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Recent changes in the prevalence of Helicobacter pylori infection among children and adults in high- or low-incidence regions of gastric cancer in China

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Chinese Medical Journal 2009年第15期122卷 1759-1763页

作者： ZHANG Dong-hong ZHOU Li-ya LIN San-ren DING Shi-gang huang Yong-hui GU Fang ZHANG Li LI Yuan CUI Rong-li MENG Ling-mei YAN Xiu-e ZHANG Jing Department of Gastroenterology Peking University Third Hospital Beijing 100191 China

Background The prevalence of Helicobacterpylori （H. pylon） infection varies by geographic locations. Studies indicate that the infection rate of H. pylori was previously high in China but that rates had been declining worldwide over recent decades. The aims of our study were：（1） to determine the current prevalence of H. pylori infection among children and adults residing in areas with high （Muping County, Shandong） and low （Yanqing County, Beijing） incidences of gastric cancer in China, and （2） to compare the prevalence for 2006 with the prevalence for the early 1990s. Methods Using Warthin-Starry silver staining of gastric mucosal biopsy specimens and H. pylori stool antigen tests （HpSA）, we tested a total of 2065 asymptomatic children aged 8-15 years and adults aged 40-79 years in the above two regions from May to July 2006. We evaluated 520 children and 526 adults from Muping, and 516 children and 503 adults from Yanqing. Subjects were selected randomly and H. pylori status was determined by HpSA in children and either HpSA or histology of gastric biopsies in adults. Data obtained in the early 1990s in the same two areas of China were also collected and studied. Results For children, the prevalence of H. pylori infection was significantly higher in Muping （37.69%） than it was in Yanqing （25.58%, P〈0.001）. In both regions, the prevalence of H. pyloriincreased with age but was not related to gender A significant difference was observed between 8-9-years old and 10-11-years old （P 〈0.05）, but not between other adjoining age groups （P 〉0.05）. From 1991 to 2006 H. pylori prevalence among 8-10-year-old children decreased in Muping （60.00% vs 32.07%, P 〈0.001）, but not Yanqing （24.06% vs 19.10%, P 〉0.05）. In the adult group, H. pylori prevalence was 50.95% in Muping, which was significantly higher than the 41.35% positive rate in Yanqing （P 〈0.01）. But there were no statistically significant differences between different age groups of 40-49, 50-59, and 60-79 years, or

关键词： Helicobacter pylori stomach neoplasms epidemiology

Molecular Analysis of the Huntington's Disease with Expanded CAG Trinucleotide Repeat in Chinese

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High Technology Letters 1995年第1期1卷 5-9页

作者： Zeng Yitao Mao Yuehua Chen Meijue ren Zhaorui Zhou gang huang Shuzhen (Shanghai Institute of Medical Genetics,Shanghai Children’s Hospital,Shanghai 200040,P.R.China) Wang Xiuying~① Yie Wenghu~② Zhao Xiangzhi~③ (①Xuzhou Medical College,Xuzhou,JiangSu,P.R.China) (②Anhui Medical University,Aanhui,P.R.China) (③Henan Psychiatrical Institute,Zhengzhou,P.R.China) Shanghai Inst of Medical Genetics Shanghai China

The polymorphic CAG repeats in the IT15 gene in Chinese normal and Huntington’s dis-ease(HD)chromosomes were determined by using nested PCR and denaturing polyacry-lamide gel electrophoretic autoradiography as well as direct sequencing analysis.A total of40 normal individuals and 122 members of 13 unrelated HD families originating from Shang-hai,Jiangsu,Zhejiang,Anhui,Shandong,Guangdong and Henan,respectively,were in-volved in this *** results showed that the(CAG)n repeat numbers in 270 normal al-leles ranged from 13 to 26 but most in 16;while in 54 HD alleles,the CAG repeats from 40to 94,with an unstable inheritance of expanded repeats in some *** was no over-lap between the normal and affected ***,the presymptomatic diagnosis in103 family members at risk for HD disclosed that 35 individuals had HD alleles,which were-in accordance with the pedigree analysis and clinical *** these results indicatedthat the dynamic mutation in IT15 gene was responsible for the genetic defect in the ChineseHD patients and that a correlation existed between the numbers of(CAG)n repeat and theonset age of the ***-of these provide valuable data for HD molecular diagnosis,ge-netic counselling and genetic health.

关键词： Huntington’s disease (HD) IT15 gene trinucleotide repeat.

