam under different boundary and loading *** nominal variables are introduced to normalize the governing equations and boundary conditions,and the general differential quadrature method(GDQM)is used to obtain the numerical *** results from current models are validated against results in the *** is clearly established that a consistent softening and toughening effects can be obtained for static bending of the Euler-Bernoulli beam based on the general strain-and stress-driven local/nonlocal piezoelectric integral models,respectively.

关键词： nonlocal piezoelectric integral model softening effect toughening effect general differential quadrature method(GDQM)

Rapid recovery of desert shrubs is attributed to imbalance of water supply to demand after disturbance in Northwest China

在线全文

学校读者我要写书评

暂无评论

Ecological Processes 2024年第2期13卷 118-129页

作者： hai Zhou Xiangyan Feng Zhibin He Qiyue Yang Heng ren Wenzhi zhao Linze Inland River Basin Research Station Chinese Ecosystem Research Network Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences University of Chinese Academy of Sciences

Background Disturbance is a key driver of changes in terrestrial ecosystems, especially in water limited regions. In the desert ecosystem of Northwest China, shrubs are often foraged by camels and this causes the shrubs lost their aboveground tissues. Although the aboveground tissue could recover after the disturbance, the mechanisms of resprouts' recovery after the disturbance are still poorly understood. We investigated the morphological and physiological characteristics and root water uptake sources of resprouts and non-disturbed seedlings of four desert shrub species that were often foraged by *** The results showed that the resprouts grew rapidly after the removal of aboveground tissue. The height and aboveground biomass of resprouts reached the level of 5-year-old seedlings following a growing season. Compared to un-disturbed seedlings, higher leaf water potential, leaf hydraulic conductance and photosynthesis rate were observed in resprouts, indicating that resprouts grew rapidly after disturbance. Furthermore, we found that the root water uptake source did not change after disturbance. This indicated that the roots of resprouts kept intact water uptake capacity after disturbance, which could keep supplying sufficient water to the aboveground tissue. Due to the removal of aboveground tissue of the resprouts, the water demand of aboveground tissue decreased, which induced an imbalance of water supply from roots to demand of aboveground tissues of resprouts. This explained the improved physiological performance and rapid recovery of resprouts after *** The imbalance of water supply to demand contributes to the rapid recovery of desert shrubs after disturbance. The findings provide insight into the eco-physiological mechanism for the maintenance of desert ecosystems that are facing disturbance.

关键词： Disturbance Resprout Physiological performance Shrub Water uptake source

Generalized Uncertainty Principle and Black Hole Entropy of Higher-Dimensional de Sitter Spacetime

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2007年第3X期48卷 465-468页

作者： zhao hai-Xia LI Huai-Fan HU Shuang-Qi zhao ren School of Chemical Engineering and Environment North University of China Taiyuan 030051 China Department of Physics Shanxi Datong University Datong 037009 China

Recently, there has been much attention devoted to resolving the quantum corrections to the Bekenstein-- Hawking black hole entropy. In particular, many researchers have expressed a vested interest in the coetticient of the logarithmic term of the black hole entropy correction term. In this paper, we calculate the correction value of the black hole entropy by utilizing the generalized uncertainty prlnciple and obtain the correction term caused by the generalized uncertainty principle. Because in our calculation we think that the Bekenstein-Hawking area theorem is still valid after considering the generalized uncertainty principle, we derive that the coefficient of the logarithmic term of the black hole entropy correction term is positive. This result is different from the known result at present. Our method is valid not only for four-dimensional spacetimes but also for higher-dimensional spacetimes. In the whole process, the physics idea is clear and calculation is simple. It offers a new way for studying the entropy correction of the complicated spacetime.

关键词： generalized uncertainty principle black hole entropy area theorem higher-dimensional spacetime

Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第9期42卷 1333-1340,I0007页

作者： Tian-Hao ren De-hai Liang Beijing National Laboratory for Molecular Sciences Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic *** the regulation mechanism is still a *** this work,we designed a series of peptides(XXLY)_(6)SSSGSS and studied their complexation and coacervation behavior with single-stranded ***“X”and“Y”are varied to combine known amounts of charged and non-charged amino acids,together with the introduction of secondary structures and pH *** show that the electrostatic interaction,which is described as charge density,controls both the strength of complexation and the degree of chain relaxation,and thus determines the growth and size of the *** hydrophobic interaction is prominent when the charges are ***,the secondary structures of peptides exhibit profound effect on the morphology of the phases,such as solid phase to liquid phase *** study gains insight into the phase separation under physiological *** is also helpful to create coacervates with desirable structures and functions.

关键词： Polyelectrolyte complex Coacervate Peptides Secondary structure Electrostatic interaction

Microstructure and tribological behavior of the nickel-coated-graphitereinforced Babbitt metal composite fabricated via selective laser melting

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 320-326页

作者： Xingke zhao Xusheng hai School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

To improve the properties of Babbitt alloys,Ni-coated-graphite-reinforced Babbitt metal composite specimens were prepared via selective laser melting(SLM),and the composites microstructures,mechanical properties,and tribological properties were studied through scanning electron microscopy(SEM),shear testing,and dry-sliding wear testing,*** results showed that most of the nickel-coated graphite(NCGr)particles were distributed at the boundaries of laser beads in the cross section of the SLM composite *** and microvoids formed at the boundaries of laser beads where NCGr particles *** the shear strength and the friction coefficient of the SLM composite specimens decreased with increasing NCGr *** shear strength and the friction coefficient of the SLM composite sample with 6 wt%NCGr were approximately 20%and 33%lower than those of the NCGr-free sample,*** friction mechanism changed from plastic shaping furrow to brittle cutting with increasing NCGr content.A practical Babbitt material with a lower friction coefficient and sufficient strength can be obtained by controlling the NCGr particle dispersion;this can be achieved by choosing NCGr particles with a thicker Ni layer and precisely controlling the laser energy input during the SLM process.

关键词： sliding wear fracture metal matrix composite laser processing lubricant additives bearings

Traveling Fronts for a Time-periodic Population Model with Dispersal

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第4期40卷 1147-1154页

作者： hai-qin zhao School of Mathematics and Statistics Xidian UniversityXi’an 710071China

In this paper,we study a class of time-periodic population model with *** is well known that the existence of the periodic traveling fronts has been ***,the uniqueness and stability of such fronts remain *** this paper,we first prove the uniqueness of non-critical periodic traveling ***,we show that all non-critical periodic traveling fronts are exponentially asymptotically stable.

关键词： periodic integro-differential equation time-periodic traveling front uniqueness stability

Chaos Control and Anti-control via a Fuzzy Neural Network Inverse System Method

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2002年第8期19卷 1054-1057页

作者： ren hai-Peng Liu Ding School of Automation and Information Engineering Xi'an University of Technology Xi'an 710048

We propose a new method for chaos control and anti-control, which is referred to as the fuzzy-neural network inverse system method (FNNIS). The Sugeno-type fuzzy-neural network (FNN) is employed to learn the kinetics of the system to be controlled. Then the FNN model is used with the inverse system method to make the system to be controlled to track the reference input. If the system to be controlled is chaotic and the reference input is non-chaotic, chaos control can be implemented via the FNNIS method. If the system to be controlled is non-chaotic and the reference input is chaotic, chaos anti-control can be implemented. Theorems about the effect of the FNN model error upon control are established. The simulation results show that this method is feasible and effective for chaos control and anti-control.

关键词： Fuzzy neural networks