慢性乙型肝炎患者免疫耐受和活动状态肝组织内HBsAg和HBcAg表达差异

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世界华人消化杂志 2017年第7期25卷 620-626页

作者：吴家箴黄仁刚杨兴祥四川省人民医院感染科四川省成都市610072

目的分析慢性乙型肝炎(chronic hepatitis B,CHB)患者在乙型肝炎病毒(hepatitis B virus,HBV)感染免疫耐受和活动状态的临床和病理学差别.方法选择102例CHB免疫耐受期患者组成免疫耐受组,215例CHB免疫清除期或再活动期患者组成免疫活动... 详细信息

目的分析慢性乙型肝炎(chronic hepatitis B,CHB)患者在乙型肝炎病毒(hepatitis B virus,HBV)感染免疫耐受和活动状态的临床和病理学差别.方法选择102例CHB免疫耐受期患者组成免疫耐受组,215例CHB免疫清除期或再活动期患者组成免疫活动组,分析两组间肝组织内乙型肝炎病毒表面抗原(hepatitis B surface antigen,HBsA g)和乙型肝炎核心抗原(hepatitis B core antigen,HBc Ag)的表达、性别、谷丙转氨酶、血清HBV DNA载量、肝脏炎症活动度分级(G)和纤维化分期(S)的差异.结果免疫耐受组的HBs Ag胞膜表达强度低于免疫活动组(P=0.037),而肝组织内HBc Ag表达强度、HBc Ag胞核表达强度显著高于免疫活动组(P=0.00).仅在免疫活动组,肝组织内HBs Ag表达强度与HBV DNA存在正相关性(P=0.019),肝组织内HBc Ag表达强度、HBc Ag胞浆和胞核表达强度与HBV DNA均存在正相关性(均P<0.05);肝组织内的HBc Ag表达强度和HBc Ag胞核表达强度与G、S存在负相关性(均P<0.05).仅在免疫耐受组,肝组织内的HBsAg胞浆表达强度与G、S存在正相关性(P=0.016和P=0.003).结论肝组织内的HBs Ag胞膜表达强度与CHB免疫活动程度呈正相关.肝细胞胞浆内表达的HBsAg有可能系免疫耐受状态机体攻击的靶抗原.肝细胞核内表达的HBc Ag即是CHB病毒复制,又是免疫耐受状态的打破进展至免疫活动状态的关键,也是肝组织炎症活跃和纤维化进展的关键.

关键词：免疫组织化学染色免疫耐受期乙型肝炎病毒表面抗原乙型肝炎核心抗原

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An Wen-Cheng An gang Fu Wei huang Hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

慢性HBV感染者肝脏病理及临床特征分析128例

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世界华人消化杂志 2009年第20期17卷 2099-2104页

作者：耿晓霞林健梅杨兴祥黄仁刚江南四川省医学科学院.四川省人民医院感染科四川省成都市610072

目的:比较慢性HBV携带者与血清ALT轻度升高慢性乙型肝炎患者肝组织病理学及临床改变的差异,并寻找与肝组织学改变相关的因素.方法:将128例患者按血清ALT水平分为3组:A组:ALT≤0.5×正常值上限(upper limits of normal,ULN),B组:0.5×ULN... 详细信息

目的:比较慢性HBV携带者与血清ALT轻度升高慢性乙型肝炎患者肝组织病理学及临床改变的差异,并寻找与肝组织学改变相关的因素.方法:将128例患者按血清ALT水平分为3组:A组:ALT≤0.5×正常值上限(upper limits of normal,ULN),B组:0.5×ULN0.05),C组的脾脏厚度较A组、B组显著增加(均P<0.01);随炎症分级的增加,血清ALT、脾脏厚度、门静脉宽度、肝内HBcAg阳性率显著增加(均P<0.05);脾脏厚度、门静脉宽度、血清HBeAg阴性患者比率随纤维化程度加重显著增加(均P<0.05).结论:慢性HBV感染者(ALT<2×ULN),肝组织均有不同程度炎症改变,伴或不伴纤维化改变,密切随访血清ALT、脾脏厚度、门静脉宽度、肝内HBcAg的表达,对于协助了解肝脏病变有一定的提示作用.

关键词：慢性乙型肝炎丙氨酸氨基转移酶组织病理学临床特征

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao huang Zhencheng huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

Efficient white-light-emitting lead-free halide double perovskites enabling full-spectrum pc-WLEDs

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Science China Materials 2025年第01期 305-306页

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

With the rapid development of solid-state lighting, an important goal of phosphor-converted white light-emitting diodes (pc-WLEDs) is to provide a healthy and comfortable fullspectrum artificial light source with a co...

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Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin